Strain Report - Rat Genome Database
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Strain: CDS/Ygl

Symbol: CDS/Ygl
Strain: CDS
Substrain: Ygl
Full Name: Cohen diabetic-sensitive rat
RGD ID: 1357191
RRID: RGD_1357191
Ontology ID: RS:0000181
Also known as: MDC-01-88; CDs/y
Type: inbred
Source: Hebrew University Hospital and Hadassah-Hebrew Medical College, Jerusalem, Israel
Origin: Cohen rats that had an oral tolerance test with blood glucose levels >180mg/dl were selected. More stringent criteria was set during the secondary inbreeding: rats with blood glucose levels >230mg/dl were selected. Brother and sister mating was carried on for 10 additional generations.
Last Known Status: Unknown





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Mammalian Phenotype

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References


Region

Strain QTL Data
Symbol Name Trait
Gluco32 Glucose level QTL 32 blood glucose amount   (VT:0000188)    
Gluco33 Glucose level QTL 33 blood glucose amount   (VT:0000188)    
Gluco34 Glucose level QTL 34 blood glucose amount   (VT:0000188)    
Gluco61 Glucose level QTL 61 blood glucose amount   (VT:0000188)    
Gluco62 Glucose level QTL 62 blood glucose amount   (VT:0000188)    
Gluco63 Glucose level QTL 63 blood glucose amount   (VT:0000188)    
Insul22 Insulin level QTL 22 blood insulin amount   (VT:0001560)    
Kidm43 Kidney mass QTL 43 kidney mass   (VT:0002707)    
Niddm71 Non-insulin dependent diabetes mellitus QTL 71 blood glucose amount   (VT:0000188)    
Niddm72 Non-insulin dependent diabetes mellitus QTL 72 blood glucose amount   (VT:0000188)    
Pancm3 Pancreatic morphology QTL 3 pancreas mass   (VT:0010144)    
Pancm4 Pancreatic morphology QTL 4 pancreas mass   (VT:0010144)    
Pur32 Proteinuria QTL 32 total urine protein amount   (VT:0000032)    
Rf60 Renal function QTL 60 blood creatinine amount   (VT:0005328)    
Rf61 Renal function QTL 61 blood creatinine amount   (VT:0005328)    
Rf62 Renal function QTL 62 blood urea nitrogen amount   (VT:0005265)    
Rf63 Renal function QTL 63 blood urea nitrogen amount   (VT:0005265)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Males that were fed the regular rat diet showed a 3 fold increase in their weight at 4-6 months whereas the males that were fed diabetogenic diet (high-sucrose low-copper) failed to thrive and doubles their weight in 4 months. Females did not show difference in growth curves irrespective of diet. 1342468
strain_characteristics They are sensitive to the diabetogenic diet. 1342468
strain_characteristics Females develop diabetes slower and show weaker metabloic phenotypes than males. 2326163
strain_life_disease 6-months old males that were fed the diabetogenic diet had low blood pressure. 1342468
strain_life_disease Males that were fed the diabetogenic diet showed increase in the blood glucose levels and became overtly diabetic. 1342468
strain_life_disease Basal fasting insulin levels were higher in these rats as compared to the CDR. 1342468
strain_life_disease Insulin levels were higher in animals that were fed diabetogenic diet than the ones fed regular diet. 1342468