Kdm5c (lysine demethylase 5C) - Rat Genome Database

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Gene: Kdm5c (lysine demethylase 5C) Rattus norvegicus
Analyze
Symbol: Kdm5c
Name: lysine demethylase 5C
RGD ID: 1560601
Description: Predicted to enable several functions, including histone H3K4 demethylase activity; identical protein binding activity; and zinc ion binding activity. Involved in response to toxic substance. Predicted to be located in cytosol and nucleoplasm. Biomarker of schizophrenia. Human ortholog(s) of this gene implicated in descending colon cancer and syndromic X-linked intellectual disability Claes-Jensen type. Orthologous to human KDM5C (lysine demethylase 5C); PARTICIPATES IN histone modification pathway; renal cell carcinoma pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC102555632; LOC317432; lysine (K)-specific demethylase 5C; lysine-specific demethylase 5C; RGD1560601; similar to Jumonji/ARID domain-containing protein 1C (SmcX protein); similar to Jumonji/ARID domain-containing protein 1C (SmcX protein) (Xe169 protein); uncharacterized LOC102555632
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X24,821,568 - 24,866,423 (+)NCBIGRCr8
mRatBN7.2X21,345,459 - 21,387,045 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX21,345,481 - 21,381,870 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X22,302,664 - 22,349,298 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX22,302,485 - 22,348,627 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X64,226,119 - 64,277,476 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X41,742,803 - 41,779,479 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX21,607,558 - 21,644,634 (+)NCBICelera
Cytogenetic MapXq13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA)
cytoplasm  (ISO)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mutations in JARID1C are associated with X-linked mental retardation, short stature and hyperreflexia. Abidi FE, etal., J Med Genet. 2008 Dec;45(12):787-93. doi: 10.1136/jmg.2008.058990. Epub 2008 Aug 12.
2. Genetic pathways involved in carcinogenesis of clear cell renal cell carcinoma: genomics towards personalized medicine. Audenet F, etal., BJU Int. 2012 Jun;109(12):1864-70. doi: 10.1111/j.1464-410X.2011.10661.x. Epub 2011 Oct 28.
3. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
4. METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer. Chen X, etal., Mol Cancer. 2020 Jun 17;19(1):106. doi: 10.1186/s12943-020-01220-7.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Lysine-specific demethylase 5C promotes hepatocellular carcinoma cell invasion through inhibition BMP7 expression. Ji X, etal., BMC Cancer. 2015 Oct 26;15:801. doi: 10.1186/s12885-015-1798-4.
7. KDM5c Promotes Colon Cancer Cell Proliferation Through the FBXW7-c-Jun Regulatory Axis. Lin H, etal., Front Oncol. 2020 Sep 16;10:535449. doi: 10.3389/fonc.2020.535449. eCollection 2020.
8. Prenatal MAM administration affects histone H3 methylation in postnatal life in the rat medial prefrontal cortex. Mackowiak M, etal., Eur Neuropsychopharmacol. 2014 Feb;24(2):271-89. doi: 10.1016/j.euroneuro.2013.05.013. Epub 2013 Aug 8.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. A novel c.2T > C mutation of the KDM5C/JARID1C gene in one large family with X-linked intellectual disability. Ounap K, etal., Eur J Med Genet. 2012 Mar;55(3):178-84. doi: 10.1016/j.ejmg.2012.01.004. Epub 2012 Jan 21.
11. Histone-modifier gene expression profiles are associated with pathological and clinical outcomes in human breast cancer. Patani N, etal., Anticancer Res. 2011 Dec;31(12):4115-25.
12. Impact of Patient Age on Molecular Alterations of Left-Sided Colorectal Tumors. Puccini A, etal., Oncologist. 2019 Mar;24(3):319-326. doi: 10.1634/theoncologist.2018-0117. Epub 2018 Jul 17.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Targeting H3K4 trimethylation in Huntington disease. Vashishtha M, etal., Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):E3027-36. doi: 10.1073/pnas.1311323110. Epub 2013 Jul 19.
18. Enhancement of Proliferation and Invasion of Gastric Cancer Cell by KDM5C Via Decrease in p53 Expression. Xu L, etal., Technol Cancer Res Treat. 2017 Apr;16(2):141-149. doi: 10.1177/1533034616629261. Epub 2016 Jul 8.
Additional References at PubMed
PMID:17320160   PMID:18078810   PMID:21960634   PMID:23246292   PMID:27214403   PMID:28262558  


Genomics

Comparative Map Data
Kdm5c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X24,821,568 - 24,866,423 (+)NCBIGRCr8
mRatBN7.2X21,345,459 - 21,387,045 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX21,345,481 - 21,381,870 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X22,302,664 - 22,349,298 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX22,302,485 - 22,348,627 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X64,226,119 - 64,277,476 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X41,742,803 - 41,779,479 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX21,607,558 - 21,644,634 (+)NCBICelera
Cytogenetic MapXq13NCBI
KDM5C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X53,176,277 - 53,225,207 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX53,176,283 - 53,225,422 (-)EnsemblGRCh38hg38GRCh38
GRCh37X53,205,459 - 53,254,389 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X53,237,378 - 53,271,329 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X53,104,473 - 53,137,625NCBI
CeleraX57,049,741 - 57,083,840 (-)NCBICelera
Cytogenetic MapXp11.22NCBI
HuRefX50,285,660 - 50,319,741 (-)NCBIHuRef
CHM1_1X53,210,762 - 53,244,827 (-)NCBICHM1_1
T2T-CHM13v2.0X52,462,547 - 52,511,471 (-)NCBIT2T-CHM13v2.0
Kdm5c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X151,015,698 - 151,062,098 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX151,016,016 - 151,057,531 (+)EnsemblGRCm39 Ensembl
GRCm38X152,233,198 - 152,279,102 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX152,233,020 - 152,274,535 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X148,667,773 - 148,708,897 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X147,573,988 - 147,614,512 (+)NCBIMGSCv36mm8
MGSCv36X129,241,757 - 129,282,281 (+)NCBIMGSCv36mm8
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
Kdm5c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955475243,666 - 278,627 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955475243,666 - 278,064 (-)NCBIChiLan1.0ChiLan1.0
KDM5C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X54,575,441 - 54,624,693 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X54,550,331 - 54,628,125 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X45,377,609 - 45,440,025 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X53,486,874 - 53,548,785 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX53,515,886 - 53,548,785 (-)Ensemblpanpan1.1panPan2
KDM5C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X44,921,271 - 44,953,338 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX44,921,816 - 44,952,616 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX36,478,724 - 36,508,722 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X45,270,006 - 45,300,013 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX45,269,379 - 45,300,556 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X44,765,224 - 44,795,215 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X45,214,884 - 45,244,860 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X45,282,205 - 45,312,192 (-)NCBIUU_Cfam_GSD_1.0
Kdm5c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X37,818,558 - 37,864,411 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936751167,920 - 203,966 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936751159,628 - 204,136 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KDM5C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX45,968,814 - 46,003,215 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X45,968,812 - 46,003,215 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X51,468,791 - 51,503,194 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KDM5C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X49,306,472 - 49,356,151 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX49,321,173 - 49,356,100 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660863,259,499 - 3,309,984 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kdm5c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624909420,077 - 455,309 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624909421,033 - 455,201 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kdm5c
131 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:257
Count of miRNA genes:174
Interacting mature miRNAs:197
Transcripts:ENSRNOT00000004600, ENSRNOT00000067288, ENSRNOT00000067782, ENSRNOT00000071867
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat

Markers in Region
RH137280  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X21,371,310 - 21,371,521 (+)MAPPERmRatBN7.2
Rnor_6.0X22,338,459 - 22,338,669NCBIRnor6.0
Rnor_6.0X22,328,450 - 22,328,660NCBIRnor6.0
Rnor_5.0X64,249,512 - 64,249,722UniSTSRnor5.0
Rnor_5.0X64,241,131 - 64,241,341UniSTSRnor5.0
RGSC_v3.4X41,768,854 - 41,769,064UniSTSRGSC3.4
RGSC_v3.41109,979,145 - 109,979,355UniSTSRGSC3.4
CeleraX21,633,283 - 21,633,493UniSTS
Cytogenetic MapXq21UniSTS
RH138851  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X21,351,028 - 21,351,193 (+)MAPPERmRatBN7.2
Rnor_6.0X22,308,246 - 22,308,410NCBIRnor6.0
Rnor_5.0X64,271,743 - 64,271,907UniSTSRnor5.0
RGSC_v3.4X41,748,357 - 41,748,521UniSTSRGSC3.4
CeleraX21,613,117 - 21,613,281UniSTS
Cytogenetic MapXq21UniSTS
Smcx  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.4X41,778,087 - 41,778,521UniSTSRGSC3.4
CeleraX21,618,170 - 21,619,375UniSTS
Cytogenetic MapXq21UniSTS
Smcx  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X21,381,268 - 21,381,703 (+)MAPPERmRatBN7.2
Rnor_6.0X22,347,905 - 22,348,339NCBIRnor6.0
Rnor_5.0X64,231,461 - 64,231,895UniSTSRnor5.0
RGSC_v3.4X41,778,087 - 41,778,521UniSTSRGSC3.4
CeleraX21,643,241 - 21,643,675UniSTS
Cytogenetic MapXq21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001419772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001064297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006227304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006227305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006227306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide FQ213185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GAPM01000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000077528   ⟹   ENSRNOP00000074157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX22,342,308 - 22,348,627 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078617   ⟹   ENSRNOP00000075375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX22,302,703 - 22,328,423 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079909   ⟹   ENSRNOP00000071836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX21,345,481 - 21,381,870 (+)Ensembl
Rnor_6.0 EnsemblX22,342,308 - 22,348,233 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082725   ⟹   ENSRNOP00000074522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX21,345,481 - 21,381,870 (+)Ensembl
Rnor_6.0 EnsemblX22,313,028 - 22,347,836 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082902   ⟹   ENSRNOP00000070936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX22,302,485 - 22,328,423 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086952   ⟹   ENSRNOP00000069719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX21,345,804 - 21,371,481 (+)Ensembl
Rnor_6.0 EnsemblX22,302,714 - 22,328,423 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087945   ⟹   ENSRNOP00000072650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX22,342,308 - 22,348,233 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX22,302,719 - 22,314,731 (+)Ensembl
RefSeq Acc Id: NM_001419772   ⟹   NP_001406701
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X24,824,874 - 24,866,423 (+)NCBI
mRatBN7.2X21,345,490 - 21,387,045 (+)NCBI
RefSeq Acc Id: XM_039100481   ⟹   XP_038956409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X24,821,568 - 24,866,423 (+)NCBI
mRatBN7.2X21,345,804 - 21,381,200 (+)NCBI
RefSeq Acc Id: XM_039100482   ⟹   XP_038956410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X24,821,568 - 24,866,423 (+)NCBI
mRatBN7.2X21,345,804 - 21,381,728 (+)NCBI
RefSeq Acc Id: XM_039100483   ⟹   XP_038956411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X24,821,568 - 24,866,423 (+)NCBI
mRatBN7.2X21,345,460 - 21,381,728 (+)NCBI
RefSeq Acc Id: XM_039100484   ⟹   XP_038956412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X24,821,568 - 24,866,423 (+)NCBI
mRatBN7.2X21,345,460 - 21,387,045 (+)NCBI
RefSeq Acc Id: XM_039100485   ⟹   XP_038956413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X24,821,568 - 24,866,423 (+)NCBI
mRatBN7.2X21,345,804 - 21,381,728 (+)NCBI
RefSeq Acc Id: XM_039100486   ⟹   XP_038956414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X24,821,568 - 24,866,423 (+)NCBI
mRatBN7.2X21,345,459 - 21,387,045 (+)NCBI
RefSeq Acc Id: XM_039100487   ⟹   XP_038956415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X24,821,568 - 24,859,885 (+)NCBI
mRatBN7.2X21,345,460 - 21,380,566 (+)NCBI
RefSeq Acc Id: XM_063280073   ⟹   XP_063136143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X24,821,568 - 24,866,423 (+)NCBI
RefSeq Acc Id: XM_063280074   ⟹   XP_063136144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X24,821,568 - 24,866,423 (+)NCBI
RefSeq Acc Id: XM_063280075   ⟹   XP_063136145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X24,821,568 - 24,866,423 (+)NCBI
Ensembl Acc Id: ENSRNOP00000070936   ⟸   ENSRNOT00000082902
Ensembl Acc Id: ENSRNOP00000074522   ⟸   ENSRNOT00000082725
Ensembl Acc Id: ENSRNOP00000072650   ⟸   ENSRNOT00000087945
Ensembl Acc Id: ENSRNOP00000074157   ⟸   ENSRNOT00000077528
Ensembl Acc Id: ENSRNOP00000071836   ⟸   ENSRNOT00000079909
Ensembl Acc Id: ENSRNOP00000069719   ⟸   ENSRNOT00000086952
Ensembl Acc Id: ENSRNOP00000075375   ⟸   ENSRNOT00000078617
RefSeq Acc Id: XP_038956414   ⟸   XM_039100486
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038956412   ⟸   XM_039100484
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038956411   ⟸   XM_039100483
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038956415   ⟸   XM_039100487
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038956410   ⟸   XM_039100482
- Peptide Label: isoform X2
- UniProtKB: V9GW19 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956413   ⟸   XM_039100485
- Peptide Label: isoform X6
- UniProtKB: A0A0G2K897 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956409   ⟸   XM_039100481
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001406701   ⟸   NM_001419772
- UniProtKB: A0A0G2K1H0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136145   ⟸   XM_063280075
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063136143   ⟸   XM_063280073
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063136144   ⟸   XM_063280074
- Peptide Label: isoform X7
Protein Domains
ARID   JmjC   JmjN   PHD-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K897-F1-model_v2 AlphaFold A0A0G2K897 1-1332 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701777
Promoter ID:EPDNEW_R12296
Type:multiple initiation site
Name:Kdm5c_1
Description:Lysine-specific demethylase 5C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X22,302,711 - 22,302,771EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560601 AgrOrtholog
BioCyc Gene G2FUF-2716 BioCyc
Ensembl Genes ENSRNOG00000057706 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079909.2 UniProtKB/TrEMBL
  ENSRNOT00000082725.2 UniProtKB/TrEMBL
  ENSRNOT00000086952.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.60 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  Cupin UniProtKB/TrEMBL
InterPro ARID/BRIGHT_DNA-bd UniProtKB/TrEMBL
  ARID_dom_sf UniProtKB/TrEMBL
  JmjC_dom UniProtKB/TrEMBL
  KDM5_C-hel UniProtKB/TrEMBL
  Lys_sp_deMease_like_dom UniProtKB/TrEMBL
  TF_JmjN UniProtKB/TrEMBL
  Zinc_finger_PHD-type_CS UniProtKB/TrEMBL
  Znf_C5HC2 UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_PHD UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene 317432 ENTREZGENE
PANTHER LYSINE-SPECIFIC DEMETHYLASE UniProtKB/TrEMBL
  LYSINE-SPECIFIC DEMETHYLASE 5C UniProtKB/TrEMBL
Pfam ARID UniProtKB/TrEMBL
  JmjC UniProtKB/TrEMBL
  JmjN UniProtKB/TrEMBL
  KDM5_C-hel UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
  PLU-1 UniProtKB/TrEMBL
  zf-C5HC2 UniProtKB/TrEMBL
PhenoGen Kdm5c PhenoGen
PROSITE ARID UniProtKB/TrEMBL
  JMJC UniProtKB/TrEMBL
  JMJN UniProtKB/TrEMBL
  ZF_PHD_1 UniProtKB/TrEMBL
  ZF_PHD_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000057706 RatGTEx
SMART ARID UniProtKB/TrEMBL
  BRIGHT UniProtKB/TrEMBL
  JmjC UniProtKB/TrEMBL
  JmjN UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
Superfamily-SCOP Clavaminate synthase-like UniProtKB/TrEMBL
  FYVE_PHD_ZnF UniProtKB/TrEMBL
  SSF46774 UniProtKB/TrEMBL
UniProt A0A0G2JW30_RAT UniProtKB/TrEMBL
  A0A0G2K1H0 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K897 ENTREZGENE, UniProtKB/TrEMBL
  V9GW19 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Kdm5c  lysine demethylase 5C  Kdm5c  lysine (K)-specific demethylase 5C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 Kdm5c  lysine (K)-specific demethylase 5C  LOC102555632  uncharacterized LOC102555632  Data merged from RGD:7576436 737654 PROVISIONAL
2013-12-18 LOC102555632  uncharacterized LOC102555632      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-11-25 Kdm5c  lysine (K)-specific demethylase 5C  RGD1560601  similar to Jumonji/ARID domain-containing protein 1C (SmcX protein)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560601  similar to Jumonji/ARID domain-containing protein 1C (SmcX protein)   RGD1560601_predicted  similar to Jumonji/ARID domain-containing protein 1C (SmcX protein) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-10 RGD1560601_predicted  similar to Jumonji/ARID domain-containing protein 1C (SmcX protein) (predicted)    similar to Jumonji/ARID domain-containing protein 1C (SmcX protein) (Xe169 protein) (predicted)  Name updated 1299863 APPROVED
2006-03-07 RGD1560601_predicted  similar to Jumonji/ARID domain-containing protein 1C (SmcX protein) (Xe169 protein) (predicted)  LOC317432  similar to Jumonji/ARID domain-containing protein 1C (SmcX protein) (Xe169 protein)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC317432  similar to Jumonji/ARID domain-containing protein 1C (SmcX protein) (Xe169 protein)      Symbol and Name status set to provisional 70820 PROVISIONAL