Hebrew University Hospital and Hadassah-Hebrew Medical College, Jerusalem, Israel; Israeli Rat Genome Center, Ashkelon, Israel
Cohen rats that had an oral tolerance test with blood glucose levels <180mg/dl were selected. More stringent criteria was set during the secondary inbreeding: rats with blood glucose levels <140mg/dl were selected. Brother and sister mating was carried on for 10 additional generations.
Males that were fed the regular rat diet showed a 3 fold increase in their weight at 4-6 months whereas the males that were fed diabetogenic diet grew at the same rate. Females did not show difference in growth curves irrespective of diet.