Ap1s2 (adaptor related protein complex 1 subunit sigma 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ap1s2 (adaptor related protein complex 1 subunit sigma 2) Rattus norvegicus
Analyze
Symbol: Ap1s2
Name: adaptor related protein complex 1 subunit sigma 2
RGD ID: 1561862
Description: Predicted to be involved in several processes, including adipose tissue development; synaptic vesicle budding from endosome; and visual learning. Predicted to localize to Golgi apparatus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability 5. Orthologous to human AP1S2 (adaptor related protein complex 1 subunit sigma 2); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: adaptor-related protein complex 1, sigma 2 subunit; AP-1 complex subunit sigma-2; LOC302671; RGD1561862; similar to Adapter-related protein complex 1 sigma 1B subunit (Sigma-adaptin 1B) (Adaptor protein complex AP-1 sigma-1B subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Clathrin assembly protein complex 1 sigma-1B small chain) (Sigma 1B s...; similar to Adapter-related protein complex 1 sigma 2 subunit (Sigma-adaptin 1B)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X30,572,746 - 30,598,961 (-)NCBI
Rnor_6.0 EnsemblX32,329,598 - 32,355,307 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X32,329,883 - 32,376,301 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X32,691,539 - 32,717,224 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X51,329,574 - 51,356,406 (-)NCBIRGSC3.4rn4RGSC3.4
CeleraX30,915,890 - 30,941,975 (-)NCBICelera
Cytogenetic MapXq14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
carmustine  (ISO)
choline  (ISO)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
L-methionine  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
N-nitrosodimethylamine  (EXP)
paracetamol  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium fluoride  (EXP)
tamibarotene  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:12477932   PMID:20203623   PMID:24928897  


Genomics

Comparative Map Data
Ap1s2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X30,572,746 - 30,598,961 (-)NCBI
Rnor_6.0 EnsemblX32,329,598 - 32,355,307 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X32,329,883 - 32,376,301 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X32,691,539 - 32,717,224 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X51,329,574 - 51,356,406 (-)NCBIRGSC3.4rn4RGSC3.4
CeleraX30,915,890 - 30,941,975 (-)NCBICelera
Cytogenetic MapXq14NCBI
AP1S2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX15,825,806 - 15,854,931 (-)EnsemblGRCh38hg38GRCh38
GRCh38X15,825,806 - 15,854,966 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X15,843,929 - 15,872,936 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,753,850 - 15,783,021 (-)NCBINCBI36hg18NCBI36
Build 34X15,603,585 - 15,632,757NCBI
CeleraX19,961,411 - 19,990,500 (-)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX13,597,581 - 13,626,785 (-)NCBIHuRef
CHM1_1X15,874,896 - 15,904,078 (-)NCBICHM1_1
Ap1s2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X162,691,427 - 162,716,662 (+)NCBIGRCm39mm39
GRCm39 EnsemblX162,692,013 - 162,716,662 (+)Ensembl
GRCm38X163,908,454 - 163,933,666 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX163,909,017 - 163,933,666 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X160,347,092 - 160,367,478 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X159,253,265 - 159,273,651 (+)NCBImm8
CeleraX147,128,574 - 147,148,961 (+)NCBICelera
Cytogenetic MapXF5NCBI
Ap1s2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555192,351,754 - 2,370,650 (+)NCBIChiLan1.0ChiLan1.0
AP1S2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X15,807,475 - 15,835,938 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX15,807,476 - 15,836,172 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X8,449,885 - 8,478,932 (-)NCBIMhudiblu_PPA_v0panPan3
AP1S2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X12,075,797 - 12,105,911 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX12,076,724 - 12,103,654 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX11,926,084 - 11,956,371 (-)NCBI
ROS_Cfam_1.0X12,037,006 - 12,067,314 (-)NCBI
UMICH_Zoey_3.1X12,106,135 - 12,136,551 (-)NCBI
UNSW_CanFamBas_1.0X12,093,621 - 12,123,810 (-)NCBI
UU_Cfam_GSD_1.0X12,118,821 - 12,149,359 (-)NCBI
Ap1s2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X5,251,240 - 5,289,320 (-)NCBI
SpeTri2.0NW_0049364705,260,984 - 5,301,552 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AP1S2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX12,367,156 - 12,398,496 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X12,367,785 - 12,397,672 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X13,312,013 - 13,341,898 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AP1S2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X14,283,175 - 14,310,453 (-)NCBI
Ap1s2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624829608,065 - 637,096 (-)NCBI

Position Markers
RH130941  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X30,572,792 - 30,572,981 (+)MAPPER
Rnor_6.0X32,329,927 - 32,330,115NCBIRnor6.0
Rnor_5.0X32,691,585 - 32,691,773UniSTSRnor5.0
RGSC_v3.4X51,329,618 - 51,329,806UniSTSRGSC3.4
CeleraX30,915,934 - 30,916,122UniSTS
RH 3.4 MapX427.23UniSTS
Cytogenetic MapXq21UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X144092703Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X166260933443848Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X428214049282140Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X595407850954078Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X15688119127888215Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1815335263153352Rat
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2159262344320739Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2159262344468300Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:431
Count of miRNA genes:216
Interacting mature miRNAs:268
Transcripts:ENSRNOT00000065075
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 39 8 19 6 8 74 2 33 11 6
Low 1 4 49 41 41 2 3 33 8 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001127531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005497961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC166480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000065075   ⟹   ENSRNOP00000063764
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX32,329,883 - 32,355,307 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081652   ⟹   ENSRNOP00000070442
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX32,329,598 - 32,355,296 (-)Ensembl
RefSeq Acc Id: NM_001127531   ⟹   NP_001121003
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X30,572,749 - 30,598,832 (-)NCBI
Rnor_6.0X32,329,883 - 32,355,307 (-)NCBI
Rnor_5.0X32,691,539 - 32,717,224 (-)NCBI
RGSC_v3.4X51,329,574 - 51,356,406 (-)RGD
CeleraX30,915,890 - 30,941,975 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256860   ⟹   XP_006256922
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X30,572,746 - 30,598,953 (-)NCBI
Rnor_6.0X32,329,883 - 32,355,440 (-)NCBI
Rnor_5.0X32,691,539 - 32,717,224 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256862   ⟹   XP_006256924
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X30,576,660 - 30,598,958 (-)NCBI
Rnor_6.0X32,333,795 - 32,355,441 (-)NCBI
Rnor_5.0X32,691,539 - 32,717,224 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017602005   ⟹   XP_017457494
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X32,333,795 - 32,371,306 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017602006   ⟹   XP_017457495
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X32,329,883 - 32,371,306 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017602007   ⟹   XP_017457496
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X32,333,795 - 32,371,306 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017602009   ⟹   XP_017457498
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X32,329,883 - 32,376,301 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017602010   ⟹   XP_017457499
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X32,329,883 - 32,376,301 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099658   ⟹   XP_038955586
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X30,576,660 - 30,598,961 (-)NCBI
RefSeq Acc Id: XM_039099659   ⟹   XP_038955587
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X30,576,660 - 30,598,961 (-)NCBI
RefSeq Acc Id: XM_039099660   ⟹   XP_038955588
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X30,576,660 - 30,598,961 (-)NCBI
RefSeq Acc Id: XM_039099661   ⟹   XP_038955589
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X30,572,746 - 30,594,447 (-)NCBI
RefSeq Acc Id: XR_005497961
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X30,572,746 - 30,598,960 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001121003   ⟸   NM_001127531
- UniProtKB: B2GV08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256922   ⟸   XM_006256860
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006256924   ⟸   XM_006256862
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017457498   ⟸   XM_017602009
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017457499   ⟸   XM_017602010
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017457495   ⟸   XM_017602006
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017457496   ⟸   XM_017602007
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017457494   ⟸   XM_017602005
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000063764   ⟸   ENSRNOT00000065075
RefSeq Acc Id: ENSRNOP00000070442   ⟸   ENSRNOT00000081652
RefSeq Acc Id: XP_038955589   ⟸   XM_039099661
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038955587   ⟸   XM_039099659
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038955588   ⟸   XM_039099660
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038955586   ⟸   XM_039099658
- Peptide Label: isoform X2
Protein Domains
Clat_adaptor_s

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701801
Promoter ID:EPDNEW_R12325
Type:multiple initiation site
Name:Ap1s2_1
Description:adaptor-related protein complex 1, sigma 2 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X32,355,318 - 32,355,378EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561862 AgrOrtholog
Ensembl Genes ENSRNOG00000038686 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000063764 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000070442 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065075 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000081652 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9102341 IMAGE-MGC_LOAD
InterPro AP_complex_ssu UniProtKB/TrEMBL
  AP_mu_sigma_su UniProtKB/TrEMBL
  Clathrin_sigma/coatomer_zeta UniProtKB/TrEMBL
  Longin-like UniProtKB/TrEMBL
KEGG Report rno:302671 UniProtKB/TrEMBL
MGC_CLONE MGC:187937 IMAGE-MGC_LOAD
NCBI Gene 302671 ENTREZGENE
PANTHER PTHR11753 UniProtKB/TrEMBL
Pfam Clat_adaptor_s UniProtKB/TrEMBL
PharmGKB AP1S2 RGD
PhenoGen Ap1s2 PhenoGen
PIRSF AP_complex_sigma UniProtKB/TrEMBL
PROSITE CLAT_ADAPTOR_S UniProtKB/TrEMBL
Superfamily-SCOP Longin_like UniProtKB/TrEMBL
UniProt A0A0G2JXX9_RAT UniProtKB/TrEMBL
  B2GV08 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-03 Ap1s2  adaptor related protein complex 1 subunit sigma 2  Ap1s2  adaptor-related protein complex 1, sigma 2 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ap1s2  adaptor-related protein complex 1, sigma 2 subunit   Ap1s2_predicted  adaptor-related protein complex 1, sigma 2 subunit (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Ap1s2_predicted  adaptor-related protein complex 1, sigma 2 subunit (predicted)  RGD1561862_predicted  similar to Adapter-related protein complex 1 sigma 2 subunit (Sigma-adaptin 1B) (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-10 RGD1561862_predicted  similar to Adapter-related protein complex 1 sigma 2 subunit (Sigma-adaptin 1B) (predicted)    similar to Adapter-related protein complex 1 sigma 1B subunit (Sigma-adaptin 1B) (Adaptor protein complex AP-1 sigma-1B subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Clathrin assembly protein complex 1 sigma-1B small chain) (Sigma 1B s... (predicted)  Name updated 1299863 APPROVED
2006-03-07 RGD1561862_predicted  similar to Adapter-related protein complex 1 sigma 1B subunit (Sigma-adaptin 1B) (Adaptor protein complex AP-1 sigma-1B subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Clathrin assembly protein complex 1 sigma-1B small chain) (Sigma 1B s... (predicted)  LOC302671  similar to Adapter-related protein complex 1 sigma 1B subunit (Sigma-adaptin 1B) (Adaptor protein complex AP-1 sigma-1B subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Clathrin assembly protein complex 1 sigma-1B small chain) (Sigma 1B s...  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC302671  similar to Adapter-related protein complex 1 sigma 1B subunit (Sigma-adaptin 1B) (Adaptor protein complex AP-1 sigma-1B subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Clathrin assembly protein complex 1 sigma-1B small chain) (Sigma 1B s...      Symbol and Name status set to provisional 70820 PROVISIONAL