Pdha1 (pyruvate dehydrogenase E1 subunit alpha 1) - Rat Genome Database

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Gene: Pdha1 (pyruvate dehydrogenase E1 subunit alpha 1) Rattus norvegicus
Analyze
Symbol: Pdha1
Name: pyruvate dehydrogenase E1 subunit alpha 1
RGD ID: 3286
Description: Enables pyruvate dehydrogenase (acetyl-transferring) activity. Involved in acetyl-CoA biosynthetic process from pyruvate. Part of pyruvate dehydrogenase complex. Used to study pyruvate decarboxylase deficiency. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; Leigh disease pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC114215; MGC94854; PDHE1-A type I; pyruvate dehydrogenase (lipoamide) alpha 1; pyruvate dehydrogenase alpha 1; pyruvate dehydrogenase E1 alpha 1; pyruvate dehydrogenase E1 alpha 1 subunit; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; pyruvate dehydrogenase E1alpha subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Pdha1l1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X38,509,158 - 38,522,986 (+)NCBIGRCr8
mRatBN7.2X34,700,481 - 34,714,309 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX34,700,409 - 34,714,311 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX35,837,874 - 35,851,694 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X39,301,516 - 39,315,336 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X34,467,574 - 34,481,394 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X37,329,779 - 37,343,410 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX37,329,779 - 37,343,410 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X37,640,725 - 37,654,356 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X55,899,491 - 55,913,319 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X55,952,967 - 55,966,789 (+)NCBI
CeleraX35,373,056 - 35,386,884 (+)NCBICelera
Cytogenetic MapXq14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
angiotensin II  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
celastrol  (ISO)
ciguatoxin CTX1B  (ISO)
cobalt dichloride  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
dinophysistoxin 1  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
duvoglustat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
Fusaric acid  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glucose  (ISO)
hydrogen peroxide  (ISO)
Ile(5)-angiotensin II  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
kojic acid  (ISO)
maneb  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methyl methanesulfonate  (ISO)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mitoxantrone  (ISO)
N-acetyl-L-cysteine  (ISO)
nefazodone  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (EXP)
perfluorooctanoic acid  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quinoline  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
sodium arsenite  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
superoxide  (ISO)
temozolomide  (ISO)
titanium dioxide  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The pyruvate dehydrogenase complex: cloning of the rat somatic E1 alpha subunit and its coordinate expression with the mRNAs for the E1 beta, E2, and E3 catalytic subunits in developing rat brain. Cullingford TE, etal., J Neurochem 1994 May;62(5):1682-90.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Mutations in the X-linked pyruvate dehydrogenase (E1) alpha subunit gene (PDHA1) in patients with a pyruvate dehydrogenase complex deficiency. Lissens W, etal., Hum Mutat 2000;15(3):209-19.
6. Pretranslational regulation of pyruvate dehydrogenase complex subunits in white adipose tissue during the suckling-weaning transition in the rat. Maury J, etal., Biochem J. 1995 Oct 15;311 ( Pt 2):531-5.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. An animal model of PDH deficiency using AAV8-siRNA vector-mediated knockdown of pyruvate dehydrogenase E1a. Ojano-Dirain C, etal., Mol Genet Metab. 2010 Oct-Nov;101(2-3):183-91. doi: 10.1016/j.ymgme.2010.07.008. Epub 2010 Jul 15.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases. Patel MS and Korotchkina LG, Exp Mol Med. 2001 Dec 31;33(4):191-7.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. Mutational study in the PDHA1 gene of 40 patients suspected of pyruvate dehydrogenase complex deficiency. Quintana E, etal., Clin Genet. 2010 May;77(5):474-82. doi: 10.1111/j.1399-0004.2009.01313.x. Epub 2009 Dec 10.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:2025639   PMID:11708858   PMID:14651853   PMID:16641100   PMID:17634366   PMID:18586888   PMID:18614015   PMID:19081061   PMID:19429050   PMID:20833797   PMID:21630459   PMID:22809973  
PMID:26503465   PMID:27871875   PMID:28376086   PMID:29476059   PMID:35352799  


Genomics

Comparative Map Data
Pdha1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X38,509,158 - 38,522,986 (+)NCBIGRCr8
mRatBN7.2X34,700,481 - 34,714,309 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX34,700,409 - 34,714,311 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX35,837,874 - 35,851,694 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X39,301,516 - 39,315,336 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X34,467,574 - 34,481,394 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X37,329,779 - 37,343,410 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX37,329,779 - 37,343,410 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X37,640,725 - 37,654,356 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X55,899,491 - 55,913,319 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X55,952,967 - 55,966,789 (+)NCBI
CeleraX35,373,056 - 35,386,884 (+)NCBICelera
Cytogenetic MapXq14NCBI
PDHA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X19,343,927 - 19,361,718 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX19,343,893 - 19,361,718 (+)EnsemblGRCh38hg38GRCh38
GRCh37X19,362,045 - 19,379,836 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X19,271,972 - 19,287,886 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X19,121,707 - 19,137,622NCBI
CeleraX23,483,337 - 23,501,163 (+)NCBICelera
Cytogenetic MapXp22.12NCBI
HuRefX17,111,170 - 17,129,001 (+)NCBIHuRef
CHM1_1X19,393,050 - 19,410,882 (+)NCBICHM1_1
T2T-CHM13v2.0X18,926,645 - 18,944,454 (+)NCBIT2T-CHM13v2.0
Pdha1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X158,905,215 - 158,921,426 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX158,905,205 - 158,921,409 (-)EnsemblGRCm39 Ensembl
GRCm38X160,122,219 - 160,138,430 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX160,122,209 - 160,138,413 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X156,560,151 - 156,576,268 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X155,466,324 - 155,482,441 (-)NCBIMGSCv36mm8
CeleraX143,366,647 - 143,382,812 (-)NCBICelera
Cytogenetic MapXF4NCBI
cM MapX73.95NCBI
Pdha1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495558697,172 - 114,928 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495558698,492 - 114,927 (-)NCBIChiLan1.0ChiLan1.0
PDHA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X21,143,429 - 21,161,379 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X21,146,848 - 21,164,769 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X11,967,944 - 11,985,837 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X19,330,622 - 19,348,443 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX19,330,508 - 19,348,443 (+)Ensemblpanpan1.1panPan2
PDHA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X15,338,364 - 15,354,011 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX15,338,202 - 15,387,458 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X15,298,232 - 15,314,012 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX15,298,193 - 15,314,012 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X15,346,993 - 15,362,754 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X15,348,770 - 15,364,534 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X15,416,047 - 15,431,830 (+)NCBIUU_Cfam_GSD_1.0
Pdha1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X8,400,113 - 8,416,930 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936844889,635 - 909,586 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936844889,720 - 906,631 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDHA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX15,700,050 - 15,718,903 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X15,699,924 - 15,718,908 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X16,947,200 - 16,966,053 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDHA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X17,804,123 - 17,820,087 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605619,671,536 - 19,689,681 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdha1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248294,154,066 - 4,169,670 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248294,154,143 - 4,170,726 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pdha1
17 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:339
Count of miRNA genes:219
Interacting mature miRNAs:257
Transcripts:ENSRNOT00000038352
Prediction methods:Miranda, Pita
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat

Markers in Region
AI170398  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X34,714,460 - 34,714,644 (+)MAPPERmRatBN7.2
Rnor_6.0X37,343,562 - 37,343,745NCBIRnor6.0
Rnor_5.0X37,654,508 - 37,654,691UniSTSRnor5.0
RGSC_v3.4X55,913,471 - 55,913,654UniSTSRGSC3.4
CeleraX35,387,036 - 35,387,219UniSTS
RH 3.4 MapX500.8UniSTS
Cytogenetic MapXq21UniSTS
RH144218  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X34,712,636 - 34,712,737 (+)MAPPERmRatBN7.2
Rnor_6.0X37,341,738 - 37,341,838NCBIRnor6.0
Rnor_5.0X37,652,684 - 37,652,784UniSTSRnor5.0
RGSC_v3.4X55,911,647 - 55,911,747UniSTSRGSC3.4
CeleraX35,385,212 - 35,385,312UniSTS
Cytogenetic MapXq21UniSTS
AA819807  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X34,713,892 - 34,714,106 (+)MAPPERmRatBN7.2
mRatBN7.21682,511,694 - 82,511,908 (-)MAPPERmRatBN7.2
mRatBN7.2X34,713,892 - 34,714,106 (-)MAPPERmRatBN7.2
mRatBN7.21682,511,694 - 82,511,908 (+)MAPPERmRatBN7.2
Rnor_6.0X37,342,994 - 37,343,207NCBIRnor6.0
Rnor_6.01688,344,652 - 88,344,865NCBIRnor6.0
Rnor_5.01687,741,383 - 87,741,596UniSTSRnor5.0
Rnor_5.0X37,653,940 - 37,654,153UniSTSRnor5.0
RGSC_v3.4X55,912,903 - 55,913,116UniSTSRGSC3.4
RGSC_v3.41687,958,417 - 87,958,630UniSTSRGSC3.4
Celera1680,231,365 - 80,231,578UniSTS
CeleraX35,386,468 - 35,386,681UniSTS
Cytogenetic MapXq21UniSTS
RH141520  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21682,512,559 - 82,512,740 (-)MAPPERmRatBN7.2
mRatBN7.21682,512,559 - 82,512,740 (+)MAPPERmRatBN7.2
mRatBN7.2X34,713,049 - 34,713,230 (-)MAPPERmRatBN7.2
mRatBN7.2X34,713,049 - 34,713,230 (+)MAPPERmRatBN7.2
Rnor_6.0X37,342,151 - 37,342,331NCBIRnor6.0
Rnor_6.01688,345,517 - 88,345,697NCBIRnor6.0
Rnor_5.0X37,653,097 - 37,653,277UniSTSRnor5.0
Rnor_5.01687,742,248 - 87,742,428UniSTSRnor5.0
RGSC_v3.4X55,912,060 - 55,912,240UniSTSRGSC3.4
RGSC_v3.41687,959,282 - 87,959,462UniSTSRGSC3.4
Celera1680,232,230 - 80,232,410UniSTS
CeleraX35,385,625 - 35,385,805UniSTS
RH 3.4 MapX503.51UniSTS
Cytogenetic Map16q12.5UniSTS
Cytogenetic MapXq21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 34 11 8
Low 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000038352   ⟹   ENSRNOP00000030279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX34,700,409 - 34,714,311 (+)Ensembl
Rnor_6.0 EnsemblX37,329,779 - 37,343,410 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088802   ⟹   ENSRNOP00000069789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX34,704,381 - 34,714,299 (+)Ensembl
Rnor_6.0 EnsemblX37,329,817 - 37,341,807 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110948   ⟹   ENSRNOP00000094690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX34,704,570 - 34,714,299 (+)Ensembl
RefSeq Acc Id: NM_001004072   ⟹   NP_001004072
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X38,509,158 - 38,522,986 (+)NCBI
mRatBN7.2X34,700,481 - 34,714,309 (+)NCBI
Rnor_6.0X37,329,779 - 37,343,410 (+)NCBI
Rnor_5.0X37,640,725 - 37,654,356 (+)NCBI
RGSC_v3.4X55,899,491 - 55,913,319 (+)RGD
CeleraX35,373,056 - 35,386,884 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001004072 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98897 (Get FASTA)   NCBI Sequence Viewer  
  EDL96148 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000030279
  ENSRNOP00000030279.7
  ENSRNOP00000069789.2
  ENSRNOP00000094690.1
GenBank Protein P26284 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001004072   ⟸   NM_001004072
- Peptide Label: precursor
- UniProtKB: P26284 (UniProtKB/Swiss-Prot),   Q4FZZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000030279   ⟸   ENSRNOT00000038352
RefSeq Acc Id: ENSRNOP00000069789   ⟸   ENSRNOT00000088802
RefSeq Acc Id: ENSRNOP00000094690   ⟸   ENSRNOT00000110948
Protein Domains
Dehydrogenase E1 component

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26284-F1-model_v2 AlphaFold P26284 1-390 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701816
Promoter ID:EPDNEW_R12333
Type:initiation region
Name:Pdha1_1
Description:pyruvate dehydrogenase E1 alpha 1 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X37,329,767 - 37,329,827EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3286 AgrOrtholog
BioCyc Gene G2FUF-2492 BioCyc
Ensembl Genes ENSRNOG00000025383 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038352 ENTREZGENE
  ENSRNOT00000038352.7 UniProtKB/TrEMBL
  ENSRNOT00000088802.2 UniProtKB/TrEMBL
  ENSRNOT00000110948.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.970 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7103543 IMAGE-MGC_LOAD
  IMAGE:7109678 IMAGE-MGC_LOAD
InterPro DH_E1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_DH_E1_asu_subgrp-y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THDP-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29554 UniProtKB/TrEMBL
MGC_CLONE MGC:114215 IMAGE-MGC_LOAD
  MGC:94854 IMAGE-MGC_LOAD
NCBI Gene 29554 ENTREZGENE
PANTHER PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA, SOMATIC FORM, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam E1_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pdha1 PhenoGen
RatGTEx ENSRNOG00000025383 RatGTEx
Superfamily-SCOP SSF52518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JW90_RAT UniProtKB/TrEMBL
  A0A8I6GKV6_RAT UniProtKB/TrEMBL
  F7FKI5_RAT UniProtKB/TrEMBL
  ODPA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4FZZ4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Pdha1  pyruvate dehydrogenase E1 subunit alpha 1  Pdha1  pyruvate dehydrogenase E1 alpha 1 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-08-23 Pdha1  pyruvate dehydrogenase E1 alpha 1 subunit  Pdha1  pyruvate dehydrogenase alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-06-20 Pdha1  pyruvate dehydrogenase alpha 1  Pdha1  pyruvate dehydrogenase (lipoamide) alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-02-26 Pdha1  pyruvate dehydrogenase (lipoamide) alpha 1  Pdha1  pyruvate dehydrogenase E1 alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pdha1  Pyruvate dehydrogenase (lipoamide) alpha 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog is detected in patients with pyruvate dehydrogenase complex deficiency disease 731230