Gene: Pdha1 (pyruvate dehydrogenase E1 subunit alpha 1) Rattus norvegicus
Analyze
Symbol:
Pdha1
Name:
pyruvate dehydrogenase E1 subunit alpha 1
Description:
Exhibits pyruvate dehydrogenase (acetyl-transferring) activity. Involved in acetyl-CoA biosynthetic process from pyruvate. Localizes to mitochondrion and pyruvate dehydrogenase complex. Used to study pyruvate decarboxylase deficiency. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; Leigh disease pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
MGC114215; MGC94854; PDHE1-A type I; pyruvate dehydrogenase (lipoamide) alpha 1; pyruvate dehydrogenase alpha 1; pyruvate dehydrogenase E1 alpha 1; pyruvate dehydrogenase E1 alpha 1 subunit; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; pyruvate dehydrogenase E1alpha subunit
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Pdha1 (pyruvate dehydrogenase E1 alpha 1) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Pdha1 (pyruvate dehydrogenase E1 alpha 1 subunit) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Pdha1 (pyruvate dehydrogenase E1 alpha 1 subunit) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Pdha1 (pyruvate dehydrogenase E1 subunit alpha 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
PDHA2 (pyruvate dehydrogenase E1 subunit alpha 2) HGNC
OrthoDB, OrthoMCL, Panther
Alliance orthologs 3
Homo sapiens (human):
PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1)
Alliance
DIOPT (PANTHER|HGNC|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Mus musculus (house mouse):
Pdha1 (pyruvate dehydrogenase E1 alpha 1)
Alliance
DIOPT (PANTHER|OrthoInspector|TreeFam|OrthoFinder)
Danio rerio (zebrafish):
pdha1a (pyruvate dehydrogenase E1 alpha 1 subunit a)
Alliance
DIOPT (PANTHER|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Saccharomyces cerevisiae (baker's yeast):
PDA1
Alliance
DIOPT (PANTHER|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Drosophila melanogaster (fruit fly):
Pdha
Alliance
DIOPT (PANTHER|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Caenorhabditis elegans (roundworm):
pdha-1
Alliance
DIOPT (PANTHER|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Related Pseudogenes:
Pdha1l1
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 X 37,329,779 - 37,343,410 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl X 37,329,779 - 37,343,410 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 X 37,640,725 - 37,654,356 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 X 55,899,491 - 55,913,319 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 X 55,952,967 - 55,966,789 (+) NCBI Celera X 35,373,056 - 35,386,884 (+) NCBI Celera Cytogenetic Map X q14 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
autistic disorder ISO RGD:736556 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 epilepsy ISO RGD:736556 8554872 ClinVar Annotator: match by term: Seizures ClinVar PMID:25741868 genetic disease ISO RGD:736556 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10679936 more ... genetic disease ISO RGD:736556 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10679936 more ... genetic disease ISO RGD:736556 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10679936 more ... genetic disease ISO RGD:736556 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:28492532 genetic disease ISO RGD:736556 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10679936 more ... Leigh Syndrome, X-Linked ISO RGD:736556 8554872 ClinVar Annotator: match by term: X-linked Leigh syndrome ClinVar PMID:28492532 Leigh Syndrome, X-Linked ISO RGD:736556 8554872 ClinVar Annotator: match by term: X-linked Leigh syndrome ClinVar Leigh Syndrome, X-Linked ISO RGD:736556 8554872 ClinVar Annotator: match by term: X-linked Leigh syndrome ClinVar PMID:23871722 more ... Leigh Syndrome, X-Linked ISO RGD:736556 8554872 ClinVar Annotator: match by term: X-linked Leigh syndrome ClinVar PMID:25741868 , PMID:28492532 Neurodevelopmental Disorders ISO RGD:736556 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868 pyruvate decarboxylase deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase complex deficiency ClinVar PMID:25741868 pyruvate decarboxylase deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Ataxia, intermittent, with pyruvate dehydrogenase, or decarboxylase, deficiency ClinVar pyruvate decarboxylase deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase e1-alpha deficiency ClinVar PMID:23871722 more ... pyruvate decarboxylase deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Ataxia, intermittent, with pyruvate dehydrogenase, or decarboxylase, deficiency ClinVar PMID:25741868 , PMID:28492532 pyruvate decarboxylase deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Ataxia, intermittent, with pyruvate dehydrogenase, or decarboxylase, deficiency ClinVar PMID:28492532 pyruvate decarboxylase deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by OMIM:312170 ClinVar PMID:21914562 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase e1-alpha deficiency ClinVar PMID:7692352 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase E1-alpha deficiency ClinVar PMID:10679936 more ... Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase E1-alpha deficiency ClinVar PMID:20002461 more ... Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase E1-alpha deficiency ClinVar PMID:10679936 more ... Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase E1-alpha deficiency ClinVar PMID:1907799 , PMID:28492532 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase E1-alpha deficiency ClinVar PMID:20691944 , PMID:28492532 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase e1-alpha deficiency ClinVar PMID:23871722 more ... Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase E1-alpha deficiency ClinVar PMID:10679936 more ... Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase E1-alpha deficiency ClinVar PMID:10679936 more ... Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase E1-alpha deficiency ClinVar PMID:10679936 , PMID:11241048 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase E1-alpha deficiency ClinVar PMID:25326635 more ... Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase E1-alpha deficiency ClinVar PMID:10775534 more ... Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase E1-alpha deficiency ClinVar PMID:17043409 more ... Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase E1-alpha deficiency ClinVar PMID:28492532 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase e1-alpha deficiency ClinVar PMID:1909401 more ... Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase E1-alpha deficiency ClinVar PMID:12551913 , PMID:28492532 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase e1-alpha deficiency ClinVar PMID:8032855 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase E1-alpha deficiency ClinVar PMID:25326635 , PMID:25741868 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase E1-alpha deficiency ClinVar PMID:28492532 , PMID:28918066 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase E1-alpha deficiency ClinVar PMID:25741868 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase e1-alpha deficiency ClinVar PMID:10486093 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase E1-alpha deficiency ClinVar PMID:21914562 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase e1-alpha deficiency ClinVar PMID:8771169 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase e1-alpha deficiency ClinVar PMID:7573035 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase E1-alpha deficiency ClinVar PMID:25741868 , PMID:28492532 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase E1-alpha deficiency ClinVar PMID:20591708 more ... Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase e1-alpha deficiency ClinVar PMID:1907799 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase e1-alpha deficiency ClinVar PMID:1909401 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase e1-alpha deficiency ClinVar PMID:1770778 , PMID:9686362 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase e1-alpha deficiency ClinVar PMID:12379317 , PMID:8199595 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase e1-alpha deficiency ClinVar PMID:2828359 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase e1-alpha deficiency ClinVar PMID:12379317 Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase E1-alpha deficiency ClinVar Pyruvate Dehydrogenase E1 Alpha Deficiency ISO RGD:736556 8554872 ClinVar Annotator: match by term: Pyruvate dehydrogenase e1-alpha deficiency ClinVar PMID:1508605 more ... syndromic X-linked intellectual disability Lubs type ISO RGD:736556 8554872 ClinVar Annotator: match by term: MECP2 duplication syndrome ClinVar PMID:25741868 visual epilepsy ISO RGD:736556 8554872 ClinVar Annotator: match by term: Seizures ClinVar PMID:25741868
Imported Annotations - CTD
Disease Progression ISO RGD:736556 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21364753 lactic acidosis ISO RGD:736556 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:2537010 Myocardial Ischemia ISO RGD:736556 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16214533 osteoarthritis ISO RGD:736556 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18784066 Prostatic Neoplasms ISO RGD:736556 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17013881 , PMID:29335542 pyruvate decarboxylase deficiency ISO RGD:736556 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:2378353 Pyruvate Metabolism, Inborn Errors ISO RGD:736556 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:2378353 Stomach Neoplasms ISO RGD:736556 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21364753 Imported Annotations - OMIM
pyruvate decarboxylase deficiency ISO RGD:736556 7240710 OMIM
(+)-catechin multiple interactions ISO RGD:736556 6480464 [Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of PDHA1 mRNA CTD PMID:24763279 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:736556 6480464 Acetylcysteine inhibits the reaction [epigallocatechin gallate results in decreased expression of PDHA1 mRNA], Acetylcysteine inhibits the reaction [epigallocatechin gallate results in decreased expression of PDHA1 protein] CTD PMID:31857147 (-)-epigallocatechin 3-gallate decreases expression ISO RGD:736556 6480464 epigallocatechin gallate results in decreased expression of PDHA1 mRNA, epigallocatechin gallate results in decreased expression of PDHA1 protein CTD PMID:31857147 17alpha-ethynylestradiol multiple interactions ISO RGD:736557 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDHA1 mRNA CTD PMID:17942748 17beta-estradiol multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in decreased expression of PDHA1 mRNA CTD PMID:26496021 2,3,7,8-tetrabromodibenzodioxine affects expression ISO RGD:736557 6480464 2 more ... CTD PMID:27604104 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:736557 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDHA1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of PDHA1 mRNA CTD PMID:32109520 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:736557 6480464 Tetrachlorodibenzodioxin affects the expression of PDHA1 mRNA CTD PMID:21570461 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2 more ... CTD PMID:32109520 3-chloropropane-1,2-diol increases expression EXP 6480464 alpha-Chlorohydrin results in increased expression of PDHA1 mRNA, alpha-Chlorohydrin results in increased expression of PDHA1 protein CTD PMID:26072098 , PMID:28522335 4,4'-diaminodiphenylmethane increases expression ISO RGD:736557 6480464 4, 4'-diaminodiphenylmethane results in increased expression of PDHA1 mRNA CTD PMID:18648102 aflatoxin B1 increases methylation ISO RGD:736556 6480464 Aflatoxin B1 results in increased methylation of PDHA1 intron CTD PMID:30157460 aldehydo-D-glucose multiple interactions ISO RGD:736556 6480464 Glucose inhibits the reaction [Dichloroacetic Acid results in decreased phosphorylation of PDHA1 protein] CTD PMID:31654802 all-trans-retinoic acid decreases expression ISO RGD:736556 6480464 Tretinoin results in decreased expression of PDHA1 mRNA CTD PMID:21934132 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PDHA1 mRNA CTD PMID:16483693 Aroclor 1254 decreases expression ISO RGD:736557 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of PDHA1 mRNA CTD PMID:23650126 arsenous acid increases expression ISO RGD:736556 6480464 Arsenic Trioxide results in increased expression of PDHA1 mRNA CTD PMID:22521957 atrazine decreases expression ISO RGD:736556 6480464 Atrazine results in decreased expression of PDHA1 mRNA CTD PMID:22378314 benzo[a]pyrene multiple interactions ISO RGD:736557 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to PDHA1 promoter] CTD PMID:19654925 benzo[a]pyrene decreases expression ISO RGD:736557 6480464 Benzo(a)pyrene results in decreased expression of PDHA1 mRNA CTD PMID:22228805 bezafibrate increases expression EXP 6480464 Bezafibrate results in increased expression of PDHA1 mRNA CTD PMID:11527545 bisphenol A increases expression ISO RGD:736557 6480464 bisphenol A results in increased expression of PDHA1 mRNA CTD PMID:22687993 bisphenol A decreases expression ISO RGD:736556 6480464 bisphenol A results in decreased expression of PDHA1 mRNA CTD PMID:29275510 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of PDHA1 gene CTD PMID:28505145 bisphenol A increases methylation ISO RGD:736557 6480464 bisphenol A results in increased methylation of PDHA1 promoter CTD PMID:27312807 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of PDHA1 mRNA CTD PMID:25181051 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in decreased expression of PDHA1 mRNA CTD PMID:26496021 bisphenol A decreases expression ISO RGD:736557 6480464 bisphenol A results in decreased expression of PDHA1 mRNA CTD PMID:22687993 cadmium atom decreases expression ISO RGD:736556 6480464 Cadmium results in decreased expression of PDHA1 mRNA CTD PMID:23369406 ciguatoxin CTX1B affects expression ISO RGD:736557 6480464 Ciguatoxins affects the expression of PDHA1 mRNA CTD PMID:18353800 cobalt dichloride decreases expression ISO RGD:736556 6480464 cobaltous chloride results in decreased expression of PDHA1 mRNA CTD PMID:19376846 D-glucose multiple interactions ISO RGD:736556 6480464 Glucose inhibits the reaction [Dichloroacetic Acid results in decreased phosphorylation of PDHA1 protein] CTD PMID:31654802 dexamethasone increases expression ISO RGD:736556 6480464 Dexamethasone results in increased expression of PDHA1 mRNA CTD PMID:25047013 diarsenic trioxide increases expression ISO RGD:736556 6480464 Arsenic Trioxide results in increased expression of PDHA1 mRNA CTD PMID:22521957 dichloroacetic acid decreases phosphorylation ISO RGD:736556 6480464 Dichloroacetic Acid results in decreased phosphorylation of PDHA1 protein CTD PMID:25630799 , PMID:31654802 dichloroacetic acid multiple interactions ISO RGD:736556 6480464 Glucose inhibits the reaction [Dichloroacetic Acid results in decreased phosphorylation of PDHA1 protein] CTD PMID:31654802 dinophysistoxin 1 affects expression ISO RGD:736556 6480464 dinophysistoxin 1 affects the expression of PDHA1 mRNA CTD PMID:28939011 diuron decreases expression EXP 6480464 Diuron results in decreased expression of PDHA1 mRNA CTD PMID:21551480 dorsomorphin multiple interactions ISO RGD:736557 6480464 dorsomorphin inhibits the reaction [Resveratrol results in increased expression of PDHA1 protein] CTD PMID:25761413 doxorubicin increases phosphorylation ISO RGD:736557 6480464 Doxorubicin results in increased phosphorylation of PDHA1 mRNA CTD PMID:29653124 doxorubicin decreases expression ISO RGD:736556 6480464 Doxorubicin results in decreased expression of PDHA1 mRNA CTD PMID:29803840 duvoglustat multiple interactions ISO RGD:736557 6480464 [1-Deoxynojirimycin co-treated with Polysaccharides] results in increased expression of PDHA1 mRNA CTD PMID:25446853 ethanol increases expression ISO RGD:736557 6480464 Ethanol results in increased expression of PDHA1 mRNA CTD PMID:19167417 ethanol increases expression EXP 6480464 Ethanol results in increased expression of PDHA1 protein CTD PMID:19609968 , PMID:23702218 flutamide increases expression EXP 6480464 Flutamide results in increased expression of PDHA1 mRNA CTD PMID:24136188 formaldehyde decreases expression ISO RGD:736556 6480464 Formaldehyde results in decreased expression of PDHA1 mRNA CTD PMID:23649840 Fusaric acid increases phosphorylation ISO RGD:736556 6480464 Fusaric Acid results in increased phosphorylation of PDHA1 protein CTD PMID:31654802 Fusaric acid decreases phosphorylation ISO RGD:736557 6480464 Fusaric Acid results in decreased phosphorylation of PDHA1 protein CTD PMID:32156565 genistein increases methylation EXP 6480464 Genistein results in increased methylation of PDHA1 gene CTD PMID:28505145 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of PDHA1 mRNA CTD PMID:22061828 glucose multiple interactions ISO RGD:736556 6480464 Glucose inhibits the reaction [Dichloroacetic Acid results in decreased phosphorylation of PDHA1 protein] CTD PMID:31654802 hydrogen peroxide multiple interactions ISO RGD:736557 6480464 [Hydrogen Peroxide co-treated with N-(oxo-5 more ... CTD PMID:31494107 isotretinoin decreases expression ISO RGD:736556 6480464 Isotretinoin results in decreased expression of PDHA1 mRNA CTD PMID:20436886 kojic acid increases expression ISO RGD:736556 6480464 kojic acid results in increased expression of PDHA1 mRNA CTD PMID:16595896 maneb multiple interactions ISO RGD:736557 6480464 [Maneb co-treated with Paraquat] results in decreased expression of PDHA1 mRNA more ... CTD PMID:23562983 , PMID:23963992 metformin multiple interactions ISO RGD:736556 6480464 Metformin results in decreased phosphorylation of and results in increased activity of PDHA1 protein CTD PMID:28576465 methamphetamine decreases expression EXP 6480464 Methamphetamine results in decreased expression of PDHA1 protein CTD PMID:19826936 methyl methanesulfonate decreases expression ISO RGD:736556 6480464 Methyl Methanesulfonate results in decreased expression of PDHA1 mRNA CTD PMID:23649840 Methylazoxymethanol acetate increases expression EXP 6480464 Methylazoxymethanol Acetate results in increased expression of PDHA1 mRNA CTD PMID:28349193 methylmercury chloride decreases expression ISO RGD:736556 6480464 methylmercuric chloride results in decreased expression of PDHA1 mRNA CTD PMID:28001369 methylparaben increases expression ISO RGD:736556 6480464 methylparaben results in increased expression of PDHA1 mRNA CTD PMID:31745603 N-acetyl-L-cysteine multiple interactions ISO RGD:736556 6480464 Acetylcysteine inhibits the reaction [epigallocatechin gallate results in decreased expression of PDHA1 mRNA], Acetylcysteine inhibits the reaction [epigallocatechin gallate results in decreased expression of PDHA1 protein] CTD PMID:31857147 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of PDHA1 mRNA CTD PMID:24136188 okadaic acid increases expression ISO RGD:736556 6480464 Okadaic Acid results in increased expression of PDHA1 mRNA CTD PMID:28939011 paracetamol decreases expression ISO RGD:736556 6480464 Acetaminophen results in decreased expression of PDHA1 mRNA CTD PMID:25704631 paraquat multiple interactions ISO RGD:736557 6480464 [Maneb co-treated with Paraquat] results in decreased expression of PDHA1 mRNA more ... CTD PMID:23562983 , PMID:23963992 perfluorooctanoic acid multiple interactions ISO RGD:736557 6480464 Dietary Fats, Unsaturated inhibits the reaction [perfluorooctanoic acid results in increased expression of PDHA1 mRNA] CTD PMID:23626681 perfluorooctanoic acid increases expression ISO RGD:736556 6480464 perfluorooctanoic acid results in increased expression of PDHA1 protein CTD PMID:26879310 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of PDHA1 mRNA CTD PMID:11527545 , PMID:19162173 pirinixic acid increases expression ISO RGD:736557 6480464 pirinixic acid results in increased expression of PDHA1 mRNA CTD PMID:23811191 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:736557 6480464 Pregnenolone Carbonitrile results in increased expression of PDHA1 mRNA CTD PMID:28903501 quinoline increases expression ISO RGD:736556 6480464 quinoline analog results in increased expression of PDHA1 protein CTD PMID:18645022 resveratrol decreases expression ISO RGD:736556 6480464 resveratrol results in decreased expression of PDHA1 mRNA CTD PMID:15582268 resveratrol increases expression ISO RGD:736557 6480464 resveratrol results in increased expression of PDHA1 protein CTD PMID:25505154 , PMID:25761413 resveratrol multiple interactions ISO RGD:736557 6480464 dorsomorphin inhibits the reaction [Resveratrol results in increased expression of PDHA1 protein], PRKAA1 gene mutant form inhibits the reaction [Resveratrol results in increased expression of PDHA1 protein] CTD PMID:25761413 resveratrol multiple interactions EXP 6480464 [resveratrol results in increased activity of PDK4 protein] which results in increased phosphorylation of PDHA1 protein CTD PMID:23824959 sodium dodecyl sulfate decreases expression ISO RGD:736556 6480464 Sodium Dodecyl Sulfate results in decreased expression of PDHA1 protein CTD PMID:21469165 sodium fluoride increases expression ISO RGD:736557 6480464 Sodium Fluoride results in increased expression of PDHA1 protein CTD PMID:28918527 superoxide affects abundance ISO RGD:736556 6480464 PDHA1 protein affects the abundance of Superoxides CTD PMID:21846590 titanium dioxide decreases expression ISO RGD:736557 6480464 titanium dioxide results in decreased expression of PDHA1 mRNA CTD PMID:23557971 triclosan decreases expression ISO RGD:736556 6480464 Triclosan results in decreased expression of PDHA1 mRNA CTD PMID:30510588 valproic acid affects expression ISO RGD:736556 6480464 Valproic Acid affects the expression of PDHA1 mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:736556 6480464 Valproic Acid results in increased expression of PDHA1 mRNA CTD PMID:23179753 , PMID:25192806 zearalenone increases expression ISO RGD:736557 6480464 Zearalenone results in increased expression of PDHA1 protein CTD PMID:25058043
Gene-Chemical Interaction Annotations
