RGD Reference Report - Pretranslational regulation of pyruvate dehydrogenase complex subunits in white adipose tissue during the suckling-weaning transition in the rat. - Rat Genome Database

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Pretranslational regulation of pyruvate dehydrogenase complex subunits in white adipose tissue during the suckling-weaning transition in the rat.

Authors: Maury, J  Kerbey, AL  Priestman, DA  Patel, MS  Girard, J  Ferre, P 
Citation: Maury J, etal., Biochem J. 1995 Oct 15;311 ( Pt 2):531-5.
RGD ID: 1599112
Pubmed: PMID:7487891   (View Abstract at PubMed)
PMCID: PMC1136031   (View Article at PubMed Central)

Total pyruvate dehydrogenase complex activity is low in white adipose tissue during the suckling period and increases markedly at weaning on to a high-carbohydrate diet. This is concomitant with an increase in the E1 alpha, E1 beta and E2 subunit protein concentration and their respective mRNAs, suggesting a pretranslational control of this phenomenon. The most marked change is seen for the E1 alpha subunit (17-fold increase in protein concentration). The changes in pyruvate dehydrogenase complex activity and subunit abundance induced by weaning on to a high-carbohydrate diet are precluded if the animals are weaned on to a high-fat diet, suggesting that the nutritional and/or related hormonal changes rather than a developmental stage are responsible for the observed adipose-tissue pyruvate dehydrogenase complex pattern.



Gene Ontology Annotations    

Biological Process

Cellular Component

Objects Annotated

Genes (Rattus norvegicus)
Dlat  (dihydrolipoamide S-acetyltransferase)
Dld  (dihydrolipoamide dehydrogenase)
Pdha1  (pyruvate dehydrogenase E1 subunit alpha 1)
Pdha2  (pyruvate dehydrogenase E1 subunit alpha 2)
Pdhb  (pyruvate dehydrogenase E1 subunit beta)


Additional Information