RGD Reference Report - Pretranslational regulation of pyruvate dehydrogenase complex subunits in white adipose tissue during the suckling-weaning transition in the rat. - Rat Genome Database

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Pretranslational regulation of pyruvate dehydrogenase complex subunits in white adipose tissue during the suckling-weaning transition in the rat.

Authors: Maury, J  Kerbey, AL  Priestman, DA  Patel, MS  Girard, J  Ferre, P 
Citation: Maury J, etal., Biochem J. 1995 Oct 15;311 ( Pt 2):531-5.
RGD ID: 1599112
Pubmed: PMID:7487891   (View Abstract at PubMed)
PMCID: PMC1136031   (View Article at PubMed Central)

Total pyruvate dehydrogenase complex activity is low in white adipose tissue during the suckling period and increases markedly at weaning on to a high-carbohydrate diet. This is concomitant with an increase in the E1 alpha, E1 beta and E2 subunit protein concentration and their respective mRNAs, suggesting a pretranslational control of this phenomenon. The most marked change is seen for the E1 alpha subunit (17-fold increase in protein concentration). The changes in pyruvate dehydrogenase complex activity and subunit abundance induced by weaning on to a high-carbohydrate diet are precluded if the animals are weaned on to a high-fat diet, suggesting that the nutritional and/or related hormonal changes rather than a developmental stage are responsible for the observed adipose-tissue pyruvate dehydrogenase complex pattern.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
DlatRatpyruvate dehydrogenase complex  IDA  RGD 
DldRatpyruvate dehydrogenase complex  IDA  RGD 
Pdha1Ratpyruvate dehydrogenase complex  IDA  RGD 
Pdha2Ratpyruvate dehydrogenase complex  IDA  RGD 
PdhbRatpyruvate dehydrogenase complex  IDA  RGD 

Molecular Function

  

Objects Annotated

Genes (Rattus norvegicus)
Dlat  (dihydrolipoamide S-acetyltransferase)
Dld  (dihydrolipoamide dehydrogenase)
Pdha1  (pyruvate dehydrogenase E1 subunit alpha 1)
Pdha2  (pyruvate dehydrogenase E1 subunit alpha 2)
Pdhb  (pyruvate dehydrogenase E1 subunit beta)


Additional Information