Prdx4 (peroxiredoxin 4) - Rat Genome Database

Name: Prdx4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Prdx4 (peroxiredoxin 4) Rattus norvegicus

Analyze

Symbol:

Prdx4

Name:

peroxiredoxin 4

RGD ID:

620043

Description:

Predicted to enable several functions, including identical protein binding activity; molecular sequestering activity; and thioredoxin peroxidase activity. Predicted to be involved in cell redox homeostasis; hydrogen peroxide catabolic process; and response to oxidative stress. Predicted to act upstream of or within several processes, including negative regulation of male germ cell proliferation; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; and protein maturation by protein folding. Located in extracellular space and smooth endoplasmic reticulum. Orthologous to human PRDX4 (peroxiredoxin 4); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

antioxidant enzyme AOE372; MGC72744; peroxiredoxin IV; peroxiredoxin-4; prx-IV; thioredoxin peroxidase AO372; thioredoxin-dependent peroxide reductase A0372; thioredoxin-dependent peroxiredoxin 4

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PRDX4 (peroxiredoxin 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Prdx4 (peroxiredoxin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Prdx4 (peroxiredoxin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PRDX4 (peroxiredoxin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PRDX4 (peroxiredoxin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Prdx4 (peroxiredoxin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PRDX4 (peroxiredoxin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PRDX4 (peroxiredoxin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Prdx4 (peroxiredoxin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PRDX4 (peroxiredoxin 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Prdx4 (peroxiredoxin 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	prdx4 (peroxiredoxin 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Jafrac2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TSA1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TSA2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	X	40,026,762 - 40,044,066 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	40,026,651 - 40,044,066 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	41,288,052 - 41,303,145 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	X	44,755,350 - 44,770,443 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	X	42,439,937 - 42,455,030 (+)	NCBI	Rnor_WKY
Rnor_6.0	X	43,495,453 - 43,512,994 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	43,497,763 - 43,512,991 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	43,799,111 - 43,816,649 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	61,501,206 - 61,516,286 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	61,554,679 - 61,569,754 (+)	NCBI
Celera	X	40,657,785 - 40,672,868 (+)	NCBI		Celera
Cytogenetic Map	X	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

allergic contact dermatitis (ISO)

autistic disorder (ISO)

diffuse large B-cell lymphoma (ISO)

Disease Progression (ISO)

glucose intolerance (ISO)

hyperglycemia (ISO)

Neurodevelopmental Disorders (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-quinic acid (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (EXP)

2-methoxy-17beta-estradiol (ISO)

3-chloropropane-1,2-diol (EXP)

4-hydroxyphenyl retinamide (ISO)

5-azacytidine (EXP)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

ammonium chloride (EXP)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bilirubin IXalpha (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

clofibric acid (EXP)

copper(II) sulfate (ISO)

coumestrol (ISO)

cycloheximide (ISO)

cyclosporin A (ISO)

cyfluthrin (ISO)

cypermethrin (ISO)

deoxycholic acid (ISO)

diarsenic trioxide (ISO)

dibenzo[a,l]pyrene (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

enzyme inhibitor (ISO)

flavonoids (EXP)

folic acid (ISO)

furan (EXP)

Ginsenoside Rh4 (ISO)

herbicide (ISO)

hydrogen peroxide (ISO)

ivermectin (ISO)

lead diacetate (ISO)

lutein (ISO)

methidathion (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

N-methyl-4-phenylpyridinium (EXP,ISO)

N-nitrosodiethylamine (EXP,ISO)

N-nitrosomorpholine (EXP)

Nonylphenol (EXP)

okadaic acid (ISO)

oxaliplatin (EXP)

ozone (ISO)

p-toluidine (EXP)

paracetamol (ISO)

paraquat (ISO)

perfluorododecanoic acid (EXP)

phenobarbital (ISO)

picloram (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

quercetin (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

streptozocin (ISO)

sunitinib (ISO)

T-2 toxin (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichlopyr (ISO)

tungsten (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vitamin E (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell redox homeostasis (IBA,ISO)

cellular oxidant detoxification (IEA)

extracellular matrix organization (ISO)

male gonad development (ISO)

negative regulation of male germ cell proliferation (ISO)

peptidyl-proline hydroxylation to 4-hydroxy-L-proline (ISO)

protein maturation by protein folding (ISO)

reactive oxygen species metabolic process (ISO)

response to oxidative stress (ISO)

spermatogenesis (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (IBA,ISO)

endoplasmic reticulum (IBA,ISO)

extracellular space (IDA)

smooth endoplasmic reticulum (IDA)

Molecular Function

antioxidant activity (IEA)

identical protein binding (ISO)

molecular adaptor activity (ISO)

molecular sequestering activity (ISO)

oxidoreductase activity (IEA)

peroxiredoxin activity (IEA)

protein binding (ISO)

thioredoxin-dependent peroxiredoxin activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	An interaction map of endoplasmic reticulum chaperones and foldases.	Jansen G, etal., Mol Cell Proteomics. 2012 Sep;11(9):710-23. doi: 10.1074/mcp.M111.016550. Epub 2012 Jun 4.
4.	Cloning of the peroxiredoxin gene family in rats and characterization of the fourth member.	Matsumoto A, etal., FEBS Lett 1999 Jan 29;443(3):246-50.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11229364	PMID:12477932	PMID:14651853	PMID:19105792	PMID:19199708	PMID:20144717	PMID:21630459	PMID:21835919	PMID:22981861	PMID:23589496	PMID:28391163	PMID:28391978
PMID:29804005

Genomics

Comparative Map Data

Prdx4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	X	40,026,762 - 40,044,066 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	40,026,651 - 40,044,066 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	41,288,052 - 41,303,145 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	X	44,755,350 - 44,770,443 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	X	42,439,937 - 42,455,030 (+)	NCBI	Rnor_WKY
Rnor_6.0	X	43,495,453 - 43,512,994 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	43,497,763 - 43,512,991 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	43,799,111 - 43,816,649 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	61,501,206 - 61,516,286 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	61,554,679 - 61,569,754 (+)	NCBI
Celera	X	40,657,785 - 40,672,868 (+)	NCBI		Celera
Cytogenetic Map	X	q21	NCBI

PRDX4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	23,667,493 - 23,686,397 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	X	23,664,262 - 23,686,397 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	23,685,610 - 23,704,514 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	23,595,566 - 23,614,435 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	23,445,301 - 23,464,171	NCBI
Celera	X	27,807,255 - 27,826,109 (+)	NCBI		Celera
Cytogenetic Map	X	p22.11	NCBI
HuRef	X	21,425,714 - 21,444,033 (+)	NCBI		HuRef
CHM1_1	X	23,716,633 - 23,735,478 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	23,251,060 - 23,269,952 (+)	NCBI		T2T-CHM13v2.0

Prdx4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	154,106,914 - 154,125,268 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	154,106,914 - 154,123,750 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	155,323,918 - 155,342,272 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	155,323,918 - 155,340,754 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	151,758,463 - 151,772,997 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	150,664,636 - 150,679,170 (-)	NCBI		MGSCv36	mm8
Celera	X	138,627,675 - 138,642,215 (-)	NCBI		Celera
Cytogenetic Map	X	F3	NCBI
cM Map	X	72.38	NCBI

Prdx4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955509	4,116,379 - 4,132,529 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955509	4,111,501 - 4,132,529 (+)	NCBI	ChiLan1.0	ChiLan1.0

PRDX4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	X	23,641,701 - 23,660,267 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	23,641,701 - 23,660,267 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	X	16,266,501 - 16,285,458 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

PRDX4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	19,361,658 - 19,383,718 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	19,361,731 - 19,383,719 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	X	19,315,949 - 19,338,234 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	19,316,017 - 19,339,141 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	19,355,530 - 19,377,666 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	19,388,566 - 19,410,845 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	19,444,866 - 19,467,081 (+)	NCBI		UU_Cfam_GSD_1.0

Prdx4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	12,281,184 - 12,298,549 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936624	859,276 - 873,860 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936624	859,281 - 873,784 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PRDX4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	19,797,550 - 19,819,571 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	19,800,153 - 19,819,575 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	21,167,657 - 21,189,764 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PRDX4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	22,113,405 - 22,136,307 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	22,116,605 - 22,136,308 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666056	24,012,393 - 24,032,362 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Prdx4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624897	95,521 - 112,920 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624897	92,977 - 112,920 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Prdx4
36 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	9
Count of miRNA genes:	8
Interacting mature miRNAs:	9
Transcripts:	ENSRNOT00000005014
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1	43491017	Rat
1298071	Edpm12	Estrogen-dependent pituitary mass QTL 12	3.2		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	X	2927898	47927898	Rat
10755455	Coatc13	Coat color QTL 13		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	4406000	49406000	Rat
631666	Iddm5	Insulin dependent diabetes mellitus QTL 5			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	4494549	49494549	Rat
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
71116	Niddm16	Non-insulin dependent diabetes mellitus QTL 16	7.81		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	15297802	60297802	Rat
1598873	Memor2	Memory QTL 2	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	X	20990947	41052531	Rat
2290375	Gluco34	Glucose level QTL 34	2.75		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	20990947	41203591	Rat

Markers in Region

AA819406

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RH 3.4 Map	4	622.42	UniSTS
Cytogenetic Map	X	p21.3	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	7	10	74	35	41	11	7
Low							1	1					1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053512	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006256951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602171	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF106945	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC059122	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473966	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219258	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219687	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220425	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220916	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223235	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228535	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000390	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000005014 ⟹ ENSRNOP00000005014

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	40,028,915 - 40,044,054 (+)	Ensembl
Rnor_6.0 Ensembl	X	43,497,763 - 43,512,991 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000105854 ⟹ ENSRNOP00000086837

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	40,026,651 - 40,044,066 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000114294 ⟹ ENSRNOP00000090392

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	40,028,875 - 40,042,215 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000114432 ⟹ ENSRNOP00000080648

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	40,028,875 - 40,038,754 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000118979 ⟹ ENSRNOP00000094200

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	40,028,915 - 40,044,066 (+)	Ensembl

RefSeq Acc Id:

NM_053512 ⟹ NP_445964

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	X	40,028,984 - 40,044,066 (+)	NCBI
Rnor_6.0	X	43,497,763 - 43,512,994 (+)	NCBI
Rnor_5.0	X	43,799,111 - 43,816,649 (+)	NCBI
RGSC_v3.4	X	61,501,206 - 61,516,286 (+)	RGD
Celera	X	40,657,785 - 40,672,868 (+)	RGD

Sequence:

show sequence

GGCAGGTGTTTTCGTGCTCGCTTGGTCATGGAAACGTGGTCCAAGCTGCTGGACGGGACCACGC
CGTCCCGTCGCTGGCGAAAGCTGGTATTGCTCCTGCCGCCTCTGCTGCTGTTCCTGTTACAGAC
TGAAGCTTTGCAGGGCTTGGAGAGTGATGATCGGTTCCGGACCCGCGAAAATGAGTGCCACTTC
TACGCTGGTGGACAAGTGTACCCCGGAGAGGTGTCCCGGGTTTCGGTCGCAGATCACTCCCTGC
ACCTAAGCAAAGCCAAGATTTCCAAGCCAGCACCTTATTGGGAAGGAACAGCTGTGATAAACGG
AGAATTCAAGGAGCTCAAATTGACCGACTATCGTGGGAAATACTTGGTTTTTTTCTTCTACCCA
CTGGATTTCACCTTTGTGTGTCCAACTGAAATCATCGCTTTTGGGGATCGAATTGAAGAATTCA
AATCTATAAATACTGAAGTGGTAGCATGCTCTGTTGATTCTCAGTTTACTCACTTGGCCTGGAT
CAATACCCCTCGAAGACAAGGAGGACTGGGGCCAATAAGGATTCCACTTCTTTCAGACCTGAAC
CATCAGATCTCAAAGGACTACGGTGTATACCTTGAGGACTCTGGACATACTCTTAGAGGGCTCT
TTATTATCGATGACAAAGGAGTCCTAAGACAGATTACTCTGAATGACCTTCCTGTGGGTAGATC
AGTGGATGAGACACTGCGTTTGGTTCAAGCCTTCCAGTACACTGACAAGCATGGAGAAGTCTGC
CCTGCTGGCTGGAAACCTGGTAGTGAAACAATAATCCCAGATCCAGCTGGAAAACTGAAGTATT
TCGACAAGCTAAACTGAAAAGTACTTCAGTTATGATGCTTAGACCTTCTCAATAAAGGTCATTG
TGTTAATTACCATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAA

hide sequence

RefSeq Acc Id:

XM_006256951 ⟹ XP_006257013

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	X	40,026,762 - 40,044,066 (+)	NCBI
Rnor_6.0	X	43,495,453 - 43,512,994 (+)	NCBI
Rnor_5.0	X	43,799,111 - 43,816,649 (+)	NCBI

Sequence:

show sequence

TGAGGGACAGAGAGTAGGTGCCAGGGAGGTGACCGACTCGGTCACTCTCCCCAGTGGGCAGAGT
GTTTACTGGGGCCCAACTGGTGAGCGGTCCCTGGTACCAACTGGGACATCTCACCTTAGCCTAG
GATAAAGAGGTGTAGGGATATATCATTCTTTTCCACCTTTTAAAACAAAGTTCAAACTTAGAGG
CCCAACTCAGGGTTTATAATTCATTAGGGCTAGTGGCTGTTTTACAGTCACCATGGATCACCGT
AGCCGTTCACGAGGCATGAGCCACAGTCGAGTCCCTGGATCTCAAATCCGAGCTCCCAGGGTCC
CACTTCCATTCCATGTTGAGCAGGAAGCTAGGGAAGGAGAAGAAACGGAGCGAGAGGTACCTCG
TCAGAGGCCTACCATCTATGTACCTCCAGAAACCGAAGAGTTACAGGAAACTGTTATGATTTCC
AAGCCAGCACCTTATTGGGAAGGAACAGCTGTGATAAACGGAGAATTCAAGGAGCTCAAATTGA
CCGACTATCGTGGGAAATACTTGGTTTTTTTCTTCTACCCACTGGATTTCACCTTTGTGTGTCC
AACTGAAATCATCGCTTTTGGGGATCGAATTGAAGAATTCAAATCTATAAATACTGAAGTGGTA
GCATGCTCTGTTGATTCTCAGTTTACTCACTTGGCCTGGATCAATACCCCTCGAAGACAAGGAG
GACTGGGGCCAATAAGGATTCCACTTCTTTCAGACCTGAACCATCAGATCTCAAAGGACTACGG
TGTATACCTTGAGGACTCTGGACATACTCTTAGAGGGCTCTTTATTATCGATGACAAAGGAGTC
CTAAGACAGATTACTCTGAATGACCTTCCTGTGGGTAGATCAGTGGATGAGACACTGCGTTTGG
TTCAAGCCTTCCAGTACACTGACAAGCATGGAGAAGTCTGCCCTGCTGGCTGGAAACCTGGTAG
TGAAACAATAATCCCAGATCCAGCTGGAAAACTGAAGTATTTCGACAAGCTAAACTGAAAAGTA
CTTCAGTTATGATGCTTAGACCTTCTCAATAAAGGTCATTGTGTTAATTACCATA

hide sequence

RefSeq Acc Id:

XM_017602171 ⟹ XP_017457660

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	X	40,028,891 - 40,044,066 (+)	NCBI
Rnor_6.0	X	43,497,671 - 43,512,994 (+)	NCBI

Sequence:

show sequence

AAGTCTCGCGAGGCCGCGCCCTTGTTCGCGCGGTCTCCAGCGCGCCCTTTTAGCTGGCTGCCTG
GCGGCGGGGGACTTGGTTTTTTAACTGAGGGATGTGTTTTCGTGCTCGCTTGGTCATGGAAACG
TGGTCCAAGCTGCTGGACGGGACCACGCCGTCCCGTCGCTGGCGAAAGCTGGTATTGCTCCTGC
CGCCTCTGCTGCTGTTCCTGTTACAGACTGAAGCTTTGCAGGGCTTGGAGAGTGATGATCGGTT
CCGGACCCGCGAAAATGAGTGCCACTTCTACGCTGGTGGACAAGTGTACCCCGGAGAGGTGTCC
CGGGTTTCGGTCGCAGATCACTCCCTGCACCTAAGCAAAGCCAAGATTTCCAAGCCAGCACCTT
ATTGGGAAGGAACAGCTGTGATAAACGGAGAATTCAAGGAGCTCAAATTGACCGACTATCGTGG
GAAATACTTGGTTTTTTTCTTCTACCCACTGGATTTCACCTTTGTGTGTCCAACTGAAATCATC
GCTTTTGGGGATCGAATTGAAGAATTCAAATCTATAAATACTGAAGTGGTAGCATGCTCTGTTG
ATTCTCAGTTTACTCACTTGGCCTGGATCAATACCCCTCGAAGACAAGGAGGACTGGGGCCAAT
AAGGATTCCACTTCTTTCAGACCTGAACCATCAGATCTCAAAGGACTACGGTGTATACCTTGAG
GACTCTGGACATACTCTTAGAGGGCTCTTTATTATCGATGACAAAGGAGTCCTAAGACAGATTA
CTCTGAATGACCTTCCTGTGGGTAGATCAGTGGATGAGACACTGCGTTTGGTTCAAGCCTTCCA
GTACACTGACAAGCATGGAGAAGATAATCCCAGATCCAGCTGGAAAACTGAAGTATTTCGACAA
GCTAAACTGAAAAGTACTTCAGTTATGATGCTTAGACCTTCTCAATAAAGGTCATTGTGTTAAT
TACCATA

hide sequence

Protein Sequences


Protein RefSeqs	NP_445964	(Get FASTA)	NCBI Sequence Viewer
	XP_006257013	(Get FASTA)	NCBI Sequence Viewer
	XP_017457660	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD17993	(Get FASTA)	NCBI Sequence Viewer
	AAH59122	(Get FASTA)	NCBI Sequence Viewer
	EDL96102	(Get FASTA)	NCBI Sequence Viewer
	EDL96103	(Get FASTA)	NCBI Sequence Viewer
	EDL96104	(Get FASTA)	NCBI Sequence Viewer
	Q9Z0V5	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_445964 ⟸ NM_053512
- Peptide Label:	precursor
- UniProtKB:	Q9Z0V5 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence METWSKLLDGTTPSRRWRKLVLLLPPLLLFLLQTEALQGLESDDRFRTRENECHFYAGGQVYPG EVSRVSVADHSLHLSKAKISKPAPYWEGTAVINGEFKELKLTDYRGKYLVFFFYPLDFTFVCPT EIIAFGDRIEEFKSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDLNHQISKDYGV YLEDSGHTLRGLFIIDDKGVLRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSE TIIPDPAGKLKYFDKLN hide sequence

RefSeq Acc Id:	XP_006257013 ⟸ XM_006256951
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AER1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDHRSRSRGMSHSRVPGSQIRAPRVPLPFHVEQEAREGEETEREVPRQRPTIYVPPETEELQET VMISKPAPYWEGTAVINGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRIEEFKSIN TEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDLNHQISKDYGVYLEDSGHTLRGLFIID DKGVLRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKL N hide sequence

RefSeq Acc Id:

XP_017457660 ⟸ XM_017602171

- Peptide Label:

isoform X2

- Sequence:

show sequence

MCFRARLVMETWSKLLDGTTPSRRWRKLVLLLPPLLLFLLQTEALQGLESDDRFRTRENECHFY
AGGQVYPGEVSRVSVADHSLHLSKAKISKPAPYWEGTAVINGEFKELKLTDYRGKYLVFFFYPL
DFTFVCPTEIIAFGDRIEEFKSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDLNH
QISKDYGVYLEDSGHTLRGLFIIDDKGVLRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEDNP
RSSWKTEVFRQAKLKSTSVMMLRPSQ

hide sequence

RefSeq Acc Id:

ENSRNOP00000005014 ⟸ ENSRNOT00000005014

RefSeq Acc Id:

ENSRNOP00000094200 ⟸ ENSRNOT00000118979

RefSeq Acc Id:

ENSRNOP00000086837 ⟸ ENSRNOT00000105854

RefSeq Acc Id:

ENSRNOP00000080648 ⟸ ENSRNOT00000114432

RefSeq Acc Id:

ENSRNOP00000090392 ⟸ ENSRNOT00000114294

Protein Domains

Thioredoxin

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9Z0V5-F1-model_v2	AlphaFold	Q9Z0V5	1-273	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701817

Promoter ID:

EPDNEW_R12341

Type:

initiation region

Name:

Prdx4_1

Description:

peroxiredoxin 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	43,497,722 - 43,497,782	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620043	AgrOrtholog
BioCyc Gene	G2FUF-2444	BioCyc
Ensembl Genes	ENSRNOG00000003763	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000005014	ENTREZGENE
	ENSRNOP00000005014.4	UniProtKB/TrEMBL
	ENSRNOP00000080648.1	UniProtKB/TrEMBL
	ENSRNOP00000086837	ENTREZGENE
	ENSRNOP00000086837.1	UniProtKB/TrEMBL
	ENSRNOP00000090392.1	UniProtKB/TrEMBL
	ENSRNOP00000094200	ENTREZGENE
	ENSRNOP00000094200.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005014	ENTREZGENE
	ENSRNOT00000005014.5	UniProtKB/TrEMBL
	ENSRNOT00000105854	ENTREZGENE
	ENSRNOT00000105854.1	UniProtKB/TrEMBL
	ENSRNOT00000114294.1	UniProtKB/TrEMBL
	ENSRNOT00000114432.1	UniProtKB/TrEMBL
	ENSRNOT00000118979	ENTREZGENE
	ENSRNOT00000118979.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:6918063	IMAGE-MGC_LOAD
InterPro	AhpC/TSA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peroxiredoxin_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Thioredoxin-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Thioredoxin_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:85274	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72744	IMAGE-MGC_LOAD
NCBI Gene	85274	ENTREZGENE
Pfam	1-cysPrx_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AhpC-TSA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Prdx4	PhenoGen
PROSITE	THIOREDOXIN_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52833	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZQ96_RAT	UniProtKB/TrEMBL
	A0A8I6AAQ6_RAT	UniProtKB/TrEMBL
	A0A8I6AER1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AL33_RAT	UniProtKB/TrEMBL
	A0A8L2Q1B0_RAT	UniProtKB/TrEMBL
	PRDX4_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-02-26	Prdx4	peroxiredoxin 4			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Prdx4	peroxiredoxin 4			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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