(-)-quinic acid multiple interactions ISO RGD:731497 6480464 [Hydrogen Peroxide co-treated with Quinic Acid analog] results in increased expression of PRDX4 mRNA CTD PMID:21751221 17alpha-ethynylestradiol multiple interactions ISO RGD:731498 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRDX4 mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression ISO RGD:731498 6480464 Ethinyl Estradiol results in increased expression of PRDX4 mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of PRDX4 mRNA CTD PMID:17108234 17beta-estradiol increases expression ISO RGD:731497 6480464 Estradiol results in increased expression of PRDX4 protein CTD PMID:18272409 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:731497 6480464 Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PRDX4 mRNA] CTD PMID:11007951 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:731498 6480464 Tetrachlorodibenzodioxin affects the expression of PRDX4 mRNA CTD PMID:21570461 , PMID:24680724 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of PRDX4 mRNA CTD PMID:18796159 , PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:731498 6480464 Tetrachlorodibenzodioxin results in increased expression of PRDX4 mRNA CTD PMID:19465110 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of PRDX4 protein CTD PMID:12361703 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:731498 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRDX4 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:731497 6480464 Tetrachlorodibenzodioxin results in increased expression of PRDX4 mRNA CTD PMID:11007951 2,4-dibromophenyl 2,4,5-tribromophenyl ether decreases expression EXP 6480464 2 more ... CTD PMID:19954255 2,4-dibromophenyl 2,4,5-tribromophenyl ether increases expression EXP 6480464 2 more ... CTD PMID:19954255 2-methoxy-17beta-estradiol increases expression ISO RGD:731497 6480464 2-Methoxyestradiol results in increased expression of PRDX4 protein CTD PMID:18272409 4-hydroxyphenyl retinamide decreases expression ISO RGD:731498 6480464 Fenretinide results in decreased expression of PRDX4 mRNA CTD PMID:28973697 5-azacytidine decreases expression EXP 6480464 Azacitidine results in decreased expression of PRDX4 protein CTD PMID:17105402 aflatoxin B1 decreases expression ISO RGD:731498 6480464 Aflatoxin B1 results in decreased expression of PRDX4 mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation ISO RGD:731497 6480464 Aflatoxin B1 results in decreased methylation of PRDX4 gene CTD PMID:27153756 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of PRDX4 mRNA CTD PMID:23630614 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PRDX4 mRNA CTD PMID:16483693 arsenous acid increases expression ISO RGD:731497 6480464 Arsenic Trioxide results in increased expression of PRDX4 protein CTD PMID:19364129 atrazine increases expression ISO RGD:731497 6480464 Atrazine results in increased expression of PRDX4 mRNA CTD PMID:22378314 benzo[a]pyrene increases expression ISO RGD:731498 6480464 Benzo(a)pyrene results in increased expression of PRDX4 mRNA CTD PMID:22228805 benzo[a]pyrene increases expression ISO RGD:731497 6480464 Benzo(a)pyrene results in increased expression of PRDX4 mRNA CTD PMID:31255691 bilirubin IXalpha decreases expression ISO RGD:731497 6480464 Bilirubin results in decreased expression of PRDX4 mRNA CTD PMID:20196124 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of PRDX4 protein CTD PMID:16400681 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of PRDX4 mRNA CTD PMID:25181051 bisphenol A affects expression ISO RGD:731497 6480464 bisphenol A affects the expression of PRDX4 mRNA CTD PMID:30903817 bisphenol A decreases methylation ISO RGD:731498 6480464 bisphenol A results in decreased methylation of PRDX4 promoter CTD PMID:27312807 bisphenol A increases expression ISO RGD:731498 6480464 bisphenol A results in increased expression of PRDX4 protein CTD PMID:24909818 bisphenol A decreases expression ISO RGD:731498 6480464 bisphenol A results in decreased expression of PRDX4 protein CTD PMID:24909818 carbon nanotube increases expression ISO RGD:731498 6480464 Nanotubes, Carbon analog results in increased expression of PRDX4 mRNA, Nanotubes, Carbon results in increased expression of PRDX4 mRNA CTD PMID:25554681 clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PRDX4 mRNA CTD PMID:17602206 copper(II) sulfate decreases expression ISO RGD:731497 6480464 Copper Sulfate results in decreased expression of PRDX4 mRNA CTD PMID:19549813 coumestrol multiple interactions ISO RGD:731497 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PRDX4 mRNA CTD PMID:19167446 cycloheximide multiple interactions ISO RGD:731497 6480464 Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PRDX4 mRNA] CTD PMID:11007951 cyclosporin A increases expression ISO RGD:731497 6480464 Cyclosporine results in increased expression of PRDX4 mRNA CTD PMID:20106945 cyclosporin A decreases expression ISO RGD:731497 6480464 Cyclosporine results in decreased expression of PRDX4 mRNA CTD PMID:25562108 cypermethrin increases expression ISO RGD:731498 6480464 cypermethrin results in increased expression of PRDX4 mRNA CTD PMID:21142847 deoxycholic acid decreases response to substance ISO RGD:731497 6480464 PRDX4 protein results in decreased susceptibility to Deoxycholic Acid CTD PMID:12507930 diarsenic trioxide increases expression ISO RGD:731497 6480464 Arsenic Trioxide results in increased expression of PRDX4 protein CTD PMID:19364129 dibenzo[a,l]pyrene decreases expression ISO RGD:731497 6480464 dibenzo(a, l)pyrene results in decreased expression of PRDX4 mRNA CTD PMID:31255691 doxorubicin affects expression ISO RGD:731497 6480464 Doxorubicin affects the expression of PRDX4 protein CTD PMID:29385562 doxorubicin increases expression ISO RGD:731497 6480464 Doxorubicin results in increased expression of PRDX4 mRNA CTD PMID:29803840 Enterolactone multiple interactions ISO RGD:731497 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PRDX4 mRNA CTD PMID:19167446 enzyme inhibitor multiple interactions ISO RGD:731497 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PRDX4 protein CTD PMID:23301498 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of PRDX4 mRNA CTD PMID:18035473 furan increases methylation EXP 6480464 furan results in increased methylation of PRDX4 gene CTD PMID:22079235 herbicide multiple interactions ISO RGD:731498 6480464 [arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide co-treated with Herbicides] results in increased expression of PRDX4 mRNA, arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Herbicides results in decreased expression of PRDX4 mRNA] CTD PMID:21318024 herbicide decreases expression ISO RGD:731498 6480464 Herbicides results in decreased expression of PRDX4 mRNA CTD PMID:21318024 hydrogen peroxide increases expression ISO RGD:731497 6480464 Hydrogen Peroxide results in increased expression of PRDX4 mRNA CTD PMID:19902159 hydrogen peroxide multiple interactions ISO RGD:731497 6480464 [Hydrogen Peroxide co-treated with Quinic Acid analog] results in increased expression of PRDX4 mRNA CTD PMID:21751221 lead diacetate decreases expression ISO RGD:731498 6480464 lead acetate results in decreased expression of PRDX4 mRNA CTD PMID:29746905 lutein increases expression ISO RGD:731498 6480464 Lutein results in increased expression of PRDX4 mRNA CTD PMID:24865317 methyl methanesulfonate decreases expression ISO RGD:731497 6480464 Methyl Methanesulfonate results in decreased expression of PRDX4 mRNA CTD PMID:23649840 methylmercury chloride increases expression ISO RGD:731497 6480464 methylmercuric chloride results in increased expression of PRDX4 mRNA CTD PMID:29581082 N-methyl-4-phenylpyridinium multiple interactions EXP 6480464 1-Methyl-4-phenylpyridinium results in increased expression of and results in increased metabolism of PRDX4 protein CTD PMID:20600802 N-methyl-4-phenylpyridinium decreases expression ISO RGD:731498 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of PRDX4 protein CTD PMID:26558463 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PRDX4 mRNA CTD PMID:17602206 N-nitrosodiethylamine multiple interactions ISO RGD:731498 6480464 RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PRDX4 mRNA] CTD PMID:17854601 N-nitrosodiethylamine increases expression ISO RGD:731498 6480464 Diethylnitrosamine results in increased expression of PRDX4 mRNA CTD PMID:17854601 N-nitrosomorpholine decreases expression EXP 6480464 N-nitrosomorpholine results in decreased expression of PRDX4 protein CTD PMID:19716841 Nonylphenol decreases expression EXP 6480464 nonylphenol results in decreased expression of PRDX4 protein CTD PMID:19260726 okadaic acid increases expression ISO RGD:731498 6480464 Okadaic Acid results in increased expression of PRDX4 mRNA CTD PMID:25270620 oxaliplatin decreases expression EXP 6480464 oxaliplatin results in decreased expression of PRDX4 mRNA CTD PMID:25729387 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PRDX4 mRNA CTD PMID:25729387 p-toluidine decreases expression EXP 6480464 4-toluidine results in decreased expression of PRDX4 mRNA CTD PMID:27638505 paracetamol decreases expression ISO RGD:731497 6480464 Acetaminophen results in decreased expression of PRDX4 mRNA CTD PMID:25704631 paraquat increases expression ISO RGD:731498 6480464 Paraquat results in increased expression of PRDX4 mRNA CTD PMID:12595580 perfluorododecanoic acid decreases expression EXP 6480464 perfluorododecanoic acid results in decreased expression of PRDX4 protein CTD PMID:26168851 phenobarbital affects expression ISO RGD:731497 6480464 Phenobarbital affects the expression of PRDX4 mRNA CTD PMID:19159669 Picloram multiple interactions ISO RGD:731498 6480464 arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Picloram results in decreased expression of PRDX4 mRNA] CTD PMID:21318024 Picloram decreases expression ISO RGD:731498 6480464 Picloram results in decreased expression of PRDX4 mRNA CTD PMID:21318024 pirinixic acid decreases expression ISO RGD:731498 6480464 pirinixic acid results in decreased expression of PRDX4 mRNA CTD PMID:23811191 propiconazole increases metabolic processing ISO RGD:731498 6480464 propiconazole results in increased metabolism of PRDX4 protein CTD PMID:19714882 quercetin increases expression ISO RGD:731497 6480464 Quercetin results in increased expression of PRDX4 protein CTD PMID:15221776 sodium arsenite increases expression ISO RGD:731497 6480464 sodium arsenite results in increased expression of PRDX4 mRNA CTD PMID:29301061 sodium fluoride increases expression ISO RGD:731498 6480464 Sodium Fluoride results in increased expression of PRDX4 protein CTD PMID:28918527 sodium fluoride decreases expression ISO RGD:731498 6480464 Sodium Fluoride results in decreased expression of PRDX4 protein CTD PMID:27548804 streptozocin multiple interactions ISO RGD:731497 6480464 PRDX4 protein inhibits the reaction [Streptozocin results in decreased expression of PRDX1 mRNA] more ... CTD PMID:20446767 streptozocin decreases expression ISO RGD:731498 6480464 Streptozocin results in decreased expression of PRDX4 mRNA CTD PMID:20446767 T-2 Toxin affects expression EXP 6480464 T-2 Toxin affects the expression of PRDX4 protein CTD PMID:26141394 titanium dioxide decreases expression ISO RGD:731498 6480464 titanium dioxide results in decreased expression of PRDX4 mRNA CTD PMID:29264374 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of PRDX4 mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PRDX4 mRNA CTD PMID:25729387 trichlopyr multiple interactions ISO RGD:731498 6480464 [arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide co-treated with triclopyr] results in increased expression of PRDX4 mRNA CTD PMID:21318024 tungsten increases expression ISO RGD:731498 6480464 Tungsten results in increased expression of PRDX4 mRNA CTD PMID:30912803 valproic acid affects expression ISO RGD:731497 6480464 Valproic Acid affects the expression of PRDX4 mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:731497 6480464 Valproic Acid results in increased expression of PRDX4 mRNA CTD PMID:26272509 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of PRDX4 mRNA CTD PMID:23034163 vitamin E decreases expression ISO RGD:731497 6480464 Vitamin E results in decreased expression of PRDX4 mRNA CTD PMID:19244175 vorinostat increases expression ISO RGD:731497 6480464 vorinostat results in increased expression of PRDX4 protein CTD PMID:20543569
Biological Process 4-hydroxyproline metabolic process ISO RGD:731498 1624291 MGI:MGI:1354385 more ... RGD MGI:MGI:5461404 , PMID:22981861 4-hydroxyproline metabolic process IEA UniProtKB:O08807 , ensembl:ENSMUSP000000263281600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell redox homeostasis ISO RGD:731498 1624291 MGI:MGI:1354385 more ... RGD MGI:MGI:5489003 , PMID:23589496 cell redox homeostasis IBA FB:FBgn0040309 more ... 13792537 PMID:21873635 GO_Central cellular oxidant detoxification IEA GO:0004601 1600115 GO_REF:0000108 GOC GO_REF:0000108 cellular oxidant detoxification IEA GO:0008379 1600115 GO_REF:0000108 GOC GO_REF:0000108 cellular oxidant detoxification IEA GO:0051920 1600115 GO_REF:0000108 GOC GO_REF:0000108 cellular oxidant detoxification IEA GO:0016209 1600115 GO_REF:0000108 GOC GO_REF:0000108 extracellular matrix organization ISO RGD:731498 1624291 MGI:MGI:1354385 more ... RGD MGI:MGI:5461404 , PMID:22981861 extracellular matrix organization IEA UniProtKB:O08807 , ensembl:ENSMUSP000000263281600115 GO_REF:0000107 Ensembl GO_REF:0000107 hydrogen peroxide catabolic process IBA FB:FBgn0040308 more ... 13792537 PMID:21873635 GO_Central male gonad development ISO RGD:731498 1624291 MGI:MGI:3848347 (MGI:MGI:3847582 , PMID:19105792) RGD MGI:MGI:3847582 , PMID:19105792 male gonad development IEA UniProtKB:O08807 , ensembl:ENSMUSP000000263281600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of male germ cell proliferation ISO RGD:731498 1624291 MGI:MGI:3848347 (MGI:MGI:3847582 , PMID:19105792) RGD MGI:MGI:3847582 , PMID:19105792 negative regulation of male germ cell proliferation IEA UniProtKB:O08807 , ensembl:ENSMUSP000000263281600115 GO_REF:0000107 Ensembl GO_REF:0000107 oxidation-reduction process ISO RGD:731498 1624291 MGI:MGI:3848347 (MGI:MGI:3847582 , PMID:19105792) RGD MGI:MGI:3847582 , PMID:19105792 oxidation-reduction process IEA UniProtKB:O08807 , ensembl:ENSMUSP000000263281600115 GO_REF:0000107 Ensembl GO_REF:0000107 peptidyl-proline hydroxylation to 4-hydroxy-L-proline IEA UniProtKB:O08807 , ensembl:ENSMUSP000000263281600115 GO_REF:0000107 Ensembl GO_REF:0000107 peptidyl-proline hydroxylation to 4-hydroxy-L-proline ISO RGD:731498 1624291 MGI:MGI:1354385 more ... RGD MGI:MGI:5461404 , PMID:22981861 protein maturation by protein folding ISO RGD:731498 1624291 MGI:MGI:1354385 more ... RGD MGI:MGI:5461404 , PMID:22981861 protein maturation by protein folding IEA UniProtKB:O08807 , ensembl:ENSMUSP000000263281600115 GO_REF:0000107 Ensembl GO_REF:0000107 reactive oxygen species metabolic process ISO RGD:731498 1624291 (MGI:MGI:1932257, PMID:11229364) RGD MGI:MGI:1932257 , PMID:11229364 response to oxidative stress IBA CGD:CAL0000174369 more ... 13792537 PMID:21873635 GO_Central response to oxidative stress IBA FB:FBgn0040308 more ... 13792537 PMID:21873635 GO_Central spermatogenesis ISO RGD:731498 1624291 MGI:MGI:3848347 (MGI:MGI:3847582 , PMID:19105792) RGD MGI:MGI:3847582 , PMID:19105792 spermatogenesis IEA UniProtKB:O08807 , ensembl:ENSMUSP000000263281600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component cell IEA GO:0045454 1600115 GO_REF:0000108 GOC GO_REF:0000108 cytoplasm ISO RGD:731498 1624291 (MGI:MGI:1932257, PMID:11229364) RGD MGI:MGI:1932257 , PMID:11229364 cytosol ISO RGD:731498 1624291 (MGI:MGI:5297647, PMID:21835919) RGD MGI:MGI:5297647 , PMID:21835919 cytosol IBA EcoGene:EG11384 more ... 13792537 PMID:21873635 GO_Central cytosol IBA FB:FBgn0040308 more ... 13792537 PMID:21873635 GO_Central endoplasmic reticulum ISO RGD:731498 1624291 (MGI:MGI:5297647, PMID:21835919) RGD MGI:MGI:5297647 , PMID:21835919 endoplasmic reticulum IBA FB:FBgn0040308 more ... 13792537 PMID:21873635 GO_Central endoplasmic reticulum IBA FB:FBgn0040308 more ... 13792537 PMID:21873635 GO_Central extracellular space IDA 633622 RGD smooth endoplasmic reticulum IDA 8553430 PMID:22665516 UniProt Molecular Function protein binding ISO RGD:731497 1624291 UniProtKB:P07237 more ... RGD PMID:17644091 more ... protein binding ISO RGD:731498 1624291 UniProtKB:Q8NBS9-1 (MGI:MGI:5926606 , PMID:24462249) RGD MGI:MGI:5926606 , PMID:24462249 protein homodimerization activity ISO RGD:731498 1624291 (MGI:MGI:5297647, PMID:21835919) RGD MGI:MGI:5297647 , PMID:21835919 protein homodimerization activity IEA UniProtKB:O08807 , ensembl:ENSMUSP000000263281600115 GO_REF:0000107 Ensembl GO_REF:0000107 thioredoxin peroxidase activity IBA FB:FBgn0040308 more ... 13792537 PMID:21873635 GO_Central
Gene-Chemical Interaction Annotations
