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Imported Disease Annotations - OMIMObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Glra2 | Rat | syndromic X-linked intellectual disability Pilorge type | | ISO | RGD:731909 | 7240710 | | OMIM | | |
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Imported Disease Annotations - OMIMObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Glra2 | Rat | syndromic X-linked intellectual disability Pilorge type | | ISO | RGD:731909 | 7240710 | | OMIM | | |
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# | Reference Title | Reference Citation |
1. | Cloning of a glycine receptor subtype expressed in rat brain and spinal cord during a specific period of neuronal development. | Akagi H, etal., FEBS Lett 1991 Apr 9;281(1-2):160-6. |
2. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
3. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
4. | Alternative splicing generates two isoforms of the alpha 2 subunit of the inhibitory glycine receptor. | Kuhse J, etal., FEBS Lett 1991 May 20;283(1):73-7. |
5. | Role of Nova-1 in regulating alpha2N, a novel glycine receptor splice variant, in developing spinal cord neurons. | Kumar DV, etal., J Neurobiol 2002 Aug;52(2):156-65. |
6. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
7. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
PMID:2155780 | PMID:2176511 | PMID:15057822 | PMID:18339511 | PMID:19528249 | PMID:22330726 | PMID:23079787 | PMID:23895467 | PMID:27382060 | PMID:38017313 |
Glra2 (Rattus norvegicus - Norway rat) |
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GLRA2 (Homo sapiens - human) |
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Glra2 (Mus musculus - house mouse) |
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Glra2 (Chinchilla lanigera - long-tailed chinchilla) |
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GLRA2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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GLRA2 (Canis lupus familiaris - dog) |
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Glra2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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GLRA2 (Sus scrofa - pig) |
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GLRA2 (Chlorocebus sabaeus - green monkey) |
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Glra2 (Heterocephalus glaber - naked mole-rat) |
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Variants in Glra2
1052 total Variants ![]() |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
D5S648 |
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GLRA2 |
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alimentary part of gastrointestinal system
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appendage
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circulatory system
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ectoderm
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endocrine system
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endoderm
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exocrine system
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hemolymphoid system
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hepatobiliary system
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integumental system
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mesenchyme
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mesoderm
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nervous system
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renal system
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reproductive system
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respiratory system
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6 | 7 | 13 | 109 | 46 | 43 | 15 | 23 | 15 | 6 | 114 | 54 | 89 | 32 | 53 | 28 |
RefSeq Transcripts | NM_012568 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_003752039 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_008773152 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_017601905 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_017601906 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039099446 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AABR07037787 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AABR07037788 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AABR07037789 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AABR07037790 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AABR07037791 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AF374197 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AJ310837 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CB715572 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH474014 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000021 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
X61159 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Ensembl Acc Id: | ENSRNOT00000004443 ⟹ ENSRNOP00000004443 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Ensembl Acc Id: | ENSRNOT00000098582 ⟹ ENSRNOP00000083002 | ||||||||
Type: | CODING | ||||||||
Position: |
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Ensembl Acc Id: | ENSRNOT00000111367 ⟹ ENSRNOP00000091317 | ||||||||
Type: | CODING | ||||||||
Position: |
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Ensembl Acc Id: | ENSRNOT00000114133 ⟹ ENSRNOP00000081734 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_012568 ⟹ NP_036700 | ||||||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_003752039 ⟹ XP_003752087 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_008773152 ⟹ XP_008771374 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039099446 ⟹ XP_038955374 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Protein RefSeqs | NP_036700 | (Get FASTA) | NCBI Sequence Viewer |
XP_003752087 | (Get FASTA) | NCBI Sequence Viewer | |
XP_008771374 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038955374 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | CAA43471 | (Get FASTA) | NCBI Sequence Viewer |
CAC35981 | (Get FASTA) | NCBI Sequence Viewer | |
EDL90533 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000004443 | ||
ENSRNOP00000091317 | |||
GenBank Protein | P22771 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_036700 ⟸ NM_012568 |
- Peptide Label: | precursor |
- UniProtKB: | Q91W28 (UniProtKB/Swiss-Prot), P22771 (UniProtKB/Swiss-Prot), A0A0G2JSH7 (UniProtKB/TrEMBL), A6K2J6 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_003752087 ⟸ XM_003752039 |
- Peptide Label: | isoform X1 |
- UniProtKB: | Q91W28 (UniProtKB/Swiss-Prot), P22771 (UniProtKB/Swiss-Prot), A0A0G2JSH7 (UniProtKB/TrEMBL), A6K2J6 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_008771374 ⟸ XM_008773152 |
- Peptide Label: | isoform X2 |
- UniProtKB: | Q91W28 (UniProtKB/Swiss-Prot), P22771 (UniProtKB/Swiss-Prot), A0A8I6GJI2 (UniProtKB/TrEMBL) |
- Sequence: |
Ensembl Acc Id: | ENSRNOP00000004443 ⟸ ENSRNOT00000004443 |
RefSeq Acc Id: | XP_038955374 ⟸ XM_039099446 |
- Peptide Label: | isoform X3 |
- UniProtKB: | A0A8I5ZW10 (UniProtKB/TrEMBL) |
Ensembl Acc Id: | ENSRNOP00000083002 ⟸ ENSRNOT00000098582 |
Ensembl Acc Id: | ENSRNOP00000081734 ⟸ ENSRNOT00000114133 |
Ensembl Acc Id: | ENSRNOP00000091317 ⟸ ENSRNOT00000111367 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P22771-F1-model_v2 | AlphaFold | P22771 | 1-452 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
Database | Acc Id | Source(s) |
AGR Gene | RGD:2705 | AgrOrtholog |
BioCyc Gene | G2FUF-2605 | BioCyc |
Ensembl Genes | ENSRNOG00000003313 | Ensembl, ENTREZGENE |
Ensembl Transcript | ENSRNOT00000004443 | ENTREZGENE |
ENSRNOT00000111367 | ENTREZGENE | |
Gene3D-CATH | 1.20.58.390 | UniProtKB/Swiss-Prot |
2.70.170.10 | UniProtKB/Swiss-Prot | |
InterPro | GABAA/Glycine_rcpt | UniProtKB/Swiss-Prot |
Glycine_rcpt_A | UniProtKB/Swiss-Prot | |
Glycine_rcpt_A2 | UniProtKB/Swiss-Prot | |
Neur_chan_lig-bd | UniProtKB/Swiss-Prot | |
Neur_chan_lig-bd_sf | UniProtKB/Swiss-Prot | |
Neur_channel | UniProtKB/Swiss-Prot | |
Neuro-gated_channel_TM_sf | UniProtKB/Swiss-Prot | |
Neuro_actylchol_rec | UniProtKB/Swiss-Prot | |
Neurotrans-gated_channel_TM | UniProtKB/Swiss-Prot | |
Neurotransmitter_ion_chnl_CS | UniProtKB/Swiss-Prot | |
KEGG Report | rno:24397 | UniProtKB/Swiss-Prot |
NCBI Gene | 24397 | ENTREZGENE |
PANTHER | PTHR18945 | UniProtKB/Swiss-Prot |
Pfam | Neur_chan_LBD | UniProtKB/Swiss-Prot |
Neur_chan_memb | UniProtKB/Swiss-Prot | |
PhenoGen | Glra2 | PhenoGen |
PRINTS | GABAARECEPTR | UniProtKB/Swiss-Prot |
GLYRALPHA | UniProtKB/Swiss-Prot | |
GLYRALPHA2 | UniProtKB/Swiss-Prot | |
NRIONCHANNEL | UniProtKB/Swiss-Prot | |
PROSITE | NEUROTR_ION_CHANNEL | UniProtKB/Swiss-Prot |
RatGTEx | ENSRNOG00000003313 | RatGTEx |
Superfamily-SCOP | SSF63712 | UniProtKB/Swiss-Prot |
SSF90112 | UniProtKB/Swiss-Prot | |
UniProt | A0A0G2JSH7 | ENTREZGENE, UniProtKB/TrEMBL |
A0A8I5ZTI8_RAT | UniProtKB/TrEMBL | |
A0A8I5ZW10 | ENTREZGENE, UniProtKB/TrEMBL | |
A0A8I6GJI2 | ENTREZGENE, UniProtKB/TrEMBL | |
A6K2J6 | ENTREZGENE, UniProtKB/TrEMBL | |
GLRA2_RAT | UniProtKB/Swiss-Prot, ENTREZGENE | |
Q91W28 | ENTREZGENE | |
UniProt Secondary | Q91W28 | UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2012-07-05 | LOC100910572 | glycine receptor subunit alpha-2-like | Symbol and Name status set to provisional | 70820 | PROVISIONAL | ||
2008-10-16 | Glra2 | glycine receptor, alpha 2 | Glra2 | glycine receptor, alpha 2 subunit | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2002-06-10 | Glra2 | Glycine receptor alpha 2 subunit (glycine receptor, neonatal) | Symbol and Name status set to approved | 70586 | APPROVED |
Note Type | Note | Reference |
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gene_transcript | contains several splice variants with heterogeneous developmental expression in the central nervous system | 728718 |