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Gene: Hsd17b10 (hydroxysteroid (17-beta) dehydrogenase 10) Rattus norvegicus
Symbol: Hsd17b10
Name: hydroxysteroid (17-beta) dehydrogenase 10
Description: Exhibits several functions, including amyloid-beta binding activity; estrogen receptor binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in Leydig cell differentiation and cell aging. Localizes to the mitochondrion. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability; pheochromocytoma; and syndromic X-linked intellectual disability type 10. Orthologous to human HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,2,2-tetramine.
Type: protein-coding
Also known as: 17-beta-HSD 10; 17-beta-hydroxysteroid dehydrogenase 10; 17I(2)-hydroxysteroid dehydrogenase type 10; 17β-hydroxysteroid dehydrogenase type 10 ; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type II; 3-hydroxyacyl-CoA dehydrogenase type-2; ABAD; amyloid beta-peptide binding protein; amyloid-beta peptide binding alcohol dehydrogenase; endoplasmic reticulum-associated amyloid beta-peptide-binding protein; ERAB; Hadh2; HSD10; hydroxyacyl-Coenzyme A dehydrogenase type II; hydroxyacyl-Coenzyme A dehydrogenase, type II; mitochondrial ribonuclease P protein 2; mitochondrial RNase P protein 2; short chain L-3-hydroxyacyl-CoA dehydrogenase; type II HADH
Homo sapiens (human) : HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10)  HGNC  Alliance
Mus musculus (house mouse) : Hsd17b10 (hydroxysteroid (17-beta) dehydrogenase 10)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsd17b10 (hydroxysteroid 17-beta dehydrogenase 10)
Pan paniscus (bonobo/pygmy chimpanzee) : HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10)
Canis lupus familiaris (dog) : HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsd17b10 (hydroxysteroid 17-beta dehydrogenase 10)
Sus scrofa (pig) : HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10)
Chlorocebus sabaeus (African green monkey) : HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10)
Heterocephalus glaber (naked mole-rat) : Hsd17b10 (hydroxysteroid 17-beta dehydrogenase 10)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X21,696,796 - 21,699,241 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX21,696,772 - 21,699,241 (+)Ensembl
Rnor_5.0X21,747,939 - 21,750,384 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X41,489,343 - 41,491,788 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X41,542,811 - 41,545,257 (+)NCBI
CeleraX21,364,462 - 21,366,907 (+)NCBICelera
Cytogenetic MapXq13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Hsd17b10
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69231
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.