Hsd17b10 (hydroxysteroid (17-beta) dehydrogenase 10) - Rat Genome Database

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Gene: Hsd17b10 (hydroxysteroid (17-beta) dehydrogenase 10) Rattus norvegicus
Analyze
Symbol: Hsd17b10
Name: hydroxysteroid (17-beta) dehydrogenase 10
RGD ID: 69231
Description: Enables several functions, including amyloid-beta binding activity; nuclear estrogen receptor binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in Leydig cell differentiation. Predicted to be located in endoplasmic reticulum and mitochondrial nucleoid. Predicted to be part of mitochondrial ribonuclease P complex and tRNA methyltransferase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in pheochromocytoma and syndromic X-linked intellectual disability type 10. Orthologous to human HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 17-beta-estradiol 17-dehydrogenase; 17-beta-HSD 10; 17-beta-hydroxysteroid dehydrogenase 10; 17I(2)-hydroxysteroid dehydrogenase type 10; 2-methyl-3-hydroxybutyryl-CoA dehydrogenase; 3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)); 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type II; 3-hydroxyacyl-CoA dehydrogenase type-2; 3alpha(or 20beta)-hydroxysteroid dehydrogenase; 7-alpha-hydroxysteroid dehydrogenase; ABAD; amyloid beta-peptide binding protein; amyloid-beta peptide binding alcohol dehydrogenase; endoplasmic reticulum-associated amyloid beta-peptide-binding protein; ERAB; Hadh2; HSD10; hydroxyacyl-Coenzyme A dehydrogenase type II; hydroxyacyl-Coenzyme A dehydrogenase, type II; MHBD; mitochondrial ribonuclease P protein 2; mitochondrial RNase P protein 2; short chain dehydrogenase/reductase family 5C member 1; short chain L-3-hydroxyacyl-CoA dehydrogenase; short-chain type dehydrogenase/reductase XH98G2; type II HADH
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X24,568,551 - 24,571,012 (+)NCBIGRCr8
mRatBN7.2X21,089,142 - 21,091,603 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX21,089,122 - 21,109,488 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX18,566,162 - 18,568,623 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X21,554,941 - 21,557,402 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X21,654,784 - 21,657,245 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X21,696,796 - 21,699,241 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX21,696,772 - 21,699,241 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X21,747,939 - 21,750,384 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X41,489,343 - 41,491,788 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X41,542,811 - 41,545,257 (+)NCBI
CeleraX21,364,462 - 21,366,907 (+)NCBICelera
Cytogenetic MapXq13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(5alpha)-cholestan-3beta-ol  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
20-hydroxycholesterol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP)
7alpha-hydroxycholesterol  (ISO)
acetamide  (EXP)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
aminoglutethimide  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
androstane-3,17-diol  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
Butylparaben  (EXP)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
captan  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
Di-n-octyl phthalate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
enzacamene  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycine  (ISO)
glyphosate  (EXP)
hydrogen sulfide  (ISO)
imidacloprid  (EXP)
ivermectin  (ISO)
L-glutamic acid  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
Nutlin-3  (ISO)
oxybenzone  (EXP)
p-tert-Amylphenol  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
PhIP  (EXP)
phlorizin  (ISO)
pirinixic acid  (ISO)
prochloraz  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tanespimycin  (ISO)
taurine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Overexpression of 17ß-hydroxysteroid dehydrogenase type 10 increases pheochromocytoma cell growth and resistance to cell death. Carlson EA, etal., BMC Cancer. 2015 Mar 22;15:166. doi: 10.1186/s12885-015-1173-5.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. The gene for the Alzheimer-associated beta-amyloid-binding protein (ERAB) is differentially expressed in the testicular Leydig cells of the azoospermic by w/w(v) mouse. Hansis C, etal., Eur J Biochem. 1998 Nov 15;258(1):53-60.
5. Abundant type 10 17 beta-hydroxysteroid dehydrogenase in the hippocampus of mouse Alzheimer's disease model. He XY, etal., Brain Res Mol Brain Res 2002 Feb 28;99(1):46-53.
6. Human brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase is a single-domain multifunctional enzyme. Characterization of a novel 17beta-hydroxysteroid dehydrogenase. He XY, etal., J Biol Chem 1999 May 21;274(21):15014-9.
7. Molecular cloning, modeling, and localization of rat type 10 17beta-hydroxysteroid dehydrogenase. He XY, etal., Mol Cell Endocrinol 2001 Jan 22;171(1-2):89-98.
8. Differentiation-dependent expression of 17beta-hydroxysteroid dehydrogenase, type 10, in the rodent testis: effect of aging in Leydig cells. Ivell R, etal., Endocrinology. 2003 Jul;144(7):3130-7.
9. Estrogen receptor alpha interacts with 17beta-hydroxysteroid dehydrogenase type 10 in mitochondria. Jazbutyte V, etal., Biochem Biophys Res Commun. 2009 Jul 10;384(4):450-4. Epub 2009 May 5.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. Recognition of structurally diverse substrates by type II 3-hydroxyacyl-CoA dehydrogenase (HADH II)/amyloid-beta binding alcohol dehydrogenase (ABAD). Powell AJ, etal., J Mol Biol. 2000 Oct 20;303(2):311-27.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Molecular characterization of the response to chemotherapy in conventional osteosarcomas: predictive value of HSD17B10 and IFITM2. Salas S, etal., Int J Cancer. 2009 Aug 15;125(4):851-60. doi: 10.1002/ijc.24457.
22. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23. An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease. Yan SD, etal., Nature 1997 Oct 16;389(6652):689-95.
24. Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease. Yao J, etal., J Neurosci. 2011 Feb 9;31(6):2313-20. doi: 10.1523/JNEUROSCI.4717-10.2011.
Additional References at PubMed
PMID:12477932   PMID:12696021   PMID:12865426   PMID:14651853   PMID:15962010   PMID:18614015   PMID:20077426   PMID:20131911   PMID:22681889   PMID:23042678   PMID:24549042   PMID:24703694  
PMID:25925575   PMID:28888424   PMID:29040705   PMID:29476059   PMID:30053369  


Genomics

Comparative Map Data
Hsd17b10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X24,568,551 - 24,571,012 (+)NCBIGRCr8
mRatBN7.2X21,089,142 - 21,091,603 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX21,089,122 - 21,109,488 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX18,566,162 - 18,568,623 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X21,554,941 - 21,557,402 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X21,654,784 - 21,657,245 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X21,696,796 - 21,699,241 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX21,696,772 - 21,699,241 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X21,747,939 - 21,750,384 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X41,489,343 - 41,491,788 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X41,542,811 - 41,545,257 (+)NCBI
CeleraX21,364,462 - 21,366,907 (+)NCBICelera
Cytogenetic MapXq13NCBI
HSD17B10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X53,431,258 - 53,434,376 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX53,431,258 - 53,434,370 (-)EnsemblGRCh38hg38GRCh38
GRCh37X53,458,206 - 53,461,323 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X53,474,931 - 53,478,048 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X53,341,230 - 53,344,341NCBI
CeleraX57,289,763 - 57,292,880 (-)NCBICelera
Cytogenetic MapXp11.22NCBI
HuRefX50,515,835 - 50,518,952 (-)NCBIHuRef
CHM1_1X53,448,673 - 53,451,790 (-)NCBICHM1_1
T2T-CHM13v2.0X52,717,601 - 52,720,718 (-)NCBIT2T-CHM13v2.0
Hsd17b10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X150,784,892 - 150,787,438 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX150,784,841 - 150,787,438 (+)EnsemblGRCm39 Ensembl
GRCm38X152,001,896 - 152,004,442 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX152,001,845 - 152,004,442 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X148,436,439 - 148,438,985 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X147,342,612 - 147,345,158 (+)NCBIMGSCv36mm8
MGSCv36X129,009,142 - 129,011,881 (+)NCBIMGSCv36mm8
CeleraX132,428,129 - 132,428,679 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
Hsd17b10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955475478,690 - 481,029 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955475478,690 - 481,029 (-)NCBIChiLan1.0ChiLan1.0
HSD17B10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X54,830,436 - 54,833,601 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X54,834,038 - 54,837,229 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X45,645,849 - 45,649,039 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X53,754,164 - 53,757,643 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX53,754,164 - 53,757,643 (-)Ensemblpanpan1.1panPan2
HSD17B10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X45,165,272 - 45,167,683 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX45,165,272 - 45,167,574 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX36,699,189 - 36,701,599 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X45,490,114 - 45,492,524 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX45,490,114 - 45,492,416 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X44,985,267 - 44,987,677 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X45,434,940 - 45,437,350 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X45,502,509 - 45,504,919 (-)NCBIUU_Cfam_GSD_1.0
Hsd17b10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X38,060,016 - 38,062,537 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936751399,701 - 402,344 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936751399,743 - 402,200 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSD17B10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX46,218,548 - 46,220,883 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X46,218,540 - 46,220,942 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X51,717,057 - 51,719,459 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSD17B10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X49,568,206 - 49,571,356 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX49,567,267 - 49,571,292 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660863,522,557 - 3,525,740 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsd17b10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624909681,731 - 684,237 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624909681,731 - 684,130 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hsd17b10
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:57
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000043559
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat

Markers in Region
RH134351  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X21,090,909 - 21,091,338 (+)MAPPERmRatBN7.2
Rnor_6.0X21,698,554 - 21,698,982NCBIRnor6.0
Rnor_5.0X21,748,198 - 21,748,626UniSTSRnor5.0
RGSC_v3.4X41,491,101 - 41,491,529UniSTSRGSC3.4
CeleraX21,366,220 - 21,366,648UniSTS
RH 3.4 Map2682.6UniSTS
Cytogenetic MapXq21UniSTS
RH142896  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X21,091,757 - 21,091,896 (+)MAPPERmRatBN7.2
Rnor_6.0X21,699,402 - 21,699,540NCBIRnor6.0
Rnor_5.0X21,747,640 - 21,747,778UniSTSRnor5.0
RGSC_v3.4X41,491,949 - 41,492,087UniSTSRGSC3.4
CeleraX21,367,068 - 21,367,206UniSTS
Cytogenetic MapXq21UniSTS
RH138828  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X21,091,752 - 21,091,892 (+)MAPPERmRatBN7.2
Rnor_6.0X21,699,397 - 21,699,536NCBIRnor6.0
Rnor_5.0X21,747,644 - 21,747,783UniSTSRnor5.0
RGSC_v3.4X41,491,944 - 41,492,083UniSTSRGSC3.4
CeleraX21,367,063 - 21,367,202UniSTS
Cytogenetic MapXq21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000043559   ⟹   ENSRNOP00000043608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX21,089,492 - 21,109,488 (+)Ensembl
Rnor_6.0 EnsemblX21,696,772 - 21,699,241 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097715   ⟹   ENSRNOP00000091740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX21,089,163 - 21,109,488 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099570   ⟹   ENSRNOP00000095150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX21,089,122 - 21,109,488 (+)Ensembl
RefSeq Acc Id: NM_031682   ⟹   NP_113870
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X24,568,551 - 24,571,012 (+)NCBI
mRatBN7.2X21,089,142 - 21,091,603 (+)NCBI
Rnor_6.0X21,696,796 - 21,699,241 (+)NCBI
Rnor_5.0X21,747,939 - 21,750,384 (-)NCBI
RGSC_v3.4X41,489,343 - 41,491,788 (+)RGD
CeleraX21,364,462 - 21,366,907 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113870 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC05747 (Get FASTA)   NCBI Sequence Viewer  
  AAF14853 (Get FASTA)   NCBI Sequence Viewer  
  AAI58588 (Get FASTA)   NCBI Sequence Viewer  
  EDL86310 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000043608.4
  ENSRNOP00000091740.1
  ENSRNOP00000095150.1
GenBank Protein O70351 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113870   ⟸   NM_031682
- UniProtKB: Q9QYD4 (UniProtKB/Swiss-Prot),   O70351 (UniProtKB/Swiss-Prot),   B0BMW2 (UniProtKB/TrEMBL),   F1LNT4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043608   ⟸   ENSRNOT00000043559
Ensembl Acc Id: ENSRNOP00000095150   ⟸   ENSRNOT00000099570
Ensembl Acc Id: ENSRNOP00000091740   ⟸   ENSRNOT00000097715

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70351-F1-model_v2 AlphaFold O70351 1-261 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701768
Promoter ID:EPDNEW_R12292
Type:multiple initiation site
Name:Hsd17b10_1
Description:hydroxysteroid (17-beta) dehydrogenase 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X21,696,801 - 21,696,861EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69231 AgrOrtholog
BioCyc Gene G2FUF-2720 BioCyc
BioCyc Pathway FAO-PWY [fatty acid beta-oxidation I (generic)] BioCyc
  PWY-5177 [glutaryl-CoA degradation] BioCyc
  PWY-7606 [docosahexaenoate biosynthesis III (6-desaturase, mammals)] BioCyc
  PWY-7726 [(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)] BioCyc
  PWY-8182 [valproate beta-oxidation] BioCyc
  PWY66-391 [fatty acid beta-oxidation VI (mammalian peroxisome)] BioCyc
BioCyc Pathway Image FAO-PWY BioCyc
  PWY-5177 BioCyc
  PWY-7606 BioCyc
  PWY-7726 BioCyc
  PWY-8182 BioCyc
  PWY66-391 BioCyc
Ensembl Genes ENSRNOG00000003049 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043559.5 UniProtKB/TrEMBL
  ENSRNOT00000097715.1 UniProtKB/TrEMBL
  ENSRNOT00000099570.1 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9089087 IMAGE-MGC_LOAD
InterPro NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:63864 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:187357 IMAGE-MGC_LOAD
NCBI Gene 63864 ENTREZGENE
PANTHER 3-HYDROXYACYL-COA DEHYDROGENASE TYPE-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHORT-CHAIN DEHYDROGENASE/REDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam adh_short UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hsd17b10 PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADH_SHORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003049 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217168
UniProt A0A8I6AFS1_RAT UniProtKB/TrEMBL
  A0A8I6AJ41_RAT UniProtKB/TrEMBL
  A0A8J8XAP0_RAT UniProtKB/TrEMBL
  B0BMW2 ENTREZGENE, UniProtKB/TrEMBL
  F1LNT4 ENTREZGENE
  HCD2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9QYD4 ENTREZGENE
UniProt Secondary F1LNT4 UniProtKB/TrEMBL
  Q9QYD4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Hsd17b10  hydroxysteroid (17-beta) dehydrogenase 10  Hadh2  hydroxyacyl-Coenzyme A dehydrogenase type II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Hadh2  hydroxyacyl-Coenzyme A dehydrogenase type II  Hsd17b10  hydroxysteroid (17-beta) dehydrogenase 10  Symbol and Name updated 1299863 APPROVED
2002-06-10 Hsd17b10  hydroxysteroid (17-beta) dehydrogenase 10      Name updated 70584 APPROVED
2002-02-27 Hsd17b10  hydroxysteroid (17-beta) dehydrogenase 10      Symbol and Name updated to reflect Human and Mouse nomenclature 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to hippocampal synaptic mitochondria 632866