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Gene: Hsd17b10 (hydroxysteroid 17-beta dehydrogenase 10) Chinchilla lanigera

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Symbol:

Hsd17b10

Name:

hydroxysteroid 17-beta dehydrogenase 10

RGD ID:

8999585

Description:

ENCODES a protein that exhibits 17-beta-hydroxysteroid dehydrogenase (NAD+) activity (ortholog); 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity (ortholog); 3-hydroxyacyl-CoA dehydrogenase activity (ortholog); INVOLVED IN androgen metabolic process (ortholog); bile acid biosynthetic process (ortholog); brexanolone metabolic process (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Atkin Syndrome (ortholog); autistic disorder (ortholog); FOUND IN endoplasmic reticulum (ortholog); mitochondrial nucleoid (ortholog); mitochondrial ribonuclease P complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

3-hydroxyacyl-CoA dehydrogenase type-2; hydroxysteroid (17-beta) dehydrogenase 10

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955475	478,690 - 481,029 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955475	478,690 - 481,029 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

Atkin Syndrome (ISO)

autistic disorder (ISO)

azoospermia (ISO)

Cornelia de Lange syndrome 2 (ISO)

COVID-19 (ISO)

genetic disease (ISO)

lung adenocarcinoma (ISO)

non-syndromic X-linked intellectual disability 1 (ISO)

osteosarcoma (ISO)

paraplegia (ISO)

pheochromocytoma (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

syndromic X-linked intellectual disability type 10 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

androgen metabolic process (ISO)

bile acid biosynthetic process (ISO)

brexanolone metabolic process (ISO)

C21-steroid hormone metabolic process (ISO)

estrogen metabolic process (ISO)

fatty acid beta-oxidation (ISO)

L-isoleucine catabolic process (ISO)

Leydig cell differentiation (ISO)

male gonad development (ISO)

mitochondrial tRNA 3'-end processing (ISO)

mitochondrial tRNA 5'-end processing (ISO)

mitochondrial tRNA methylation (ISO)

mitochondrion organization (ISO)

protein homotetramerization (ISO)

Cellular Component

endoplasmic reticulum (ISO)

mitochondrial nucleoid (ISO)

mitochondrial ribonuclease P complex (ISO)

mitochondrion (ISO)

tRNA methyltransferase complex (ISO)

Molecular Function

17-beta-hydroxysteroid dehydrogenase (NAD+) activity (ISO)

3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity (ISO)

3-hydroxyacyl-CoA dehydrogenase activity (ISO)

acetoacetyl-CoA reductase activity (ISO)

amyloid-beta binding (ISO)

chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity (ISO)

cholate 7-alpha-dehydrogenase (NAD+) activity (ISO)

estradiol 17-beta-dehydrogenase [NAD(P)+] activity (ISO)

identical protein binding (ISO)

isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity (ISO)

NAD binding (ISO)

nuclear estrogen receptor binding (ISO)

protein binding (ISO)

steroid binding (ISO)

testosterone dehydrogenase (NAD+) activity (ISO)

testosterone dehydrogenase [NAD(P)+] activity (ISO)

tRNA binding (ISO)

ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway (ISO)

3-hydroxyacyl-CoA dehydrogenase deficiency pathway (ISO)

3-hydroxyisobutyric aciduria pathway (ISO)

3-methylcrotonyl CoA carboxylase 1 deficiency pathway (ISO)

3-methylglutaconic aciduria type 1 pathway (ISO)

3-methylglutaconic aciduria type 3 pathway (ISO)

fatty acid beta degradation pathway (ISO)

fatty acid elongation pathway (ISO)

isobutyryl-CoA dehydrogenase deficiency pathway (ISO)

isovaleric acidemia pathway (ISO)

maple syrup urine disease pathway (ISO)

methylmalonate semialdehyde dehydrogenase deficiency pathway (ISO)

methylmalonic acidemia pathway (ISO)

propionic acidemia pathway (ISO)

valine, leucine and isoleucine degradation pathway (ISO)

valproic acid pharmacokinetics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Hsd17b10
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955475	478,690 - 481,029 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955475	478,690 - 481,029 (-)	NCBI	ChiLan1.0	ChiLan1.0

HSD17B10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	53,431,258 - 53,434,376 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	53,431,258 - 53,434,370 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	53,458,206 - 53,461,323 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	53,474,931 - 53,478,048 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	53,341,230 - 53,344,341	NCBI
Celera	X	57,289,763 - 57,292,880 (-)	NCBI		Celera
Cytogenetic Map	X	p11.22	NCBI
HuRef	X	50,515,835 - 50,518,952 (-)	NCBI		HuRef
CHM1_1	X	53,448,673 - 53,451,790 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	52,717,601 - 52,720,718 (-)	NCBI		T2T-CHM13v2.0

Hsd17b10
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	150,784,892 - 150,787,438 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	150,784,841 - 150,787,438 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	152,001,896 - 152,004,442 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	152,001,845 - 152,004,442 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	148,436,439 - 148,438,985 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	147,342,612 - 147,345,158 (+)	NCBI		MGSCv36	mm8
MGSCv36	X	129,009,142 - 129,011,881 (+)	NCBI		MGSCv36	mm8
Celera	X	132,428,129 - 132,428,679 (-)	NCBI		Celera
Cytogenetic Map	X	F3	NCBI
cM Map	X	68.46	NCBI

Hsd17b10
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	24,568,551 - 24,571,012 (+)	NCBI		GRCr8
mRatBN7.2	X	21,089,142 - 21,091,603 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	21,089,122 - 21,109,488 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	18,566,162 - 18,568,623 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	21,554,941 - 21,557,402 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	21,654,784 - 21,657,245 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	21,696,796 - 21,699,241 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	21,696,772 - 21,699,241 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	21,747,939 - 21,750,384 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	41,489,343 - 41,491,788 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	41,542,811 - 41,545,257 (+)	NCBI
Celera	X	21,364,462 - 21,366,907 (+)	NCBI		Celera
Cytogenetic Map	X	q13	NCBI

HSD17B10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	54,830,436 - 54,833,601 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	54,834,038 - 54,837,229 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	45,645,849 - 45,649,039 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	53,754,164 - 53,757,643 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	53,754,164 - 53,757,643 (-)	Ensembl	panpan1.1		panPan2

HSD17B10
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	45,165,272 - 45,167,683 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	45,165,272 - 45,167,574 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	36,699,189 - 36,701,599 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	45,490,114 - 45,492,524 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	45,490,114 - 45,492,416 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	44,985,267 - 44,987,677 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	45,434,940 - 45,437,350 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	45,502,509 - 45,504,919 (-)	NCBI		UU_Cfam_GSD_1.0

Hsd17b10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	38,060,016 - 38,062,537 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936751	399,701 - 402,344 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936751	399,743 - 402,200 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HSD17B10
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	46,218,548 - 46,220,883 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	46,218,540 - 46,220,942 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	51,717,057 - 51,719,459 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HSD17B10
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	49,568,206 - 49,571,356 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	49,567,267 - 49,571,292 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666086	3,522,557 - 3,525,740 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hsd17b10
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624909	681,731 - 684,237 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624909	681,731 - 684,130 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005401494	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01054692	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCQ01166613	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000009421 ⟹ ENSCLAP00000009292

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955475	478,690 - 481,029 (-)	Ensembl

RefSeq Acc Id:

XM_005401494 ⟹ XP_005401551

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955475	478,690 - 481,029 (-)	NCBI

Sequence:

show sequence

GGCCAATCAGTGACGCCTGTGAAAAAAAAGGCCCAAAGCCCTCCAGTGGTGAGACCGGCGCAAG
ATGGCCGCGGCGAGTCGCAGTGTGAAGGGCCTCGTAGCAGTAATAACCGGAGGAGCCTCAGGCC
TTGGCTTGGCTACAGCAGAGCGACTGGTGGGGCAAGGGGCTTCTGCTGTGCTTCTGGACTTGCC
CAACTCTGATGGAGAGGCCCAGGCCAAGAAATTAGGGAAGAGCTGTGTGTTTGCCCCAACTGAC
GTGACATCTGAGAAGGATGTACAGACAGCCTTGACTCTAGCAAAGGAAAATTTTGGCCATGTGG
ATGTGGCCGTCAACTGTGCAGGTATTGCAGTGGCCAGTAAGACATATAACTTAAAGAAGAAGCA
GGCCCACAACTTGGAGGACTTCCAGCGAGTTATCAATGTGAATCTCTTAGGCACCTTCAATGTG
ATCCGCCTGGTTGCTGGTGAGATGGGCCAGAATGAGCCAGACCCGGGAGGCCAACGTGGGGTTA
TCATCAACACTGCCAGTGTGGCTGCCTTTGAGGGCCAGGTTGGACAAGCTGCATACTCTGCATC
CAAGGGAGGCATAGTGGGCATGACACTGCCCATTGCTCGGGATCTGGCTCCCATGGGCATCCGG
GTGATGACCATTGCTCCAGGCCTGTTTGGCACCCCACTGCTGACTACCCTCCCAGAAAAGGTAC
GCAACTTCTTGGCCACCCAGATACCTTTTCCCACCCGACTTGGAGACCCTGCTGAGTATGCTCA
TCTGGTACAGACCATAATTGAGAACCCATTCCTCAATGGAGAGGTCATCCGGCTGGATGGGGCC
ATCCGCATGCAACCTTGAACAGAGAAGGCAGGGAAAACACAGGCTCTTGTGCCTTACCTTCCCC
TGAGGAAGCCTAATAGCCATTTTGTGTCCACCTATCAATTGCCTTTGTGACTAATAAAGTCTCT
TTCATGGGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005401551	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000009292
	ENSCLAP00000009292.1

RefSeq Acc Id:

XP_005401551 ⟸ XM_005401494

- UniProtKB:

A0A8C2V3J7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAASRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSDGEAQAKKLGKSCVFAPTD
VTSEKDVQTALTLAKENFGHVDVAVNCAGIAVASKTYNLKKKQAHNLEDFQRVINVNLLGTFNV
IRLVAGEMGQNEPDPGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPMGIR
VMTIAPGLFGTPLLTTLPEKVRNFLATQIPFPTRLGDPAEYAHLVQTIIENPFLNGEVIRLDGA
IRMQP

hide sequence

Ensembl Acc Id:

ENSCLAP00000009292 ⟸ ENSCLAT00000009421

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000006462	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000009421	ENTREZGENE
	ENSCLAT00000009421.1	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	Sc_DH/Rdtase_CS	UniProtKB/TrEMBL
	SDR_fam	UniProtKB/TrEMBL
NCBI Gene	Hsd17b10	ENTREZGENE
PANTHER	3-HYDROXYACYL-COA DEHYDROGENASE TYPE-2	UniProtKB/TrEMBL
	SHORT-CHAIN DEHYDROGENASE/REDUCTASE	UniProtKB/TrEMBL
Pfam	adh_short	UniProtKB/TrEMBL
PRINTS	GDHRDH	UniProtKB/TrEMBL
	SDRFAMILY	UniProtKB/TrEMBL
PROSITE	ADH_SHORT	UniProtKB/TrEMBL
SMART	PKS_KR	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
UniProt	A0A8C2V3J7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Hsd17b10	hydroxysteroid 17-beta dehydrogenase 10		hydroxysteroid (17-beta) dehydrogenase 10	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Annotations - SMPDB