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Gene: HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10) Homo sapiens
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Symbol: HSD17B10
Name: hydroxysteroid 17-beta dehydrogenase 10
Description: Exhibits 3-hydroxyacyl-CoA dehydrogenase activity; tRNA binding activity; and testosterone dehydrogenase [NAD(P)] activity. Involved in mitochondrial tRNA processing; mitochondrion organization; and protein homotetramerization. Localizes to the mitochondrial ribonuclease P complex. Implicated in non-syndromic X-linked intellectual disability; pheochromocytoma; and syndromic X-linked intellectual disability type 10. Biomarker of Alzheimer's disease and osteosarcoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 17b-HSD10; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type-2; AB-binding alcohol dehydrogenase; ABAD; amyloid-beta peptide binding alcohol dehydrogenase; CAMR; DUPXp11.22; endoplasmic reticulum-associated amyloid beta-peptide-binding protein; ERAB; HADH2; HCD2; HSD10MD; hydroxysteroid (17-beta) dehydrogenase 10; hydroxysteroid dehydrogenase 10; mental retardation, X-linked 17; mental retardation, X-linked 31; mental retardation, X-linked, syndromic 10; MHBD; mitochondrial ribonuclease P protein 2; mitochondrial RNase P subunit 2; MRPP2; MRX17; MRX31; MRXS10; SCHAD; SDR5C1; short chain dehydrogenase/reductase family 5C member 1; short chain dehydrogenase/reductase family 5C, member 1; short chain L-3-hydroxyacyl-CoA dehydrogenase type 2; short chain type dehydrogenase/reductase XH98G2
Orthologs:
Mus musculus (house mouse) : Hsd17b10 (hydroxysteroid (17-beta) dehydrogenase 10)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hsd17b10 (hydroxysteroid (17-beta) dehydrogenase 10)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsd17b10 (hydroxysteroid 17-beta dehydrogenase 10)
Pan paniscus (bonobo/pygmy chimpanzee) : HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10)
Canis lupus familiaris (dog) : HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsd17b10 (hydroxysteroid 17-beta dehydrogenase 10)
Sus scrofa (pig) : HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10)
Chlorocebus sabaeus (African green monkey) : HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10)
Heterocephalus glaber (naked mole-rat) : Hsd17b10 (hydroxysteroid 17-beta dehydrogenase 10)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 EnsemblX53,431,258 - 53,434,370 (-)Ensembl
GRCh38 EnsemblX53,431,258 - 53,434,373 (-)Ensembl
GRCh38X53,431,258 - 53,434,376 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X53,458,206 - 53,461,323 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X53,474,931 - 53,478,048 (-)NCBINCBI36hg18NCBI36
Build 34X53,341,230 - 53,344,341NCBI
CeleraX57,289,763 - 57,292,880 (-)NCBI
Cytogenetic MapXp11.22NCBI
HuRefX50,515,835 - 50,518,952 (-)NCBIHuRef
CHM1_1X53,448,673 - 53,451,790 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Genomics

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Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

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Nomenclature History
 
More on HSD17B10
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732223
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.