Phex (phosphate regulating endopeptidase homolog, X-linked) - Rat Genome Database
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Gene: Phex (phosphate regulating endopeptidase homolog, X-linked) Rattus norvegicus
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Symbol: Phex
Name: phosphate regulating endopeptidase homolog, X-linked
RGD ID: 3323
Description: Predicted to have metal ion binding activity and metalloendopeptidase activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; cellular response to vitamin D; and response to insulin-like growth factor stimulus. Predicted to localize to Golgi apparatus; endoplasmic reticulum; and perinuclear region of cytoplasm. Biomarker of kidney failure. Human ortholog(s) of this gene implicated in X-linked dominant hypophosphatemic rickets. Orthologous to human PHEX (phosphate regulating endopeptidase homolog X-linked); INTERACTS WITH acrylamide; alachlor; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: metalloendopeptidase homolog PEX; PEX; phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets); Phosphate regulating neutral endopeptidase on the X chromosome (X-linked hypophosphatemia XLH); phosphate-regulating neutral endopeptidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X40,460,047 - 40,717,982 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX40,460,047 - 40,717,982 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X40,772,810 - 41,031,710 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X58,911,144 - 59,168,857 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X58,964,612 - 59,222,310 (+)NCBI
CeleraX38,233,227 - 38,472,933 (+)NCBICelera
Cytogenetic MapXq21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(2E,4E)-hexa-2,4-dienoic acid  (ISO)
1,4-dioxane  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-diaminotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
3-methylcholanthrene  (ISO)
7,12-dimethyltetraphene  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
aflatoxin M1  (ISO)
alachlor  (EXP)
all-trans-retinoic acid  (ISO)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
anthracene-1,8,9-triol  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
biphenyl-2-ol  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (EXP,ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
DDT  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
erythrosin B  (ISO)
fenvalerate  (EXP)
glycerol 2-phosphate  (ISO)
iron dichloride  (ISO)
iron trichloride  (ISO)
levamisole  (ISO)
Mezerein  (ISO)
nitrofen  (EXP)
oxaliplatin  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphonoformic acid  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
propionic acid  (ISO)
saccharin  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
styrene oxide  (ISO)
thyroxine  (ISO)
tin(II) chloride (anhydrous)  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
XL147  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. Brewer AJ, etal., Am J Physiol Renal Physiol. 2004 Apr;286(4):F739-48. Epub 2003 Dec 23.
2. Francis F, etal., Genome Res 1997 Jun;7(6):573-85.
3. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. GOA data from the GO Consortium
5. Hines ER, etal., J Biol Chem. 2004 Nov 5;279(45):46406-14. Epub 2004 Aug 25.
6. Holm IA, etal., Am J Hum Genet. 1997 Apr;60(4):790-7.
7. Lorenz-Depiereux B, etal., Mamm Genome. 2004 Mar;15(3):151-61.
8. Matsuki Y, etal., J Dent Res 1995 Jan;74(1):307-12.
9. Megerian CA, etal., Hear Res. 2008 Mar;237(1-2):90-105. doi: 10.1016/j.heares.2008.01.002. Epub 2008 Jan 15.
10. Meyer MH and Meyer RA Jr, Endocrine. 2000 Aug;13(1):81-7.
11. MGD data from the GO Consortium
12. NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. NO_AUTHOR Nat Genet. 1995 Oct;11(2):130-6.
14. OMIM Disease Annotation Pipeline
15. Owen C, etal., J Cell Biochem. 2012 Jul;113(7):2432-41. doi: 10.1002/jcb.24115.
16. Pellicelli M, etal., J Cell Physiol. 2012 Jun;227(6):2378-87. doi: 10.1002/jcp.22973.
17. RGD automated data pipeline
18. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. RGD automated import pipeline for gene-chemical interactions
20. RGD comprehensive gene curation
21. Strom TM, etal., Hum Mol Genet. 1997 Feb;6(2):165-71.
22. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23. Uno JK, etal., Gastroenterology. 2006 Aug;131(2):497-509.
24. Zoidis E, etal., Eur J Endocrinol 2002 Jan;146(1):97-105.
25. Zoidis E, etal., Mol Cell Endocrinol. 2000 Oct 25;168(1-2):41-51.
Additional References at PubMed
PMID:11409890   PMID:11811562   PMID:15843468   PMID:22206666   PMID:23174213  


Genomics

Comparative Map Data
Phex
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X40,460,047 - 40,717,982 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX40,460,047 - 40,717,982 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X40,772,810 - 41,031,710 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X58,911,144 - 59,168,857 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X58,964,612 - 59,222,310 (+)NCBI
CeleraX38,233,227 - 38,472,933 (+)NCBICelera
Cytogenetic MapXq21NCBI
PHEX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX22,032,325 - 22,251,310 (+)EnsemblGRCh38hg38GRCh38
GRCh38X22,032,325 - 22,251,310 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X22,050,921 - 22,266,478 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X21,960,842 - 22,176,399 (+)NCBINCBI36hg18NCBI36
Build 34X21,810,215 - 22,025,985NCBI
CeleraX26,171,770 - 26,387,304 (+)NCBI
Cytogenetic MapXp22.11NCBI
HuRefX19,791,354 - 20,006,299 (+)NCBIHuRef
CHM1_1X22,081,014 - 22,300,110 (+)NCBICHM1_1
Phex
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X155,945,071 - 156,198,282 (-)NCBIGRCm39mm39
GRCm38X157,162,075 - 157,415,286 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX157,162,075 - 157,415,312 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X153,596,618 - 153,853,218 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X152,502,794 - 152,759,383 (-)NCBImm8
CeleraX140,419,752 - 140,667,816 (-)NCBICelera
Cytogenetic MapXF4NCBI
cM MapX72.38NCBI
Phex
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555092,357,263 - 2,546,802 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555092,357,263 - 2,546,802 (+)NCBIChiLan1.0ChiLan1.0
PHEX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X22,017,678 - 22,235,560 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX22,017,681 - 22,232,501 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X14,663,847 - 14,859,294 (+)NCBIMhudiblu_PPA_v0panPan3
PHEX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX17,829,158 - 18,035,775 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1X17,830,714 - 18,038,755 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Phex
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366242,124,479 - 2,312,847 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHEX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX18,203,174 - 18,418,004 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X18,199,396 - 18,420,985 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X19,362,855 - 19,605,399 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PHEX
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 EnsemblX20,522,498 - 20,734,599 (+)Ensembl
ChlSab1.1X20,507,619 - 20,733,367 (+)NCBI
Phex
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248296,960,740 - 7,151,752 (+)NCBI

Position Markers
DXMgh2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X40,653,281 - 40,653,423NCBIRnor6.0
Rnor_5.0X40,962,512 - 40,962,654UniSTSRnor5.0
RGSC_v3.4X59,112,160 - 59,112,303RGDRGSC3.4
RGSC_v3.4X59,112,161 - 59,112,303UniSTSRGSC3.4
RGSC_v3.1X59,165,629 - 59,165,772RGD
CeleraX38,416,332 - 38,416,474UniSTS
Cytogenetic MapXq21UniSTS
RH 2.0 Map21423.4RGD


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X144092703Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X428214049282140Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X595407850954078Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X15688119127888215Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1815335263153352Rat
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2159262344320739Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2159262344468300Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:730
Count of miRNA genes:326
Interacting mature miRNAs:434
Transcripts:ENSRNOT00000010970
Prediction methods:Microtar, Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 6
Low 10 8 2 2 2 3 3 46 8 23 5 3
Below cutoff 30 21 11 15 11 5 5 28 24 13 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07038117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07038118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07038119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07038120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07038121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07038122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07038123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07038124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07038125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07038126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07038127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07038128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07038129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07038130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07038131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07038132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07038133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07038134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07038135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ001637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000010970   ⟹   ENSRNOP00000010970
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX40,460,047 - 40,717,982 (+)Ensembl
RefSeq Acc Id: NM_013004   ⟹   NP_037136
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X40,460,047 - 40,717,982 (+)NCBI
Rnor_5.0X40,772,810 - 41,031,710 (+)NCBI
RGSC_v3.4X58,911,144 - 59,168,857 (+)RGD
CeleraX38,233,227 - 38,472,933 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037136 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA04890 (Get FASTA)   NCBI Sequence Viewer  
  EDL96111 (Get FASTA)   NCBI Sequence Viewer  
  EDL96112 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037136   ⟸   NM_013004
- Sequence:
RefSeq Acc Id: ENSRNOP00000010970   ⟸   ENSRNOT00000010970
Protein Domains
Peptidase_M13   Peptidase_M13_N

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3323 AgrOrtholog
Ensembl Genes ENSRNOG00000023440 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000010970 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010970 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.1380.10 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M13 UniProtKB/TrEMBL
  Peptidase_M13_C UniProtKB/TrEMBL
  Peptidase_M13_dom_2 UniProtKB/TrEMBL
  Peptidase_M13_N UniProtKB/TrEMBL
KEGG Report rno:25512 UniProtKB/TrEMBL
NCBI Gene 25512 ENTREZGENE
PANTHER Peptidase_M13 UniProtKB/TrEMBL
Pfam Peptidase_M13 UniProtKB/TrEMBL
  Peptidase_M13_N UniProtKB/TrEMBL
PhenoGen Phex PhenoGen
PRINTS NEPRILYSIN UniProtKB/TrEMBL
PROSITE NEPRILYSIN UniProtKB/TrEMBL
TIGR TC210957
UniGene Rn.37861 ENTREZGENE
UniProt G3V723_RAT UniProtKB/TrEMBL
  O35812_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-26 Phex  phosphate regulating endopeptidase homolog, X-linked  Phex  phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Phex  phosphate regulating gene with homologies to endopeptidases on the X chromosome     Phosphate regulating neutral endopeptidase on the X chromosome (X-linked hypophosphatemia XLH)  Name updated 629478 APPROVED
2002-06-10 Phex  Phosphate regulating neutral endopeptidase on the X chromosome (X-linked hypophosphatemia XLH)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed mainly in bones, teeth and lungs 724649
gene_regulation induced in lungs and bones by IGF-I and GH 724649