Cdkl5 (cyclin-dependent kinase-like 5) - Rat Genome Database
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Gene: Cdkl5 (cyclin-dependent kinase-like 5) Rattus norvegicus
Analyze
Symbol: Cdkl5
Name: cyclin-dependent kinase-like 5
RGD ID: 2324133
Description: Exhibits Rac GTPase binding activity. Involved in neuron migration; positive regulation of GTPase activity; and positive regulation of neuron projection development. Localizes to dendrite; perinuclear region of cytoplasm; and synapse. Colocalizes with ruffle membrane. Human ortholog(s) of this gene implicated in Rett syndrome; early infantile epileptic encephalopathy 2; intellectual disability; and visual epilepsy. Orthologous to human CDKL5 (cyclin dependent kinase like 5); INTERACTS WITH 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil; methimazole.
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC100362725
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X35,536,396 - 35,773,204 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX35,599,258 - 35,771,711 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X35,864,921 - 36,102,409 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X55,033,499 - 55,228,646 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX34,451,035 - 34,675,154 (+)NCBICelera
Cytogenetic MapXq14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

Additional References at PubMed
PMID:15917271   PMID:16935860   PMID:22922712   PMID:25931508   PMID:27940108   PMID:29420175   PMID:30288694  


Genomics

Comparative Map Data
Cdkl5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X35,536,396 - 35,773,204 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX35,599,258 - 35,771,711 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X35,864,921 - 36,102,409 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X55,033,499 - 55,228,646 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX34,451,035 - 34,675,154 (+)NCBICelera
Cytogenetic MapXq14NCBI
CDKL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX18,425,583 - 18,653,629 (+)EnsemblGRCh38hg38GRCh38
GRCh38X18,425,608 - 18,653,629 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X18,443,725 - 18,671,749 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X18,353,646 - 18,581,670 (+)NCBINCBI36hg18NCBI36
Build 34X18,203,413 - 18,431,402NCBI
CeleraX22,563,823 - 22,791,841 (+)NCBI
Cytogenetic MapXp22.13NCBI
HuRefX16,199,185 - 16,425,423 (+)NCBIHuRef
CHM1_1X18,474,049 - 18,702,829 (+)NCBICHM1_1
Cdkl5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X159,567,304 - 159,777,677 (-)NCBIGRCm39mm39
GRCm38X160,784,308 - 160,994,681 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX160,771,923 - 160,994,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X157,222,240 - 157,432,613 (-)NCBIGRCm37mm9NCBIm37
CeleraX144,024,211 - 144,235,023 (-)NCBICelera
Cytogenetic MapXF4NCBI
cM MapX73.95NCBI
Cdkl5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955586809,386 - 997,485 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955586791,886 - 997,713 (-)NCBIChiLan1.0ChiLan1.0
CDKL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X18,412,018 - 18,638,735 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX18,492,329 - 18,638,735 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X11,047,357 - 11,261,172 (+)NCBIMhudiblu_PPA_v0panPan3
CDKL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX14,512,178 - 14,725,233 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1X14,512,226 - 14,725,348 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cdkl5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936844101,815 - 271,254 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDKL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX14,858,931 - 15,078,855 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X14,858,826 - 15,096,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X16,199,743 - 16,304,073 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDKL5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X16,955,540 - 17,101,513 (+)NCBI
Cdkl5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248293,288,239 - 3,479,620 (+)NCBI

Position Markers
DXRat87  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X35,640,424 - 35,640,574NCBIRnor6.0
Rnor_5.0X35,968,452 - 35,968,602UniSTSRnor5.0
RGSC_v3.4X55,143,816 - 55,143,967RGDRGSC3.4
RGSC_v3.4X55,143,817 - 55,143,967UniSTSRGSC3.4
RGSC_v3.1X55,197,285 - 55,197,436RGD
CeleraX34,553,241 - 34,553,391UniSTS
RH 3.4 MapX490.8UniSTS
RH 3.4 MapX490.8RGD
RH 2.0 Map21394.4RGD
SHRSP x BN MapX13.77RGD
DXGot31  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X35,757,676 - 35,757,830NCBIRnor6.0
Rnor_5.0X36,085,492 - 36,085,646UniSTSRnor5.0
RGSC_v3.4X55,250,372 - 55,250,527RGDRGSC3.4
RGSC_v3.4X55,250,373 - 55,250,527UniSTSRGSC3.4
RGSC_v3.1X55,303,841 - 55,303,996RGD
CeleraX34,658,491 - 34,658,645UniSTS
AU048188  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X35,586,631 - 35,586,902NCBIRnor6.0
Rnor_5.0X35,915,155 - 35,915,426UniSTSRnor5.0
RGSC_v3.4X55,085,126 - 55,085,397UniSTSRGSC3.4
CeleraX34,501,867 - 34,502,138UniSTS
RH136752  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X35,756,174 - 35,756,334NCBIRnor6.0
Rnor_5.0X36,083,990 - 36,084,150UniSTSRnor5.0
RGSC_v3.4X55,248,871 - 55,249,031UniSTSRGSC3.4
CeleraX34,656,989 - 34,657,149UniSTS
RH137814  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X35,716,998 - 35,717,201NCBIRnor6.0
Rnor_5.0X36,045,026 - 36,045,229UniSTSRnor5.0
RGSC_v3.4X55,220,260 - 55,220,463UniSTSRGSC3.4
CeleraX34,629,098 - 34,629,301UniSTS
RH 3.4 MapX503.01UniSTS
AI577388  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X35,745,469 - 35,745,578NCBIRnor6.0
Rnor_5.0X36,073,285 - 36,073,394UniSTSRnor5.0
RGSC_v3.4X55,238,356 - 55,238,465UniSTSRGSC3.4
CeleraX34,646,626 - 34,646,735UniSTS
RH 3.4 MapX490.3UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X144092703Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X428214049282140Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X595407850954078Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X15688119127888215Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1815335263153352Rat
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2159262344320739Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2159262344468300Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:73
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000005061, ENSRNOT00000072627
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 40 9 10
Low 1 43 55 41 19 41 8 8 34 35 32 1 8
Below cutoff 2 3

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_017588222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07037925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07037926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07037927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07037928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07037929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07037930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07037931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07037932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07037933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01110072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ807484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU351881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000005061   ⟹   ENSRNOP00000005061
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX35,599,291 - 35,771,711 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000072627   ⟹   ENSRNOP00000067316
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX35,599,258 - 35,771,711 (+)Ensembl
RefSeq Acc Id: XM_017588222   ⟹   XP_017443711
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
CeleraX34,451,035 - 34,637,510 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017588223   ⟹   XP_017443712
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
CeleraX34,514,284 - 34,637,510 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017588224   ⟹   XP_017443713
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
CeleraX34,514,284 - 34,675,154 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602290   ⟹   XP_017457779
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X35,536,396 - 35,725,432 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602291   ⟹   XP_017457780
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X35,536,396 - 35,725,432 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602292   ⟹   XP_017457781
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X35,536,396 - 35,773,204 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_017443711   ⟸   XM_017588222
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017443713   ⟸   XM_017588224
- Peptide Label: isoform X3
- UniProtKB: D3ZG85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017443712   ⟸   XM_017588223
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017457781   ⟸   XM_017602292
- Peptide Label: isoform X3
- UniProtKB: D3ZG85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457779   ⟸   XM_017602290
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017457780   ⟸   XM_017602291
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000067316   ⟸   ENSRNOT00000072627
RefSeq Acc Id: ENSRNOP00000005061   ⟸   ENSRNOT00000005061
Protein Domains
Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2324133 AgrOrtholog
Ensembl Genes ENSRNOG00000003742 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000005061 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000067316 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005061 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000072627 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
NCBI Gene 100362725 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Cdkl5 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniGene Rn.121553 ENTREZGENE
UniProt D3ZG85 ENTREZGENE, UniProtKB/TrEMBL
  E2E1S0_RAT UniProtKB/TrEMBL
UniProt Secondary E1U7Q0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-30 Cdkl5  cyclin-dependent kinase-like 5  LOC100362725  cyclin-dependent kinase-like 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100362725  cyclin-dependent kinase-like 5      Symbol and Name status set to provisional 70820 PROVISIONAL