Cdkl5 (cyclin-dependent kinase-like 5) - Rat Genome Database

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Gene: Cdkl5 (cyclin-dependent kinase-like 5) Rattus norvegicus
Analyze
Symbol: Cdkl5
Name: cyclin-dependent kinase-like 5
RGD ID: 2324133
Description: Enables small GTPase binding activity. Involved in several processes, including positive regulation of Rac protein signal transduction; positive regulation of dendritic spine development; and positive regulation of neurogenesis. Located in dendrite; perinuclear region of cytoplasm; and ruffle membrane. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in Rett syndrome; developmental and epileptic encephalopathy 2; and intellectual disability. Orthologous to human CDKL5 (cyclin dependent kinase like 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100362725
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X37,566,320 - 37,796,766 (+)NCBIGRCr8
mRatBN7.2X33,757,605 - 33,988,075 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX33,821,257 - 33,986,582 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X35,536,396 - 35,773,204 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX35,599,258 - 35,771,711 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X35,864,921 - 36,102,409 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X55,033,499 - 55,228,646 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX34,451,035 - 34,675,154 (+)NCBICelera
Cytogenetic MapXq14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Recurrent mutations in the CDKL5 gene: genotype-phenotype relationships. Bahi-Buisson N, etal., Am J Med Genet A. 2012 Jul;158A(7):1612-9. doi: 10.1002/ajmg.a.35401. Epub 2012 Jun 7.
2. CDKL5, a protein associated with rett syndrome, regulates neuronal morphogenesis via Rac1 signaling. Chen Q, etal., J Neurosci. 2010 Sep 22;30(38):12777-86. doi: 10.1523/JNEUROSCI.1102-10.2010.
3. Novel mutations in cyclin-dependent kinase-like 5 (CDKL5) gene in Indian cases of Rett syndrome. Das DK, etal., Neuromolecular Med. 2013 Mar;15(1):218-25. doi: 10.1007/s12017-012-8212-z. Epub 2012 Dec 15.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Historic, clinical, and prognostic features of epileptic encephalopathies caused by CDKL5 mutations. Moseley BD, etal., Pediatr Neurol. 2012 Feb;46(2):101-5. doi: 10.1016/j.pediatrneurol.2011.11.007.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Neurodevelopmental and neurobehavioral characteristics in males and females with CDKL5 duplications. Szafranski P, etal., Eur J Hum Genet. 2015 Jul;23(7):915-21. doi: 10.1038/ejhg.2014.217. Epub 2014 Oct 15.
10. Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development. Zhu YC, etal., Proc Natl Acad Sci U S A. 2013 May 28;110(22):9118-23. doi: 10.1073/pnas.1300003110. Epub 2013 May 13.
Additional References at PubMed
PMID:15917271   PMID:16935860   PMID:20211261   PMID:22922712   PMID:25931508   PMID:27940108   PMID:29420175   PMID:30288694   PMID:36759195   PMID:38877552  


Genomics

Comparative Map Data
Cdkl5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X37,566,320 - 37,796,766 (+)NCBIGRCr8
mRatBN7.2X33,757,605 - 33,988,075 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX33,821,257 - 33,986,582 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X35,536,396 - 35,773,204 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX35,599,258 - 35,771,711 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X35,864,921 - 36,102,409 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X55,033,499 - 55,228,646 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX34,451,035 - 34,675,154 (+)NCBICelera
Cytogenetic MapXq14NCBI
CDKL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X18,425,608 - 18,653,629 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX18,425,583 - 18,653,629 (+)EnsemblGRCh38hg38GRCh38
GRCh37X18,443,728 - 18,671,749 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X18,353,646 - 18,581,670 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X18,203,413 - 18,431,402NCBI
CeleraX22,563,823 - 22,791,841 (+)NCBICelera
Cytogenetic MapXp22.13NCBI
HuRefX16,199,185 - 16,425,423 (+)NCBIHuRef
CHM1_1X18,474,049 - 18,702,829 (+)NCBICHM1_1
T2T-CHM13v2.0X18,008,223 - 18,236,232 (+)NCBIT2T-CHM13v2.0
Cdkl5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X159,567,241 - 159,777,673 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX159,554,919 - 159,777,700 (-)EnsemblGRCm39 Ensembl
GRCm38X160,784,308 - 160,994,681 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX160,771,923 - 160,994,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X157,222,240 - 157,432,613 (-)NCBIGRCm37MGSCv37mm9NCBIm37
CeleraX144,024,211 - 144,235,023 (-)NCBICelera
Cytogenetic MapXF4NCBI
cM MapX73.95NCBI
Cdkl5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955586809,386 - 997,485 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955586791,886 - 997,713 (-)NCBIChiLan1.0ChiLan1.0
CDKL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X20,222,401 - 20,431,439 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X20,225,793 - 20,434,831 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X11,047,357 - 11,261,172 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X18,412,018 - 18,638,735 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX18,492,329 - 18,638,735 (+)Ensemblpanpan1.1panPan2
CDKL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X14,512,226 - 14,725,348 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX14,512,178 - 14,725,233 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X14,472,365 - 14,691,693 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX14,472,377 - 14,692,899 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X14,539,994 - 14,752,603 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X14,533,192 - 14,745,807 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X14,596,867 - 14,809,610 (+)NCBIUU_Cfam_GSD_1.0
Cdkl5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X7,612,076 - 7,808,649 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936844160,833 - 271,901 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936844101,815 - 271,254 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDKL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX14,952,225 - 15,078,855 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X14,858,826 - 15,096,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X16,199,743 - 16,304,073 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDKL5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X16,955,540 - 17,101,513 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605618,759,157 - 18,974,830 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdkl5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248293,356,580 - 3,472,832 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248293,288,239 - 3,479,620 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdkl5
778 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:73
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000005061, ENSRNOT00000072627
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat

Markers in Region
DXRat87  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X37,674,240 - 37,674,391 (+)Marker Load Pipeline
mRatBN7.2X33,865,542 - 33,865,693 (+)MAPPERmRatBN7.2
Rnor_6.0X35,640,424 - 35,640,574NCBIRnor6.0
Rnor_5.0X35,968,452 - 35,968,602UniSTSRnor5.0
RGSC_v3.4X55,143,816 - 55,143,967RGDRGSC3.4
RGSC_v3.4X55,143,817 - 55,143,967UniSTSRGSC3.4
RGSC_v3.1X55,197,285 - 55,197,436RGD
CeleraX34,553,241 - 34,553,391UniSTS
RH 3.4 MapX490.8UniSTS
RH 3.4 MapX490.8RGD
RH 2.0 Map21394.4RGD
SHRSP x BN MapX13.77RGD
DXGot31  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X37,780,068 - 37,780,225 (+)Marker Load Pipeline
mRatBN7.2X33,971,379 - 33,971,534 (+)MAPPERmRatBN7.2
Rnor_6.0X35,757,676 - 35,757,830NCBIRnor6.0
Rnor_5.0X36,085,492 - 36,085,646UniSTSRnor5.0
RGSC_v3.4X55,250,372 - 55,250,527RGDRGSC3.4
RGSC_v3.4X55,250,373 - 55,250,527UniSTSRGSC3.4
RGSC_v3.1X55,303,841 - 55,303,996RGD
CeleraX34,658,491 - 34,658,645UniSTS
AU048188  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X37,617,330 - 37,617,602 (+)Marker Load Pipeline
mRatBN7.2X33,808,623 - 33,808,895 (+)MAPPERmRatBN7.2
Rnor_6.0X35,586,631 - 35,586,902NCBIRnor6.0
Rnor_5.0X35,915,155 - 35,915,426UniSTSRnor5.0
RGSC_v3.4X55,085,126 - 55,085,397UniSTSRGSC3.4
CeleraX34,501,867 - 34,502,138UniSTS
RH136752  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X33,969,877 - 33,970,038 (+)MAPPERmRatBN7.2
Rnor_6.0X35,756,174 - 35,756,334NCBIRnor6.0
Rnor_5.0X36,083,990 - 36,084,150UniSTSRnor5.0
RGSC_v3.4X55,248,871 - 55,249,031UniSTSRGSC3.4
CeleraX34,656,989 - 34,657,149UniSTS
RH137814  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X33,941,749 - 33,941,953 (+)MAPPERmRatBN7.2
Rnor_6.0X35,716,998 - 35,717,201NCBIRnor6.0
Rnor_5.0X36,045,026 - 36,045,229UniSTSRnor5.0
RGSC_v3.4X55,220,260 - 55,220,463UniSTSRGSC3.4
CeleraX34,629,098 - 34,629,301UniSTS
RH 3.4 MapX503.01UniSTS
AI577388  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X33,959,355 - 33,959,465 (+)MAPPERmRatBN7.2
Rnor_6.0X35,745,469 - 35,745,578NCBIRnor6.0
Rnor_5.0X36,073,285 - 36,073,394UniSTSRnor5.0
RGSC_v3.4X55,238,356 - 55,238,465UniSTSRGSC3.4
CeleraX34,646,626 - 34,646,735UniSTS
RH 3.4 MapX490.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000005061   ⟹   ENSRNOP00000005061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX33,821,257 - 33,986,582 (+)Ensembl
Rnor_6.0 EnsemblX35,599,291 - 35,771,711 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000072627   ⟹   ENSRNOP00000067316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX33,821,257 - 33,986,582 (+)Ensembl
Rnor_6.0 EnsemblX35,599,258 - 35,771,711 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095927   ⟹   ENSRNOP00000088060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX33,821,257 - 33,960,174 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104285   ⟹   ENSRNOP00000078764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX33,821,290 - 33,986,582 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107431   ⟹   ENSRNOP00000082790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX33,821,257 - 33,960,174 (+)Ensembl
RefSeq Acc Id: NM_001421533   ⟹   NP_001408462
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X37,566,378 - 37,765,738 (+)NCBI
mRatBN7.2X33,757,663 - 33,957,044 (+)NCBI
RefSeq Acc Id: XM_017602290   ⟹   XP_017457779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X37,566,320 - 37,765,738 (+)NCBI
mRatBN7.2X33,757,605 - 33,957,044 (+)NCBI
Rnor_6.0X35,536,396 - 35,725,432 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039100454   ⟹   XP_038956382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X37,579,479 - 37,765,738 (+)NCBI
mRatBN7.2X33,770,763 - 33,957,044 (+)NCBI
RefSeq Acc Id: XM_039100455   ⟹   XP_038956383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X37,566,320 - 37,796,766 (+)NCBI
mRatBN7.2X33,757,605 - 33,988,075 (+)NCBI
RefSeq Acc Id: XM_063279693   ⟹   XP_063135763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X37,583,974 - 37,796,766 (+)NCBI
RefSeq Acc Id: XP_017457779   ⟸   XM_017602290
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZVL4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067316   ⟸   ENSRNOT00000072627
Ensembl Acc Id: ENSRNOP00000005061   ⟸   ENSRNOT00000005061
RefSeq Acc Id: XP_038956383   ⟸   XM_039100455
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZVL4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956382   ⟸   XM_039100454
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZVL4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082790   ⟸   ENSRNOT00000107431
Ensembl Acc Id: ENSRNOP00000078764   ⟸   ENSRNOT00000104285
Ensembl Acc Id: ENSRNOP00000088060   ⟸   ENSRNOT00000095927
RefSeq Acc Id: NP_001408462   ⟸   NM_001421533
- UniProtKB: A0A8I6A725 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135763   ⟸   XM_063279693
- Peptide Label: isoform X3
- UniProtKB: A0A8I6G3S6 (UniProtKB/TrEMBL),   D3ZG85 (UniProtKB/TrEMBL),   E1U7Q0 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZG85-F1-model_v2 AlphaFold D3ZG85 1-934 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2324133 AgrOrtholog
BioCyc Gene G2FUF-2511 BioCyc
Ensembl Genes ENSRNOG00000003742 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005061 ENTREZGENE
  ENSRNOT00000005061.7 UniProtKB/TrEMBL
  ENSRNOT00000072627.4 UniProtKB/TrEMBL
  ENSRNOT00000095927.1 UniProtKB/TrEMBL
  ENSRNOT00000104285.1 UniProtKB/TrEMBL
  ENSRNOT00000107431.1 UniProtKB/TrEMBL
  ENSRNOT00000150186 ENTREZGENE
  ENSRNOT00000174042 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CDK UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
NCBI Gene 100362725 ENTREZGENE
PANTHER CELL DIVISION PROTEIN KINASE UniProtKB/TrEMBL
  CYCLIN-DEPENDENT KINASE-LIKE 5 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Cdkl5 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003742 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I5ZVL4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A725 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G3S6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZG85 ENTREZGENE, UniProtKB/TrEMBL
  E1U7Q0 ENTREZGENE
  E2E1S0_RAT UniProtKB/TrEMBL
UniProt Secondary E1U7Q0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-30 Cdkl5  cyclin-dependent kinase-like 5  LOC100362725  cyclin-dependent kinase-like 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100362725  cyclin-dependent kinase-like 5      Symbol and Name status set to provisional 70820 PROVISIONAL