Mid1 (midline 1) - Rat Genome Database

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Gene: Mid1 (midline 1) Rattus norvegicus
Analyze
Symbol: Mid1
Name: midline 1
RGD ID: 2640
Description: Predicted to enable several functions, including microtubule binding activity; protein homodimerization activity; and ubiquitin protein ligase binding activity. Predicted to be involved in positive regulation of stress-activated MAPK cascade; protein localization to microtubule; and regulation of microtubule cytoskeleton organization. Predicted to act upstream of or within negative regulation of microtubule depolymerization. Predicted to be located in Golgi apparatus; cytosol; and microtubule cytoskeleton. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Opitz GBBB syndrome. Orthologous to human MID1 (midline 1); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase Midline-1; finger on X and Y (in rat only on X); Fxy; midline 1 (Opitz/BBB syndrome); midline-1; Midline1; RING finger protein Midline-1; RING-type E3 ubiquitin transferase Midline-1; tripartite motif-containing protein 18
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X27,678,248 - 28,053,049 (-)NCBIGRCr8
mRatBN7.2X24,116,674 - 24,491,205 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX24,120,293 - 24,248,353 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX25,102,036 - 25,230,478 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X28,523,075 - 28,651,528 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X24,768,159 - 24,896,216 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X25,458,782 - 25,839,941 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX25,458,771 - 25,628,272 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X25,869,975 - 26,249,296 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X44,751,950 - 44,879,999 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X44,805,418 - 44,933,468 (-)NCBI
CeleraX24,547,301 - 24,674,105 (-)NCBICelera
Cytogenetic MapXq13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl trisulfide  (ISO)
dichloroacetic acid  (ISO)
diisononyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenvalerate  (EXP)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (EXP)
GW 7647  (EXP,ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
succimer  (ISO)
testosterone  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Widely spaced alternative promoters, conserved between human and rodent, control expression of the Opitz syndrome gene MID1. Landry JR and Mager DL, Genomics 2002 Nov;80(5):499-508.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Evolutionary rate of a gene affected by chromosomal position. Perry J and Ashworth A, Curr Biol 1999 Sep 9;9(17):987-9.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11806752   PMID:15070402   PMID:17438131   PMID:18005432   PMID:18949047   PMID:22493164   PMID:22829933   PMID:25416956  


Genomics

Comparative Map Data
Mid1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X27,678,248 - 28,053,049 (-)NCBIGRCr8
mRatBN7.2X24,116,674 - 24,491,205 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX24,120,293 - 24,248,353 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX25,102,036 - 25,230,478 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X28,523,075 - 28,651,528 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X24,768,159 - 24,896,216 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X25,458,782 - 25,839,941 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX25,458,771 - 25,628,272 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X25,869,975 - 26,249,296 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X44,751,950 - 44,879,999 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X44,805,418 - 44,933,468 (-)NCBI
CeleraX24,547,301 - 24,674,105 (-)NCBICelera
Cytogenetic MapXq13NCBI
MID1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X10,445,310 - 10,833,683 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX10,445,310 - 10,833,654 (-)EnsemblGRCh38hg38GRCh38
GRCh37X10,413,350 - 10,851,802 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X10,373,596 - 10,761,730 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X10,225,901 - 10,398,195NCBI
CeleraX14,584,610 - 14,973,762 (-)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX8,245,662 - 8,632,012 (-)NCBIHuRef
CHM1_1X10,443,740 - 10,882,213 (-)NCBICHM1_1
T2T-CHM13v2.0X10,027,869 - 10,416,213 (-)NCBIT2T-CHM13v2.0
Mid1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X168,468,178 - 168,773,692 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX168,468,195 - 168,773,794 (+)EnsemblGRCm39 Ensembl
GRCm38X169,685,199 - 169,990,798 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX169,685,199 - 170,005,736 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X166,123,179 - 166,428,730 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X165,029,352 - 165,344,845 (+)NCBIMGSCv36mm8
CeleraX152,849,611 - 153,131,383 (+)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX79.19NCBI
Mid1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555442,484,854 - 2,719,112 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555442,379,766 - 2,718,282 (+)NCBIChiLan1.0ChiLan1.0
MID1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X12,247,798 - 12,635,811 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X12,251,464 - 12,483,362 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X3,075,834 - 3,463,845 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X10,328,476 - 10,715,914 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX10,328,476 - 10,459,284 (-)Ensemblpanpan1.1panPan2
MID1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X7,087,890 - 7,438,553 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX7,089,831 - 7,194,267 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX7,042,862 - 7,395,336 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X7,033,632 - 7,390,212 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX7,036,207 - 7,242,435 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X7,023,168 - 7,375,574 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X7,058,915 - 7,411,617 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X7,049,392 - 7,406,171 (-)NCBIUU_Cfam_GSD_1.0
Mid1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X414,418 - 767,610 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936470414,409 - 576,669 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936470414,420 - 576,717 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MID1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX7,237,942 - 7,620,011 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X7,235,386 - 7,906,049 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X7,630,961 - 7,771,708 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MID1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X8,897,424 - 9,289,187 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX8,895,602 - 9,076,871 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605610,595,252 - 10,977,148 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mid1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248823,627,879 - 3,876,526 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248823,504,660 - 3,876,526 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mid1
1673 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:91
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000004873
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat

Markers in Region
DXRat85  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X24,126,708 - 24,127,019 (+)MAPPERmRatBN7.2
Rnor_6.0X25,468,817 - 25,469,127NCBIRnor6.0
Rnor_5.0X25,880,010 - 25,880,320UniSTSRnor5.0
RGSC_v3.4X44,758,364 - 44,758,676RGDRGSC3.4
RGSC_v3.4X44,758,366 - 44,758,676UniSTSRGSC3.4
RGSC_v3.1X44,811,819 - 44,812,280RGD
CeleraX24,553,717 - 24,554,027UniSTS
SHRSP x BN MapX6.8999RGD
SHRSP x BN MapX6.8999UniSTS
Cytogenetic MapXq21UniSTS
DXGot43  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X24,184,822 - 24,185,068 (+)MAPPERmRatBN7.2
Rnor_6.0X25,527,228 - 25,527,473NCBIRnor6.0
Rnor_5.0X25,938,421 - 25,938,666UniSTSRnor5.0
RGSC_v3.4X44,816,472 - 44,816,718RGDRGSC3.4
RGSC_v3.4X44,816,473 - 44,816,718UniSTSRGSC3.4
RGSC_v3.1X44,869,941 - 44,870,187RGD
Cytogenetic MapXq21UniSTS
DXUia1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X24,152,281 - 24,152,398 (+)MAPPERmRatBN7.2
Rnor_6.0X25,494,390 - 25,494,506NCBIRnor6.0
Rnor_5.0X25,905,583 - 25,905,699UniSTSRnor5.0
RGSC_v3.4X44,783,938 - 44,784,055RGDRGSC3.4
RGSC_v3.4X44,783,939 - 44,784,055UniSTSRGSC3.4
RGSC_v3.1X44,837,407 - 44,837,524RGD
CeleraX24,579,290 - 24,579,406UniSTS
Cytogenetic MapXq21UniSTS
PMC311143P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X24,160,061 - 24,160,163 (+)MAPPERmRatBN7.2
Rnor_6.0X25,502,169 - 25,502,270NCBIRnor6.0
Rnor_5.0X25,913,362 - 25,913,463UniSTSRnor5.0
RGSC_v3.4X44,791,718 - 44,791,819UniSTSRGSC3.4
CeleraX24,587,069 - 24,587,170UniSTS
Cytogenetic MapXq21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001431605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF186461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY112905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF217427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF217428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF217429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000004873   ⟹   ENSRNOP00000004873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX24,120,293 - 24,248,353 (-)Ensembl
Rnor_6.0 EnsemblX25,462,401 - 25,590,048 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086414   ⟹   ENSRNOP00000072598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX25,458,771 - 25,628,272 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098663   ⟹   ENSRNOP00000084119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX24,120,293 - 24,157,772 (-)Ensembl
RefSeq Acc Id: NM_022927   ⟹   NP_075216
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X27,681,867 - 27,809,920 (-)NCBI
mRatBN7.2X24,120,293 - 24,248,353 (-)NCBI
Rnor_6.0X25,462,401 - 25,590,048 (-)NCBI
Rnor_5.0X25,869,975 - 26,249,296 (-)NCBI
RGSC_v3.4X44,751,950 - 44,879,999 (-)RGD
CeleraX24,547,301 - 24,674,105 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256825   ⟹   XP_006256887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X27,678,248 - 27,848,420 (-)NCBI
mRatBN7.2X24,116,674 - 24,286,857 (-)NCBI
Rnor_6.0X25,458,782 - 25,629,434 (-)NCBI
Rnor_5.0X25,869,975 - 26,249,296 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017602142   ⟹   XP_017457631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X27,678,248 - 28,053,049 (-)NCBI
mRatBN7.2X24,116,674 - 24,491,205 (-)NCBI
Rnor_6.0X25,458,782 - 25,839,941 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017602143   ⟹   XP_017457632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X27,678,248 - 27,906,559 (-)NCBI
mRatBN7.2X24,116,674 - 24,345,018 (-)NCBI
Rnor_6.0X25,458,782 - 25,688,440 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099997   ⟹   XP_038955925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X27,678,248 - 27,907,110 (-)NCBI
mRatBN7.2X24,116,674 - 24,345,464 (-)NCBI
RefSeq Acc Id: XM_039099998   ⟹   XP_038955926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X27,678,248 - 27,848,422 (-)NCBI
mRatBN7.2X24,116,674 - 24,286,857 (-)NCBI
RefSeq Acc Id: NP_075216   ⟸   NM_022927
- UniProtKB: P82458 (UniProtKB/Swiss-Prot),   A6K2D8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256887   ⟸   XM_006256825
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017457631   ⟸   XM_017602142
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017457632   ⟸   XM_017602143
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000004873   ⟸   ENSRNOT00000004873
Ensembl Acc Id: ENSRNOP00000072598   ⟸   ENSRNOT00000086414
RefSeq Acc Id: XP_038955925   ⟸   XM_039099997
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038955926   ⟸   XM_039099998
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000084119   ⟸   ENSRNOT00000098663
Protein Domains
B box-type   B30.2/SPRY   COS   Fibronectin type-III   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P82458-F1-model_v2 AlphaFold P82458 1-667 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701779
Promoter ID:EPDNEW_R12303
Type:single initiation site
Name:Mid1_2
Description:midline 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12304  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X25,590,000 - 25,590,060EPDNEW
RGD ID:13701787
Promoter ID:EPDNEW_R12304
Type:initiation region
Name:Mid1_1
Description:midline 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12303  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X25,628,244 - 25,628,304EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2640 AgrOrtholog
BioCyc Gene G2FUF-2681 BioCyc
Ensembl Genes ENSRNOG00000003613 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055022432 UniProtKB/Swiss-Prot
  ENSRNOG00060023380 UniProtKB/Swiss-Prot
  ENSRNOG00065023150 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004873.7 UniProtKB/Swiss-Prot
  ENSRNOT00000098663.1 UniProtKB/TrEMBL
  ENSRNOT00055038574 UniProtKB/Swiss-Prot
  ENSRNOT00060040616 UniProtKB/Swiss-Prot
  ENSRNOT00065039580 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot
  4.10.830.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zinc/RING finger domain, C3HC4 (zinc finger) UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bbox_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Butyrophylin_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COS_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E3_ligase_FN3/SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MID1 UniProtKB/Swiss-Prot
  MID1_Bbox1_Zfn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MID1_Bbox2_Zfn UniProtKB/TrEMBL
  Midline-1_COS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf-RING_euk UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Znf_B-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54252 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 54252 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24099:SF23 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANCHR-like_BBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-B_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-RING_UBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mid1 PhenoGen
PRINTS BUTYPHLNCDUF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_BBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003613 RatGTEx
  ENSRNOG00055022432 RatGTEx
  ENSRNOG00060023380 RatGTEx
  ENSRNOG00065023150 RatGTEx
SMART BBC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP B-box zinc-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6G9W9_RAT UniProtKB/TrEMBL
  A6K2D8 ENTREZGENE, UniProtKB/TrEMBL
  P82458 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-06-25 Mid1  midline 1  Mid1  midline 1 (Opitz/BBB syndrome)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-02-27 Mid1  midline 1 (Opitz/BBB syndrome)  Mid1  midline 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Mid1  midline 1      Name updated 70584 APPROVED
2001-06-12 Fxy  Finger on X and Y (in rat only on X)      Symbol and Name withdrawn 62408 WITHDRAWN
2001-06-12 Mid1  Midline1      Symbol and Name updated to reflect Human and Mouse nomenclature 62408 APPROVED