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Gene: MID2 (midline 2) Homo sapiens
Symbol: MID2
Name: midline 2
Description: Exhibits microtubule binding activity; phosphoprotein binding activity; and protein dimerization activity. Involved in several processes, including negative regulation of viral process; positive regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of NF-kappaB transcription factor activity. Localizes to the microtubule. Implicated in non-syndromic X-linked intellectual disability.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ37715; FLJ41813; FXY2; midin 2; midin-2; midline defect 2; midline-2; MRX101; probable E3 ubiquitin-protein ligase MID2; RING finger protein 60; RING-type E3 ubiquitin transferase MID2; RNF60; TRIM1; tripartite motif protein 1; tripartite motif-containing protein 1
Mus musculus (house mouse) : Mid2 (midline 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mid2 (midline 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mid2 (midline 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MID2 (midline 2)
Canis lupus familiaris (dog) : MID2 (midline 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mid2 (midline 2)
Sus scrofa (pig) : MID2 (midline 2)
Chlorocebus sabaeus (African green monkey) : MID2 (midline 2)
Heterocephalus glaber (naked mole-rat) : Mid2 (midline 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 EnsemblX107,825,755 - 107,927,193 (+)Ensembl
GRCh38X107,820,453 - 107,931,637 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X107,068,889 - 107,174,867 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X106,956,116 - 107,057,077 (+)NCBINCBI36hg18NCBI36
CeleraX107,540,045 - 107,645,826 (+)NCBI
Cytogenetic MapXq22.3NCBI
HuRefX96,692,632 - 96,797,758 (+)NCBIHuRef
CHM1_1X106,979,937 - 107,085,716 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MID2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1602493
Created: 2007-04-27
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.