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Gene: MID1 (midline 1) Homo sapiens
Symbol: MID1
Name: midline 1
Description: Exhibits several functions, including microtubule binding activity; protein dimerization activity; and ubiquitin protein ligase binding activity. Involved in positive regulation of stress-activated MAPK cascade and protein localization to microtubule. Localizes to the microtubule. Colocalizes with the cytoplasmic microtubule. Implicated in Opitz-GBBB syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BBBG1; E3 ubiquitin-protein ligase Midline-1; FLJ57031; FLJ58683; FLJ76288; FXY; GBBB1; MIDIN; midline 1 RING finger protein; midline-1; OGS1; Opitz/BBB syndrome; OS; OSX; putative transcription factor XPRF; RING finger protein 59; RING finger protein Midline-1; RING-type E3 ubiquitin transferase Midline-1; RNF59; TRIM18; tripartite motif protein TRIM18; tripartite motif-containing protein 18; XPRF; zinc finger on X and Y, mouse, homolog of; ZNFXY
Mus musculus (house mouse) : Mid1 (midline 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mid1 (midline 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mid1 (midline 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MID1 (midline 1)
Canis lupus familiaris (dog) : MID1 (midline 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mid1 (midline 1)
Sus scrofa (pig) : MID1 (midline 1)
Chlorocebus sabaeus (African green monkey) : MID1 (midline 1)
Heterocephalus glaber (naked mole-rat) : Mid1 (midline 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 EnsemblX10,445,310 - 10,833,654 (-)Ensembl
GRCh38X10,445,310 - 10,833,683 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X10,413,350 - 10,851,829 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X10,373,596 - 10,761,730 (-)NCBINCBI36hg18NCBI36
Build 34X10,225,901 - 10,398,195NCBI
CeleraX14,584,610 - 14,973,762 (-)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX8,245,662 - 8,632,012 (-)NCBIHuRef
CHM1_1X10,443,740 - 10,882,213 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on MID1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732275
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.