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Gene: Mid1 (midline 1) Mus musculus
Symbol: Mid1
Name: midline 1
Description: Predicted to have several functions, including microtubule binding activity; protein dimerization activity; and ubiquitin protein ligase binding activity. Involved in negative regulation of microtubule depolymerization. Localizes to the cytoplasm and microtubule cytoskeleton. Predicted to colocalize with the cytoplasmic microtubule. Used to study Opitz-GBBB syndrome and microphthalmia. Human ortholog(s) of this gene implicated in Opitz-GBBB syndrome. Is expressed in several structures, including 1st branchial arch; brain; genitourinary system; sensory organ; and spinal cord. Orthologous to human MID1 (midline 1); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-methylcholanthrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 61B3-R; DXHXS1141; E3 ubiquitin-protein ligase Midline-1; Fxy; MGC60591; midin; midline-1; RING finger protein Midline-1; RING-type E3 ubiquitin transferase Midline-1; Trim18; tripartite motif-containing protein 18
Homo sapiens (human) : MID1 (midline 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mid1 (midline 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mid1 (midline 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MID1 (midline 1)
Canis lupus familiaris (dog) : MID1 (midline 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mid1 (midline 1)
Sus scrofa (pig) : MID1 (midline 1)
Chlorocebus sabaeus (green monkey) : MID1 (midline 1)
Heterocephalus glaber (naked mole-rat) : Mid1 (midline 1)
more info ...
Related Pseudogenes: Mid1-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 EnsemblX169,685,199 - 170,005,736 (+)Ensembl
GRCm38X169,685,199 - 169,990,798 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X166,123,179 - 166,428,730 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X165,029,352 - 165,344,845 (+)NCBImm8
CeleraX152,849,563 - 153,131,383 (+)NCBICelera
Cytogenetic MapX F5NCBI
cM MapX79.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Mid1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732276
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.