Bmx (BMX non-receptor tyrosine kinase)

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Gene: Bmx (BMX non-receptor tyrosine kinase) Rattus norvegicus

Analyze

Symbol:

Bmx

Name:

BMX non-receptor tyrosine kinase

RGD ID:

1565643

Description:

Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in B cell receptor signaling pathway; adaptive immune response; and protein autophosphorylation. Predicted to be located in nucleoplasm and ruffle membrane. Orthologous to human BMX (BMX non-receptor tyrosine kinase); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; endosulfan.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

cytoplasmic tyrosine-protein kinase BMX; LOC367786; RGD1565643; similar to protein tyrosine kinase Bmx

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BMX (BMX non-receptor tyrosine kinase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Bmx (BMX non-receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Bmx (BMX non-receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BMX (BMX non-receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BMX (BMX non-receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Bmx (BMX non-receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BMX (BMX non-receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BMX (BMX non-receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Bmx (BMX non-receptor tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	BTK (Bruton tyrosine kinase)	HGNC	OrthoDB
Alliance orthologs ³
Mus musculus (house mouse):	Bmx (BMX non-receptor tyrosine kinase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	BMX (BMX non-receptor tyrosine kinase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Btk29A	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	X	30,227,251 - 30,290,015 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	30,227,251 - 30,289,993 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	31,259,834 - 31,322,436 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	X	34,697,126 - 34,759,876 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	X	30,884,657 - 30,947,292 (+)	NCBI	Rnor_WKY
Rnor_6.0	X	31,976,231 - 32,046,326 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	31,984,612 - 32,045,448 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	32,349,437 - 32,417,878 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	50,982,940 - 51,047,351 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	30,571,855 - 30,633,715 (+)	NCBI		Celera
Cytogenetic Map	X	q14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Fanconi anemia (ISO)

genetic disease (ISO)

multiple congenital anomalies-hypotonia-seizures syndrome 2 (ISO)

Neurodevelopmental Disorders (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (ISO)

6-propyl-2-thiouracil (EXP)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroprene (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

doxorubicin (ISO)

endosulfan (EXP)

gentamycin (EXP)

omeprazole (ISO)

paracetamol (EXP,ISO)

ponatinib (ISO)

tetraphene (ISO)

trichloroethene (EXP)

valproic acid (ISO)

vanadium atom (ISO)

vanadium(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adaptive immune response (IBA)

B cell receptor signaling pathway (IBA)

intracellular signal transduction (IEA)

protein autophosphorylation (ISO)

signal transduction (ISO)

Cellular Component

cytoplasm (IEA)

nucleoplasm (IEA,ISO)

plasma membrane (ISO)

ruffle membrane (ISO)

Molecular Function

ATP binding (IEA)

metal ion binding (IEA)

non-membrane spanning protein tyrosine kinase activity (IBA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10688651	PMID:11331870	PMID:21929872	PMID:22723969	PMID:24785188

Genomics

Comparative Map Data

Bmx
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	X	30,227,251 - 30,290,015 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	30,227,251 - 30,289,993 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	31,259,834 - 31,322,436 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	X	34,697,126 - 34,759,876 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	X	30,884,657 - 30,947,292 (+)	NCBI	Rnor_WKY
Rnor_6.0	X	31,976,231 - 32,046,326 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	31,984,612 - 32,045,448 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	32,349,437 - 32,417,878 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	50,982,940 - 51,047,351 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	30,571,855 - 30,633,715 (+)	NCBI		Celera
Cytogenetic Map	X	q14	NCBI

BMX
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	15,500,807 - 15,556,519 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	X	15,464,246 - 15,556,529 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	15,518,930 - 15,574,642 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	15,428,821 - 15,484,573 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	X	19,634,383 - 19,690,144 (+)	NCBI		Celera
Cytogenetic Map	X	p22.2	NCBI
HuRef	X	13,280,437 - 13,329,298 (+)	NCBI		HuRef
CHM1_1	X	15,549,836 - 15,605,599 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	15,083,780 - 15,139,496 (+)	NCBI		T2T-CHM13v2.0

Bmx
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	162,975,838 - 163,041,189 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	162,975,838 - 163,041,189 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	164,192,842 - 164,258,193 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	164,192,842 - 164,258,193 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	160,630,774 - 160,696,125 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	159,536,967 - 159,602,298 (-)	NCBI		MGSCv36	mm8
Celera	X	147,407,328 - 147,474,033 (-)	NCBI		Celera
Cytogenetic Map	X	F5	NCBI

Bmx
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955519	2,638,081 - 2,689,650 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955519	2,638,081 - 2,689,601 (-)	NCBI	ChiLan1.0	ChiLan1.0

BMX
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	X	15,410,655 - 15,466,415 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	15,410,655 - 15,466,415 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	X	8,129,158 - 8,184,910 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

BMX
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	11,742,805 - 11,795,437 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	11,738,365 - 11,795,436 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	11,649,493 - 11,702,008 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	11,704,650 - 11,756,150 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	11,710,976 - 11,756,149 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	11,767,214 - 11,819,905 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	11,761,559 - 11,813,987 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	11,786,755 - 11,839,476 (+)	NCBI		UU_Cfam_GSD_1.0

Bmx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	4,914,576 - 4,962,152 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	4,914,756 - 4,962,129 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936470	4,914,643 - 4,962,134 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BMX
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	12,044,386 - 12,096,039 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	12,044,110 - 12,096,042 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	13,004,754 - 13,055,687 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BMX
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	13,973,078 - 14,028,492 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	13,981,472 - 14,028,122 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666056	15,815,758 - 15,862,877 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bmx
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624829	297,351 - 344,164 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624829	297,187 - 344,555 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Bmx
284 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	225
Count of miRNA genes:	160
Interacting mature miRNAs:	185
Transcripts:	ENSRNOT00000005181
Prediction methods:	Miranda, Pita, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1	43491017	Rat
70165	Bp64	Blood pressure QTL 64	5.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	1448129	31706553	Rat
1298071	Edpm12	Estrogen-dependent pituitary mass QTL 12	3.2		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	X	2927898	47927898	Rat
10755455	Coatc13	Coat color QTL 13		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	4406000	49406000	Rat
631666	Iddm5	Insulin dependent diabetes mellitus QTL 5			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	4494549	49494549	Rat
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
71116	Niddm16	Non-insulin dependent diabetes mellitus QTL 16	7.81		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	15297802	60297802	Rat
1598873	Memor2	Memory QTL 2	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	X	20990947	41052531	Rat
2290375	Gluco34	Glucose level QTL 34	2.75		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	20990947	41203591	Rat

Markers in Region

px-24c3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	30,228,854 - 30,229,044 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	31,977,835 - 31,978,024	NCBI	Rnor6.0
Rnor_5.0	X	32,351,041 - 32,351,230	UniSTS	Rnor5.0
RGSC_v3.4	X	50,984,544 - 50,984,733	UniSTS	RGSC3.4
Celera	X	30,573,459 - 30,573,648	UniSTS
Cytogenetic Map	X	q21	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium
Low	3	43	14	10	15	10	2	2	19	20	40	11	2
Below cutoff			43	31	4	31	6	9	55	15	1		6

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099943	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000384	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000005181 ⟹ ENSRNOP00000005181

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	30,227,251 - 30,289,993 (+)	Ensembl
Rnor_6.0 Ensembl	X	31,984,612 - 32,045,448 (+)	Ensembl

RefSeq Acc Id:

NM_001109016 ⟹ NP_001102486

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	X	30,227,251 - 30,289,993 (+)	NCBI
Rnor_6.0	X	31,976,231 - 32,046,326 (+)	NCBI
Rnor_5.0	X	32,349,437 - 32,417,878 (+)	NCBI
RGSC_v3.4	X	50,982,940 - 51,047,351 (+)	RGD
Celera	X	30,571,855 - 30,633,715 (+)	RGD

Sequence:

show sequence

CAGCCATTTCTGACCCAACAGCCAGAAAAAATGTGACACAATTCACTGCTGCTGGAGAGAAGAC
AGCCCGAAGTTGAGTTCTTGCAGGAGCAGCTTCGCTTCACCGTGGTGAACCCCAGGGAGGCAGA
AGAAGCCTAAATGGACAACAATATGGATAGTAAATCCATTTTGGAAGAACTGCTTCTCAAAAAG
TCACAGCAAAAGAAGAAAATGTCACCTATTAATTACAAGGAGCGGCTTTTTGTTCTAACCAAAA
CAAGCCTTTCCTACTATGAATATGACAAAATGAAACGAGGAAGCAGAAAAGGATCGATAGAAGT
TAAGAAAATCCGATGTGTGGAAAAAGTCAACCTTGAGGAGCAGACACCCGTGGAGAGACAGTAT
CCATTTCAGATTGTGTACAAAGATGGGCTTCTTTATGTCTATGCGTCGAATGAAGAGAGCCGAT
GTCAGTGGTTGAAAGCGCTGCAAAAAGAGATACGGGGCAACCCCCACCTGTTGATCAAGTATCA
CAGTGGCTTCTTTGTGGATGGGAAGTTCCTGTGTTGCCAGCAGAGCTGCAAAGCAGCCCCAGGA
TGCACTCTCTGGGAAGCATATGCTGATCTGCACATTGCAATCAGTGATGAGAAACACAGAGCCC
CCACTTTTCCAGAGAGGATACTGAAGATCCCAAGGGCAGTTCCCATTCTCAAAATGGATGCATC
ATCCTCAAGTGCCATTCCACCCCAATATGACAGCCACTTAAAGAAAAGTTATGACTCCCAGCCA
ACCGTCAACATACGCTATATTCCAAGGGAAGACTGCCCTGACTGGTGGCAAATAAGGAAACCGA
AAAGTGAGGAAGACATTGCCCGCAGTAACCAATTGGAAAGAAATATTGTATCTCACAGCCCCTC
AAAGATGTCATGGGGATTCCCTGAGTCAAGTTCATCTGAAGAAGAGGAAAATCTGGATGCTTAT
GACTGGTTTGCTGGGAATATCTCCAGGTCACAATCTGAGCAGTTACTGAGACAAAAGGGAAAAG
AAGGCGCATTCATGGTGAGGAATTCCAGCCAGATGGGGATGTACACCGTGTCCTTATTCAGCAA
GGCTGTAAATGACAAAAAAGGAACTGTCAAACATTATCACGTGCATACCAATGCTGAAAATAAA
TTATACTTGGCTGAAAACTACTGCTTTGATTCTATTCCAAAGCTCATTCACTATCACCAACATA
ATTCAGCAGGCATGATCACAAGGCTCCGCCACCCAGTGTCAACCAAGGCCAACAAGGTCCCGGT
GTCTGTGGCTCTGGGAAGTGGAATTTGGGAACTGAAAAGAGAAGAGATCGCCTTGTTGAAGGAG
CTGGGCAGTGGCCAGTTTGGAGTGGTCCAGCTGGGCAAGTGGAAGGGGCAGTATTCTGTGGCTG
TAAAGATGATCAAGGAGGGCGCCATGTCAGAAGATGAATTCTTTCAGGAGGCCCAGACCATGAT
GAAACTCAGCCATCCCAAGCTGGTGAAATTCTATGGCGTATGCTCAAAGAAATACCCCATCTAT
ATAGTAACAGAGTATATAACGAATGGTTGCTTGCTTAATTACCTGAAGAATCATGGGAAAGGAC
TAGAAAGCTCCCAGCTCTTAGAAATGTGCTATGATGTCTGTGAAGGCATGGCCTTCTTGGAGAG
CCATCAGTTCATACATCGGGATTTGGCTGCTCGGAACTGTTTGGTGGACAGTGATCTCTCCGTG
AAAGTCTCAGACTTTGGAATGACGAGATATGTCCTTGATGACCAGTATGTCAGTTCAGTAGGAA
CCAAGTTTCCAGTCAAGTGGTCGGCCCCAGAGGTGTTTCACTATTTCAAATACAGCAGCAAGTC
GGACGTATGGGCGTTTGGGATCCTGATGTGGGAGGTGTTTAGCCTAGGCAAGCAGCCCTATGAC
TTATATGATAACTCTGAAGTGGTTGTGAAGGTCTCCCAGGGCCACAGACTCTACCGGCCCCAAC
TAGCATCAGACACTATCTACCAGATAATGTACAGCTGCTGGCATGAGCTTCCAGAAAAGCGCCC
CACATTTCAGCAACTCCTATCTGCCATAGAACCACTCCGGGAACAAGATAAGCCATGAAGAGAA
ATTTCAGAATGGTGATGAAAATGAATATAAACATTGACCAACACTCTCATTGTTTGTAAGGGGA
GTAGAAAGACGCCATGTATTATAGCTAGTTCTTAATAATGGTCTGTGTATTGTTTAACTGTTAT
ATTACCTACCAAGAAAAGCAAGGTAGGAAACAAGGTATTTCTTTGAAATTTAGCTTAAATTGGT
CATTTTTGTTTGTGCTGCTTTTAATGTACTACTTCCCAGACTATGGTAGAAGTTCATTTTTAGA
TTACACTTTCCAAAGGGTGTGTACTGTGTATAAAGGGAGAGCGGGATTGAAAAGGTAATTTGTT
GGGAGTTCAGTTTTTTTCTATTGGCACTTGTGTGGTAATTAAATATCTTTTCAAGAACAGAAAT
GTGTATGTTTGCTTCTGTATGAGAAATGTCTCAGGCATTTGAATATTTGTTCTCCAGTTTGTGG
CACTGTTTGTAGAGGTTTAGGAAGAATGGCCTCGATGGAGGAATTATGTCAATAGGGCAGGCTT
TGAGAGCTTAAGGCTTCACCCTACCTGTAGTTTACTTCTTGCATGCAGTTCAAGATGTGAGCTC
TCAGAAGCTGAAGAAGTGGCTTAGTGGTTAAGAACACTGGCTGTTCCTCCAGAGGACACAGGTT
CAATTCCCAGAACTGCACAGTGGCTTACAACTTGTCTATGAATCCAGTTCTAAAGAATATTATG
GCTTCTTCTAGCCTTCACGCGTACCTAGTACACATGTGGTACACCAACATATATACAAGCAAAG
AAGAAAACTAAAGGGTGGGAGCTCTCAGCATCCTGCTCTGTCTGCCATGTCTGCAAGTAGCCTT
TGACCTGCCATTTTGAACTCTCTCTCTGGAACTATAAGCA

hide sequence

RefSeq Acc Id:

XM_039099943 ⟹ XP_038955871

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	X	30,234,677 - 30,290,015 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102486	(Get FASTA)	NCBI Sequence Viewer
	XP_038955871	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL90515	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001102486 ⟸ NM_001109016

- UniProtKB:

F1LVI0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDNNMDSKSILEELLLKKSQQKKKMSPINYKERLFVLTKTSLSYYEYDKMKRGSRKGSIEVKKI
RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRCQWLKALQKEIRGNPHLLIKYHSGF
FVDGKFLCCQQSCKAAPGCTLWEAYADLHIAISDEKHRAPTFPERILKIPRAVPILKMDASSSS
AIPPQYDSHLKKSYDSQPTVNIRYIPREDCPDWWQIRKPKSEEDIARSNQLERNIVSHSPSKMS
WGFPESSSSEEEENLDAYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQMGMYTVSLFSKAVN
DKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPVSVA
LGSGIWELKREEIALLKELGSGQFGVVQLGKWKGQYSVAVKMIKEGAMSEDEFFQEAQTMMKLS
HPKLVKFYGVCSKKYPIYIVTEYITNGCLLNYLKNHGKGLESSQLLEMCYDVCEGMAFLESHQF
IHRDLAARNCLVDSDLSVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVW
AFGILMWEVFSLGKQPYDLYDNSEVVVKVSQGHRLYRPQLASDTIYQIMYSCWHELPEKRPTFQ
QLLSAIEPLREQDKP

hide sequence

RefSeq Acc Id:

ENSRNOP00000005181 ⟸ ENSRNOT00000005181

RefSeq Acc Id:	XP_038955871 ⟸ XM_039099943
- Peptide Label:	isoform X1

Protein Domains

PH Protein kinase SH2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LVI0-F1-model_v2	AlphaFold	F1LVI0	1-654	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1565643	AgrOrtholog
BioCyc Gene	G2FUF-2584	BioCyc
Ensembl Genes	ENSRNOG00000003705	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000005181	ENTREZGENE
	ENSRNOP00000005181.8	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005181	ENTREZGENE
	ENSRNOT00000005181.8	UniProtKB/TrEMBL
Gene3D-CATH	2.30.29.30	UniProtKB/TrEMBL
	3.30.505.10	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	BMX_SH2	UniProtKB/TrEMBL
	Kinase-like_dom	UniProtKB/TrEMBL
	PH_type	UniProtKB/TrEMBL
	Pleckstrin_homology	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/TrEMBL
	Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	Znf_Btk_motif	UniProtKB/TrEMBL
NCBI Gene	367786	ENTREZGENE
PANTHER	PTHR24418:SF91	UniProtKB/TrEMBL
	TYROSINE-PROTEIN KINASE	UniProtKB/TrEMBL
Pfam	BTK	UniProtKB/TrEMBL
	PF00169	UniProtKB/TrEMBL
	Pkinase_Tyr	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
PhenoGen	Bmx	PhenoGen
PRINTS	SH2DOMAIN	UniProtKB/TrEMBL
	TECBTKDOMAIN	UniProtKB/TrEMBL
	TYRKINASE	UniProtKB/TrEMBL
PROSITE	PH_DOMAIN	UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	ZF_BTK	UniProtKB/TrEMBL
SMART	BTK	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SM00233	UniProtKB/TrEMBL
	TyrKc	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
	PH domain-like	UniProtKB/TrEMBL
	SSF55550	UniProtKB/TrEMBL
UniProt	F1LVI0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-07	Bmx	BMX non-receptor tyrosine kinase	RGD1565643_predicted	similar to protein tyrosine kinase Bmx (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1565643_predicted	similar to protein tyrosine kinase Bmx (predicted)	LOC367786	similar to protein tyrosine kinase Bmx	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC367786	similar to protein tyrosine kinase Bmx			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar