Gene: Clcn4 (chloride voltage-gated channel 4) Rattus norvegicus
Symbol: Clcn4
Name: chloride voltage-gated channel 4
Description: Predicted to have chloride ion binding activity; solute:proton antiporter activity; and voltage-gated chloride channel activity. Predicted to be involved in chloride transport. Predicted to localize to the cytoplasm and integral component of plasma membrane. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human CLCN4 (chloride voltage-gated channel 4); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: chloride channel 4; chloride channel 4-2; chloride channel protein 4; chloride channel, voltage-sensitive 4; chloride transporter ClC-4; clC-4; Clcn4-2; h(+)/Cl(-) exchange transporter 4; MGC105433; putative chloride channel (similar to Mm Clcn4-2); putative chloride channel 4-2
Homo sapiens (human) : CLCN4 (chloride voltage-gated channel 4)  HGNC  Alliance
Mus musculus (house mouse) : Clcn4 (chloride channel, voltage-sensitive 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Clcn4 (chloride voltage-gated channel 4)
Pan paniscus (bonobo/pygmy chimpanzee) : CLCN4 (chloride voltage-gated channel 4)
Canis lupus familiaris (dog) : CLCN4 (chloride voltage-gated channel 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Clcn4 (chloride voltage-gated channel 4)
Sus scrofa (pig) : CLCN4 (chloride voltage-gated channel 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X25,016,177 - 25,082,563 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X25,427,399 - 25,493,756 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X44,355,648 - 44,419,524 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X44,436,114 - 44,471,196 (+)NCBI
CeleraX24,157,917 - 24,221,792 (+)NCBICelera
Cytogenetic MapXq13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Clcn4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 708381
Created: 2003-09-23
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.