Car5b (carbonic anhydrase 5B) - Rat Genome Database

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Gene: Car5b (carbonic anhydrase 5B) Rattus norvegicus
Analyze
Symbol: Car5b
Name: carbonic anhydrase 5B
RGD ID: 1549783
Description: Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to act upstream of or within response to bacterium. Predicted to be active in mitochondrion. Orthologous to human CA5B (carbonic anhydrase 5B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CA-VB; Ca5b; carbonate dehydratase VB; carbonic anhydrase 5B, mitochondrial; carbonic anhydrase VB, mitochondrial; MGC93720
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X34,106,553 - 34,166,651 (+)NCBIGRCr8
mRatBN7.2X30,474,697 - 30,534,797 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX30,474,784 - 30,533,837 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX31,520,092 - 31,566,687 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X34,957,057 - 35,003,669 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X31,144,294 - 31,190,893 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X32,232,106 - 32,291,124 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX32,232,142 - 32,292,072 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X32,597,409 - 32,652,981 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X51,241,437 - 51,290,433 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX30,830,281 - 30,876,988 (+)NCBICelera
Cytogenetic MapXq14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
mitochondrion  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10677517   PMID:15489334   PMID:18614015   PMID:23012479  


Genomics

Comparative Map Data
Car5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X34,106,553 - 34,166,651 (+)NCBIGRCr8
mRatBN7.2X30,474,697 - 30,534,797 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX30,474,784 - 30,533,837 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX31,520,092 - 31,566,687 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X34,957,057 - 35,003,669 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X31,144,294 - 31,190,893 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X32,232,106 - 32,291,124 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX32,232,142 - 32,292,072 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X32,597,409 - 32,652,981 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X51,241,437 - 51,290,433 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX30,830,281 - 30,876,988 (+)NCBICelera
Cytogenetic MapXq14NCBI
CA5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X15,738,270 - 15,788,411 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX15,688,830 - 15,788,411 (+)EnsemblGRCh38hg38GRCh38
GRCh37X15,756,393 - 15,806,534 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,666,333 - 15,715,669 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X15,516,081 - 15,562,315NCBI
CeleraX19,872,853 - 19,923,232 (+)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX13,510,606 - 13,559,489 (+)NCBIHuRef
CHM1_1X15,787,366 - 15,836,721 (+)NCBICHM1_1
T2T-CHM13v2.0X15,321,214 - 15,371,343 (+)NCBIT2T-CHM13v2.0
Car5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X162,759,818 - 162,811,006 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX162,759,818 - 162,810,993 (-)EnsemblGRCm39 Ensembl
GRCm38X163,976,822 - 164,028,010 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX163,976,822 - 164,027,997 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X160,414,754 - 160,465,942 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X159,323,196 - 159,372,102 (-)NCBIMGSCv36mm8
CeleraX147,196,469 - 147,247,766 (-)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.03NCBI
Ca5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555192,412,289 - 2,455,280 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555192,415,722 - 2,455,052 (-)NCBIChiLan1.0ChiLan1.0
CA5B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X17,527,320 - 17,581,111 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X17,525,852 - 17,584,497 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X8,325,881 - 8,410,506 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X15,629,967 - 15,678,112 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX15,658,816 - 15,764,323 (+)Ensemblpanpan1.1panPan2
PanPan1.1 EnsemblX15,658,816 - 15,764,323 (+)NCBIpanpan1.1panPan2
CA5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X11,908,426 - 12,042,327 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX11,930,884 - 12,040,221 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX11,809,477 - 11,892,620 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X11,869,327 - 12,003,333 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X11,932,374 - 12,072,571 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X11,926,678 - 12,059,951 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X11,951,875 - 12,085,347 (+)NCBIUU_Cfam_GSD_1.0
Ca5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X5,184,444 - 5,230,212 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364705,184,483 - 5,230,214 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364705,184,489 - 5,227,855 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX12,224,159 - 12,365,025 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X12,295,393 - 12,332,283 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X13,188,075 - 13,222,663 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CA5B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X14,197,561 - 14,240,294 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX14,197,651 - 14,243,626 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605615,985,256 - 16,095,069 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ca5b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624829457,244 - 571,168 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624829455,731 - 572,603 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Car5b
290 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:171
Count of miRNA genes:134
Interacting mature miRNAs:146
Transcripts:ENSRNOT00000047354
Prediction methods:Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 2 25 5 11
Low 3 31 35 25 17 25 8 10 52 10 34 8
Below cutoff 12 16 16 16 1 22 2

Sequence


RefSeq Acc Id: ENSRNOT00000047354   ⟹   ENSRNOP00000043235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX30,474,803 - 30,533,837 (+)Ensembl
Rnor_6.0 EnsemblX32,232,142 - 32,292,072 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101751   ⟹   ENSRNOP00000080254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX30,474,784 - 30,533,837 (+)Ensembl
RefSeq Acc Id: NM_001005551   ⟹   NP_001005551
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X34,119,026 - 34,165,641 (+)NCBI
mRatBN7.2X30,487,172 - 30,533,787 (+)NCBI
Rnor_6.0X32,244,448 - 32,291,063 (+)NCBI
Rnor_5.0X32,597,409 - 32,652,981 (+)NCBI
RGSC_v3.4X51,241,437 - 51,290,433 (+)RGD
CeleraX30,830,281 - 30,876,988 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256859   ⟹   XP_006256921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X34,106,553 - 34,166,651 (+)NCBI
mRatBN7.2X30,474,697 - 30,534,797 (+)NCBI
Rnor_6.0X32,232,106 - 32,291,124 (+)NCBI
Rnor_5.0X32,597,409 - 32,652,981 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099656   ⟹   XP_038955584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X34,112,797 - 34,166,651 (+)NCBI
mRatBN7.2X30,480,943 - 30,534,797 (+)NCBI
RefSeq Acc Id: XM_039099657   ⟹   XP_038955585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X34,106,553 - 34,166,651 (+)NCBI
mRatBN7.2X30,474,697 - 30,534,797 (+)NCBI
RefSeq Acc Id: NP_001005551   ⟸   NM_001005551
- Peptide Label: precursor
- UniProtKB: Q66HG6 (UniProtKB/Swiss-Prot),   A6K2L9 (UniProtKB/TrEMBL),   A0A8I5ZPN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256921   ⟸   XM_006256859
- Peptide Label: isoform X1
- UniProtKB: Q66HG6 (UniProtKB/Swiss-Prot),   A6K2L9 (UniProtKB/TrEMBL),   A0A8I5ZPN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043235   ⟸   ENSRNOT00000047354
RefSeq Acc Id: XP_038955585   ⟸   XM_039099657
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZPN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955584   ⟸   XM_039099656
- Peptide Label: isoform X1
- UniProtKB: Q66HG6 (UniProtKB/Swiss-Prot),   A6K2L9 (UniProtKB/TrEMBL),   A0A8I5ZPN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000080254   ⟸   ENSRNOT00000101751
Protein Domains
Alpha-carbonic anhydrase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66HG6-F1-model_v2 AlphaFold Q66HG6 1-317 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701799
Promoter ID:EPDNEW_R12323
Type:initiation region
Name:Ca5b_1
Description:carbonic anhydrase 5B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X32,232,136 - 32,232,196EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1549783 AgrOrtholog
BioCyc Gene G2FUF-2571 BioCyc
Ensembl Genes ENSRNOG00000029330 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047354 ENTREZGENE
  ENSRNOT00000047354.5 UniProtKB/Swiss-Prot
  ENSRNOT00000101751 ENTREZGENE
  ENSRNOT00000101751.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7106842 IMAGE-MGC_LOAD
InterPro CA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:302669 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93720 IMAGE-MGC_LOAD
NCBI Gene 302669 ENTREZGENE
PANTHER PTHR18952 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18952:SF25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Car5b PhenoGen
PROSITE ALPHA_CA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALPHA_CA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029330 RatGTEx
SMART Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51069 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZPN0 ENTREZGENE, UniProtKB/TrEMBL
  A6K2L9 ENTREZGENE, UniProtKB/TrEMBL
  CAH5B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-18 Car5b  carbonic anhydrase 5B  Ca5b  carbonic anhydrase 5B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-04-16 Ca5b  carbonic anhydrase 5B  Car5b  carbonic anhydrase 5B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2018-03-16 Car5b  carbonic anhydrase 5B  Ca5b  carbonic anhydrase 5B  Symbol changed 629549 APPROVED
2016-05-20 Ca5b  carbonic anhydrase 5B  Car5b  carbonic anhydrase 5B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-18 Car5b  carbonic anhydrase 5B  Car5b  carbonic anhydrase 5B, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-05-14 Car5b  carbonic anhydrase 5B, mitochondrial  Car5b  carbonic anhydrase 5b, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-20 Car5b  carbonic anhydrase 5B, mitochondrial  Ca5b  carbonic anhydrase VB, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-15 Ca5b  carbonic anhydrase VB, mitochondrial      Symbol and Name status set to provisional 70820 PROVISIONAL