Sat1 (spermidine/spermine N1-acetyl transferase 1) - Rat Genome Database

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Gene: Sat1 (spermidine/spermine N1-acetyl transferase 1) Rattus norvegicus
Analyze
Symbol: Sat1
Name: spermidine/spermine N1-acetyl transferase 1
RGD ID: 1586174
Description: Enables N-acetyltransferase activity and spermidine binding activity. Involved in polyamine catabolic process and spermidine acetylation. Located in cytosol. Orthologous to human SAT1 (spermidine/spermine N1-acetyltransferase 1); PARTICIPATES IN polyamine metabolic pathway; spermidine metabolic pathway; spermine metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ab2-402; diamine acetyltransferase; diamine acetyltransferase 1; diamine N-acetyltransferase 1; MGC72945; Sat; Sat_mapped; Spermidine / spermine N1-acyltransferase (diamine acetyltransferase); spermidine/spermine N1-acetyl transferase; spermidine/spermine N1-acetyl transferase (mapped); SSAT
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X40,158,354 - 40,161,641 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX40,157,046 - 40,196,813 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX41,400,954 - 41,404,237 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X44,868,255 - 44,871,538 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X42,552,839 - 42,556,122 (+)NCBIRnor_WKY
Rnor_6.0X43,626,480 - 43,629,767 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX43,625,169 - 43,629,765 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X43,930,760 - 43,934,043 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X61,634,964 - 61,638,247 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX40,786,371 - 40,789,654 (+)NCBICelera
Cytogenetic MapXq21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methylphenanthrene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
amphetamine  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chlorpromazine  (EXP)
choline  (ISO)
Cinobufagin  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diquat  (ISO)
DISTAMYCIN A  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
elesclomol  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
fenofibrate  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
ibuprofen  (EXP,ISO)
ICI D1694  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lucanthone  (ISO)
mercury dibromide  (ISO)
metformin  (EXP)
methoctramine tetrahydrochloride  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mitomycin C  (ISO)
N(1),N(12)-diethylspermine  (ISO)
N-acetyl-L-cysteine  (ISO)
nefazodone  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
oxaliplatin  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
spermidine  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (EXP)
trovafloxacin  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Aminooxy analogues of spermidine as inhibitors of spermine synthase and substrates of hepatic polyamine acetylating activity. Eloranta TO, etal., J Biochem. 1990 Oct;108(4):593-8.
2. Effect of mitoguazone on polyamine oxidase activity in rat liver. Ferioli ME, etal., Toxicol Appl Pharmacol. 2004 Dec 1;201(2):105-11.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Spermidine/spermine N1-acetyl transferase activity in rat brain following transient focal cerebral ischemia and reperfusion. Nagesh Babu G, etal., Neurosci Lett. 2001 Mar 2;300(1):17-20.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Semenza GL Physiology (Bethesda). 2009 Apr;24:97-106.
10. A perspective of polyamine metabolism. Wallace HM, etal., Biochem J. 2003 Nov 15;376(Pt 1):1-14.
Additional References at PubMed
PMID:11866539   PMID:12477932   PMID:15213272   PMID:15958588   PMID:16189514   PMID:16455797   PMID:17371273   PMID:18062919   PMID:19369292   PMID:19751803   PMID:25416956  


Genomics

Comparative Map Data
Sat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X40,158,354 - 40,161,641 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX40,157,046 - 40,196,813 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX41,400,954 - 41,404,237 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X44,868,255 - 44,871,538 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X42,552,839 - 42,556,122 (+)NCBIRnor_WKY
Rnor_6.0X43,626,480 - 43,629,767 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX43,625,169 - 43,629,765 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X43,930,760 - 43,934,043 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X61,634,964 - 61,638,247 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX40,786,371 - 40,789,654 (+)NCBICelera
Cytogenetic MapXq21NCBI
SAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X23,783,173 - 23,786,210 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX23,783,173 - 23,786,210 (+)EnsemblGRCh38hg38GRCh38
GRCh37X23,801,290 - 23,804,327 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X23,711,225 - 23,714,248 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X23,560,960 - 23,563,982NCBI
CeleraX27,919,647 - 27,922,702 (+)NCBICelera
Cytogenetic MapXp22.11NCBI
HuRefX21,540,756 - 21,543,811 (+)NCBIHuRef
CHM1_1X23,832,183 - 23,835,235 (+)NCBICHM1_1
T2T-CHM13v2.0X23,366,856 - 23,369,893 (+)NCBIT2T-CHM13v2.0
Sat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X153,996,122 - 153,999,445 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX153,996,128 - 153,999,445 (-)EnsemblGRCm39 Ensembl
GRCm38X155,213,126 - 155,216,449 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX155,213,132 - 155,216,449 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X151,647,681 - 151,650,952 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X150,553,854 - 150,557,125 (-)NCBIMGSCv36mm8
CeleraX138,521,426 - 138,524,697 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX72.38NCBI
Sat1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555094,198,651 - 4,202,483 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555094,198,876 - 4,202,103 (+)NCBIChiLan1.0ChiLan1.0
SAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X23,756,604 - 23,759,743 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX23,756,691 - 23,760,349 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X16,382,735 - 16,385,790 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X19,461,945 - 19,464,209 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX19,463,109 - 19,464,116 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X19,416,189 - 19,419,200 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX19,416,179 - 19,420,521 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X19,455,311 - 19,458,318 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X19,488,812 - 19,491,807 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X19,544,765 - 19,547,782 (+)NCBIUU_Cfam_GSD_1.0
Sat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X12,397,902 - 12,401,062 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936624756,761 - 759,979 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX19,907,906 - 19,910,974 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X19,908,037 - 19,910,553 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X21,278,235 - 21,280,753 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig CytomapXpNCBI
SAT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X22,231,915 - 22,234,981 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX22,231,855 - 22,235,031 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605624,126,114 - 24,129,269 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sat1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624897176,278 - 181,912 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624897176,414 - 179,322 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:30
Interacting mature miRNAs:30
Transcripts:ENSRNOT00000068078
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 39 57 41 19 41 8 10 74 35 38 11 8
Low 4 1 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000068078   ⟹   ENSRNOP00000062939
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX40,158,472 - 40,161,641 (+)Ensembl
Rnor_6.0 EnsemblX43,626,480 - 43,629,765 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086311   ⟹   ENSRNOP00000068531
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX40,157,046 - 40,196,813 (+)Ensembl
Rnor_6.0 EnsemblX43,625,169 - 43,629,406 (+)Ensembl
RefSeq Acc Id: NM_001007667   ⟹   NP_001007668
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X40,158,354 - 40,161,637 (+)NCBI
Rnor_6.0X43,626,480 - 43,629,763 (+)NCBI
Rnor_5.0X43,930,760 - 43,934,043 (+)NCBI
RGSC_v3.4X61,634,964 - 61,638,247 (+)RGD
CeleraX40,786,371 - 40,789,654 (+)RGD
Sequence:
RefSeq Acc Id: XM_008773228   ⟹   XP_008771450
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X40,158,447 - 40,161,641 (+)NCBI
Rnor_6.0X43,626,545 - 43,629,767 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773230   ⟹   XP_008771452
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X40,158,446 - 40,161,641 (+)NCBI
Rnor_6.0X43,626,542 - 43,629,767 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099646   ⟹   XP_038955574
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X40,158,446 - 40,161,641 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001007668   ⟸   NM_001007667
- UniProtKB: Q6P9U6 (UniProtKB/TrEMBL),   D3ZFF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771450   ⟸   XM_008773228
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008771452   ⟸   XM_008773230
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000062939   ⟸   ENSRNOT00000068078
RefSeq Acc Id: ENSRNOP00000068531   ⟸   ENSRNOT00000086311
RefSeq Acc Id: XP_038955574   ⟸   XM_039099646
- Peptide Label: isoform X2
Protein Domains
N-acetyltransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TP41-F1-model_v2 AlphaFold Q7TP41 1-210 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586174 AgrOrtholog
BioCyc Gene G2FUF-2440 BioCyc
BioCyc Pathway PWY-0 [putrescine degradation III] BioCyc
  PWY-6117 [spermine and spermidine degradation I] BioCyc
Ensembl Genes ENSRNOG00000003809 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000062939 ENTREZGENE
  ENSRNOP00000062939.3 UniProtKB/TrEMBL
  ENSRNOP00000068531 ENTREZGENE
  ENSRNOP00000068531.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068078 ENTREZGENE
  ENSRNOT00000068078.3 UniProtKB/TrEMBL
  ENSRNOT00000086311 ENTREZGENE
  ENSRNOT00000086311.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6921572 IMAGE-MGC_LOAD
InterPro Acyl_CoA_acyltransferase UniProtKB/TrEMBL
  GCN5-rel_AcTrfase UniProtKB/TrEMBL
  SAT1 UniProtKB/TrEMBL
KEGG Report rno:302642 UniProtKB/TrEMBL
MGC_CLONE MGC:72945 IMAGE-MGC_LOAD
NCBI Gene 302642 ENTREZGENE
PANTHER PTHR10545:SF36 UniProtKB/TrEMBL
Pfam Acetyltransf_1 UniProtKB/TrEMBL
PhenoGen Sat1 PhenoGen
PROSITE GNAT UniProtKB/TrEMBL
Superfamily-SCOP Acyl_CoA_acyltransferase UniProtKB/TrEMBL
UniProt A0A8J8XCW9_RAT UniProtKB/TrEMBL
  D3ZFF5 ENTREZGENE
  Q6P9U6 ENTREZGENE, UniProtKB/TrEMBL
  Q7TP41_RAT UniProtKB/TrEMBL
UniProt Secondary D3ZFF5 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Sat1  spermidine/spermine N1-acetyl transferase 1  Sat  spermidine/spermine N1-acetyl transferase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   spermidine/spermine N1-acetyl transferase  Sat  spermidine/spermine N1-acetyl transferase (mapped)  Name updated 737654 APPROVED
2007-04-12 Sat  spermidine/spermine N1-acetyl transferase (mapped)  Sat_mapped  spermidine/spermine N1-acetyl transferase (mapped)  Data Merged 737654 APPROVED
2006-11-19 Sat  spermidine/spermine N1-acetyl transferase (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Sat_mapped  spermidine/spermine N1-acetyl transferase (mapped)      Symbol and Name updated 1556543 APPROVED
2002-06-10 Sat  Spermidine / spermine N1-acyltransferase (diamine acetyltransferase)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function mouse homolog N1 acetylates spermidine and spermine 1300195
gene_process mouse homolog is rate-controlling enzyme in back-conversion of spermidine and spermine 1300195