Dusp1 (dual specificity phosphatase 1) - Rat Genome Database

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Gene: Dusp1 (dual specificity phosphatase 1) Rattus norvegicus
Analyze
Symbol: Dusp1
Name: dual specificity phosphatase 1
RGD ID: 620897
Description: Enables growth factor binding activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; regulation of apoptotic process; and response to hydrogen peroxide. Predicted to be active in cytoplasm and nucleus. Used to study Huntington's disease. Biomarker of several diseases, including autoimmune disease (multiple); diabetic encephalopathy; pancreatitis; portal hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human DUSP1 (dual specificity phosphatase 1); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; angiotensin II signaling pathway via AT2 receptor; INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3CH134; 3CH134/CL100 PTPase; CL100; dual specificity phosphatase; dual specificity protein phosphatase 1; MAP kinase phosphatase 1; Map kinase phosphatase-1; mitogen-activated protein (MAP) kinase phosphatase-1; mitogen-activated protein kinase phosphatase 1; Mkp-1; Mkp1; oxidative stress-inducible protein tyrosine phosphatase; protein tyrosine phosphatase non-receptor type 16; protein tyrosine phosphatase, non-receptor type 16; protein-tyrosine phosphatase CL100; protein-tyrosine phosphatase non-receptor type 16; Ptpn16
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81017,184,853 - 17,187,646 (+)NCBIGRCr8
mRatBN7.21016,680,478 - 16,683,275 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1021,430,403 - 21,433,194 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010464,443 - 467,234 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01016,408,838 - 16,411,630 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01016,970,642 - 16,973,425 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1016,970,626 - 16,973,418 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01016,867,381 - 16,870,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41016,942,913 - 16,945,696 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11016,943,975 - 16,946,743 (+)NCBI
Celera1016,333,248 - 16,336,031 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Dusp1RatAmyloid Neuropathies  ISODUSP1 (Homo sapiens)7771547mRNA more ...RGD 
Dusp1Ratanti-basement membrane glomerulonephritis  IEP 633769mRNA:increased expression:glomerulusRGD 
Dusp1Ratarteriosclerosis  ISODusp1 (Mus musculus)2298676protein:increased expression:aortaRGD 
Dusp1Ratbreast cancer severityISODUSP1 (Homo sapiens)7495850DNA:hypermethylation:promoterRGD 
Dusp1Ratbreast cancer  ISODUSP1 (Homo sapiens)7495809protein:increased expression:mammary glandRGD 
Dusp1Ratbreast cancer disease_progressionISODUSP1 (Homo sapiens)7495851 RGD 
Dusp1Ratbreast cancer  ISODUSP1 (Homo sapiens)2298697protein:increased expression:T cellRGD 
Dusp1RatCarotid Artery Injuries  IEP 7771579 RGD 
Dusp1Ratcolitis severityISODusp1 (Mus musculus)7771532 RGD 
Dusp1Ratcontact dermatitis treatmentISODusp1 (Mus musculus)7771535 RGD 
Dusp1RatCOVID-19  ISODUSP1 (Homo sapiens)9068941mRNA:increased expression:CD14++ monocytes (human)RGDPMID:32377375 and REF_RGD_ID:32716422
Dusp1Ratdiabetic encephalopathy  IEP 7771546associated with Diabetes Mellitus and ExperimentalRGD 
Dusp1RatExperimental Diabetes Mellitus  IEP 2298672mRNA and protein:decreased expression:ventricle myocardiumRGD 
Dusp1RatExperimental Diabetes Mellitus  IEP 7771540mRNA:increased expression:retinaRGD 
Dusp1RatExperimental Mammary Neoplasms treatmentISODUSP1 (Homo sapiens)5129167 RGD 
Dusp1RatExperimental Seizures  IEP 728656 RGD 
Dusp1RatExperimental Seizures  IEP 2298690protein:increased expression:brainRGD 
Dusp1RatFetal Growth Retardation  IEP 7771581 RGD 
Dusp1Ratglucose intolerance resistanceISODusp1 (Mus musculus)2298673 RGD 
Dusp1RatHuntington's disease treatmentIMP 7771544 RGD 
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Original Reference(s)
Dusp1Ratatrial heart septal defect 7  ISODUSP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Atrial septal defect-atrioventricular conduction defects syndromeClinVarPMID:17891520 more ...
Dusp1RatAtrial Septal Defect with Atrioventricular Conduction Defects  ISODUSP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Atrial septal defect with atrioventricular conduction defectsClinVarPMID:17891520 more ...
Dusp1Rathydrocephalus  ISODUSP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital hydrocephalusClinVarPMID:29983323
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Original Reference(s)
Dusp1Ratcontact dermatitis  ISODUSP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25724174
Dusp1Ratendometriosis  ISODUSP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21063030
Dusp1Ratjuvenile rheumatoid arthritis  ISODUSP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19565504
Dusp1RatMyocardial Ischemia  ISODUSP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16214533
Dusp1RatSpine Osteoarthritis  ISODUSP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:34697729

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Original Reference(s)
Dusp1Rat(+)-catechin multiple interactionsISODUSP1 (Homo sapiens)6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of DUSP1 mRNA and [Oxygen deficiency co-treated with Catechin] results in decreased expression of DUSP1 mRNACTDPMID:24763279 and PMID:35883890
Dusp1Rat(-)-alpha-phellandrene increases expressionISODUSP1 (Homo sapiens)6480464alpha phellandrene results in increased expression of DUSP1 mRNACTDPMID:25075043
Dusp1Rat(1->4)-beta-D-glucan multiple interactionsISODusp1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of DUSP1 mRNACTDPMID:36331819
Dusp1Rat(S)-nicotine increases expressionISODusp1 (Mus musculus)6480464Nicotine results in increased expression of DUSP1 mRNACTDPMID:17456735
Dusp1Rat1,2,4-trimethylbenzene increases expressionEXP 6480464pseudocumene results in increased expression of DUSP1 proteinCTDPMID:17337753
Dusp1Rat1,2-dimethylhydrazine decreases expressionISODusp1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of DUSP1 mRNACTDPMID:22206623
Dusp1Rat1,4-phenylenediamine increases expressionISODUSP1 (Homo sapiens)64804644-phenylenediamine results in increased expression of DUSP1 mRNACTDPMID:16314067
Dusp1Rat1-chloro-2,4-dinitrobenzene increases expressionISODUSP1 (Homo sapiens)6480464Dinitrochlorobenzene results in increased expression of DUSP1 mRNACTDPMID:16314067
Dusp1Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of DUSP1 mRNACTDPMID:17108234
Dusp1Rat17beta-estradiol affects expressionISODUSP1 (Homo sapiens)6480464Estradiol affects the expression of DUSP1 mRNACTDPMID:14699072
Dusp1Rat17beta-estradiol increases expressionISODusp1 (Mus musculus)6480464Estradiol results in increased expression of DUSP1 mRNACTDPMID:39298647
Dusp1Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of DUSP1 mRNACTDPMID:32145629
Dusp1Rat17beta-estradiol decreases expressionISODUSP1 (Homo sapiens)6480464Estradiol results in decreased expression of DUSP1 mRNACTDPMID:19167446
Dusp1Rat17beta-estradiol affects expressionISODusp1 (Mus musculus)6480464Estradiol affects the expression of DUSP1 mRNACTDPMID:15598610
Dusp1Rat17beta-estradiol multiple interactionsISODUSP1 (Homo sapiens)6480464[Progesterone co-treated with Estradiol] results in increased expression of DUSP1 mRNA and Estradiol inhibits the reaction [Dexamethasone results in increased expression of DUSP1 mRNA]CTDPMID:17404688 and PMID:23183181
Dusp1Rat17beta-estradiol increases expressionISODUSP1 (Homo sapiens)6480464Estradiol results in increased expression of DUSP1 mRNACTDPMID:19153601
Dusp1Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISODUSP1 (Homo sapiens)64804642 more ...CTDPMID:25305463
Dusp1Rat2,3',4,4',5-Pentachlorobiphenyl increases expressionISODusp1 (Mus musculus)64804642 more ...CTDPMID:31388691
Dusp1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISODUSP1 (Homo sapiens)6480464pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of DUSP1 mRNA]CTDPMID:20064835
Dusp1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of DUSP1 mRNACTDPMID:33387578

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Biological Process
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Dusp1Ratcellular response to chemokine involved_inISODUSP1 (Homo sapiens)1624291 PMID:22991462RGDPMID:22991462
Dusp1Ratcellular response to chemokine involved_inIEAUniProtKB:P28562 and ensembl:ENSP000002392231600115GO_REF:0000107EnsemblGO_REF:0000107
Dusp1Ratcellular response to hormone stimulus  IEP 2298683 RGD 
Dusp1Ratendoderm formation involved_inIBAPANTHER:PTN000017039 and ZFIN:ZDB-GENE-040426-7091600115GO_REF:0000033GO_CentralGO_REF:0000033
Dusp1Ratintracellular signal transduction  IDA 628467 RGD 
Dusp1Ratnegative regulation of apoptotic process  IMP 2298685 RGD 
Dusp1Ratnegative regulation of cell adhesion involved_inISODUSP1 (Homo sapiens)1624291 PMID:22991462RGDPMID:22991462
Dusp1Ratnegative regulation of cell adhesion involved_inIEAUniProtKB:P28562 and ensembl:ENSP000002392231600115GO_REF:0000107EnsemblGO_REF:0000107
Dusp1Ratnegative regulation of cell population proliferation involved_inIEAUniProtKB:P28563 and ensembl:ENSMUSP000000250251600115GO_REF:0000107EnsemblGO_REF:0000107
Dusp1Ratnegative regulation of cell population proliferation involved_inISODusp1 (Mus musculus)1624291 PMID:8355678RGDPMID:8355678
Dusp1Ratnegative regulation of DNA biosynthetic process  IDA 7771571 RGD 
Dusp1Ratnegative regulation of ERK1 and ERK2 cascade  IMP 7771545 RGD 
Dusp1Ratnegative regulation of MAP kinase activity involved_inISSUniProtKB:P285621600115GO_REF:0000024UniProtGO_REF:0000024
Dusp1Ratnegative regulation of MAP kinase activity involved_inISODUSP1 (Homo sapiens)1624291 PMID:7593328RGDPMID:7593328
Dusp1Ratnegative regulation of MAPK cascade involved_inISSUniProtKB:P285631600115GO_REF:0000024UniProtGO_REF:0000024
Dusp1Ratnegative regulation of MAPK cascade involved_inIEAUniProtKB:P28563 and ensembl:ENSMUSP000000250251600115GO_REF:0000107EnsemblGO_REF:0000107
Dusp1Ratnegative regulation of MAPK cascade involved_inISODusp1 (Mus musculus)1624291 PMID:8221888RGDPMID:8221888
Dusp1Ratnegative regulation of MAPK cascade involved_inISSUniProtKB:Q917901600115GO_REF:0000024UniProtGO_REF:0000024
Dusp1Ratnegative regulation of meiotic cell cycle involved_inISSUniProtKB:Q917901600115GO_REF:0000024UniProtGO_REF:0000024
Dusp1Ratnegative regulation of monocyte chemotaxis involved_inISODUSP1 (Homo sapiens)1624291 PMID:22991462RGDPMID:22991462
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Cellular Component
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Dusp1Ratcytoplasm located_inISODUSP1 (Homo sapiens)1624291 PMID:7593328RGDPMID:7593328
Dusp1Ratcytoplasm located_inISSUniProtKB:P285621600115GO_REF:0000024UniProtGO_REF:0000024
Dusp1Ratcytoplasm located_inIEAUniProtKB:P28562 and ensembl:ENSP000002392231600115GO_REF:0000107EnsemblGO_REF:0000107
Dusp1Ratcytoplasm is_active_inIBAFB:FBgn0036844 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dusp1Ratnucleus located_inISODUSP1 (Homo sapiens)1624291 PMID:7593328RGDPMID:7593328
Dusp1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Dusp1Ratnucleus located_inIEAUniProtKB:P28562 and ensembl:ENSP000002392231600115GO_REF:0000107EnsemblGO_REF:0000107
Dusp1Ratnucleus is_active_inIBAPANTHER:PTN000806857 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dusp1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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Dusp1Ratgrowth factor binding  IPIReg1a (Rattus norvegicus)10044027 RGD 
Dusp1Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Dusp1RatMAP kinase tyrosine/serine/threonine phosphatase activity  TAS 628467 RGD 
Dusp1RatMAP kinase tyrosine/serine/threonine phosphatase activity enablesIEAUniProtKB:P28563 and ensembl:ENSMUSP000000250251600115GO_REF:0000107EnsemblGO_REF:0000107
Dusp1RatMAP kinase tyrosine/serine/threonine phosphatase activity enablesIEAInterPro:IPR008343 and InterPro:IPR0204201600115GO_REF:0000002InterProGO_REF:0000002
Dusp1RatMAP kinase tyrosine/serine/threonine phosphatase activity enablesISODusp1 (Mus musculus)1624291 PMID:8221888RGDPMID:8221888
Dusp1RatMAP kinase tyrosine/serine/threonine phosphatase activity enablesISSUniProtKB:P285631600115GO_REF:0000024UniProtGO_REF:0000024
Dusp1RatMAP kinase tyrosine/serine/threonine phosphatase activity enablesISSUniProtKB:Q917901600115GO_REF:0000024UniProtGO_REF:0000024
Dusp1Ratmitogen-activated protein kinase binding enablesISSUniProtKB:P285631600115GO_REF:0000024UniProtGO_REF:0000024
Dusp1Ratmitogen-activated protein kinase binding enablesIEAUniProtKB:P28563 and ensembl:ENSMUSP000000250251600115GO_REF:0000107EnsemblGO_REF:0000107
Dusp1Ratmitogen-activated protein kinase binding enablesISODusp1 (Mus musculus)1624291UniProtKB:P63085 and PMID:8221888RGDPMID:8221888
Dusp1Ratphosphoprotein phosphatase activity enablesIBACGD:CAL0000191382 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dusp1Ratphosphoprotein phosphatase activity enablesIEAUniProtKB-KW:KW-09041600115GO_REF:0000043UniProtGO_REF:0000043
Dusp1Ratphosphoprotein phosphatase activity enablesIEAARBA:ARBA000276511600115GO_REF:0000117UniProtGO_REF:0000117
Dusp1Ratprotein binding enablesISODUSP1 (Homo sapiens)1624291UniProtKB:P0CG47 more ...RGDPMID:10617468 more ...
Dusp1Ratprotein serine/threonine phosphatase activity enablesISSUniProtKB:P285631600115GO_REF:0000024UniProtGO_REF:0000024
Dusp1Ratprotein serine/threonine phosphatase activity enablesIEAUniProtKB:P28563 and ensembl:ENSMUSP000000250251600115GO_REF:0000107EnsemblGO_REF:0000107
Dusp1Ratprotein serine/threonine phosphatase activity enablesIEARHEA:20629 and RHEA:470041600115GO_REF:0000116RHEAGO_REF:0000116
Dusp1Ratprotein serine/threonine phosphatase activity enablesISODusp1 (Mus musculus)1624291 PMID:8355678RGDPMID:8355678
Dusp1Ratprotein serine/threonine phosphatase activity enablesIEAEC:3.1.3.161600115GO_REF:0000003UniProtGO_REF:0000003
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

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Original Reference(s)
Dusp1Ratmitogen activated protein kinase signaling pathway   IEA 6907045 KEGGrno:04010

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#
Reference Title
Reference Citation
1. Glutamine suppresses DNFB-induced contact dermatitis by deactivating p38 mitogen-activated protein kinase via induction of MAPK phosphatase-1. Ayush O, etal., J Invest Dermatol. 2013 Mar;133(3):723-31. doi: 10.1038/jid.2012.373. Epub 2012 Oct 18.
2. Differential activation of mitogen-activated protein kinases by H2O2 and O2- in vascular smooth muscle cells. Baas AS and Berk BC, Circ Res. 1995 Jul;77(1):29-36.
3. The mitogen-activated protein kinase phosphatase-1 (MKP-1) gene is a potential methylation biomarker for malignancy of breast cancer. Chen FM, etal., Exp Mol Med. 2012 May 31;44(5):356-62. doi: 10.3858/emm.2012.44.5.040.
4. Levels of potential oral cancer salivary mRNA biomarkers in oral cancer patients in remission and oral lichen planus patients. Cheng YS, etal., Clin Oral Investig. 2013 Jul 28.
5. Blunting of the immediate-early gene and mitogenic response in hepatectomized type 1 diabetic animals. Chin S, etal., Am J Physiol. 1995 Oct;269(4 Pt 1):E691-700.
6. Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors. Cook KL, etal., Cancer Res. 2010 Nov 1;70(21):8319-28. Epub 2010 Sep 13.
7. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
8. Ginsenoside Rg(1) inhibits rat left ventricular hypertrophy induced by abdominal aorta coarctation: involvement of calcineurin and mitogen-activated protein kinase signalings. Deng J, etal., Eur J Pharmacol. 2009 Apr 17;608(1-3):42-7. doi: 10.1016/j.ejphar.2009.01.048.
9. Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma. Denkert C, etal., Int J Cancer. 2002 Dec 10;102(5):507-13.
10. Mitogen-activated protein kinase phosphatase-1 (MKP-1) in retinal ischemic preconditioning. Dreixler JC, etal., Exp Eye Res. 2011 Oct;93(4):340-9. doi: 10.1016/j.exer.2010.10.011. Epub 2010 Nov 20.
11. A negative regulator of MAP kinase causes depressive behavior. Duric V, etal., Nat Med. 2010 Nov;16(11):1328-32. doi: 10.1038/nm.2219. Epub 2010 Oct 17.
12. Oxidative stress-inducible protein tyrosine phosphatase in glomerulonephritis. Feng L, etal., Kidney Int 1995 Dec;48(6):1920-8.
13. Ginsenoside Rg1 inhibits vascular intimal hyperplasia in balloon-injured rat carotid artery by down-regulation of extracellular signal-regulated kinase 2. Gao Y, etal., J Ethnopharmacol. 2011 Nov 18;138(2):472-8. doi: 10.1016/j.jep.2011.09.029. Epub 2011 Sep 22.
14. Transient expression of the mitogen-activated protein kinase phosphatase MKP-1 (3CH134/ERP1) in the rat brain after limbic epilepsy. Gass P, etal., Brain Res Mol Brain Res. 1996 Sep 5;41(1-2):74-80.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Map kinase phosphatases (MKP's) are early responsive genes during induction of cerulein hyperstimulation pancreatitis. Hofken T, etal., Biochem Biophys Res Commun. 2000 Sep 24;276(2):680-5.
18. [Study on expression of mkp-1 and P-ERK in acutecontusive spinal cord injury rat's model]. Hong ZH, etal., Fen Zi Xi Bao Sheng Wu Xue Bao. 2008 Jun;41(3):207-12.
19. Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis. Horiuchi M, etal., J Biol Chem. 1997 Jul 25;272(30):19022-6.
20. Recombinant human erythropoietin protects against experimental spinal cord trauma injury by regulating expression of the proteins MKP-1 and p-ERK. Huang H, etal., J Int Med Res. 2009 Mar-Apr;37(2):511-9.
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PMID:1406996   PMID:7593328   PMID:8106404   PMID:8221888   PMID:8355678   PMID:15255935   PMID:16301819   PMID:16387640   PMID:17498703   PMID:17698050   PMID:18460465   PMID:18566605  
PMID:18824214   PMID:19050284   PMID:19103603   PMID:19289102   PMID:19901158   PMID:19956915   PMID:20032197   PMID:20829434   PMID:21179843   PMID:21575605   PMID:22810097   PMID:22914751  
PMID:22991462   PMID:23056550   PMID:23584919   PMID:24287620   PMID:25410305   PMID:25474904   PMID:25805336   PMID:27696308   PMID:28413926   PMID:28549965   PMID:28551880   PMID:29094779  
PMID:29565504   PMID:30618065   PMID:32160475   PMID:32656992   PMID:32959171   PMID:33448324   PMID:33666084   PMID:33950345   PMID:34023293   PMID:34562585   PMID:36110124   PMID:36279933  
PMID:36336032   PMID:37340011   PMID:37776398   PMID:38424085   PMID:38499157  



Dusp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81017,184,853 - 17,187,646 (+)NCBIGRCr8
mRatBN7.21016,680,478 - 16,683,275 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1021,430,403 - 21,433,194 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010464,443 - 467,234 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01016,408,838 - 16,411,630 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01016,970,642 - 16,973,425 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1016,970,626 - 16,973,418 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01016,867,381 - 16,870,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41016,942,913 - 16,945,696 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11016,943,975 - 16,946,743 (+)NCBI
Celera1016,333,248 - 16,336,031 (+)NCBICelera
Cytogenetic Map10q12NCBI
DUSP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385172,768,096 - 172,771,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5172,768,096 - 172,771,195 (-)EnsemblGRCh38hg38GRCh38
GRCh375172,195,099 - 172,198,198 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365172,127,707 - 172,130,809 (-)NCBINCBI36Build 36hg18NCBI36
Build 345172,127,706 - 172,130,809NCBI
Celera5168,227,970 - 168,231,080 (-)NCBICelera
Cytogenetic Map5q35.1NCBI
HuRef5167,290,428 - 167,293,538 (-)NCBIHuRef
CHM1_15171,627,607 - 171,630,717 (-)NCBICHM1_1
T2T-CHM13v2.05173,308,211 - 173,311,310 (-)NCBIT2T-CHM13v2.0
Dusp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391726,724,565 - 26,727,446 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1726,724,564 - 26,781,102 (-)EnsemblGRCm39 Ensembl
GRCm381726,505,591 - 26,508,472 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,505,590 - 26,562,128 (-)EnsemblGRCm38mm10GRCm38
MGSCv371726,642,536 - 26,645,417 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361726,233,191 - 26,236,061 (-)NCBIMGSCv36mm8
Celera1727,037,972 - 27,040,854 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.28NCBI
Dusp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540825,481,294 - 25,484,381 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540825,481,294 - 25,484,381 (-)NCBIChiLan1.0ChiLan1.0
DUSP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24167,907,023 - 167,912,350 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15166,046,565 - 166,049,728 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05168,121,536 - 168,124,671 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15175,032,797 - 175,035,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5175,032,803 - 175,035,960 (-)Ensemblpanpan1.1panPan2
DUSP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1439,588,833 - 39,591,065 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl439,588,339 - 39,590,514 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha439,532,575 - 39,535,635 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0439,959,081 - 39,962,196 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl439,959,082 - 39,962,196 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1439,775,072 - 39,778,139 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0439,964,700 - 39,967,755 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0440,474,741 - 40,477,792 (+)NCBIUU_Cfam_GSD_1.0
Dusp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721393,965,491 - 93,968,377 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366092,688,181 - 2,690,408 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366092,688,170 - 2,691,057 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1651,458,020 - 51,461,086 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11651,457,924 - 51,461,095 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21655,768,679 - 55,770,832 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12374,931,421 - 74,934,510 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2374,929,863 - 74,934,532 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660343,678,128 - 3,681,246 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Dusp1
39 total Variants

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:69
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000005383
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 31 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat

1 to 10 of 31 rows
RH127362  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21016,682,936 - 16,683,138 (+)MAPPERmRatBN7.2
Rnor_6.01016,973,089 - 16,973,288NCBIRnor6.0
Rnor_5.01016,869,828 - 16,870,027UniSTSRnor5.0
RGSC_v3.41016,945,360 - 16,945,559UniSTSRGSC3.4
Celera1016,335,695 - 16,335,894UniSTS
RH 3.4 Map10147.48UniSTS
Cytogenetic Map10q12UniSTS
AI137479  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21016,679,107 - 16,679,229 (+)MAPPERmRatBN7.2
Rnor_6.01016,969,258 - 16,969,380NCBIRnor6.0
Rnor_5.01016,865,996 - 16,866,118UniSTSRnor5.0
RGSC_v3.41016,941,529 - 16,941,651UniSTSRGSC3.4
Celera1016,331,863 - 16,331,985UniSTS
Cytogenetic Map10q12UniSTS
G06586  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21016,682,648 - 16,683,014 (+)MAPPERmRatBN7.2
Rnor_6.01016,972,801 - 16,973,165NCBIRnor6.0
Rnor_5.01016,869,540 - 16,869,904UniSTSRnor5.0
RGSC_v3.41016,945,072 - 16,945,436UniSTSRGSC3.4
Celera1016,335,407 - 16,335,771UniSTS
Cytogenetic Map10q12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000005383   ⟹   ENSRNOP00000005383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1016,970,626 - 16,973,418 (+)Ensembl
RefSeq Acc Id: NM_053769   ⟹   NP_446221
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81017,184,853 - 17,187,646 (+)NCBI
mRatBN7.21016,680,478 - 16,683,275 (+)NCBI
Rnor_6.01016,970,642 - 16,973,425 (+)NCBI
Rnor_5.01016,867,381 - 16,870,164 (+)NCBI
RGSC_v3.41016,942,913 - 16,945,696 (+)RGD
Celera1016,333,248 - 16,336,031 (+)RGD
Sequence:
Protein RefSeqs NP_446221 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA03432 (Get FASTA)   NCBI Sequence Viewer  
  AAB36123 (Get FASTA)   NCBI Sequence Viewer  
  AAK55327 (Get FASTA)   NCBI Sequence Viewer  
  CAA58828 (Get FASTA)   NCBI Sequence Viewer  
  EDM04049 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000088885
GenBank Protein Q64623 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446221   ⟸   NM_053769
- UniProtKB: Q548G6 (UniProtKB/Swiss-Prot),   Q64623 (UniProtKB/Swiss-Prot),   Q63683 (UniProtKB/TrEMBL),   A6HDE4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005383   ⟸   ENSRNOT00000005383
Rhodanese   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Name Modeler Protein Id AA Range Protein Structure
AF-Q64623-F1-model_v2 AlphaFold Q64623 1-367 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697090
Promoter ID:EPDNEW_R7614
Type:single initiation site
Name:Dusp1_1
Description:dual specificity phosphatase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01016,970,633 - 16,970,693EPDNEW


1 to 40 of 45 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-25634 BioCyc
Ensembl Genes ENSRNOG00000003977 Ensembl
  ENSRNOG00000069024 ENTREZGENE
Ensembl Transcript ENSRNOT00000110433 ENTREZGENE
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot
  3.90.190.10 UniProtKB/Swiss-Prot
InterPro Atypical_DUSP_famB UniProtKB/Swiss-Prot
  Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot
  MKP UniProtKB/Swiss-Prot
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot
  Rhodanese-like_dom UniProtKB/Swiss-Prot
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot
  Tyr_Pase_AS UniProtKB/Swiss-Prot
  Tyr_Pase_cat UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot
KEGG Report rno:114856 UniProtKB/Swiss-Prot
NCBI Gene 114856 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot
  DUAL SPECIFICITY PROTEIN PHOSPHATASE 1 UniProtKB/Swiss-Prot
Pfam DSPc UniProtKB/Swiss-Prot
  Rhodanese UniProtKB/Swiss-Prot
PhenoGen Dusp1 PhenoGen
PIRSF MAPK_Ptase UniProtKB/Swiss-Prot
PRINTS ADSPHPHTASE UniProtKB/Swiss-Prot
  ADSPHPHTASEB UniProtKB/Swiss-Prot
  MAPKPHPHTASE UniProtKB/Swiss-Prot
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003977 RatGTEx
  ENSRNOG00000069024 RatGTEx
SMART DSPc UniProtKB/Swiss-Prot
  PTPc_motif UniProtKB/Swiss-Prot
  RHOD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot
  SSF52821 UniProtKB/Swiss-Prot
UniProt A0A8I6AJQ7_RAT UniProtKB/TrEMBL
  A6HDE4 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 45 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Dusp1  dual specificity phosphatase 1  Ptpn16  protein tyrosine phosphatase, non-receptor type 16  Symbol and Name updated 1299863 APPROVED
2002-08-07 Ptpn16        Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_function inactivates MAP kinases by dual dephosphorylation (on threonine/tyrosine) 628467
gene_regulation expression was induced by insulin and delayed by hyperosmolarity 633768
gene_regulation mRNA is induced in GH4C1 pituitary cells by the thyrotropin-releasing hormone (TRH)through a rapid and transient, Ca++- dependent mechanism 628467
gene_regulation induction by the epidermal growth factor (EGF) is Ca++-independent and transcription is regulated by a calcium-sensitive elongation block in the first exon 628467