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Gene: Dusp1 (dual specificity phosphatase 1) Rattus norvegicus
Symbol: Dusp1
Name: dual specificity phosphatase 1
Description: Exhibits growth factor binding activity and protein tyrosine/threonine phosphatase activity. Involved in several processes, including negative regulation of nitrogen compound metabolic process; regulation of apoptotic process; and response to testosterone. Localizes to nucleus. Used to study Huntington's disease. Biomarker of several diseases, including anti-basement membrane glomerulonephritis; brain disease (multiple); hypertension; pancreatitis; and portal hypertension. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human DUSP1 (dual specificity phosphatase 1); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; angiotensin II signaling pathway via AT2 receptor; INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3CH134; 3CH134/CL100 PTPase; CL100; dual specificity phosphatase; dual specificity protein phosphatase 1; MAP kinase phosphatase 1; Map kinase phosphatase-1; mitogen-activated protein (MAP) kinase phosphatase-1; mitogen-activated protein kinase phosphatase 1; Mkp-1; Mkp1; oxidative stress-inducible protein tyrosine phosphatase; protein tyrosine phosphatase non-receptor type 16; protein tyrosine phosphatase, non-receptor type 16; protein-tyrosine phosphatase CL100; protein-tyrosine phosphatase non-receptor type 16; Ptpn16
Homo sapiens (human) : DUSP1 (dual specificity phosphatase 1)  HGNC  Alliance
Mus musculus (house mouse) : Dusp1 (dual specificity phosphatase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dusp1 (dual specificity phosphatase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DUSP1 (dual specificity phosphatase 1)
Canis lupus familiaris (dog) : DUSP1 (dual specificity phosphatase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dusp1 (dual specificity phosphatase 1)
Sus scrofa (pig) : DUSP1 (dual specificity phosphatase 1)
Chlorocebus sabaeus (African green monkey) : DUSP1 (dual specificity phosphatase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01016,970,642 - 16,973,425 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1016,970,626 - 16,973,418 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01016,867,381 - 16,870,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41016,942,913 - 16,945,696 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11016,943,975 - 16,946,743 (+)NCBI
Celera1016,333,248 - 16,336,031 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Dusp1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620897
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.