Dusp1 (dual specificity phosphatase 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Dusp1 (dual specificity phosphatase 1) Rattus norvegicus
Analyze
Symbol: Dusp1
Name: dual specificity phosphatase 1
RGD ID: 620897
Description: Enables growth factor binding activity and protein tyrosine/threonine phosphatase activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; regulation of apoptotic process; and response to testosterone. Located in nucleus. Used to study Huntington's disease. Biomarker of autoimmune disease (multiple); brain disease (multiple); hypertension; pancreatitis; and portal hypertension. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human DUSP1 (dual specificity phosphatase 1); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; angiotensin II signaling pathway via AT2 receptor; INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3CH134; 3CH134/CL100 PTPase; CL100; dual specificity phosphatase; dual specificity protein phosphatase 1; MAP kinase phosphatase 1; Map kinase phosphatase-1; mitogen-activated protein (MAP) kinase phosphatase-1; mitogen-activated protein kinase phosphatase 1; Mkp-1; Mkp1; oxidative stress-inducible protein tyrosine phosphatase; protein tyrosine phosphatase non-receptor type 16; protein tyrosine phosphatase, non-receptor type 16; protein-tyrosine phosphatase CL100; protein-tyrosine phosphatase non-receptor type 16; Ptpn16
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21016,680,489 - 16,683,276 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1021,430,403 - 21,433,194 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.010464,443 - 467,234 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01016,408,838 - 16,411,630 (+)NCBIRnor_WKY
Rnor_6.01016,970,642 - 16,973,425 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1016,970,626 - 16,973,418 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01016,867,381 - 16,870,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41016,942,913 - 16,945,696 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11016,943,975 - 16,946,743 (+)NCBI
Celera1016,333,248 - 16,336,031 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-alpha-phellandrene  (ISO)
(S)-nicotine  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-azacytidine  (ISO)
8-Br-cAMP  (ISO)
acetic acid  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (EXP,ISO)
ADP  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-phellandrene  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
ampicillin  (ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
ATP  (ISO)
auraptene  (ISO)
azathioprine  (ISO)
azoxystrobin  (EXP)
bazedoxifene  (ISO)
benzalkonium chloride  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buta-1,3-diene  (ISO)
butylated hydroxyanisole  (ISO)
butyric acid  (EXP)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chlorobenzene  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
ciglitazone  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
clopidogrel  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cumene  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
D-penicillamine  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
dextran sulfate  (ISO)
diazinon  (EXP,ISO)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dieldrin  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dipyridamole  (EXP,ISO)
diquat  (ISO)
dizocilpine maleate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
Erionite  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
eugenol  (ISO)
fenvalerate  (EXP)
ferric oxide  (ISO)
fluoranthene  (EXP,ISO)
fluticasone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glutathione  (EXP)
glycidol  (EXP)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
haloperidol  (EXP)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
irinotecan  (EXP)
isoprenaline  (ISO)
kenpaullone  (EXP)
ketoconazole  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
linagliptin  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
malathion  (ISO)
malvidin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mesalamine  (EXP)
metacetamol  (ISO)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
miconazole  (EXP)
mifepristone  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
naphthalenes  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
poly(propylene imine) macromolecule  (ISO)
Polygodial  (EXP)
potassium chloride  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propanal  (ISO)
prostaglandin E2  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
ranitidine  (EXP)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salmeterol xinafoate  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
senecionine  (ISO)
sertraline  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
succimer  (ISO)
sulfur dioxide  (ISO)
T-2 toxin  (EXP,ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
taurine  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thiabendazole  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
topiramate  (EXP)
topotecan  (EXP)
torcetrapib  (ISO)
toxaphene  (EXP)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vandetanib  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc acetate  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO,ISS)
nucleus  (IBA,IDA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Glutamine suppresses DNFB-induced contact dermatitis by deactivating p38 mitogen-activated protein kinase via induction of MAPK phosphatase-1. Ayush O, etal., J Invest Dermatol. 2013 Mar;133(3):723-31. doi: 10.1038/jid.2012.373. Epub 2012 Oct 18.
2. Differential activation of mitogen-activated protein kinases by H2O2 and O2- in vascular smooth muscle cells. Baas AS and Berk BC, Circ Res. 1995 Jul;77(1):29-36.
3. The mitogen-activated protein kinase phosphatase-1 (MKP-1) gene is a potential methylation biomarker for malignancy of breast cancer. Chen FM, etal., Exp Mol Med. 2012 May 31;44(5):356-62. doi: 10.3858/emm.2012.44.5.040.
4. Levels of potential oral cancer salivary mRNA biomarkers in oral cancer patients in remission and oral lichen planus patients. Cheng YS, etal., Clin Oral Investig. 2013 Jul 28.
5. Blunting of the immediate-early gene and mitogenic response in hepatectomized type 1 diabetic animals. Chin S, etal., Am J Physiol. 1995 Oct;269(4 Pt 1):E691-700.
6. Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors. Cook KL, etal., Cancer Res. 2010 Nov 1;70(21):8319-28. Epub 2010 Sep 13.
7. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
8. Ginsenoside Rg(1) inhibits rat left ventricular hypertrophy induced by abdominal aorta coarctation: involvement of calcineurin and mitogen-activated protein kinase signalings. Deng J, etal., Eur J Pharmacol. 2009 Apr 17;608(1-3):42-7. doi: 10.1016/j.ejphar.2009.01.048.
9. Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma. Denkert C, etal., Int J Cancer. 2002 Dec 10;102(5):507-13.
10. Mitogen-activated protein kinase phosphatase-1 (MKP-1) in retinal ischemic preconditioning. Dreixler JC, etal., Exp Eye Res. 2011 Oct;93(4):340-9. doi: 10.1016/j.exer.2010.10.011. Epub 2010 Nov 20.
11. A negative regulator of MAP kinase causes depressive behavior. Duric V, etal., Nat Med. 2010 Nov;16(11):1328-32. doi: 10.1038/nm.2219. Epub 2010 Oct 17.
12. Oxidative stress-inducible protein tyrosine phosphatase in glomerulonephritis. Feng L, etal., Kidney Int 1995 Dec;48(6):1920-8.
13. Transient expression of the mitogen-activated protein kinase phosphatase MKP-1 (3CH134/ERP1) in the rat brain after limbic epilepsy. Gass P, etal., Brain Res Mol Brain Res. 1996 Sep 5;41(1-2):74-80.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Map kinase phosphatases (MKP's) are early responsive genes during induction of cerulein hyperstimulation pancreatitis. Hofken T, etal., Biochem Biophys Res Commun. 2000 Sep 24;276(2):680-5.
17. [Study on expression of mkp-1 and P-ERK in acutecontusive spinal cord injury rat's model]. Hong ZH, etal., Fen Zi Xi Bao Sheng Wu Xue Bao. 2008 Jun;41(3):207-12.
18. Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis. Horiuchi M, etal., J Biol Chem. 1997 Jul 25;272(30):19022-6.
19. Recombinant human erythropoietin protects against experimental spinal cord trauma injury by regulating expression of the proteins MKP-1 and p-ERK. Huang H, etal., J Int Med Res. 2009 Mar-Apr;37(2):511-9.
20. AT2 receptors: functional relevance in cardiovascular disease. Jones ES, etal., Pharmacol Ther. 2008 Dec;120(3):292-316. Epub 2008 Aug 31.
21. Despite activation of EGF-receptor-ERK signaling pathway, epithelial proliferation is impaired in portal hypertensive gastric mucosa: relevance of MKP-1, c-fos, c-myc, and cyclin D1 expression. Kawanaka H, etal., Life Sci. 2001 Nov 9;69(25-26):3019-33.
22. The expression of dual-specificity phosphatase 1 mRNA is downregulated in lesional psoriatic skin. Kjellerup RB, etal., Br J Dermatol. 2013 Feb;168(2):339-45. doi: 10.1111/bjd.12020.
23. Over-expression of map kinase phosphatase-1 (MKP-1) suppresses neuronal death through regulating JNK signaling in hypoxia/re-oxygenation. Koga S, etal., Brain Res. 2012 Feb 3;1436:137-46. doi: 10.1016/j.brainres.2011.12.004. Epub 2011 Dec 8.
24. Regulation of MAP kinases by MAP kinase phosphatases. Kondoh K and Nishida E, Biochim Biophys Acta. 2007 Aug;1773(8):1227-37. Epub 2006 Dec 8.
25. Cell replication in the arterial wall: activation of signaling pathway following in vivo injury. Koyama H, etal., Circ Res. 1998 Apr 6;82(6):713-21.
26. Peripheral T lymphocytes from women with breast cancer exhibit abnormal protein expression of several signaling molecules. Kurt RA, etal., Int J Cancer. 1998 Sep 25;78(1):16-20.
27. Spinal cannabinoid receptor type 2 agonist reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatases in a rat model of neuropathic pain. Landry RP, etal., J Pain. 2012 Sep;13(9):836-48. doi: 10.1016/j.jpain.2012.05.013. Epub 2012 Aug 14.
28. Mitogen-activated protein kinase and mitogen-activated kinase phosphatase-1 expression in the Noble rat model of sex hormone-induced prostatic dysplasia and carcinoma. Leav I, etal., Lab Invest. 1996 Sep;75(3):361-70.
29. Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway. Lee J, etal., J Biol Chem. 2012 Jun 29;287(27):22799-811. doi: 10.1074/jbc.M111.337378. Epub 2012 May 18.
30. Osmotic regulation of insulin-induced mitogen-activated protein kinase phosphatase (MKP-1) expression in H4IIE rat hepatoma cells. Lornejad-Schafer MR, etal., Biochem J 2003 Apr 15;371(Pt 2):609-19.
31. Mitogen-activated protein kinase phosphatase 1 is overexpressed in prostate cancers and is inversely related to apoptosis. Magi-Galluzzi C, etal., Lab Invest. 1997 Jan;76(1):37-51.
32. Knockout of Mkp-1 exacerbates colitis in Il-10-deficient mice. Matta R, etal., Am J Physiol Gastrointest Liver Physiol. 2012 Jun 1;302(11):G1322-35. doi: 10.1152/ajpgi.00018.2012. Epub 2012 Mar 29.
33. LDL stimulates mitogen-activated protein kinase phosphatase-1 expression, independent of LDL receptors, in vascular smooth muscle cells. Metzler B, etal., Arterioscler Thromb Vasc Biol. 1999 Aug;19(8):1862-71.
34. Activation of ERK1/2 MAP kinases in familial amyloidotic polyneuropathy. Monteiro FA, etal., J Neurochem. 2006 Apr;97(1):151-61. Epub 2006 Mar 3.
35. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. Muda M, etal., J Biol Chem 1996 Feb 23;271(8):4319-26.
36. Pancreatic reg I binds MKP-1 and regulates cyclin D in pancreatic-derived cells. Mueller CM, etal., J Surg Res. 2008 Nov;150(1):137-43. doi: 10.1016/j.jss.2008.03.047. Epub 2008 Apr 28.
37. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
38. Mitogen activated protein kinase phosphatase-1 prevents the development of tactile sensitivity in a rodent model of neuropathic pain. Ndong C, etal., Mol Pain. 2012 Apr 27;8:34.
39. Mitogen-activated protein kinases and mitogen-activated protein kinase phosphatases mediate the inhibitory effects of all-trans retinoic acid on the hypertrophic growth of cardiomyocytes. Palm-Leis A, etal., J Biol Chem. 2004 Dec 24;279(52):54905-17. Epub 2004 Oct 18.
40. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
41. Norepinephrine induction of mitogen-activated protein kinase phosphatase-1 expression in rat pinealocytes: distinct roles of alpha- and beta-adrenergic receptors. Price DM, etal., Endocrinology. 2004 Dec;145(12):5723-33. Epub 2004 Sep 9.
42. Mitogen-activated protein kinase phosphatase-1 (MKP-1): >100-fold nocturnal and norepinephrine-induced changes in the rat pineal gland. Price DM, etal., FEBS Lett. 2004 Nov 5;577(1-2):220-6.
43. Mitogen-activated protein kinase phosphatase-1 (MKP-1) preferentially dephosphorylates p42/44MAPK but not p38MAPK in rat pinealocytes. Price DM, etal., J Neurochem. 2007 Jun;101(6):1685-93. Epub 2007 Apr 16.
44. Temporal and spatial regulation of the expression of BAD2, a MAP kinase phosphatase, during seizure, kindling, and long-term potentiation. Qian Z, etal., Learn Mem 1994 Sep-Oct;1(3):180-8.
45. Potential role for mitogen-activated protein kinase phosphatase-1 in the development of atherosclerotic lesions in mouse models. Reddy ST, etal., Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1676-81. Epub 2004 Jul 8.
46. GOA pipeline RGD automated data pipeline
47. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
48. Mitogen-activated protein kinase phosphatase-1 in human breast cancer independently predicts prognosis and is repressed by doxorubicin. Rojo F, etal., Clin Cancer Res. 2009 May 15;15(10):3530-9. doi: 10.1158/1078-0432.CCR-08-2070. Epub 2009 May 5.
49. MAP kinase phosphatase-1 gene transcription in rat neuroendocrine cells is modulated by a calcium-sensitive block to elongation in the first exon. Ryser S, etal., J Biol Chem 2001 Sep 7;276(36):33319-27.
50. c-Jun NH2 terminal kinase activation and decreased expression of mitogen-activated protein kinase phosphatase-1 play important roles in invasion and angiogenesis of urothelial carcinomas. Shimada K, etal., Am J Pathol. 2007 Sep;171(3):1003-12. Epub 2007 Aug 9.
51. CD40-modulated dual-specificity phosphatases MAPK phosphatase (MKP)-1 and MKP-3 reciprocally regulate Leishmania major infection. Srivastava N, etal., J Immunol. 2011 May 15;186(10):5863-72. doi: 10.4049/jimmunol.1003957. Epub 2011 Apr 6.
52. MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in Huntington's disease via additive effects of JNK and p38 inhibition. Taylor DM, etal., J Neurosci. 2013 Feb 6;33(6):2313-25. doi: 10.1523/JNEUROSCI.4965-11.2013.
53. Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer. Wang HY, etal., Cancer Lett. 2003 Mar 10;191(2):229-37.
54. [Effects of pioglitazone on MKP-1 and TSP-1 expression in early stages of diabetic retinopathy induced by streptozotocin]. Wang JY, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2006 Sep;35(5):529-34.
55. Expression changes of mitogen-activated protein kinase phosphatase-1 (MKP-1) in myocardium of streptozotocin-induced diabetic rats. Weng Y, etal., Exp Clin Endocrinol Diabetes. 2007 Jul;115(7):455-60.
56. Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity. Wu JJ, etal., Cell Metab. 2006 Jul;4(1):61-73.
57. [Effect of traditional Chinese medicine on expression of extracellular signal-regulating kinase-1 and mitogen activated protein kinase phosphatase-1 in brain and liver of fetal rats with fetal growth restriction]. Wu Y, etal., Zhonghua Fu Chan Ke Za Zhi. 2002 Nov;37(11):672-5.
58. Cellular defense against H2O2-induced apoptosis via MAP kinase-MKP-1 pathway. Xu Q, etal., Free Radic Biol Med. 2004 Apr 15;36(8):985-93.
59. Induction of mitogen-activated protein kinase phosphatase-1 during acute hypertension. Xu Q, etal., Hypertension. 1997 Jul;30(1 Pt 1):106-11.
60. Inhibition of protein tyrosine/mitogen-activated protein kinase phosphatase activity is associated with D2 dopamine receptor supersensitivity in a rat model of Parkinson's disease. Zhen X, etal., Mol Pharmacol 2002 Dec;62(6):1356-63.
61. Expression changes of growth-associated protein-43 (GAP-43) and mitogen-activated protein kinase phosphatase-1 (MKP-1) and in hippocampus of streptozotocin-induced diabetic cognitive impairment rats. Zhou J, etal., Exp Neurol. 2007 Aug;206(2):201-8. Epub 2007 May 21.
62. Dexamethasone suppresses monocyte chemoattractant protein-1 production via mitogen activated protein kinase phosphatase-1 dependent inhibition of Jun N-terminal kinase and p38 mitogen-activated protein kinase in activated rat microglia. Zhou Y, etal., J Neurochem. 2007 Aug;102(3):667-78. Epub 2007 Apr 2.
Additional References at PubMed
PMID:1406996   PMID:7593328   PMID:8106404   PMID:8221888   PMID:8355678   PMID:15255935   PMID:16301819   PMID:16387640   PMID:17498703   PMID:17698050   PMID:18460465   PMID:18566605  
PMID:18824214   PMID:19050284   PMID:19103603   PMID:19289102   PMID:19901158   PMID:19956915   PMID:20032197   PMID:20829434   PMID:21179843   PMID:21575605   PMID:22810097   PMID:22914751  
PMID:22991462   PMID:23056550   PMID:23584919   PMID:24287620   PMID:25410305   PMID:25474904   PMID:25805336   PMID:27696308   PMID:28413926   PMID:28549965   PMID:28551880   PMID:29094779  
PMID:29565504   PMID:30618065   PMID:32160475   PMID:32656992   PMID:32959171   PMID:33448324   PMID:33666084   PMID:33950345   PMID:34023293   PMID:34562585   PMID:36110124   PMID:36279933  
PMID:36336032  


Genomics

Comparative Map Data
Dusp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21016,680,489 - 16,683,276 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1021,430,403 - 21,433,194 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.010464,443 - 467,234 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01016,408,838 - 16,411,630 (+)NCBIRnor_WKY
Rnor_6.01016,970,642 - 16,973,425 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1016,970,626 - 16,973,418 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01016,867,381 - 16,870,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41016,942,913 - 16,945,696 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11016,943,975 - 16,946,743 (+)NCBI
Celera1016,333,248 - 16,336,031 (+)NCBICelera
Cytogenetic Map10q12NCBI
DUSP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385172,768,096 - 172,771,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5172,768,096 - 172,771,195 (-)EnsemblGRCh38hg38GRCh38
GRCh375172,195,099 - 172,198,198 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365172,127,707 - 172,130,809 (-)NCBINCBI36Build 36hg18NCBI36
Build 345172,127,706 - 172,130,809NCBI
Celera5168,227,970 - 168,231,080 (-)NCBICelera
Cytogenetic Map5q35.1NCBI
HuRef5167,290,428 - 167,293,538 (-)NCBIHuRef
CHM1_15171,627,607 - 171,630,717 (-)NCBICHM1_1
T2T-CHM13v2.05173,308,211 - 173,311,310 (-)NCBIT2T-CHM13v2.0
Dusp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391726,724,565 - 26,727,446 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1726,724,564 - 26,781,102 (-)EnsemblGRCm39 Ensembl
GRCm381726,505,591 - 26,508,472 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,505,590 - 26,562,128 (-)EnsemblGRCm38mm10GRCm38
MGSCv371726,642,536 - 26,645,417 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361726,233,191 - 26,236,061 (-)NCBIMGSCv36mm8
Celera1727,037,972 - 27,040,854 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.28NCBI
Dusp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540825,481,294 - 25,484,381 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540825,481,294 - 25,484,381 (-)NCBIChiLan1.0ChiLan1.0
DUSP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15175,032,797 - 175,035,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5175,032,803 - 175,035,960 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05168,121,536 - 168,124,671 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
DUSP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1439,588,833 - 39,591,065 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl439,588,339 - 39,590,514 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha439,532,575 - 39,535,635 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0439,959,081 - 39,962,196 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl439,959,082 - 39,962,196 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1439,775,072 - 39,778,139 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0439,964,700 - 39,967,755 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0440,474,741 - 40,477,792 (+)NCBIUU_Cfam_GSD_1.0
Dusp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721393,965,491 - 93,968,377 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366092,688,181 - 2,690,408 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366092,688,170 - 2,691,057 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1651,458,020 - 51,461,086 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11651,457,924 - 51,461,095 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21655,768,679 - 55,770,832 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12374,931,421 - 74,934,510 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2374,929,863 - 74,934,532 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660343,678,128 - 3,681,246 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Dusp1
38 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:69
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000005383
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat

Markers in Region
RH127362  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21016,682,936 - 16,683,138 (+)MAPPERmRatBN7.2
Rnor_6.01016,973,089 - 16,973,288NCBIRnor6.0
Rnor_5.01016,869,828 - 16,870,027UniSTSRnor5.0
RGSC_v3.41016,945,360 - 16,945,559UniSTSRGSC3.4
Celera1016,335,695 - 16,335,894UniSTS
RH 3.4 Map10147.48UniSTS
Cytogenetic Map10q12UniSTS
AI137479  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21016,679,107 - 16,679,229 (+)MAPPERmRatBN7.2
Rnor_6.01016,969,258 - 16,969,380NCBIRnor6.0
Rnor_5.01016,865,996 - 16,866,118UniSTSRnor5.0
RGSC_v3.41016,941,529 - 16,941,651UniSTSRGSC3.4
Celera1016,331,863 - 16,331,985UniSTS
Cytogenetic Map10q12UniSTS
G06586  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21016,682,648 - 16,683,014 (+)MAPPERmRatBN7.2
Rnor_6.01016,972,801 - 16,973,165NCBIRnor6.0
Rnor_5.01016,869,540 - 16,869,904UniSTSRnor5.0
RGSC_v3.41016,945,072 - 16,945,436UniSTSRGSC3.4
Celera1016,335,407 - 16,335,771UniSTS
Cytogenetic Map10q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 50 34 19 34 8 11 72 35 32 11 8
Low 7 7 7 2 9
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005383   ⟹   ENSRNOP00000005383
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1016,970,626 - 16,973,418 (+)Ensembl
RefSeq Acc Id: NM_053769   ⟹   NP_446221
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21016,680,489 - 16,683,276 (+)NCBI
Rnor_6.01016,970,642 - 16,973,425 (+)NCBI
Rnor_5.01016,867,381 - 16,870,164 (+)NCBI
RGSC_v3.41016,942,913 - 16,945,696 (+)RGD
Celera1016,333,248 - 16,336,031 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_446221   ⟸   NM_053769
- UniProtKB: Q548G6 (UniProtKB/Swiss-Prot),   Q64623 (UniProtKB/Swiss-Prot),   Q63683 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005383   ⟸   ENSRNOT00000005383
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64623-F1-model_v2 AlphaFold Q64623 1-367 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697090
Promoter ID:EPDNEW_R7614
Type:single initiation site
Name:Dusp1_1
Description:dual specificity phosphatase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01016,970,633 - 16,970,693EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620897 AgrOrtholog
BioCyc Gene G2FUF-25634 BioCyc
Ensembl Genes ENSRNOG00000003977 Ensembl
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Atypical_DUSP_famB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MKP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114856 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 114856 ENTREZGENE
Pfam DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dusp1 PhenoGen
PIRSF MAPK_Ptase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ADSPHPHTASEB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPKPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52821 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt DUS1_RAT UniProtKB/Swiss-Prot
  Q548G6 ENTREZGENE
  Q63683 ENTREZGENE, UniProtKB/TrEMBL
  Q64623 ENTREZGENE
UniProt Secondary Q548G6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Dusp1  dual specificity phosphatase 1  Ptpn16  protein tyrosine phosphatase, non-receptor type 16  Symbol and Name updated 1299863 APPROVED
2002-08-07 Ptpn16        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function inactivates MAP kinases by dual dephosphorylation (on threonine/tyrosine) 628467
gene_regulation expression was induced by insulin and delayed by hyperosmolarity 633768
gene_regulation mRNA is induced in GH4C1 pituitary cells by the thyrotropin-releasing hormone (TRH)through a rapid and transient, Ca++- dependent mechanism 628467
gene_regulation induction by the epidermal growth factor (EGF) is Ca++-independent and transcription is regulated by a calcium-sensitive elongation block in the first exon 628467