DUSP1 (dual specificity phosphatase 1) - Rat Genome Database

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Gene: DUSP1 (dual specificity phosphatase 1) Homo sapiens
Analyze
Symbol: DUSP1
Name: dual specificity phosphatase 1
RGD ID: 732954
HGNC Page HGNC:3064
Description: Enables protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Involved in several processes, including cellular response to chemokine; negative regulation of monocyte chemotaxis; and negative regulation of p38MAPK cascade. Located in cytoplasm and nucleus. Implicated in breast cancer. Biomarker of several diseases, including breast cancer; major depressive disorder; psoriasis; reproductive organ cancer (multiple); and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CL 100; CL100; dual specificity protein phosphatase 1; dual specificity protein phosphatase hVH1; HVH1; MAP kinase phosphatase 1; mitogen-activated protein kinase phosphatase 1; MKP-1; MKP1; protein tyrosine phosphatase, non-receptor type 16; protein-tyrosine phosphatase CL100; PTPN10; serine/threonine specific protein phosphatase
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385172,768,096 - 172,771,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5172,768,096 - 172,771,195 (-)EnsemblGRCh38hg38GRCh38
GRCh375172,195,099 - 172,198,198 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365172,127,707 - 172,130,809 (-)NCBINCBI36Build 36hg18NCBI36
Build 345172,127,706 - 172,130,809NCBI
Celera5168,227,970 - 168,231,080 (-)NCBICelera
Cytogenetic Map5q35.1NCBI
HuRef5167,290,428 - 167,293,538 (-)NCBIHuRef
CHM1_15171,627,607 - 171,630,717 (-)NCBICHM1_1
T2T-CHM13v2.05173,308,211 - 173,311,310 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(-)-alpha-phellandrene  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
2-methylcholine  (EXP)
2-palmitoylglycerol  (EXP)
2-tert-butylhydroquinone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-phenylprop-2-enal  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP)
acetic acid  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP,ISO)
ADP  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-phellandrene  (EXP)
amiodarone  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
ampicillin  (EXP)
antimony(0)  (EXP)
antimycin A  (EXP)
antirheumatic drug  (EXP)
Aroclor 1254  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
ATP  (EXP)
auraptene  (EXP)
azathioprine  (EXP)
azoxystrobin  (ISO)
bazedoxifene  (EXP)
benzalkonium chloride  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bexarotene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butylated hydroxyanisole  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
calcitriol  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
cerium trichloride  (EXP)
CGP 52608  (EXP)
chlorobenzene  (EXP)
chloropicrin  (EXP)
chloroprene  (ISO)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (ISO)
choline  (ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
clopidogrel  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (EXP)
cortisol  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP,ISO)
cumene  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (EXP)
cylindrospermopsin  (EXP)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (EXP)
diazinon  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
dieldrin  (EXP,ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (EXP)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
dipyridamole  (ISO)
diquat  (EXP)
dizocilpine maleate  (ISO)
dorsomorphin  (EXP)
doxorubicin  (ISO)
Enterolactone  (EXP)
epoxiconazole  (ISO)
Erionite  (ISO)
erlotinib hydrochloride  (EXP)
ethanol  (ISO)
eugenol  (EXP)
fenvalerate  (ISO)
ferric oxide  (ISO)
fluoranthene  (ISO)
fluticasone  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
furan  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycidol  (ISO)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
haloperidol  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
imidacloprid  (ISO)
indometacin  (EXP)
irinotecan  (ISO)
iron dichloride  (EXP)
isoprenaline  (ISO)
kenpaullone  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
linagliptin  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
malathion  (EXP)
malvidin  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
menadione  (EXP,ISO)
mercury dibromide  (EXP)
mesalamine  (ISO)
metacetamol  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methimazole  (ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
methylarsonic acid  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
methylmercury(1+)  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naphthalene  (ISO)
naphthalenes  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP)
nicotine  (ISO)
nitric oxide  (EXP)
orphenadrine  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenol  (EXP)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
picoxystrobin  (EXP)
pifithrin-?  (EXP)
pirinixic acid  (ISO)
piroxicam  (EXP)
poly(propylene imine) macromolecule  (EXP)
Polygodial  (ISO)
potassium chloride  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
propanal  (EXP)
prostaglandin E2  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (EXP)
ranitidine  (ISO)
resorcinol  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
Salmeterol xinafoate  (EXP)
SB 203580  (ISO)
SB 431542  (EXP)
SB-239063  (ISO)
SCH 23390  (ISO)
senecionine  (ISO)
sertraline  (EXP)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP)
Soman  (ISO)
succimer  (ISO)
sulfadimethoxine  (ISO)
sulfur dioxide  (EXP)
T-2 toxin  (EXP,ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
taurine  (ISO)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thalidomide  (EXP)
thapsigargin  (EXP)
thiabendazole  (ISO)
thimerosal  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topiramate  (ISO)
topotecan  (ISO)
torcetrapib  (EXP)
toxaphene  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP,ISO)
Triptolide  (EXP)
trovafloxacin  (ISO)
tunicamycin  (ISO)
undecane  (ISO)
urethane  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vanadyl sulfate  (EXP)
vandetanib  (EXP)
vinclozolin  (ISO)
vincristine  (EXP)
zinc acetate  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA,IEA)
nucleus  (IBA,IDA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Glutamine suppresses DNFB-induced contact dermatitis by deactivating p38 mitogen-activated protein kinase via induction of MAPK phosphatase-1. Ayush O, etal., J Invest Dermatol. 2013 Mar;133(3):723-31. doi: 10.1038/jid.2012.373. Epub 2012 Oct 18.
2. The mitogen-activated protein kinase phosphatase-1 (MKP-1) gene is a potential methylation biomarker for malignancy of breast cancer. Chen FM, etal., Exp Mol Med. 2012 May 31;44(5):356-62. doi: 10.3858/emm.2012.44.5.040.
3. Levels of potential oral cancer salivary mRNA biomarkers in oral cancer patients in remission and oral lichen planus patients. Cheng YS, etal., Clin Oral Investig. 2013 Jul 28.
4. Blunting of the immediate-early gene and mitogenic response in hepatectomized type 1 diabetic animals. Chin S, etal., Am J Physiol. 1995 Oct;269(4 Pt 1):E691-700.
5. Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors. Cook KL, etal., Cancer Res. 2010 Nov 1;70(21):8319-28. Epub 2010 Sep 13.
6. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
7. Ginsenoside Rg(1) inhibits rat left ventricular hypertrophy induced by abdominal aorta coarctation: involvement of calcineurin and mitogen-activated protein kinase signalings. Deng J, etal., Eur J Pharmacol. 2009 Apr 17;608(1-3):42-7. doi: 10.1016/j.ejphar.2009.01.048.
8. Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma. Denkert C, etal., Int J Cancer. 2002 Dec 10;102(5):507-13.
9. Mitogen-activated protein kinase phosphatase-1 (MKP-1) in retinal ischemic preconditioning. Dreixler JC, etal., Exp Eye Res. 2011 Oct;93(4):340-9. doi: 10.1016/j.exer.2010.10.011. Epub 2010 Nov 20.
10. A negative regulator of MAP kinase causes depressive behavior. Duric V, etal., Nat Med. 2010 Nov;16(11):1328-32. doi: 10.1038/nm.2219. Epub 2010 Oct 17.
11. Oxidative stress-inducible protein tyrosine phosphatase in glomerulonephritis. Feng L, etal., Kidney Int 1995 Dec;48(6):1920-8.
12. Ginsenoside Rg1 inhibits vascular intimal hyperplasia in balloon-injured rat carotid artery by down-regulation of extracellular signal-regulated kinase 2. Gao Y, etal., J Ethnopharmacol. 2011 Nov 18;138(2):472-8. doi: 10.1016/j.jep.2011.09.029. Epub 2011 Sep 22.
13. Transient expression of the mitogen-activated protein kinase phosphatase MKP-1 (3CH134/ERP1) in the rat brain after limbic epilepsy. Gass P, etal., Brain Res Mol Brain Res. 1996 Sep 5;41(1-2):74-80.
14. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
15. Map kinase phosphatases (MKP's) are early responsive genes during induction of cerulein hyperstimulation pancreatitis. Hofken T, etal., Biochem Biophys Res Commun. 2000 Sep 24;276(2):680-5.
16. [Study on expression of mkp-1 and P-ERK in acutecontusive spinal cord injury rat's model]. Hong ZH, etal., Fen Zi Xi Bao Sheng Wu Xue Bao. 2008 Jun;41(3):207-12.
17. Recombinant human erythropoietin protects against experimental spinal cord trauma injury by regulating expression of the proteins MKP-1 and p-ERK. Huang H, etal., J Int Med Res. 2009 Mar-Apr;37(2):511-9.
18. AT2 receptors: functional relevance in cardiovascular disease. Jones ES, etal., Pharmacol Ther. 2008 Dec;120(3):292-316. Epub 2008 Aug 31.
19. Defective mitogen-activated protein kinase (ERK2) signaling in gastric mucosa of portal hypertensive rats: potential therapeutic implications. Kawanaka H, etal., Hepatology. 2001 Nov;34(5):990-9. doi: 10.1053/jhep.2001.28507.
20. Despite activation of EGF-receptor-ERK signaling pathway, epithelial proliferation is impaired in portal hypertensive gastric mucosa: relevance of MKP-1, c-fos, c-myc, and cyclin D1 expression. Kawanaka H, etal., Life Sci. 2001 Nov 9;69(25-26):3019-33.
21. The expression of dual-specificity phosphatase 1 mRNA is downregulated in lesional psoriatic skin. Kjellerup RB, etal., Br J Dermatol. 2013 Feb;168(2):339-45. doi: 10.1111/bjd.12020.
22. Over-expression of map kinase phosphatase-1 (MKP-1) suppresses neuronal death through regulating JNK signaling in hypoxia/re-oxygenation. Koga S, etal., Brain Res. 2012 Feb 3;1436:137-46. doi: 10.1016/j.brainres.2011.12.004. Epub 2011 Dec 8.
23. Regulation of MAP kinases by MAP kinase phosphatases. Kondoh K and Nishida E, Biochim Biophys Acta. 2007 Aug;1773(8):1227-37. Epub 2006 Dec 8.
24. Cell replication in the arterial wall: activation of signaling pathway following in vivo injury. Koyama H, etal., Circ Res. 1998 Apr 6;82(6):713-21.
25. Peripheral T lymphocytes from women with breast cancer exhibit abnormal protein expression of several signaling molecules. Kurt RA, etal., Int J Cancer. 1998 Sep 25;78(1):16-20.
26. Spinal cannabinoid receptor type 2 agonist reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatases in a rat model of neuropathic pain. Landry RP, etal., J Pain. 2012 Sep;13(9):836-48. doi: 10.1016/j.jpain.2012.05.013. Epub 2012 Aug 14.
27. Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway. Lee J, etal., J Biol Chem. 2012 Jun 29;287(27):22799-811. doi: 10.1074/jbc.M111.337378. Epub 2012 May 18.
28. Mitogen-activated protein kinase phosphatase 1 is overexpressed in prostate cancers and is inversely related to apoptosis. Magi-Galluzzi C, etal., Lab Invest. 1997 Jan;76(1):37-51.
29. Knockout of Mkp-1 exacerbates colitis in Il-10-deficient mice. Matta R, etal., Am J Physiol Gastrointest Liver Physiol. 2012 Jun 1;302(11):G1322-35. doi: 10.1152/ajpgi.00018.2012. Epub 2012 Mar 29.
30. Activation of ERK1/2 MAP kinases in familial amyloidotic polyneuropathy. Monteiro FA, etal., J Neurochem. 2006 Apr;97(1):151-61. Epub 2006 Mar 3.
31. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. Muda M, etal., J Biol Chem 1996 Feb 23;271(8):4319-26.
32. Mitogen activated protein kinase phosphatase-1 prevents the development of tactile sensitivity in a rodent model of neuropathic pain. Ndong C, etal., Mol Pain. 2012 Apr 27;8:34.
33. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
34. Potential role for mitogen-activated protein kinase phosphatase-1 in the development of atherosclerotic lesions in mouse models. Reddy ST, etal., Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1676-81. Epub 2004 Jul 8.
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Mitogen-activated protein kinase phosphatase-1 in human breast cancer independently predicts prognosis and is repressed by doxorubicin. Rojo F, etal., Clin Cancer Res. 2009 May 15;15(10):3530-9. doi: 10.1158/1078-0432.CCR-08-2070. Epub 2009 May 5.
37. c-Jun NH2 terminal kinase activation and decreased expression of mitogen-activated protein kinase phosphatase-1 play important roles in invasion and angiogenesis of urothelial carcinomas. Shimada K, etal., Am J Pathol. 2007 Sep;171(3):1003-12. Epub 2007 Aug 9.
38. CD40-modulated dual-specificity phosphatases MAPK phosphatase (MKP)-1 and MKP-3 reciprocally regulate Leishmania major infection. Srivastava N, etal., J Immunol. 2011 May 15;186(10):5863-72. doi: 10.4049/jimmunol.1003957. Epub 2011 Apr 6.
39. MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in Huntington's disease via additive effects of JNK and p38 inhibition. Taylor DM, etal., J Neurosci. 2013 Feb 6;33(6):2313-25. doi: 10.1523/JNEUROSCI.4965-11.2013.
40. Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer. Wang HY, etal., Cancer Lett. 2003 Mar 10;191(2):229-37.
41. [Effects of pioglitazone on MKP-1 and TSP-1 expression in early stages of diabetic retinopathy induced by streptozotocin]. Wang JY, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2006 Sep;35(5):529-34.
42. Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing. Wen W, etal., Cell Discov. 2020 May 4;6:31. doi: 10.1038/s41421-020-0168-9. eCollection 2020.
43. Expression changes of mitogen-activated protein kinase phosphatase-1 (MKP-1) in myocardium of streptozotocin-induced diabetic rats. Weng Y, etal., Exp Clin Endocrinol Diabetes. 2007 Jul;115(7):455-60.
44. Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity. Wu JJ, etal., Cell Metab. 2006 Jul;4(1):61-73.
45. [Effect of traditional Chinese medicine on expression of extracellular signal-regulating kinase-1 and mitogen activated protein kinase phosphatase-1 in brain and liver of fetal rats with fetal growth restriction]. Wu Y, etal., Zhonghua Fu Chan Ke Za Zhi. 2002 Nov;37(11):672-5.
46. Induction of mitogen-activated protein kinase phosphatase-1 during acute hypertension. Xu Q, etal., Hypertension. 1997 Jul;30(1 Pt 1):106-11.
47. Expression changes of growth-associated protein-43 (GAP-43) and mitogen-activated protein kinase phosphatase-1 (MKP-1) and in hippocampus of streptozotocin-induced diabetic cognitive impairment rats. Zhou J, etal., Exp Neurol. 2007 Aug;206(2):201-8. Epub 2007 May 21.
Additional References at PubMed
PMID:1406996   PMID:7535770   PMID:7593328   PMID:7616230   PMID:7806236   PMID:8106404   PMID:8168826   PMID:8221888   PMID:8389479   PMID:8390041   PMID:8626452   PMID:9571625  
PMID:9599409   PMID:9828130   PMID:10022904   PMID:10617468   PMID:11062068   PMID:11278799   PMID:11359773   PMID:12080474   PMID:12356755   PMID:12391149   PMID:12477932   PMID:12506119  
PMID:12765304   PMID:12890671   PMID:12947325   PMID:12960255   PMID:14551204   PMID:14680833   PMID:14702039   PMID:14724291   PMID:15059515   PMID:15173070   PMID:15247770   PMID:15339908  
PMID:15448190   PMID:15489334   PMID:15569826   PMID:15590693   PMID:15614136   PMID:15677475   PMID:16044158   PMID:16081065   PMID:16109884   PMID:16224818   PMID:16286470   PMID:16289033  
PMID:16293973   PMID:16387640   PMID:16951204   PMID:17073741   PMID:17131384   PMID:17489738   PMID:17498703   PMID:17560945   PMID:17638884   PMID:17681939   PMID:17761948   PMID:17848570  
PMID:18003751   PMID:18089824   PMID:18095520   PMID:18178562   PMID:18314542   PMID:18367666   PMID:18403641   PMID:18434324   PMID:18441094   PMID:18477563   PMID:18490444   PMID:18519678  
PMID:18723442   PMID:18726921   PMID:18782768   PMID:19020052   PMID:19032224   PMID:19117950   PMID:19262425   PMID:19411256   PMID:19553005   PMID:19604093   PMID:19648110   PMID:19697705  
PMID:19724859   PMID:19755862   PMID:19793766   PMID:19797979   PMID:19892016   PMID:19913121   PMID:19940143   PMID:20043958   PMID:20089808   PMID:20100830   PMID:20145951   PMID:20228065  
PMID:20347885   PMID:20353815   PMID:20375469   PMID:20555314   PMID:20628086   PMID:20672047   PMID:20673984   PMID:20689807   PMID:20708668   PMID:20803086   PMID:20805296   PMID:20829434  
PMID:20868379   PMID:20890299   PMID:20936779   PMID:21060794   PMID:21454676   PMID:21507959   PMID:21547253   PMID:21715333   PMID:21733716   PMID:21803700   PMID:21840882   PMID:21873635  
PMID:21911040   PMID:21959016   PMID:21960346   PMID:21988832   PMID:22014408   PMID:22020934   PMID:22200679   PMID:22301548   PMID:22743041   PMID:22991462   PMID:23030431   PMID:23097457  
PMID:23149933   PMID:23169297   PMID:23333304   PMID:23625220   PMID:23728617   PMID:23825193   PMID:24080497   PMID:24086554   PMID:24155659   PMID:24267255   PMID:24308939   PMID:24339725  
PMID:24578378   PMID:24658355   PMID:24692548   PMID:25044272   PMID:25204653   PMID:25241761   PMID:25241763   PMID:25296132   PMID:25312268   PMID:25370852   PMID:25377473   PMID:25389768  
PMID:25593344   PMID:25617504   PMID:25638726   PMID:25724669   PMID:25798824   PMID:25858560   PMID:25872469   PMID:25943894   PMID:26111828   PMID:26158762   PMID:26176177   PMID:26280733  
PMID:26329166   PMID:26457672   PMID:26465331   PMID:26546680   PMID:26689986   PMID:26769965   PMID:26825339   PMID:26829212   PMID:27314954   PMID:27422607   PMID:27432908   PMID:27538525  
PMID:27551049   PMID:27572311   PMID:27599524   PMID:27880917   PMID:28065597   PMID:28112450   PMID:28129656   PMID:28299397   PMID:28330703   PMID:28384165   PMID:28413926   PMID:28650468  
PMID:28675297   PMID:28801478   PMID:28983624   PMID:29052270   PMID:29234123   PMID:29257221   PMID:29434446   PMID:29472726   PMID:29956792   PMID:30061089   PMID:30157211   PMID:30191967  
PMID:30198887   PMID:30246457   PMID:30262569   PMID:30536303   PMID:30647800   PMID:30967632   PMID:31061093   PMID:31246497   PMID:31316508   PMID:31323199   PMID:31328390   PMID:31330530  
PMID:31811110   PMID:31857702   PMID:31980649   PMID:32866608   PMID:33056982   PMID:33448324   PMID:33780908   PMID:33940385   PMID:34024253   PMID:34303662   PMID:34431063   PMID:34436551  
PMID:34578413   PMID:34697729   PMID:34778900   PMID:34785669   PMID:35008797   PMID:35236965   PMID:35332432   PMID:35500847   PMID:35689852   PMID:35809838   PMID:35910761   PMID:35911442  
PMID:37215986   PMID:37511459   PMID:37715430   PMID:37814866   PMID:37878495  


Genomics

Comparative Map Data
DUSP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385172,768,096 - 172,771,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5172,768,096 - 172,771,195 (-)EnsemblGRCh38hg38GRCh38
GRCh375172,195,099 - 172,198,198 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365172,127,707 - 172,130,809 (-)NCBINCBI36Build 36hg18NCBI36
Build 345172,127,706 - 172,130,809NCBI
Celera5168,227,970 - 168,231,080 (-)NCBICelera
Cytogenetic Map5q35.1NCBI
HuRef5167,290,428 - 167,293,538 (-)NCBIHuRef
CHM1_15171,627,607 - 171,630,717 (-)NCBICHM1_1
T2T-CHM13v2.05173,308,211 - 173,311,310 (-)NCBIT2T-CHM13v2.0
Dusp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391726,724,565 - 26,727,446 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1726,724,564 - 26,781,102 (-)EnsemblGRCm39 Ensembl
GRCm381726,505,591 - 26,508,472 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,505,590 - 26,562,128 (-)EnsemblGRCm38mm10GRCm38
MGSCv371726,642,536 - 26,645,417 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361726,233,191 - 26,236,061 (-)NCBIMGSCv36mm8
Celera1727,037,972 - 27,040,854 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.28NCBI
Dusp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81017,184,853 - 17,187,646 (+)NCBIGRCr8
mRatBN7.21016,680,478 - 16,683,275 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1021,430,403 - 21,433,194 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010464,443 - 467,234 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01016,408,838 - 16,411,630 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01016,970,642 - 16,973,425 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1016,970,626 - 16,973,418 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01016,867,381 - 16,870,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41016,942,913 - 16,945,696 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11016,943,975 - 16,946,743 (+)NCBI
Celera1016,333,248 - 16,336,031 (+)NCBICelera
Cytogenetic Map10q12NCBI
Dusp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540825,481,294 - 25,484,381 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540825,481,294 - 25,484,381 (-)NCBIChiLan1.0ChiLan1.0
DUSP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24167,907,023 - 167,912,350 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15166,046,565 - 166,049,728 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05168,121,536 - 168,124,671 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15175,032,797 - 175,035,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5175,032,803 - 175,035,960 (-)Ensemblpanpan1.1panPan2
DUSP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1439,588,833 - 39,591,065 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl439,588,339 - 39,590,514 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha439,532,575 - 39,535,635 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0439,959,081 - 39,962,196 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl439,959,082 - 39,962,196 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1439,775,072 - 39,778,139 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0439,964,700 - 39,967,755 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0440,474,741 - 40,477,792 (+)NCBIUU_Cfam_GSD_1.0
Dusp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721393,965,491 - 93,968,377 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366092,688,181 - 2,690,408 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366092,688,170 - 2,691,057 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1651,458,020 - 51,461,086 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11651,457,924 - 51,461,095 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21655,768,679 - 55,770,832 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12374,931,421 - 74,934,510 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2374,929,863 - 74,934,532 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660343,678,128 - 3,681,246 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in DUSP1
9 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q32-35.3(chr5:149714592-181272151)x3 copy number gain See cases [RCV000051863] Chr5:149714592..181272151 [GRCh38]
Chr5:149094155..180699152 [GRCh37]
Chr5:149074348..180631758 [NCBI36]
Chr5:5q32-35.3		 pathogenic
GRCh38/hg38 5q33.3-35.3(chr5:160029980-181269805)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051865]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051865]|See cases [RCV000051865] Chr5:160029980..181269805 [GRCh38]
Chr5:159456987..180696806 [GRCh37]
Chr5:159389565..180629412 [NCBI36]
Chr5:5q33.3-35.3		 pathogenic
GRCh38/hg38 5q34-35.3(chr5:168689326-181269946)x3 copy number gain See cases [RCV000051866] Chr5:168689326..181269946 [GRCh38]
Chr5:168116331..180696947 [GRCh37]
Chr5:168048909..180629553 [NCBI36]
Chr5:5q34-35.3		 pathogenic
GRCh38/hg38 5q33.3-35.3(chr5:156825512-181269805)x3 copy number gain See cases [RCV000133847] Chr5:156825512..181269805 [GRCh38]
Chr5:156252523..180696806 [GRCh37]
Chr5:156185101..180629412 [NCBI36]
Chr5:5q33.3-35.3		 pathogenic
GRCh38/hg38 5q34-35.3(chr5:164386701-181269805)x3 copy number gain See cases [RCV000135546] Chr5:164386701..181269805 [GRCh38]
Chr5:163813707..180696806 [GRCh37]
Chr5:163746285..180629412 [NCBI36]
Chr5:5q34-35.3		 pathogenic
GRCh38/hg38 5q35.1-35.3(chr5:169334755-181285301)x3 copy number gain See cases [RCV000141249] Chr5:169334755..181285301 [GRCh38]
Chr5:168761759..180712302 [GRCh37]
Chr5:168694337..180644908 [NCBI36]
Chr5:5q35.1-35.3		 pathogenic
GRCh37/hg19 5q35.1(chr5:172097061-172421802)x3 copy number gain Breast ductal adenocarcinoma [RCV000207298] Chr5:172097061..172421802 [GRCh37]
Chr5:5q35.1		 uncertain significance
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3		 likely benign
NM_004417.4(DUSP1):c.1087A>G (p.Thr363Ala) single nucleotide variant Inborn genetic diseases [RCV003245185] Chr5:172768779 [GRCh38]
Chr5:172195782 [GRCh37]
Chr5:5q35.1		 uncertain significance
GRCh37/hg19 5q34-35.1(chr5:164207156-172799124)x1 copy number loss See cases [RCV000447112] Chr5:164207156..172799124 [GRCh37]
Chr5:5q34-35.1		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3		 pathogenic
GRCh37/hg19 5q35.1-35.3(chr5:171396359-180719789)x3 copy number gain See cases [RCV000448458] Chr5:171396359..180719789 [GRCh37]
Chr5:5q35.1-35.3		 pathogenic
GRCh37/hg19 5q35.1-35.3(chr5:172031248-180719789)x3 copy number gain See cases [RCV000512068] Chr5:172031248..180719789 [GRCh37]
Chr5:5q35.1-35.3		 pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q33.2-35.3(chr5:155344802-180693344)x3 copy number gain not provided [RCV000745284] Chr5:155344802..180693344 [GRCh37]
Chr5:5q33.2-35.3		 pathogenic
NM_004417.4(DUSP1):c.855T>C (p.Phe285=) single nucleotide variant not provided [RCV000902953] Chr5:172769011 [GRCh38]
Chr5:172196014 [GRCh37]
Chr5:5q35.1		 likely benign
NM_004417.4(DUSP1):c.342C>G (p.Arg114=) single nucleotide variant not provided [RCV000918591] Chr5:172770611 [GRCh38]
Chr5:172197614 [GRCh37]
Chr5:5q35.1		 likely benign
GRCh37/hg19 5q34-35.2(chr5:166421173-173324843)x1 copy number loss Atrial septal defect 7 [RCV000853560] Chr5:166421173..173324843 [GRCh37]
Chr5:5q34-35.2		 pathogenic
GRCh37/hg19 5q35.1-35.3(chr5:170805664-180719789)x3 copy number gain 5q35 microduplication syndrome [RCV001263227] Chr5:170805664..180719789 [GRCh37]
Chr5:5q35.1-35.3		 pathogenic
GRCh37/hg19 5q32-35.3(chr5:149010383-180719789) copy number gain Hunter-McAlpine craniosynostosis [RCV002280612] Chr5:149010383..180719789 [GRCh37]
Chr5:5q32-35.3		 pathogenic
NC_000005.9:g.172068277_172342131dup duplication Congenital hydrocephalus [RCV000845242] Chr5:172068277..172342131 [GRCh37]
Chr5:5q35.1		 uncertain significance
GRCh37/hg19 5q34-35.1(chr5:164207156-172799124) copy number loss not specified [RCV002053537] Chr5:164207156..172799124 [GRCh37]
Chr5:5q34-35.1		 pathogenic
NC_000005.9:g.(?_172089144)_(172774583_?)del deletion Atrial septal defect 7 [RCV003113469] Chr5:172089144..172774583 [GRCh37]
Chr5:5q35.1		 pathogenic
NC_000005.9:g.(?_171765373)_(172939426_?)dup duplication not provided [RCV003122302] Chr5:171765373..172939426 [GRCh37]
Chr5:5q35.1-35.2		 uncertain significance
GRCh37/hg19 5q35.1-35.3(chr5:170350336-180719789)x3 copy number gain See cases [RCV002292398] Chr5:170350336..180719789 [GRCh37]
Chr5:5q35.1-35.3		 pathogenic
NM_004417.4(DUSP1):c.179T>C (p.Met60Thr) single nucleotide variant Inborn genetic diseases [RCV003259763] Chr5:172770774 [GRCh38]
Chr5:172197777 [GRCh37]
Chr5:5q35.1		 uncertain significance
GRCh37/hg19 5q33.1-35.2(chr5:150535183-172906793)x3 copy number gain not provided [RCV002474507] Chr5:150535183..172906793 [GRCh37]
Chr5:5q33.1-35.2		 pathogenic
NM_004417.4(DUSP1):c.175G>T (p.Ala59Ser) single nucleotide variant Inborn genetic diseases [RCV002864156] Chr5:172770778 [GRCh38]
Chr5:172197781 [GRCh37]
Chr5:5q35.1		 uncertain significance
NM_004417.4(DUSP1):c.950G>T (p.Cys317Phe) single nucleotide variant Inborn genetic diseases [RCV002732579] Chr5:172768916 [GRCh38]
Chr5:172195919 [GRCh37]
Chr5:5q35.1		 uncertain significance
NM_004417.4(DUSP1):c.953C>G (p.Ser318Trp) single nucleotide variant Inborn genetic diseases [RCV002886851] Chr5:172768913 [GRCh38]
Chr5:172195916 [GRCh37]
Chr5:5q35.1		 uncertain significance
NM_004417.4(DUSP1):c.275C>A (p.Ala92Asp) single nucleotide variant Inborn genetic diseases [RCV003211419] Chr5:172770678 [GRCh38]
Chr5:172197681 [GRCh37]
Chr5:5q35.1		 uncertain significance
GRCh37/hg19 5q35.1-35.2(chr5:171836503-176517734)x1 copy number loss not provided [RCV003485492] Chr5:171836503..176517734 [GRCh37]
Chr5:5q35.1-35.2		 pathogenic
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR101-2hsa-miR-101-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21068409
MIR101-1hsa-miR-101-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21068409

Predicted Target Of
Summary Value
Count of predictions:301
Count of miRNA genes:255
Interacting mature miRNAs:280
Transcripts:ENST00000239223
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
GDB:371394  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375172,195,239 - 172,195,534UniSTSGRCh37
Build 365172,127,845 - 172,128,140RGDNCBI36
Celera5168,228,116 - 168,228,411RGD
Cytogenetic Map5q34UniSTS
HuRef5167,290,574 - 167,290,869UniSTS
DUSP1_317  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375172,194,884 - 172,195,719UniSTSGRCh37
Build 365172,127,489 - 172,128,325RGDNCBI36
Celera5168,227,761 - 168,228,596RGD
HuRef5167,290,219 - 167,291,054UniSTS
UniSTS:30977  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375172,195,125 - 172,195,279UniSTSGRCh37
Build 365172,127,730 - 172,127,885RGDNCBI36
Celera5168,228,002 - 168,228,156RGD
HuRef5167,290,460 - 167,290,614UniSTS
WI-22759  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375172,197,415 - 172,197,550UniSTSGRCh37
Build 365172,130,021 - 172,130,156RGDNCBI36
Celera5168,230,292 - 168,230,427RGD
Cytogenetic Map5q34UniSTS
HuRef5167,292,750 - 167,292,885UniSTS
GeneMap99-GB4 RH Map5638.84UniSTS
Whitehead-RH Map5535.0UniSTS
G06586  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375172,195,359 - 172,195,708UniSTSGRCh37
Build 365172,127,965 - 172,128,314RGDNCBI36
Celera5168,228,236 - 168,228,585RGD
Cytogenetic Map5q34UniSTS
HuRef5167,290,694 - 167,291,043UniSTS
DUSP4  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375172,196,599 - 172,196,781UniSTSGRCh37
Celera5168,229,476 - 168,229,658UniSTS
HuRef5167,291,934 - 167,292,116UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 369 1422 388 49 373 31 2197 184 429 78 347 683 21 1 822 1375
Medium 2051 1569 1338 575 1284 434 2128 2008 3288 339 1112 924 154 382 1413 5 2
Low 19 291 32 5 17 2 1 6 1
Below cutoff 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_004417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA843403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC022217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ227912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS300525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ301957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ695205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI574182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U01669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X68277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000239223   ⟹   ENSP00000239223
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5172,768,096 - 172,771,195 (-)Ensembl
RefSeq Acc Id: NM_004417   ⟹   NP_004408
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385172,768,096 - 172,771,195 (-)NCBI
GRCh375172,195,093 - 172,198,203 (-)ENTREZGENE
GRCh375172,195,093 - 172,198,203 (-)NCBI
Build 365172,127,707 - 172,130,809 (-)NCBI Archive
HuRef5167,290,428 - 167,293,538 (-)ENTREZGENE
CHM1_15171,627,607 - 171,630,717 (-)NCBI
T2T-CHM13v2.05173,308,211 - 173,311,310 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_004408   ⟸   NM_004417
- UniProtKB: D3DQL9 (UniProtKB/Swiss-Prot),   Q2V508 (UniProtKB/Swiss-Prot),   P28562 (UniProtKB/Swiss-Prot),   B4DRR4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000239223   ⟸   ENST00000239223
Protein Domains
Rhodanese   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28562-F1-model_v2 AlphaFold P28562 1-367 view protein structure

Promoters
RGD ID:6803021
Promoter ID:HG_KWN:51793
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000252943,   UC003MBU.1
Position:
Human AssemblyChrPosition (strand)Source
Build 365172,129,781 - 172,131,642 (-)MPROMDB
RGD ID:6871556
Promoter ID:EPDNEW_H8943
Type:initiation region
Name:DUSP1_1
Description:dual specificity phosphatase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385172,771,195 - 172,771,255EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3064 AgrOrtholog
COSMIC DUSP1 COSMIC
Ensembl Genes ENSG00000120129 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000239223 ENTREZGENE
  ENST00000239223.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000120129 GTEx
HGNC ID HGNC:3064 ENTREZGENE
Human Proteome Map DUSP1 Human Proteome Map
InterPro Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MKP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1843 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 1843 ENTREZGENE
OMIM 600714 OMIM
PANTHER DUAL SPECIFICITY PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUAL SPECIFICITY PROTEIN PHOSPHATASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27519 PharmGKB
PIRSF MAPK_Ptase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ADSPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPKPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52821 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B4DRR4 ENTREZGENE, UniProtKB/TrEMBL
  B4DU40_HUMAN UniProtKB/TrEMBL
  D3DQL9 ENTREZGENE
  DUS1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q2V508 ENTREZGENE
UniProt Secondary D3DQL9 UniProtKB/Swiss-Prot
  Q2V508 UniProtKB/Swiss-Prot