RGD Reference Report - AT2 receptors: functional relevance in cardiovascular disease. - Rat Genome Database

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AT2 receptors: functional relevance in cardiovascular disease.

Authors: Jones, ES  Vinh, A  McCarthy, CA  Gaspari, TA  Widdop, RE 
Citation: Jones ES, etal., Pharmacol Ther. 2008 Dec;120(3):292-316. Epub 2008 Aug 31.
RGD ID: 5133675
Pubmed: PMID:18804122   (View Abstract at PubMed)
PMCID: PMC7112668   (View Article at PubMed Central)
DOI: DOI:10.1016/j.pharmthera.2008.08.009   (Journal Full-text)

The renin angiotensin system (RAS) is intricately involved in normal cardiovascular homeostasis. Excessive stimulation by the octapeptide angiotensin II contributes to a range of cardiovascular pathologies and diseases via angiotensin type 1 receptor (AT1R) activation. On the other hand, tElsevier Inc.he angiotensin type 2 receptor (AT2R) is thought to counter-regulate AT1R function. In this review, we describe the enhanced expression and function of AT2R in various cardiovascular disease settings. In addition, we illustrate that the RAS consists of a family of angiotensin peptides that exert cardiovascular effects that are often distinct from those of Ang II. During cardiovascular disease, there is likely to be an increased functional importance of AT2R, stimulated by Ang II, or even shorter angiotensin peptide fragments, to limit AT1R-mediated overactivity and cardiovascular pathologies.



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Objects Annotated

Genes (Rattus norvegicus)
Dusp1  (dual specificity phosphatase 1)
Ptpn6  (protein tyrosine phosphatase, non-receptor type 6)

Genes (Mus musculus)
Dusp1  (dual specificity phosphatase 1)
Ptpn6  (protein tyrosine phosphatase, non-receptor type 6)

Genes (Homo sapiens)
DUSP1  (dual specificity phosphatase 1)
PTPN6  (protein tyrosine phosphatase non-receptor type 6)


Additional Information