Dusp1 (dual specificity phosphatase 1) - Rat Genome Database

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Gene: Dusp1 (dual specificity phosphatase 1) Mus musculus
Analyze
Symbol: Dusp1
Name: dual specificity phosphatase 1
RGD ID: 732955
MGI Page MGI
Description: Enables mitogen-activated protein kinase binding activity and phosphoprotein phosphatase activity. Involved in negative regulation of MAPK cascade; negative regulation of cell population proliferation; and protein dephosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human DUSP1 (dual specificity phosphatase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3CH134; dual specificity protein phosphatase 1; e; erp; MAP kinase phosphatase 1; mitogen-activated protein kinase phosphatase 1; mitogen-activated protein kinase phosphatase-1; MKP; mkp-; mkp-1; MKP1; protein tyrosine phosphatase, non-receptor type 16; protein-tyrosine phosphatase 3CH134; protein-tyrosine phosphatase ERP; Ptp; Ptpn16; U19515
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391726,724,565 - 26,727,446 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1726,724,564 - 26,781,102 (-)EnsemblGRCm39 Ensembl
GRCm381726,505,591 - 26,508,472 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,505,590 - 26,562,128 (-)EnsemblGRCm38mm10GRCm38
MGSCv371726,642,536 - 26,645,417 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361726,233,191 - 26,236,061 (-)NCBIMGSCv36mm8
Celera1727,037,972 - 27,040,854 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.28NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-alpha-phellandrene  (ISO)
(S)-nicotine  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2-butoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
8-Br-cAMP  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
ADP  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
ampicillin  (ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
ATP  (ISO)
auraptene  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
bazedoxifene  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (EXP)
butylated hydroxyanisole  (EXP)
butyric acid  (ISO)
C.I. Natural Red 20  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (EXP)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chlorobenzene  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
choline  (EXP)
ciglitazone  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clofibric acid  (ISO)
clopidogrel  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
cumene  (EXP)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
dextran sulfate  (EXP)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP,ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dipyridamole  (EXP,ISO)
diquat  (ISO)
dizocilpine maleate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (EXP)
Erionite  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (EXP)
eugenol  (ISO)
fenvalerate  (ISO)
ferric oxide  (EXP)
fluoranthene  (EXP,ISO)
fluticasone  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycidol  (ISO)
glyphosate  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
haloperidol  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
imidacloprid  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isoprenaline  (EXP)
kenpaullone  (ISO)
ketoconazole  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
linagliptin  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
malathion  (ISO)
malvidin  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
menadione  (EXP,ISO)
mercury dibromide  (ISO)
mesalamine  (ISO)
metacetamol  (EXP)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
miconazole  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naphthalene  (EXP)
naphthalenes  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
nitric oxide  (ISO)
orphenadrine  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
poly(propylene imine) macromolecule  (ISO)
Polygodial  (ISO)
potassium chloride  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
ranitidine  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salmeterol xinafoate  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SCH 23390  (ISO)
senecionine  (EXP)
sertraline  (ISO)
Shikonin  (EXP)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
Soman  (ISO)
succimer  (EXP)
sulfur dioxide  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (EXP)
taurine  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thiabendazole  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
topiramate  (ISO)
topotecan  (ISO)
torcetrapib  (ISO)
toxaphene  (ISO)
tremolite asbestos  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP,ISO)
Triptolide  (ISO)
trovafloxacin  (EXP)
tunicamycin  (EXP)
undecane  (ISO)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vanadyl sulfate  (ISO)
vandetanib  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
nucleus  (IBA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cellular respiration  (IAGP)
abnormal chemokine level  (IAGP)
abnormal chemokine secretion  (IAGP)
abnormal circulating alanine transaminase level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendrite morphology  (IAGP)
abnormal depression-related behavior  (IAGP)
abnormal eating behavior  (IAGP)
abnormal innate immunity  (IAGP)
abnormal interleukin level  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal muscle development  (IAGP)
abnormal muscle regeneration  (IAGP)
abnormal myoblast differentiation  (IAGP)
abnormal nitric oxide homeostasis  (IAGP)
abnormal superior cervical ganglion morphology  (IAGP)
decreased abdominal fat pad weight  (IAGP)
decreased anxiety-related response  (IAGP)
decreased body size  (IAGP)
decreased body temperature  (IAGP)
decreased body weight  (IAGP)
decreased circulating alanine transaminase level  (IEA)
decreased circulating cholesterol level  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased epididymal fat pad weight  (IAGP)
decreased fat cell size  (IAGP)
decreased grip strength  (IAGP)
decreased liver weight  (IAGP)
decreased myoblast proliferation  (IAGP)
decreased skeletal muscle fiber diameter  (IAGP)
decreased skeletal muscle fiber size  (IAGP)
decreased skeletal muscle weight  (IAGP)
decreased susceptibility to age related obesity  (IAGP)
decreased susceptibility to age-related hepatic steatosis  (IAGP)
decreased susceptibility to diet-induced hepatic steatosis  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased total body fat amount  (IAGP)
dystrophic muscle  (IAGP)
hypotension  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased circulating interferon-gamma level  (IAGP)
increased circulating interleukin-10 level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased energy expenditure  (IAGP)
increased granulocyte number  (IAGP)
increased hepatic glucose production  (IAGP)
increased interleukin-1 beta secretion  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased mast cell degranulation  (IAGP)
increased neuron apoptosis  (IAGP)
increased prostaglandin level  (IAGP)
increased respiratory quotient  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased sensitivity to xenobiotic induced morbidity/mortality  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased susceptibility to induced arthritis  (IAGP)
increased susceptibility to type I hypersensitivity reaction  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
lung inflammation  (IAGP)
myositis  (IAGP)
pulmonary edema  (IAGP)
skeletal muscle fiber degeneration  (IAGP)
small liver  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. A growing family of dual specificity phosphatases with low molecular masses. Aoki N, etal., J Biochem (Tokyo) 2001 Jul;130(1):133-40.
2. Glutamine suppresses DNFB-induced contact dermatitis by deactivating p38 mitogen-activated protein kinase via induction of MAPK phosphatase-1. Ayush O, etal., J Invest Dermatol. 2013 Mar;133(3):723-31. doi: 10.1038/jid.2012.373. Epub 2012 Oct 18.
3. The mitogen-activated protein kinase phosphatase-1 (MKP-1) gene is a potential methylation biomarker for malignancy of breast cancer. Chen FM, etal., Exp Mol Med. 2012 May 31;44(5):356-62. doi: 10.3858/emm.2012.44.5.040.
4. Levels of potential oral cancer salivary mRNA biomarkers in oral cancer patients in remission and oral lichen planus patients. Cheng YS, etal., Clin Oral Investig. 2013 Jul 28.
5. Blunting of the immediate-early gene and mitogenic response in hepatectomized type 1 diabetic animals. Chin S, etal., Am J Physiol. 1995 Oct;269(4 Pt 1):E691-700.
6. Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors. Cook KL, etal., Cancer Res. 2010 Nov 1;70(21):8319-28. Epub 2010 Sep 13.
7. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
8. Ginsenoside Rg(1) inhibits rat left ventricular hypertrophy induced by abdominal aorta coarctation: involvement of calcineurin and mitogen-activated protein kinase signalings. Deng J, etal., Eur J Pharmacol. 2009 Apr 17;608(1-3):42-7. doi: 10.1016/j.ejphar.2009.01.048.
9. Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma. Denkert C, etal., Int J Cancer. 2002 Dec 10;102(5):507-13.
10. Mitogen-activated protein kinase phosphatase-1 (MKP-1) in retinal ischemic preconditioning. Dreixler JC, etal., Exp Eye Res. 2011 Oct;93(4):340-9. doi: 10.1016/j.exer.2010.10.011. Epub 2010 Nov 20.
11. A negative regulator of MAP kinase causes depressive behavior. Duric V, etal., Nat Med. 2010 Nov;16(11):1328-32. doi: 10.1038/nm.2219. Epub 2010 Oct 17.
12. Oxidative stress-inducible protein tyrosine phosphatase in glomerulonephritis. Feng L, etal., Kidney Int 1995 Dec;48(6):1920-8.
13. Transient expression of the mitogen-activated protein kinase phosphatase MKP-1 (3CH134/ERP1) in the rat brain after limbic epilepsy. Gass P, etal., Brain Res Mol Brain Res. 1996 Sep 5;41(1-2):74-80.
14. Map kinase phosphatases (MKP's) are early responsive genes during induction of cerulein hyperstimulation pancreatitis. Hofken T, etal., Biochem Biophys Res Commun. 2000 Sep 24;276(2):680-5.
15. [Study on expression of mkp-1 and P-ERK in acutecontusive spinal cord injury rat's model]. Hong ZH, etal., Fen Zi Xi Bao Sheng Wu Xue Bao. 2008 Jun;41(3):207-12.
16. Recombinant human erythropoietin protects against experimental spinal cord trauma injury by regulating expression of the proteins MKP-1 and p-ERK. Huang H, etal., J Int Med Res. 2009 Mar-Apr;37(2):511-9.
17. AT2 receptors: functional relevance in cardiovascular disease. Jones ES, etal., Pharmacol Ther. 2008 Dec;120(3):292-316. Epub 2008 Aug 31.
18. Despite activation of EGF-receptor-ERK signaling pathway, epithelial proliferation is impaired in portal hypertensive gastric mucosa: relevance of MKP-1, c-fos, c-myc, and cyclin D1 expression. Kawanaka H, etal., Life Sci. 2001 Nov 9;69(25-26):3019-33.
19. The expression of dual-specificity phosphatase 1 mRNA is downregulated in lesional psoriatic skin. Kjellerup RB, etal., Br J Dermatol. 2013 Feb;168(2):339-45. doi: 10.1111/bjd.12020.
20. Over-expression of map kinase phosphatase-1 (MKP-1) suppresses neuronal death through regulating JNK signaling in hypoxia/re-oxygenation. Koga S, etal., Brain Res. 2012 Feb 3;1436:137-46. doi: 10.1016/j.brainres.2011.12.004. Epub 2011 Dec 8.
21. Regulation of MAP kinases by MAP kinase phosphatases. Kondoh K and Nishida E, Biochim Biophys Acta. 2007 Aug;1773(8):1227-37. Epub 2006 Dec 8.
22. Cell replication in the arterial wall: activation of signaling pathway following in vivo injury. Koyama H, etal., Circ Res. 1998 Apr 6;82(6):713-21.
23. Peripheral T lymphocytes from women with breast cancer exhibit abnormal protein expression of several signaling molecules. Kurt RA, etal., Int J Cancer. 1998 Sep 25;78(1):16-20.
24. Spinal cannabinoid receptor type 2 agonist reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatases in a rat model of neuropathic pain. Landry RP, etal., J Pain. 2012 Sep;13(9):836-48. doi: 10.1016/j.jpain.2012.05.013. Epub 2012 Aug 14.
25. Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway. Lee J, etal., J Biol Chem. 2012 Jun 29;287(27):22799-811. doi: 10.1074/jbc.M111.337378. Epub 2012 May 18.
26. Mitogen-activated protein kinase phosphatase 1 is overexpressed in prostate cancers and is inversely related to apoptosis. Magi-Galluzzi C, etal., Lab Invest. 1997 Jan;76(1):37-51.
27. Knockout of Mkp-1 exacerbates colitis in Il-10-deficient mice. Matta R, etal., Am J Physiol Gastrointest Liver Physiol. 2012 Jun 1;302(11):G1322-35. doi: 10.1152/ajpgi.00018.2012. Epub 2012 Mar 29.
28. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
29. MGDs mouse GO annotations MGD data from the GO Consortium
30. MGD IEA MGD IEA
31. Activation of ERK1/2 MAP kinases in familial amyloidotic polyneuropathy. Monteiro FA, etal., J Neurochem. 2006 Apr;97(1):151-61. Epub 2006 Mar 3.
32. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. Muda M, etal., J Biol Chem 1996 Feb 23;271(8):4319-26.
33. Mitogen activated protein kinase phosphatase-1 prevents the development of tactile sensitivity in a rodent model of neuropathic pain. Ndong C, etal., Mol Pain. 2012 Apr 27;8:34.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. Potential role for mitogen-activated protein kinase phosphatase-1 in the development of atherosclerotic lesions in mouse models. Reddy ST, etal., Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1676-81. Epub 2004 Jul 8.
36. Mouse MP Annotation Import Pipeline RGD automated import pipeline
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Mitogen-activated protein kinase phosphatase-1 in human breast cancer independently predicts prognosis and is repressed by doxorubicin. Rojo F, etal., Clin Cancer Res. 2009 May 15;15(10):3530-9. doi: 10.1158/1078-0432.CCR-08-2070. Epub 2009 May 5.
39. MAP kinase phosphatase-1 gene transcription in rat neuroendocrine cells is modulated by a calcium-sensitive block to elongation in the first exon. Ryser S, etal., J Biol Chem 2001 Sep 7;276(36):33319-27.
40. c-Jun NH2 terminal kinase activation and decreased expression of mitogen-activated protein kinase phosphatase-1 play important roles in invasion and angiogenesis of urothelial carcinomas. Shimada K, etal., Am J Pathol. 2007 Sep;171(3):1003-12. Epub 2007 Aug 9.
41. CD40-modulated dual-specificity phosphatases MAPK phosphatase (MKP)-1 and MKP-3 reciprocally regulate Leishmania major infection. Srivastava N, etal., J Immunol. 2011 May 15;186(10):5863-72. doi: 10.4049/jimmunol.1003957. Epub 2011 Apr 6.
42. MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in Huntington's disease via additive effects of JNK and p38 inhibition. Taylor DM, etal., J Neurosci. 2013 Feb 6;33(6):2313-25. doi: 10.1523/JNEUROSCI.4965-11.2013.
43. Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer. Wang HY, etal., Cancer Lett. 2003 Mar 10;191(2):229-37.
44. [Effects of pioglitazone on MKP-1 and TSP-1 expression in early stages of diabetic retinopathy induced by streptozotocin]. Wang JY, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2006 Sep;35(5):529-34.
45. Expression changes of mitogen-activated protein kinase phosphatase-1 (MKP-1) in myocardium of streptozotocin-induced diabetic rats. Weng Y, etal., Exp Clin Endocrinol Diabetes. 2007 Jul;115(7):455-60.
46. Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity. Wu JJ, etal., Cell Metab. 2006 Jul;4(1):61-73.
47. [Effect of traditional Chinese medicine on expression of extracellular signal-regulating kinase-1 and mitogen activated protein kinase phosphatase-1 in brain and liver of fetal rats with fetal growth restriction]. Wu Y, etal., Zhonghua Fu Chan Ke Za Zhi. 2002 Nov;37(11):672-5.
48. Induction of mitogen-activated protein kinase phosphatase-1 during acute hypertension. Xu Q, etal., Hypertension. 1997 Jul;30(1 Pt 1):106-11.
49. Expression changes of growth-associated protein-43 (GAP-43) and mitogen-activated protein kinase phosphatase-1 (MKP-1) and in hippocampus of streptozotocin-induced diabetic cognitive impairment rats. Zhou J, etal., Exp Neurol. 2007 Aug;206(2):201-8. Epub 2007 May 21.
Additional References at PubMed
PMID:1741163   PMID:8221888   PMID:8274454   PMID:8355678   PMID:8557379   PMID:8806681   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11139479   PMID:11217851   PMID:11279073  
PMID:12444149   PMID:12466851   PMID:12477932   PMID:12511574   PMID:12639923   PMID:14578290   PMID:14610273   PMID:14681479   PMID:15269202   PMID:15485842   PMID:15489334   PMID:15590669  
PMID:15614136   PMID:15629424   PMID:15677475   PMID:15722358   PMID:15899879   PMID:16141072   PMID:16141073   PMID:16288200   PMID:16380512   PMID:16380513   PMID:16387640   PMID:16424221  
PMID:16461893   PMID:16537649   PMID:16543941   PMID:16602821   PMID:16869965   PMID:16880258   PMID:16978838   PMID:17158101   PMID:17337450   PMID:17404316   PMID:17440214   PMID:17442735  
PMID:17611196   PMID:17636038   PMID:17699753   PMID:17761948   PMID:18003751   PMID:18187551   PMID:18281381   PMID:18417546   PMID:18460465   PMID:18467446   PMID:18504304   PMID:18508759  
PMID:18535250   PMID:18554416   PMID:18566605   PMID:18625721   PMID:18682602   PMID:18723442   PMID:18761321   PMID:18782768   PMID:18845168   PMID:18945810   PMID:18950753   PMID:19494320  
PMID:19542371   PMID:19651781   PMID:19696743   PMID:19748894   PMID:19762714   PMID:19828354   PMID:19846601   PMID:19890037   PMID:19892016   PMID:19920356   PMID:19940143   PMID:20093631  
PMID:20100830   PMID:20173047   PMID:20196119   PMID:20228065   PMID:20371627   PMID:20404153   PMID:20404768   PMID:20483921   PMID:20506480   PMID:20547488   PMID:20561086   PMID:20619710  
PMID:20685880   PMID:20702711   PMID:20727407   PMID:20884649   PMID:20926767   PMID:20935641   PMID:21068409   PMID:21199871   PMID:21224048   PMID:21228211   PMID:21258786   PMID:21267068  
PMID:21521693   PMID:21533046   PMID:21547253   PMID:21558315   PMID:21677750   PMID:21698455   PMID:21715333   PMID:21723158   PMID:21764456   PMID:21852324   PMID:21873635   PMID:21956667  
PMID:21987635   PMID:22001906   PMID:22014408   PMID:22172035   PMID:22198506   PMID:22275313   PMID:22294037   PMID:22301548   PMID:22361726   PMID:22464096   PMID:22522596   PMID:22585571  
PMID:22623522   PMID:22701344   PMID:22794213   PMID:22898817   PMID:22899855   PMID:22991462   PMID:22993413   PMID:23030431   PMID:23055528   PMID:23109722   PMID:23139409   PMID:23184513  
PMID:23595884   PMID:24126911   PMID:24244156   PMID:24248350   PMID:24269279   PMID:24374966   PMID:24578378   PMID:24686178   PMID:24721909   PMID:24842488   PMID:24956536   PMID:25204653  
PMID:25261746   PMID:25287866   PMID:25310910   PMID:25312268   PMID:25312648   PMID:25389768   PMID:25657047   PMID:25737586   PMID:25799226   PMID:25951516   PMID:26019272   PMID:26518653  
PMID:26562438   PMID:26566083   PMID:26811378   PMID:26849227   PMID:27066978   PMID:27357344   PMID:27459239   PMID:27670844   PMID:27689697   PMID:27783995   PMID:27795299   PMID:28238855  
PMID:28247283   PMID:28265004   PMID:28319094   PMID:28359564   PMID:28759036   PMID:28959039   PMID:29149759   PMID:29241671   PMID:29317435   PMID:29393354   PMID:29619028   PMID:30061089  
PMID:30563203   PMID:30938680   PMID:31267372   PMID:31474996   PMID:31518515   PMID:31767833   PMID:31786712   PMID:31837322   PMID:32414764   PMID:34034704   PMID:34039638   PMID:34234775  
PMID:34431160   PMID:34553752   PMID:34580177   PMID:34944516   PMID:35364055   PMID:35409238   PMID:35429501   PMID:35944900   PMID:36504038  


Genomics

Comparative Map Data
Dusp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391726,724,565 - 26,727,446 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1726,724,564 - 26,781,102 (-)EnsemblGRCm39 Ensembl
GRCm381726,505,591 - 26,508,472 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,505,590 - 26,562,128 (-)EnsemblGRCm38mm10GRCm38
MGSCv371726,642,536 - 26,645,417 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361726,233,191 - 26,236,061 (-)NCBIMGSCv36mm8
Celera1727,037,972 - 27,040,854 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.28NCBI
DUSP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385172,768,096 - 172,771,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5172,768,096 - 172,771,195 (-)EnsemblGRCh38hg38GRCh38
GRCh375172,195,099 - 172,198,198 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365172,127,707 - 172,130,809 (-)NCBINCBI36Build 36hg18NCBI36
Build 345172,127,706 - 172,130,809NCBI
Celera5168,227,970 - 168,231,080 (-)NCBICelera
Cytogenetic Map5q35.1NCBI
HuRef5167,290,428 - 167,293,538 (-)NCBIHuRef
CHM1_15171,627,607 - 171,630,717 (-)NCBICHM1_1
T2T-CHM13v2.05173,308,211 - 173,311,310 (-)NCBIT2T-CHM13v2.0
Dusp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21016,680,489 - 16,683,276 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1021,430,403 - 21,433,194 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.010464,443 - 467,234 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01016,408,838 - 16,411,630 (+)NCBIRnor_WKY
Rnor_6.01016,970,642 - 16,973,425 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1016,970,626 - 16,973,418 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01016,867,381 - 16,870,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41016,942,913 - 16,945,696 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11016,943,975 - 16,946,743 (+)NCBI
Celera1016,333,248 - 16,336,031 (+)NCBICelera
Cytogenetic Map10q12NCBI
Dusp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540825,481,294 - 25,484,381 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540825,481,294 - 25,484,381 (-)NCBIChiLan1.0ChiLan1.0
DUSP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15175,032,797 - 175,035,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5175,032,803 - 175,035,960 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05168,121,536 - 168,124,671 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
DUSP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1439,588,833 - 39,591,065 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl439,588,339 - 39,590,514 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha439,532,575 - 39,535,635 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0439,959,081 - 39,962,196 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl439,959,082 - 39,962,196 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1439,775,072 - 39,778,139 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0439,964,700 - 39,967,755 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0440,474,741 - 40,477,792 (+)NCBIUU_Cfam_GSD_1.0
Dusp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721393,965,491 - 93,968,377 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366092,688,181 - 2,690,408 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366092,688,170 - 2,691,057 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1651,458,020 - 51,461,086 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11651,457,924 - 51,461,095 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21655,768,679 - 55,770,832 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12374,931,421 - 74,934,510 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2374,929,863 - 74,934,532 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660343,678,128 - 3,681,246 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir101ammu-miR-101a-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21068409
Mir101ammu-miR-101a-5pMirecordsexternal_info{unchanged}NA21068409

Predicted Target Of
Summary Value
Count of predictions:614
Count of miRNA genes:433
Interacting mature miRNAs:502
Transcripts:ENSMUST00000025025, ENSMUST00000126178, ENSMUST00000146077
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301615Cfld3_mcystic fibrosis lung disease 3 (mouse)Not determined17127081639Mouse
1300613Pcyts4_mplasmacytoma susceptibility 4 (mouse)Not determined17127081639Mouse
1302100Circp2_mcircadian photosensitivity 2 (mouse)Not determined17129198453Mouse
12910527Nrq1a_mnoise-induced hearing loss resistant QTL 1a (mouse)17129198453Mouse
12910528Nrq1_mnoise-induced hearing loss resistant QTL 1 (mouse)17129198453Mouse
13524851Asrq8_macoustic startle response 8 (mouse)17131030170Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17334817537348299Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
1301327Lmr7_mleishmaniasis resistance 7 (mouse)Not determined17485475227715939Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17689393640893936Mouse
4141608Phl1_mprogressive hearing loss 1 (mouse)Not determined17787584329487423Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17858491442585149Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17858491442585149Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171087811944878219Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1120648439364059Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1188597145886119Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171199818445998184Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171245178746451787Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171264696146646961Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171412337248123496Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171506165249061760Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171506165249061760Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171506165249061760Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171506165249061760Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171681972150819843Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171681972150819843Mouse
1302038Radpf1_mradiation pulmonary fibrosis 1 (mouse)Not determined171683545533819843Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171702994351030078Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171746220851462345Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171746220851462345Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171746220851462345Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171746220851462345Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171817541252178214Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171841835752420983Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171842214152424327Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171914502553145025Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172507658355712970Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172558491443976235Mouse
12903990Opfaq5_mopen field activity QTL 5 (mouse)172595092528992098Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172605118560051352Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172640101252911704Mouse
1300602Eye2_meye weight 2 (mouse)Not determined172650533741105037Mouse

Markers in Region
RH125291  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381726,505,743 - 26,505,909UniSTSGRCm38
MGSCv371726,642,688 - 26,642,854UniSTSGRCm37
Celera1727,038,124 - 27,038,290UniSTS
Cytogenetic Map17A2-CUniSTS
Dusp1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381726,505,734 - 26,506,582UniSTSGRCm38
MGSCv371726,642,679 - 26,643,527UniSTSGRCm37
Celera1727,038,115 - 27,038,964UniSTS
Cytogenetic Map17A2-CUniSTS
cM Map1713.0UniSTS
PMC156147P11  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381726,507,032 - 26,507,164UniSTSGRCm38
MGSCv371726,643,977 - 26,644,109UniSTSGRCm37
Celera1727,039,414 - 27,039,546UniSTS
Cytogenetic Map17A2-CUniSTS
Dusp1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381726,507,142 - 26,507,631UniSTSGRCm38
MGSCv371726,644,087 - 26,644,576UniSTSGRCm37
Celera1727,039,524 - 27,040,013UniSTS
Cytogenetic Map17A2-CUniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC122252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S64851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U19515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X61940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000011196
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1726,773,228 - 26,780,473 (-)Ensembl
GRCm38.p6 Ensembl1726,554,254 - 26,561,499 (-)Ensembl
RefSeq Acc Id: ENSMUST00000025025   ⟹   ENSMUSP00000025025
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1726,724,564 - 26,727,493 (-)Ensembl
GRCm38.p6 Ensembl1726,505,590 - 26,508,519 (-)Ensembl
RefSeq Acc Id: ENSMUST00000126178
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1726,724,565 - 26,727,448 (-)Ensembl
GRCm38.p6 Ensembl1726,505,591 - 26,508,474 (-)Ensembl
RefSeq Acc Id: ENSMUST00000146077
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1726,725,490 - 26,726,697 (-)Ensembl
GRCm38.p6 Ensembl1726,506,516 - 26,507,723 (-)Ensembl
RefSeq Acc Id: ENSMUST00000235532   ⟹   ENSMUSP00000157700
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1726,724,565 - 26,781,102 (-)Ensembl
GRCm38.p6 Ensembl1726,505,591 - 26,562,128 (-)Ensembl
RefSeq Acc Id: ENSMUST00000236661   ⟹   ENSMUSP00000157446
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1726,724,565 - 26,727,446 (-)Ensembl
GRCm38.p6 Ensembl1726,505,591 - 26,508,472 (-)Ensembl
RefSeq Acc Id: NM_013642   ⟹   NP_038670
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391726,724,565 - 26,727,446 (-)NCBI
GRCm381726,505,591 - 26,508,472 (-)ENTREZGENE
MGSCv371726,642,536 - 26,645,417 (-)RGD
Celera1727,037,972 - 27,040,854 (-)RGD
cM Map17 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_038670   ⟸   NM_013642
- UniProtKB: P28563 (UniProtKB/Swiss-Prot),   Q3U8K3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000157446   ⟸   ENSMUST00000236661
RefSeq Acc Id: ENSMUSP00000025025   ⟸   ENSMUST00000025025
RefSeq Acc Id: ENSMUSP00000157700   ⟸   ENSMUST00000235532
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28563-F1-model_v2 AlphaFold P28563 1-367 view protein structure

Promoters
RGD ID:13675246
Promoter ID:EPDNEW_M21772
Type:multiple initiation site
Name:Dusp1_1
Description:Mus musculus dual specificity phosphatase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381726,508,472 - 26,508,532EPDNEW
RGD ID:6828015
Promoter ID:MM_KWN:22691
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000047766,   OTTMUST00000047767,   OTTMUST00000084788
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361726,644,521 - 26,646,377 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:105120 AgrOrtholog
Ensembl Genes ENSMUSG00000024190 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000025025 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000157446.2 UniProtKB/TrEMBL
  ENSMUSP00000157700.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000025025 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000235532.2 UniProtKB/TrEMBL
  ENSMUST00000236661.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Atypical_DUSP_famB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MKP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19252 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:105120 ENTREZGENE
NCBI Gene 19252 ENTREZGENE
Pfam DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dusp1 PhenoGen
PIRSF MAPK_Ptase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ADSPHPHTASEB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPKPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52821 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494B924_MOUSE UniProtKB/TrEMBL
  A0A494B9K9_MOUSE UniProtKB/TrEMBL
  DUS1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3U8K3 ENTREZGENE, UniProtKB/TrEMBL
  Q3UCQ6_MOUSE UniProtKB/TrEMBL