Dusp1 (dual specificity phosphatase 1) - Rat Genome Database

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Gene: Dusp1 (dual specificity phosphatase 1) Mus musculus
Symbol: Dusp1
Name: dual specificity phosphatase 1
RGD ID: 732955
Description: Enables mitogen-activated protein kinase binding activity and phosphoprotein phosphatase activity. Involved in negative regulation of MAPK cascade; negative regulation of cell population proliferation; and protein dephosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human DUSP1 (dual specificity phosphatase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3CH134; dual specificity protein phosphatase 1; e; erp; MAP kinase phosphatase 1; mitogen-activated protein kinase phosphatase 1; mitogen-activated protein kinase phosphatase-1; MKP; mkp-; mkp-1; MKP1; protein tyrosine phosphatase, non-receptor type 16; protein-tyrosine phosphatase 3CH134; protein-tyrosine phosphatase ERP; Ptp; Ptpn16; U19515
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391726,724,565 - 26,727,446 (-)NCBIGRCm39mm39
GRCm39 Ensembl1726,724,564 - 26,781,102 (-)Ensembl
GRCm381726,505,591 - 26,508,472 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,505,590 - 26,562,128 (-)EnsemblGRCm38mm10GRCm38
MGSCv371726,642,536 - 26,645,417 (-)NCBIGRCm37mm9NCBIm37
MGSCv361726,233,191 - 26,236,061 (-)NCBImm8
Celera1727,037,972 - 27,040,854 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.28NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(S)-nicotine  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2-butoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
ampicillin  (ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
auraptene  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
bazedoxifene  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (EXP)
butylated hydroxyanisole  (EXP)
butyric acid  (ISO)
C.I. Natural Red 20  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (EXP)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
cerium trichloride  (ISO)
chlorobenzene  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
choline  (EXP)
ciglitazone  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clofibric acid  (ISO)
clopidogrel  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
cumene  (EXP)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
dextran sulfate  (EXP)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP,ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dipyridamole  (EXP,ISO)
diquat  (ISO)
dizocilpine maleate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
Erionite  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (EXP)
eugenol  (ISO)
fenvalerate  (ISO)
ferric oxide  (EXP)
fluoranthene  (EXP,ISO)
fluticasone  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycidol  (ISO)
glyphosate  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
haloperidol  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (EXP,ISO)
imidacloprid  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isoprenaline  (EXP)
kenpaullone  (ISO)
ketoconazole  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
malathion  (ISO)
malvidin  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
menadione  (EXP,ISO)
mercury dibromide  (ISO)
metacetamol  (EXP)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
miconazole  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naphthalene  (EXP)
naphthalenes  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
nitric oxide  (ISO)
orphenadrine  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
poly(propylene imine) macromolecule  (ISO)
Polygodial  (ISO)
potassium chloride  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
ranitidine  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
Salmeterol xinafoate  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SCH 23390  (ISO)
sertraline  (ISO)
Shikonin  (EXP)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
Soman  (ISO)
succimer  (EXP)
sulfur dioxide  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (EXP)
taurine  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thiabendazole  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
topiramate  (ISO)
topotecan  (ISO)
torcetrapib  (ISO)
toxaphene  (ISO)
tremolite asbestos  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP,ISO)
Triptolide  (ISO)
tunicamycin  (EXP)
undecane  (ISO)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vanadyl sulfate  (ISO)
vandetanib  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
nucleus  (IBA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cellular respiration  (IAGP)
abnormal chemokine level  (IAGP)
abnormal chemokine secretion  (IAGP)
abnormal circulating alanine transaminase level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendrite morphology  (IAGP)
abnormal depression-related behavior  (IAGP)
abnormal eating behavior  (IAGP)
abnormal innate immunity  (IAGP)
abnormal interleukin level  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal muscle development  (IAGP)
abnormal muscle regeneration  (IAGP)
abnormal myoblast differentiation  (IAGP)
abnormal nitric oxide homeostasis  (IAGP)
abnormal superior cervical ganglion morphology  (IAGP)
decreased abdominal fat pad weight  (IAGP)
decreased anxiety-related response  (IAGP)
decreased body size  (IAGP)
decreased body temperature  (IAGP)
decreased body weight  (IAGP)
decreased circulating alanine transaminase level  (IEA)
decreased circulating cholesterol level  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased epididymal fat pad weight  (IAGP)
decreased fat cell size  (IAGP)
decreased grip strength  (IAGP)
decreased liver weight  (IAGP)
decreased myoblast proliferation  (IAGP)
decreased skeletal muscle fiber diameter  (IAGP)
decreased skeletal muscle fiber size  (IAGP)
decreased skeletal muscle weight  (IAGP)
decreased susceptibility to age related obesity  (IAGP)
decreased susceptibility to age-related hepatic steatosis  (IAGP)
decreased susceptibility to diet-induced hepatic steatosis  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased total body fat amount  (IAGP)
dystrophic muscle  (IAGP)
hypotension  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased circulating interferon-gamma level  (IAGP)
increased circulating interleukin-10 level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased energy expenditure  (IAGP)
increased granulocyte number  (IAGP)
increased hepatic glucose production  (IAGP)
increased interleukin-1 beta secretion  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased mast cell degranulation  (IAGP)
increased neuron apoptosis  (IAGP)
increased prostaglandin level  (IAGP)
increased respiratory quotient  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased sensitivity to xenobiotic induced morbidity/mortality  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased susceptibility to induced arthritis  (IAGP)
increased susceptibility to type I hypersensitivity reaction  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
lung inflammation  (IAGP)
myositis  (IAGP)
pulmonary edema  (IAGP)
skeletal muscle fiber degeneration  (IAGP)
small liver  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
weight loss  (IAGP)

References - curated
1. Aoki N, etal., J Biochem (Tokyo) 2001 Jul;130(1):133-40.
2. Ayush O, etal., J Invest Dermatol. 2013 Mar;133(3):723-31. doi: 10.1038/jid.2012.373. Epub 2012 Oct 18.
3. Chen FM, etal., Exp Mol Med. 2012 May 31;44(5):356-62. doi: 10.3858/emm.2012.44.5.040.
4. Cheng YS, etal., Clin Oral Investig. 2013 Jul 28.
5. Chin S, etal., Am J Physiol. 1995 Oct;269(4 Pt 1):E691-700.
6. Cook KL, etal., Cancer Res. 2010 Nov 1;70(21):8319-28. Epub 2010 Sep 13.
7. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
8. Deng J, etal., Eur J Pharmacol. 2009 Apr 17;608(1-3):42-7. doi: 10.1016/j.ejphar.2009.01.048.
9. Denkert C, etal., Int J Cancer. 2002 Dec 10;102(5):507-13.
10. Dreixler JC, etal., Exp Eye Res. 2011 Oct;93(4):340-9. doi: 10.1016/j.exer.2010.10.011. Epub 2010 Nov 20.
11. Duric V, etal., Nat Med. 2010 Nov;16(11):1328-32. doi: 10.1038/nm.2219. Epub 2010 Oct 17.
12. Feng L, etal., Kidney Int 1995 Dec;48(6):1920-8.
13. Gass P, etal., Brain Res Mol Brain Res. 1996 Sep 5;41(1-2):74-80.
14. Hofken T, etal., Biochem Biophys Res Commun. 2000 Sep 24;276(2):680-5.
15. Hong ZH, etal., Fen Zi Xi Bao Sheng Wu Xue Bao. 2008 Jun;41(3):207-12.
16. Huang H, etal., J Int Med Res. 2009 Mar-Apr;37(2):511-9.
17. Jones ES, etal., Pharmacol Ther. 2008 Dec;120(3):292-316. Epub 2008 Aug 31.
18. Kawanaka H, etal., Life Sci. 2001 Nov 9;69(25-26):3019-33.
19. Kjellerup RB, etal., Br J Dermatol. 2013 Feb;168(2):339-45. doi: 10.1111/bjd.12020.
20. Koga S, etal., Brain Res. 2012 Feb 3;1436:137-46. doi: 10.1016/j.brainres.2011.12.004. Epub 2011 Dec 8.
21. Kondoh K and Nishida E, Biochim Biophys Acta. 2007 Aug;1773(8):1227-37. Epub 2006 Dec 8.
22. Koyama H, etal., Circ Res. 1998 Apr 6;82(6):713-21.
23. Kurt RA, etal., Int J Cancer. 1998 Sep 25;78(1):16-20.
24. Landry RP, etal., J Pain. 2012 Sep;13(9):836-48. doi: 10.1016/j.jpain.2012.05.013. Epub 2012 Aug 14.
25. Lee J, etal., J Biol Chem. 2012 Jun 29;287(27):22799-811. doi: 10.1074/jbc.M111.337378. Epub 2012 May 18.
26. Magi-Galluzzi C, etal., Lab Invest. 1997 Jan;76(1):37-51.
27. Matta R, etal., Am J Physiol Gastrointest Liver Physiol. 2012 Jun 1;302(11):G1322-35. doi: 10.1152/ajpgi.00018.2012. Epub 2012 Mar 29.
28. MGD and Homologene mouse data transfer
29. MGD data from the GO Consortium
31. Monteiro FA, etal., J Neurochem. 2006 Apr;97(1):151-61. Epub 2006 Mar 3.
32. Muda M, etal., J Biol Chem 1996 Feb 23;271(8):4319-26.
33. Ndong C, etal., Mol Pain. 2012 Apr 27;8:34.
34. Pipeline to import KEGG annotations from KEGG into RGD
35. Reddy ST, etal., Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1676-81. Epub 2004 Jul 8.
36. RGD automated import pipeline
37. RGD automated import pipeline for gene-chemical interactions
38. Rojo F, etal., Clin Cancer Res. 2009 May 15;15(10):3530-9. doi: 10.1158/1078-0432.CCR-08-2070. Epub 2009 May 5.
39. Ryser S, etal., J Biol Chem 2001 Sep 7;276(36):33319-27.
40. Shimada K, etal., Am J Pathol. 2007 Sep;171(3):1003-12. Epub 2007 Aug 9.
41. Srivastava N, etal., J Immunol. 2011 May 15;186(10):5863-72. doi: 10.4049/jimmunol.1003957. Epub 2011 Apr 6.
42. Taylor DM, etal., J Neurosci. 2013 Feb 6;33(6):2313-25. doi: 10.1523/JNEUROSCI.4965-11.2013.
43. Wang HY, etal., Cancer Lett. 2003 Mar 10;191(2):229-37.
44. Wang JY, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2006 Sep;35(5):529-34.
45. Weng Y, etal., Exp Clin Endocrinol Diabetes. 2007 Jul;115(7):455-60.
46. Wu JJ, etal., Cell Metab. 2006 Jul;4(1):61-73.
47. Wu Y, etal., Zhonghua Fu Chan Ke Za Zhi. 2002 Nov;37(11):672-5.
48. Xu Q, etal., Hypertension. 1997 Jul;30(1 Pt 1):106-11.
49. Zhou J, etal., Exp Neurol. 2007 Aug;206(2):201-8. Epub 2007 May 21.
Additional References at PubMed
PMID:1741163   PMID:8221888   PMID:8274454   PMID:8355678   PMID:8557379   PMID:8806681   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11279073   PMID:12444149  
PMID:12466851   PMID:12477932   PMID:12511574   PMID:12639923   PMID:14578290   PMID:14610273   PMID:14681479   PMID:15269202   PMID:15485842   PMID:15489334   PMID:15590669   PMID:15614136  
PMID:15629424   PMID:15677475   PMID:15722358   PMID:15899879   PMID:16141072   PMID:16141073   PMID:16288200   PMID:16380512   PMID:16380513   PMID:16387640   PMID:16424221   PMID:16461893  
PMID:16537649   PMID:16543941   PMID:16602821   PMID:16869965   PMID:16880258   PMID:16978838   PMID:17158101   PMID:17337450   PMID:17404316   PMID:17440214   PMID:17442735   PMID:17611196  
PMID:17636038   PMID:17699753   PMID:17761948   PMID:18003751   PMID:18187551   PMID:18281381   PMID:18417546   PMID:18460465   PMID:18467446   PMID:18504304   PMID:18508759   PMID:18535250  
PMID:18554416   PMID:18566605   PMID:18625721   PMID:18682602   PMID:18723442   PMID:18761321   PMID:18782768   PMID:18845168   PMID:18945810   PMID:18950753   PMID:19494320   PMID:19542371  
PMID:19651781   PMID:19696743   PMID:19748894   PMID:19762714   PMID:19828354   PMID:19846601   PMID:19890037   PMID:19892016   PMID:19920356   PMID:19940143   PMID:20093631   PMID:20100830  
PMID:20173047   PMID:20196119   PMID:20228065   PMID:20371627   PMID:20404153   PMID:20404768   PMID:20483921   PMID:20506480   PMID:20547488   PMID:20561086   PMID:20619710   PMID:20685880  
PMID:20702711   PMID:20727407   PMID:20884649   PMID:20926767   PMID:20935641   PMID:21068409   PMID:21199871   PMID:21224048   PMID:21228211   PMID:21258786   PMID:21267068   PMID:21521693  
PMID:21533046   PMID:21547253   PMID:21558315   PMID:21677750   PMID:21698455   PMID:21715333   PMID:21723158   PMID:21764456   PMID:21852324   PMID:21873635   PMID:21956667   PMID:21987635  
PMID:22001906   PMID:22014408   PMID:22172035   PMID:22198506   PMID:22275313   PMID:22294037   PMID:22301548   PMID:22361726   PMID:22464096   PMID:22522596   PMID:22585571   PMID:22623522  
PMID:22701344   PMID:22794213   PMID:22898817   PMID:22899855   PMID:22991462   PMID:22993413   PMID:23030431   PMID:23055528   PMID:23109722   PMID:23139409   PMID:23184513   PMID:23595884  
PMID:24126911   PMID:24244156   PMID:24248350   PMID:24269279   PMID:24374966   PMID:24578378   PMID:24686178   PMID:24721909   PMID:24842488   PMID:25204653   PMID:25261746   PMID:25287866  
PMID:25310910   PMID:25312268   PMID:25312648   PMID:25389768   PMID:25657047   PMID:25737586   PMID:25799226   PMID:25951516   PMID:26019272   PMID:26518653   PMID:26562438   PMID:26566083  
PMID:26811378   PMID:26849227   PMID:27066978   PMID:27357344   PMID:27459239   PMID:27670844   PMID:27689697   PMID:27783995   PMID:27795299   PMID:28238855   PMID:28247283   PMID:28265004  
PMID:28319094   PMID:28359564   PMID:28759036   PMID:28959039   PMID:29149759   PMID:29241671   PMID:29317435   PMID:29393354   PMID:29619028   PMID:30061089   PMID:30563203   PMID:30938680  
PMID:31267372   PMID:31474996   PMID:31518515   PMID:31767833   PMID:31786712   PMID:31837322   PMID:32414764   PMID:34034704   PMID:34039638   PMID:34234775   PMID:34553752  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391726,724,565 - 26,727,446 (-)NCBIGRCm39mm39
GRCm39 Ensembl1726,724,564 - 26,781,102 (-)Ensembl
GRCm381726,505,591 - 26,508,472 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,505,590 - 26,562,128 (-)EnsemblGRCm38mm10GRCm38
MGSCv371726,642,536 - 26,645,417 (-)NCBIGRCm37mm9NCBIm37
MGSCv361726,233,191 - 26,236,061 (-)NCBImm8
Celera1727,037,972 - 27,040,854 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.28NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl5172,768,096 - 172,771,195 (-)EnsemblGRCh38hg38GRCh38
GRCh385172,768,096 - 172,771,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375172,195,099 - 172,198,198 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365172,127,707 - 172,130,809 (-)NCBINCBI36hg18NCBI36
Build 345172,127,706 - 172,130,809NCBI
Celera5168,227,970 - 168,231,080 (-)NCBI
Cytogenetic Map5q35.1NCBI
HuRef5167,290,428 - 167,293,538 (-)NCBIHuRef
CHM1_15171,627,607 - 171,630,717 (-)NCBICHM1_1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21016,680,489 - 16,683,276 (+)NCBImRatBN7.2
Rnor_6.01016,970,642 - 16,973,425 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1016,970,626 - 16,973,418 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01016,867,381 - 16,870,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41016,942,913 - 16,945,696 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11016,943,975 - 16,946,743 (+)NCBI
Celera1016,333,248 - 16,336,031 (+)NCBICelera
Cytogenetic Map10q12NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540825,481,294 - 25,484,381 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540825,481,294 - 25,484,381 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.15175,032,797 - 175,035,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5175,032,803 - 175,035,960 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05168,121,536 - 168,124,671 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1439,588,833 - 39,591,065 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl439,588,339 - 39,590,514 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha439,532,575 - 39,535,635 (+)NCBI
ROS_Cfam_1.0439,959,081 - 39,962,196 (+)NCBI
ROS_Cfam_1.0 Ensembl439,959,082 - 39,962,196 (+)Ensembl
UMICH_Zoey_3.1439,775,072 - 39,778,139 (+)NCBI
UNSW_CanFamBas_1.0439,964,700 - 39,967,755 (+)NCBI
UU_Cfam_GSD_1.0440,474,741 - 40,477,792 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440721393,965,491 - 93,968,377 (+)NCBI
SpeTri2.0NW_0049366092,688,170 - 2,691,057 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1651,458,020 - 51,461,086 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11651,457,924 - 51,461,095 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21655,768,679 - 55,770,832 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12374,931,421 - 74,934,510 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2374,929,863 - 74,934,532 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660343,678,128 - 3,681,246 (+)NCBIVero_WHO_p1.0

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381726,505,743 - 26,505,909UniSTSGRCm38
MGSCv371726,642,688 - 26,642,854UniSTSGRCm37
Celera1727,038,124 - 27,038,290UniSTS
Cytogenetic Map17A2-CUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381726,505,734 - 26,506,582UniSTSGRCm38
MGSCv371726,642,679 - 26,643,527UniSTSGRCm37
Celera1727,038,115 - 27,038,964UniSTS
Cytogenetic Map17A2-CUniSTS
cM Map1713.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381726,507,032 - 26,507,164UniSTSGRCm38
MGSCv371726,643,977 - 26,644,109UniSTSGRCm37
Celera1727,039,414 - 27,039,546UniSTS
Cytogenetic Map17A2-CUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381726,507,142 - 26,507,631UniSTSGRCm38
MGSCv371726,644,087 - 26,644,576UniSTSGRCm37
Celera1727,039,524 - 27,040,013UniSTS
Cytogenetic Map17A2-CUniSTS

QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300613Pcyts4_mplasmacytoma susceptibility 4 (mouse)Not determined17126862710Mouse
1301615Cfld3_mcystic fibrosis lung disease 3 (mouse)Not determined17126862710Mouse
1302100Circp2_mcircadian photosensitivity 2 (mouse)Not determined17128979566Mouse
12910527Nrq1a_mnoise-induced hearing loss resistant QTL 1a (mouse)17128979566Mouse
12910528Nrq1_mnoise-induced hearing loss resistant QTL 1 (mouse)17128979566Mouse
13524851Asrq8_macoustic startle response 8 (mouse)17130809908Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17312791337128037Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17392461548559063Mouse
1301327Lmr7_mleishmaniasis resistance 7 (mouse)Not determined17480447727496965Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined480447745359340Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17480447746158776Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17480447747574740Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined480447765330362Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17667496240674962Mouse
4141608Phl1_mprogressive hearing loss 1 (mouse)Not determined17765701129268449Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17836594042366175Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17836594042366175Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined17986241186688972Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171065914544659245Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1098759739053168Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1166699745667145Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171177921045779210Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171206732483054339Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171223281346232813Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171242798746427987Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171390439847904522Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171484267848842786Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171484267848842786Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171484267848842786Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171484267848842786Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171660074750600869Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171660074750600869Mouse
1301505Tir1_mtrypanosome infection response 1 (mouse)Not determined171660074750600869Mouse
1302038Radpf1_mradiation pulmonary fibrosis 1 (mouse)Not determined171661519333600869Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171681096950811104Mouse
1302042Acsns3_mAngiostrongylus costaricensis nematode susceptibility 3 (mouse)Not determined171724323451243371Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171724323451243371Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171724323451243371Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171724323451243371Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171724323451243371Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171795643651959238Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171819938152202007Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171820316552205351Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171883413352834133Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172430185958301973Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172485760955405969Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172536594043665344Mouse
12903990Opfaq5_mopen field activity QTL 5 (mouse)172573195128773124Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172574029459740461Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172618203852604676Mouse
1300602Eye2_meye weight 2 (mouse)Not determined172628636340794146Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir101ammu-miR-101a-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21068409

Predicted Target Of
Summary Value
Count of predictions:614
Count of miRNA genes:433
Interacting mature miRNAs:502
Transcripts:ENSMUST00000025025, ENSMUST00000126178, ENSMUST00000146077
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.



Nucleotide Sequences
RefSeq Transcripts NM_013642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC122252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S64851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U19515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X61940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000011196
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1726,773,228 - 26,780,473 (-)Ensembl
GRCm38.p6 Ensembl1726,554,254 - 26,561,499 (-)Ensembl
RefSeq Acc Id: ENSMUST00000025025   ⟹   ENSMUSP00000025025
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1726,724,564 - 26,727,493 (-)Ensembl
GRCm38.p6 Ensembl1726,505,590 - 26,508,519 (-)Ensembl
RefSeq Acc Id: ENSMUST00000126178
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1726,724,565 - 26,727,448 (-)Ensembl
GRCm38.p6 Ensembl1726,505,591 - 26,508,474 (-)Ensembl
RefSeq Acc Id: ENSMUST00000146077
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1726,725,490 - 26,726,697 (-)Ensembl
GRCm38.p6 Ensembl1726,506,516 - 26,507,723 (-)Ensembl
RefSeq Acc Id: ENSMUST00000235532   ⟹   ENSMUSP00000157700
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1726,724,565 - 26,781,102 (-)Ensembl
GRCm38.p6 Ensembl1726,505,591 - 26,562,128 (-)Ensembl
RefSeq Acc Id: ENSMUST00000236661   ⟹   ENSMUSP00000157446
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1726,724,565 - 26,727,446 (-)Ensembl
GRCm38.p6 Ensembl1726,505,591 - 26,508,472 (-)Ensembl
RefSeq Acc Id: NM_013642   ⟹   NP_038670
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391726,724,565 - 26,727,446 (-)NCBI
GRCm381726,505,591 - 26,508,472 (-)ENTREZGENE
MGSCv371726,642,536 - 26,645,417 (-)RGD
Celera1727,037,972 - 27,040,854 (-)RGD
Reference Sequences
RefSeq Acc Id: NP_038670   ⟸   NM_013642
- UniProtKB: P28563 (UniProtKB/Swiss-Prot),   Q3U8K3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000157446   ⟸   ENSMUST00000236661
RefSeq Acc Id: ENSMUSP00000025025   ⟸   ENSMUST00000025025
RefSeq Acc Id: ENSMUSP00000157700   ⟸   ENSMUST00000235532
RGD ID:13675246
Promoter ID:EPDNEW_M21772
Type:multiple initiation site
Description:Mus musculus dual specificity phosphatase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381726,508,472 - 26,508,532EPDNEW
RGD ID:6828015
Promoter ID:MM_KWN:22691
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000047766,   OTTMUST00000047767,   OTTMUST00000084788
Mouse AssemblyChrPosition (strand)Source
MGSCv361726,644,521 - 26,646,377 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:105120 AgrOrtholog
Ensembl Genes ENSMUSG00000024190 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000025025 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000157446 UniProtKB/TrEMBL
  ENSMUSP00000157700 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000025025 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000235532 UniProtKB/TrEMBL
  ENSMUST00000236661 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Atypical_DUSP_famB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MKP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19252 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dusp1 PhenoGen
PIRSF MAPK_Ptase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52821 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494B924_MOUSE UniProtKB/TrEMBL