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Gene: Grm1 (glutamate metabotropic receptor 1) Rattus norvegicus
Symbol: Grm1
Name: glutamate metabotropic receptor 1
RGD ID: 2742
Description: Exhibits G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential; estrogen receptor binding activity; and identical protein binding activity. Involved in several processes, including G protein-coupled glutamate receptor signaling pathway; regulation of glutamatergic synaptic transmission; and sensory perception of pain. Localizes to several cellular components, including dendritic spine; glutamatergic synapse; and synaptic membrane. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Orthologous to human GRM1 (glutamate metabotropic receptor 1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; glutamate signaling pathway; Huntington's disease pathway; INTERACTS WITH (+)-pilocarpine; (S)-3,5-dihydroxyphenylglycine; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: G protein coupled receptor family C group 1 member A; G protein coupled receptor, family C, group 1, member A; glutamate receptor, metabotropic 1; Gprc1a; metabotropic glutamate receptor 1; mGluR1
Homo sapiens (human) : GRM1 (glutamate metabotropic receptor 1)  HGNC  Alliance
Mus musculus (house mouse) : Grm1 (glutamate receptor, metabotropic 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grm1 (glutamate metabotropic receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GRM1 (glutamate metabotropic receptor 1)
Canis lupus familiaris (dog) : GRM1 (glutamate metabotropic receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grm1 (glutamate metabotropic receptor 1)
Sus scrofa (pig) : GRM1 (glutamate metabotropic receptor 1)
Chlorocebus sabaeus (African green monkey) : GRM1 (glutamate metabotropic receptor 1)
Heterocephalus glaber (naked mole-rat) : Grm1 (glutamate metabotropic receptor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.014,753,141 - 5,165,859 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14,753,144 - 5,165,859 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.016,413,420 - 6,685,561 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.016,815,959 - 6,818,380 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415,318,617 - 5,744,593 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.115,318,616 - 5,744,590 (-)NCBI
Celera13,589,875 - 3,976,624 (-)NCBICelera
Cytogenetic Map1p13NCBI
SHRSP x BN Map15.6799RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Grm1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2742
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.