Grm1 (glutamate metabotropic receptor 1) - Rat Genome Database

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Gene: Grm1 (glutamate metabotropic receptor 1) Rattus norvegicus
Analyze
Symbol: Grm1
Name: glutamate metabotropic receptor 1
RGD ID: 2742
Description: Exhibits G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential; estrogen receptor binding activity; and identical protein binding activity. Involved in several processes, including G protein-coupled glutamate receptor signaling pathway; calcium-mediated signaling; and regulation of glutamatergic synaptic transmission. Localizes to several cellular components, including dendritic spine; glutamatergic synapse; and synaptic membrane. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Orthologous to human GRM1 (glutamate metabotropic receptor 1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; glutamate signaling pathway; Huntington's disease pathway; INTERACTS WITH (+)-pilocarpine; (S)-3,5-dihydroxyphenylglycine; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: G protein coupled receptor family C group 1 member A; G protein coupled receptor, family C, group 1, member A; glutamate receptor, metabotropic 1; Gprc1a; metabotropic glutamate receptor 1; mGluR1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.215,058,285 - 5,453,170 (-)NCBI
Rnor_6.0 Ensembl14,753,144 - 5,165,859 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.014,753,141 - 5,165,859 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.016,413,420 - 6,685,561 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.016,815,959 - 6,818,380 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415,318,617 - 5,744,593 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.115,318,616 - 5,744,590 (-)NCBI
Celera13,589,875 - 3,976,624 (-)NCBICelera
SHRSP x BN Map15.6799RGD
Cytogenetic Map1p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Agassandian K and Cassell MD, Brain Res. 2008 Aug 21;1226:39-55. Epub 2008 Jun 11.
2. Baude A, etal., Neuron. 1993 Oct;11(4):771-87.
3. Brakeman PR, etal., Nature 1997 Mar 20;386(6622):284-8.
4. Croci C, etal., J Biol Chem. 2003 Dec 12;278(50):50682-90. Epub 2003 Sep 30.
5. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Gee CE, etal., J Physiol 2003 Feb 1;546(Pt 3):655-64.
7. Gillard SE, etal., J Comp Neurol 2003 Jun 30;461(3):317-32.
8. GOA data from the GO Consortium
9. Kim SJ, etal., Nature 2003 Nov 20;426(6964):285-91. Epub 2003 Nov 12.
10. Kitano J, etal., J Neurosci 2002 Feb 15;22(4):1280-9.
11. Kuo J, etal., Endocrinology. 2009 Mar;150(3):1369-76. Epub 2008 Oct 23.
12. Kushmerick C, etal., J Neurosci 2004 Jun 30;24(26):5955-65.
13. Luján R, etal., J Chem Neuroanat. 1997 Oct;13(4):219-41.
14. Maeda J, etal., Neurosci Lett 2003 Jan 23;336(3):171-4.
15. MGD data from the GO Consortium
16. NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Neugebauer V, etal., J Neurosci 2003 Jan 1;23(1):52-63.
18. OMIM Disease Annotation Pipeline
19. Online Mendelian Inheritance in Man, OMIM (TM).
20. Pampillo M, etal., Neurosci Lett 2002 Jul 19;327(2):95-8.
21. Pipeline to import KEGG annotations from KEGG into RGD
22. Poisik OV, etal., J Neurosci 2003 Jan 1;23(1):122-30.
23. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. RGD automated import pipeline for gene-chemical interactions
25. Rives ML, etal., EMBO J. 2009 Aug 5;28(15):2195-208. doi: 10.1038/emboj.2009.177. Epub 2009 Jul 9.
26. Soloviev MM, etal., Biochim Biophys Acta 1999 Jul 7;1446(1-2):161-6.
27. Wittmann M, etal., Neuroscience. 2001;105(4):881-9.
28. Wyneken U, etal., Neuroscience. 2001;102(1):65-74.
29. Xiao B, etal., Neuron 1998 Oct;21(4):707-16.
Additional References at PubMed
PMID:1309649   PMID:1438218   PMID:1656524   PMID:1847995   PMID:8312606   PMID:9647694   PMID:10469171   PMID:10846166   PMID:10945991   PMID:11356865   PMID:11487615   PMID:11562444  
PMID:11897107   PMID:12213280   PMID:12411524   PMID:12694926   PMID:12898387   PMID:14596868   PMID:15044519   PMID:15086529   PMID:15152047   PMID:15176087   PMID:15372499   PMID:15579147  
PMID:15738140   PMID:15862522   PMID:16051747   PMID:16393337   PMID:16394070   PMID:16410359   PMID:16421200   PMID:16497716   PMID:16719794   PMID:16763042   PMID:16885225   PMID:16905160  
PMID:16931548   PMID:16982110   PMID:17030435   PMID:17156362   PMID:17228082   PMID:17250682   PMID:17292864   PMID:17303286   PMID:17331504   PMID:17360426   PMID:17548216   PMID:17640528  
PMID:17672856   PMID:18003824   PMID:18022605   PMID:18056795   PMID:18174329   PMID:18479833   PMID:18510247   PMID:18554818   PMID:18602428   PMID:18691652   PMID:18716215   PMID:19005059  
PMID:19094988   PMID:19186170   PMID:19413649   PMID:19490024   PMID:19508696   PMID:19549872   PMID:19628026   PMID:19657020   PMID:19776280   PMID:19807846   PMID:19879871   PMID:19894497  
PMID:19961906   PMID:20043967   PMID:20151362   PMID:20180987   PMID:20193665   PMID:20519363   PMID:20603338   PMID:20826542   PMID:20848228   PMID:21052544   PMID:21162731   PMID:21185314  
PMID:21269340   PMID:21576272   PMID:21593322   PMID:21613584   PMID:21668889   PMID:21749491   PMID:21795692   PMID:21849555   PMID:21880942   PMID:21980366   PMID:21984253   PMID:22172929  
PMID:22311599   PMID:22362014   PMID:22442667   PMID:22486777   PMID:22973005   PMID:23426668   PMID:23978512   PMID:24495291   PMID:24603153   PMID:24626340   PMID:25113912   PMID:25149878  
PMID:25158311   PMID:25161282   PMID:25266126   PMID:25377770   PMID:25421413   PMID:25449406   PMID:25451626   PMID:25894678   PMID:25934040   PMID:26033576   PMID:26095359   PMID:26134564  
PMID:26318863   PMID:26389591   PMID:26758963   PMID:27041217   PMID:27306787   PMID:27542344   PMID:27618534   PMID:27721389   PMID:27796752   PMID:28009293   PMID:28088471   PMID:28886343  
PMID:28948209   PMID:29097780   PMID:29253887   PMID:30222904   PMID:30590038   PMID:30599269   PMID:30607810   PMID:31146278   PMID:31369778   PMID:31600563   PMID:31710636   PMID:31919348  


Genomics

Comparative Map Data
Grm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.215,058,285 - 5,453,170 (-)NCBI
Rnor_6.0 Ensembl14,753,144 - 5,165,859 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.014,753,141 - 5,165,859 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.016,413,420 - 6,685,561 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.016,815,959 - 6,818,380 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415,318,617 - 5,744,593 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.115,318,616 - 5,744,590 (-)NCBI
Celera13,589,875 - 3,976,624 (-)NCBICelera
SHRSP x BN Map15.6799RGD
Cytogenetic Map1p13NCBI
GRM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6146,027,646 - 146,437,601 (+)EnsemblGRCh38hg38GRCh38
GRCh386146,027,634 - 146,437,601 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376146,348,843 - 146,758,737 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366146,392,112 - 146,800,427 (+)NCBINCBI36hg18NCBI36
Build 346146,392,111 - 146,800,427NCBI
Celera6147,089,147 - 147,499,119 (+)NCBI
Cytogenetic Map6q24.3NCBI
HuRef6143,912,141 - 144,322,105 (+)NCBIHuRef
CHM1_16146,612,129 - 147,021,949 (+)NCBICHM1_1
Grm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391010,561,803 - 10,958,126 (-)NCBIGRCm39mm39
GRCm39 Ensembl1010,561,803 - 10,958,100 (-)Ensembl
GRCm381010,686,059 - 11,082,382 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1010,686,059 - 11,082,356 (-)EnsemblGRCm38mm10GRCm38
MGSCv371010,408,551 - 10,802,129 (-)NCBIGRCm37mm9NCBIm37
MGSCv361010,378,943 - 10,772,546 (-)NCBImm8
Celera1010,578,372 - 10,975,041 (-)NCBICelera
Cytogenetic Map10A1NCBI
Grm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543614,264,387 - 14,644,622 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543614,264,470 - 14,377,581 (-)NCBIChiLan1.0ChiLan1.0
GRM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16148,535,492 - 148,945,327 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6148,537,036 - 148,947,047 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06143,819,364 - 144,231,304 (+)NCBIMhudiblu_PPA_v0panPan3
GRM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1137,205,817 - 37,600,048 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl137,206,542 - 37,598,134 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha138,098,496 - 38,490,369 (+)NCBI
ROS_Cfam_1.0137,381,684 - 37,767,160 (+)NCBI
UMICH_Zoey_3.1137,260,006 - 37,645,862 (+)NCBI
UNSW_CanFamBas_1.0137,124,615 - 37,516,108 (+)NCBI
UU_Cfam_GSD_1.0137,448,182 - 37,846,268 (+)NCBI
Grm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946132,167,285 - 132,544,694 (+)NCBI
SpeTri2.0NW_00493662591,229 - 468,242 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl119,173,791 - 19,572,769 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1119,183,221 - 19,572,853 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2121,438,453 - 21,816,533 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRM1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11325,380,855 - 25,816,945 (-)NCBI
Grm1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247537,994,419 - 8,498,243 (-)NCBI

Position Markers
D1Got3  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.014,946,906 - 4,947,122NCBIRnor6.0
Rnor_5.016,604,430 - 6,604,646UniSTSRnor5.0
RGSC_v3.415,501,535 - 5,501,752RGDRGSC3.4
RGSC_v3.415,501,536 - 5,501,752UniSTSRGSC3.4
RGSC_v3.115,501,536 - 5,501,752RGD
Celera13,771,599 - 3,771,815UniSTS
RH 3.4 Map186.7RGD
RH 3.4 Map186.7UniSTS
RH 2.0 Map10.0RGD
Cytogenetic Map1p13UniSTS
D1Arb40  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.014,755,798 - 4,756,125NCBIRnor6.0
Rnor_5.016,416,074 - 6,416,401UniSTSRnor5.0
RGSC_v3.415,321,271 - 5,321,598UniSTSRGSC3.4
RGSC_v3.115,321,270 - 5,321,598RGD
Celera13,592,529 - 3,592,856UniSTS
Cytogenetic Map1p13UniSTS
GRM1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.014,755,795 - 4,756,021NCBIRnor6.0
Rnor_5.016,416,071 - 6,416,297UniSTSRnor5.0
RGSC_v3.415,321,268 - 5,321,494UniSTSRGSC3.4
Celera13,592,526 - 3,592,752UniSTS
Cytogenetic Map1p13UniSTS
GDB:4585461  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02219,570,237 - 219,571,389NCBIRnor6.0
Rnor_6.014,808,164 - 4,808,630NCBIRnor6.0
Rnor_5.016,469,160 - 6,469,626UniSTSRnor5.0
RGSC_v3.42212,765,766 - 212,766,918UniSTSRGSC3.4
RGSC_v3.415,373,322 - 5,373,788UniSTSRGSC3.4
Celera2196,980,884 - 196,982,036UniSTS
Cytogenetic Map2q41UniSTS
Cytogenetic Map1p13UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124368159Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128468970Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1134993530Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1134993530Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)1134993530Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1164407321Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)125439343579402Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)125439343579402Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)125439343579402Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)125439386904217Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1186804543724576Rat
1300170Rf6Renal function QTL 63.14renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)1383915911314658Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1457869349578693Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:856
Count of miRNA genes:328
Interacting mature miRNAs:443
Transcripts:ENSRNOT00000019319, ENSRNOT00000044325
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 40
Low 28 8
Below cutoff 7 6 1 6 5 5 6 29 5 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019319   ⟹   ENSRNOP00000019319
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl14,753,144 - 5,165,859 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000044325   ⟹   ENSRNOP00000047790
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl14,753,144 - 5,165,859 (-)Ensembl
RefSeq Acc Id: NM_001114330   ⟹   NP_001107802
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.215,058,292 - 5,453,170 (-)NCBI
Rnor_6.014,753,144 - 5,165,859 (-)NCBI
Rnor_5.016,413,420 - 6,685,561 (-)NCBI
Rnor_5.016,815,959 - 6,818,380 (-)NCBI
RGSC_v3.415,318,617 - 5,744,593 (-)RGD
Celera13,589,875 - 3,976,624 (-)RGD
Sequence:
RefSeq Acc Id: NM_017011   ⟹   NP_058707
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.215,058,292 - 5,453,170 (-)NCBI
Rnor_6.014,753,144 - 5,165,859 (-)NCBI
Rnor_5.016,413,420 - 6,685,561 (-)NCBI
Rnor_5.016,815,959 - 6,818,380 (-)NCBI
RGSC_v3.415,318,617 - 5,744,593 (-)RGD
Celera13,589,875 - 3,976,624 (-)RGD
Sequence:
RefSeq Acc Id: XM_017588777   ⟹   XP_017444266
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.215,058,285 - 5,453,155 (-)NCBI
Rnor_6.014,753,141 - 5,165,809 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058707   ⟸   NM_017011
- Peptide Label: isoform alpha precursor
- Sequence:
RefSeq Acc Id: NP_001107802   ⟸   NM_001114330
- Peptide Label: isoform beta precursor
- UniProtKB: P23385 (UniProtKB/Swiss-Prot),   Q9WTJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444266   ⟸   XM_017588777
- Peptide Label: isoform X1
- UniProtKB: G3V7U1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000047790   ⟸   ENSRNOT00000044325
RefSeq Acc Id: ENSRNOP00000019319   ⟸   ENSRNOT00000019319
Protein Domains
G_PROTEIN_RECEP_F3_4   LRRCT   LRRNT

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 4756272 4756273 C A snv MR/N (MCW), MR/N (MCW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 5321745 5321746 C A snv MR/N (KNAW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2742 AgrOrtholog
BIND 144392
Ensembl Genes ENSRNOG00000014290 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00000038539 UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000019319 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000047790 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000064155 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002348 UniProtKB/TrEMBL
  ENSRNOT00000019319 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000044325 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.50.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cys-rich_flank_reg_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_9-Cys_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_9-Cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_mtglu_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_mtglu_rcpt_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metabotropic_Glu_rcpt_Homer-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24414 UniProtKB/Swiss-Prot
  rno:246296 UniProtKB/Swiss-Prot
NCBI Gene 24414 ENTREZGENE
Pfam 7tm_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GluR_Homer-bdg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NCD3G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grm1 PhenoGen
PRINTS GPCRMGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MTABOTROPC1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MTABOTROPICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GluR_Homer-bdg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3V7U1 ENTREZGENE, UniProtKB/TrEMBL
  GRM1_RAT UniProtKB/Swiss-Prot
  LRC15_RAT UniProtKB/Swiss-Prot
  M0R476_RAT UniProtKB/TrEMBL
  P23385 ENTREZGENE
  Q9WTJ1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Grm1  glutamate metabotropic receptor 1  Grm1  glutamate receptor, metabotropic 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Grm1  glutamate receptor, metabotropic 1      Symbol and Name updated 629477 APPROVED
2003-03-12 Grm1  glutamate receptor, metabotropic 1  Gprc1a  G protein coupled receptor, family C, group 1, member A  Data Merged 628472 PROVISIONAL
2002-11-06 Grm1  glutamate receptor, metabotropic 1    Glutamate receptor, metabotropic 1  Name updated 625702 APPROVED
2002-06-10 Gprc1a  G protein coupled receptor, family C, group 1, member A      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Grm1  Glutamate receptor, metabotropic 1      Symbol and Name status set to approved 70586 APPROVED