Aldh9a1 (aldehyde dehydrogenase 9 family, member A1)

Gene: Aldh9a1 (aldehyde dehydrogenase 9 family, member A1) Rattus norvegicus

Analyze

Symbol:

Aldh9a1

Name:

aldehyde dehydrogenase 9 family, member A1

RGD ID:

68409

Description:

Enables several functions, including NAD binding activity; identical protein binding activity; and oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. Involved in kidney development and liver development. Located in cytoplasm. Orthologous to human ALDH9A1 (aldehyde dehydrogenase 9 family member A1); PARTICIPATES IN carnitine biosynthetic pathway; arginine and proline metabolic pathway; ascorbate and aldarate metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

4-trimethylaminobutyraldehyde dehydrogenase; 4-trimethylaminobutyraldehyde dehydrogenase-like; aldehyde dehydrogenase 9A1; aldehyde dehydrogenase family 9 member A1; aldehyde dehydrogenase family 9, subfamily A1; formaldehyde dehydrogenase; gamma-aminobutyraldehyde dehydrogenase; gamma-trimethylaminobutyraldehyde dehydrogenase; LOC100910278; Tmaba-dh; TMABADH

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	82,038,679 - 82,055,478 (+)	NCBI		GRCr8
mRatBN7.2	13	79,505,738 - 79,522,539 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	79,505,695 - 79,540,568 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	82,135,618 - 82,152,413 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	83,442,832 - 83,459,515 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	80,680,560 - 80,697,225 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	85,580,828 - 85,597,497 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	85,580,828 - 85,597,493 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	90,223,961 - 90,240,186 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	83,017,312 - 83,034,047 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	83,031,512 - 83,047,451 (+)	NCBI
Celera	13	79,210,686 - 79,227,775 (+)	NCBI		Celera
Cytogenetic Map	13	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (ISO)

COVID-19 (ISO)

gastrointestinal stromal tumor (ISO)

parathyroid carcinoma (ISO)

prostate cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetaldehyde (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

arecoline (ISO)

arsenite(3-) (ISO)

azoxystrobin (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

bromobenzene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (EXP)

cannabidiol (ISO)

chlorpyrifos (EXP)

choline (EXP,ISO)

ciprofibrate (ISO)

cisplatin (ISO)

clofibrate (ISO)

clofibric acid (ISO)

clotrimazole (EXP)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dibutyl phthalate (EXP,ISO)

doxorubicin (ISO)

fenpyroximate (ISO)

flutamide (EXP)

folic acid (EXP,ISO)

fulvestrant (ISO)

gentamycin (EXP)

glafenine (EXP)

glyphosate (EXP)

hydralazine (ISO)

imidacloprid (EXP)

indometacin (EXP)

inulin (ISO)

isobutanol (ISO)

ivermectin (ISO)

L-methionine (EXP,ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

methapyrilene (EXP)

methimazole (EXP)

methoxyacetic acid (EXP)

methylmercury chloride (EXP)

microcystin-LR (EXP)

Monobutylphthalate (EXP)

ozone (EXP)

paclitaxel (ISO)

paracetamol (ISO)

perfluorododecanoic acid (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

PhIP (EXP)

picoxystrobin (ISO)

pirinixic acid (ISO)

quercetin (EXP)

rac-lactic acid (ISO)

resveratrol (ISO)

rotenone (ISO)

SB 431542 (ISO)

sodium arsenite (EXP)

sulfadimethoxine (EXP)

sunitinib (ISO)

tacrolimus hydrate (ISO)

tetrachloromethane (EXP)

thiabendazole (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carnitine biosynthetic process (IEA,ISO,TAS)

carnitine metabolic process (ISO)

cellular aldehyde metabolic process (ISO,ISS)

kidney development (IEP)

liver development (IEP)

protein homotetramerization (ISO,ISS)

Cellular Component

cytoplasm (IDA,ISO)

cytosol (IEA,ISO)

Molecular Function

4-trimethylammoniobutyraldehyde dehydrogenase activity (IBA,IDA,IEA,ISO)

aldehyde dehydrogenase (NAD+) activity (IDA,ISO)

amine binding (IDA)

aminobutyraldehyde dehydrogenase (NAD+) activity (IBA,IDA,ISO)

formaldehyde dehydrogenase (NAD+) activity (ISO,ISS)

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity (IEA)

identical protein binding (IPI)

NAD binding (IDA)

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (IEA,ISO)

small molecule binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

arginine and proline metabolic pathway (IEA)

ascorbate and aldarate metabolic pathway (IEA)

beta-alanine metabolic pathway (IEA)

carnitine biosynthetic pathway (ISO)

fatty acid metabolic pathway (IEA)

gluconeogenesis pathway (IEA)

glycerolipid metabolic pathway (IEA)

glycolysis pathway (IEA)

glycolysis/gluconeogenesis pathway (IEA)

histidine metabolic pathway (IEA)

lysine degradation pathway (IEA)

propanoate metabolic pathway (IEA)

pyruvate metabolic pathway (IEA)

tryptophan metabolic pathway (IEA)

valine, leucine and isoleucine degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Aldehyde dehydrogenase (EC 1.2.1.3): comparison of subcellular localization of the third isozyme that dehydrogenates gamma-aminobutyraldehyde in rat, guinea pig and human liver.	Ambroziak W, etal., Comp Biochem Physiol B. 1991;100(2):321-7. doi: 10.1016/0305-0491(91)90382-n.
2.	Ontogeny of Na(+)/L-carnitine transporter and of gamma-trimethylaminobutyraldehyde dehydrogenase and gamma-butyrobetaine hydroxylase genes expression in rat kidney.	Garcia-Delgado M, etal., Mech Ageing Dev. 2009 Apr;130(4):227-33. Epub 2008 Dec 27.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
15.	Aldehyde dehydrogenase from rat intestinal mucosa: purification and characterization of an isozyme with high affinity for gamma-aminobutyraldehyde.	Testore G, etal., Int J Biochem Cell Biol. 1999 Jul;31(7):777-86.
16.	Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis.	Vaz FM, etal., J Biol Chem 2000 Mar 10;275(10):7390-4.

Additional References at PubMed

PMID:2925663	PMID:8645224	PMID:15489334	PMID:18614015	PMID:19056867	PMID:23376485	PMID:23533145	PMID:26010099	PMID:26316108	PMID:30914451

Genomics

Comparative Map Data

Aldh9a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	82,038,679 - 82,055,478 (+)	NCBI		GRCr8
mRatBN7.2	13	79,505,738 - 79,522,539 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	79,505,695 - 79,540,568 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	82,135,618 - 82,152,413 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	83,442,832 - 83,459,515 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	80,680,560 - 80,697,225 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	85,580,828 - 85,597,497 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	85,580,828 - 85,597,493 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	90,223,961 - 90,240,186 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	83,017,312 - 83,034,047 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	83,031,512 - 83,047,451 (+)	NCBI
Celera	13	79,210,686 - 79,227,775 (+)	NCBI		Celera
Cytogenetic Map	13	q24	NCBI

ALDH9A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	165,662,216 - 165,698,562 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	165,662,216 - 165,698,562 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	165,631,453 - 165,667,799 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	163,898,073 - 163,934,524 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	162,363,110 - 162,399,758	NCBI
Celera	1	138,736,605 - 138,773,321 (-)	NCBI		Celera
Cytogenetic Map	1	q24.1	NCBI
HuRef	1	136,878,922 - 136,915,629 (-)	NCBI		HuRef
CHM1_1	1	167,054,030 - 167,090,476 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	165,008,653 - 165,044,991 (-)	NCBI		T2T-CHM13v2.0

Aldh9a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	167,177,560 - 167,196,100 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	167,177,560 - 167,196,101 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	167,349,963 - 167,368,530 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	167,349,991 - 167,368,532 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	169,280,122 - 169,298,661 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	169,186,888 - 169,204,961 (+)	NCBI		MGSCv36	mm8
Celera	1	169,767,504 - 169,786,077 (+)	NCBI		Celera
Cytogenetic Map	1	H2.3	NCBI
cM Map	1	74.74	NCBI

Aldh9a1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955462	10,998,147 - 11,017,360 (+)	NCBI	ChiLan1.0	ChiLan1.0

ALDH9A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	84,066,891 - 84,103,431 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	83,735,548 - 83,772,060 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	141,094,261 - 141,130,613 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	144,883,828 - 144,919,718 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	144,883,839 - 144,919,670 (-)	Ensembl	panpan1.1		panPan2

ALDH9A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	17,644,464 - 17,664,462 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	17,644,459 - 17,663,886 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	17,701,135 - 17,721,198 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	17,699,030 - 17,719,264 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	38	17,698,130 - 17,718,197 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	18,049,253 - 18,069,354 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	18,343,405 - 18,363,616 (+)	NCBI		UU_Cfam_GSD_1.0

Aldh9a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	101,783,295 - 101,803,263 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936481	19,630,045 - 19,650,009 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ALDH9A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	4	85,029,914 - 85,057,650 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	92,685,909 - 92,713,569 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ALDH9A1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	63,184,220 - 63,223,865 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666055	64,944,943 - 64,983,521 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aldh9a1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624826	3,994,183 - 4,026,696 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624826	3,994,188 - 4,026,437 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Aldh9a1
126 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	617
Count of miRNA genes:	278
Interacting mature miRNAs:	337
Transcripts:	ENSRNOT00000005611
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	46088046	91088046	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	56056920	101056920	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
8655945	Rf61	Renal function QTL 61	3.6		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	13	69060519	86800898	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	46197976	84753113	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	37415584	80753406	Rat
12879444	Bp397	Blood pressure QTL 397			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45049404	90049404	Rat
1331783	Bp221	Blood pressure QTL 221	3.72886		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	69060519	86800898	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	74023918	97213863	Rat
12879441	Bp396	Blood pressure QTL 396			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45699983	90699983	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	65103704	106807694	Rat
1300166	Kidm6	Kidney mass QTL 6	3.93		kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	13	69060519	86800898	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	39754544	84754544	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	34535218	79535218	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	38433408	83433408	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	74862117	85581182	Rat
738026	Lnnr5	Liver neoplastic nodule remodeling QTL 5	3.29		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	59874408	85581182	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	65103704	106807694	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
12879471	Bp398	Blood pressure QTL 398			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45514719	90514719	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	37262092	82262092	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	37415584	82415584	Rat
1641901	Alcrsp6	Alcohol response QTL 6			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	13	52362171	97362171	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	61825626	106807694	Rat
11530006	Niddm72	Non-insulin dependent diabetes mellitus QTL 72		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	74023918	80753406	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	74862117	101339893	Rat

Markers in Region

RH140157

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	13	90,239,895 - 90,240,076	NCBI	Rnor5.0
Rnor_5.0	13	90,144,166 - 90,144,347	NCBI	Rnor5.0
Rnor_5.0	14	67,745,544 - 67,745,725	NCBI	Rnor5.0
RGSC_v3.4	14	68,349,092 - 68,349,272	UniSTS	RGSC3.4
RGSC_v3.4	13	83,033,757 - 83,033,937	UniSTS	RGSC3.4
Celera	14	62,422,419 - 62,422,599	UniSTS
Celera	13	79,227,485 - 79,227,665	UniSTS
RH 3.4 Map	13	523.5	UniSTS
Cytogenetic Map	13	q24	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF170918	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC074019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211187	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000005611 ⟹ ENSRNOP00000005611

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	79,505,725 - 79,522,539 (+)	Ensembl
Rnor_6.0 Ensembl	13	85,580,828 - 85,597,493 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095838 ⟹ ENSRNOP00000096230

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	79,505,784 - 79,540,568 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105128 ⟹ ENSRNOP00000097830

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	79,505,695 - 79,521,753 (+)	Ensembl

RefSeq Acc Id:

NM_022273 ⟹ NP_071609

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	82,038,679 - 82,055,478 (+)	NCBI
mRatBN7.2	13	79,505,738 - 79,522,539 (+)	NCBI
Rnor_6.0	13	85,580,828 - 85,597,497 (+)	NCBI
Rnor_5.0	13	90,223,961 - 90,240,186 (+)	NCBI
RGSC_v3.4	13	83,017,312 - 83,034,047 (+)	RGD
Celera	13	79,210,686 - 79,227,775 (+)	RGD

Sequence:

show sequence

GTTTCTCAGTGCAGTCGGACCTGTGCTGACCTCGCTCCTCCGCGTACCCCGGCCTGCAGCAGTC
GCCGCCATGAGCACTGGCACCTTCGTCGTGTCGCAGCCGCTCAACTACCGCGGCGGGGCCCGCG
TGGAGCCGGTGGATGCCTCCGGCACGGAGAAAGCGTTCGAGCCAGCCACCGGCCGAGAGATAGC
TACTTTCAAGTGTTCGGGAGAAAAGGAAGTAAATTTGGCTGTTGAAAATGCAAAAGCTGCCTTT
AAAATCTGGAGTAAGAAAAGCGGCTTGGAGCGTTGTCAAGTCCTCTTAGAGGCTGCCCGGATAA
TAAAGGAACGGAGGGATGAAATTGCCATTATGGAGACCATCAACAACGGGAAGTCCATATTTGA
GGCTCGCCTGGATGTTGACACTTCCTGGCAGTGCCTGGAATACTATGCAGGCCTGGCTGCGTCC
ATGGCGGGAGAGCACATCCAGCTCCCAGGAGGGTCCTTTGGCTACACCAGAAGAGAACCACTTG
GGGTGTGTTTGGGGATAGGAGCATGGAACTACCCCTTCCAGATTGCCTGTTGGAAGTCTGCTCC
GGCTTTGGCTTGTGGTAATGCCATGATCTTTAAGCCCTCTCCCTTCACGCCTGTGTCTGCTCTG
CTCCTGGCTGAGATCTACACCAAAGCCGGTGCGCCTAACGGCCTCTTCAACGTGGTGCAAGGTG
GGGCTGCCACAGGCCAGTTTCTGTGTCAGCATCGTGATGTGGCCAAAGTCTCCTTCACTGGAAG
CGTGCCCACTGGCATGAAGATCATGGAGATGGCCGCTAAAGGAATCAAACCCATTACTTTGGAA
CTTGGGGGCAAATCTCCTCTGATCATTTTCTCTGACTGTAATATGAAGAATGCTGTGAAGGGGG
CCTTGCTGGCCAACTTCCTCACACAAGGACAGGTGTGCTGCAACGGCACTAGAGTGTTTGTGCA
AAAGGAAATTGCTGACGCATTTACAAAGGAAGTTGTGAGGCAGACTCAGAGGATAAAGATTGGG
GACCCACTTCTGGAAGATACAAGGATGGGCCCACTCATCAATGCCCCGCACCTGGAGCGAGTCC
TCGGGTTTGTCAGGTCTGCAAAGGAGCAGGGTGCCACTGTGCTGTGTGGTGGAGAGCCGTATGC
CCCGGAGGATCCTAAGTTAAAACATGGATATTACATGACACCTTGCATTTTAACTAATTGCACA
GATGACATGACTTGTGTAAAAGAAGAGATCTTTGGGCCAGTTATGTCCATTCTAACATTTGAGA
CTGAAGCCGAGGTTCTGGAGCGGGCCAATGACACCACGTTTGGACTAGCAGCTGGGGTCTTTAC
CAGGGACATTCAGAGGGCGCACAGGGTGGCGGCTGAGCTGCAGGCCGGAACGTGCTACATTAAC
AACTATAACGTCAGCCCGGTGGAGTTGCCCTTTGGTGGATACAAGAAGTCAGGATTTGGCAGAG
AGAACGGCCGAGTGACGATTGAGTACTATTCACAGCTGAAGACGGTGTGTGTGGAGATGGGGGA
CGTGGAGTCGCCTTTTGAAAACCAGTGACGTACATGGCCAAGCTGTGCAATGAGTCGGCTGCCT
TGATTGACAGGCAGTGTAACTGAATAGCTTCTTACATCCAGGCTTTGGGTCATTAGTGTGATAA
TGGGTCAGTATTGTCCTCTGTCTTGCAGTCACCTTCCCAATTGAAAATGTGCACAAGTGCCTTT
CCGATGGTAGCCAGGGAACCTGTTCTTCCAGGAAGTTCCGGAGAAACCGGTAAACCTCAGCAAC
ACTGTTCAGACATGGGCAGGCCACAGCTCTGCTCATACACATTCGTCCCACCAACAATGGCAGT
TTTCTAGTTTGATTTAAAGGCCTTCCTTCCTGGTTTCCTGGTGAATCAGATATATGTTCTTTGT
TCATTGACAACTAAAACACAAATTCTTAAATTAGAGGCAGTGGTGTGGTGCATGCCTCTAATCC
CAGCACTTGGGAGGCAGAGGCAGGTACATATCTGAGTTCGAGGCCAGCCTGGTCTACAGAGTGA
GTTCCAGTACAACCAGGGCTACACAAATTAACCCTGTCTTGAAAAACCAAAAATAAATAAGAAG
TGCATTTTAAAAAGTTGTTATTCGGAGACATTAAAGTCTTAATACTTGTGGAAAATGTGATTCA
TTGGCATTTAAAAAGCTATGTTCTTCTTGGCTAGCAAGACAGCTCAGTGGGTAAGGTCTTAGCA
CATAAGCCCCGTGACCTCAGTTTTATCCCCAGAACTCACATCAAGGTGGTAGCCCCTCCCCCAA
TCCATATAATGCACAATAATTAAATCTTTCTCAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_071609	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF43598	(Get FASTA)	NCBI Sequence Viewer
	AAH74019	(Get FASTA)	NCBI Sequence Viewer
	EDM09283	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000005611.6
	ENSRNOP00000096230.1
	ENSRNOP00000097830.1
GenBank Protein	Q9JLJ3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_071609 ⟸ NM_022273

- UniProtKB:

Q6GMM4 (UniProtKB/Swiss-Prot), Q9JLJ3 (UniProtKB/Swiss-Prot), A0A8I6AQJ5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSTGTFVVSQPLNYRGGARVEPVDASGTEKAFEPATGREIATFKCSGEKEVNLAVENAKAAFKI
WSKKSGLERCQVLLEAARIIKERRDEIAIMETINNGKSIFEARLDVDTSWQCLEYYAGLAASMA
GEHIQLPGGSFGYTRREPLGVCLGIGAWNYPFQIACWKSAPALACGNAMIFKPSPFTPVSALLL
AEIYTKAGAPNGLFNVVQGGAATGQFLCQHRDVAKVSFTGSVPTGMKIMEMAAKGIKPITLELG
GKSPLIIFSDCNMKNAVKGALLANFLTQGQVCCNGTRVFVQKEIADAFTKEVVRQTQRIKIGDP
LLEDTRMGPLINAPHLERVLGFVRSAKEQGATVLCGGEPYAPEDPKLKHGYYMTPCILTNCTDD
MTCVKEEIFGPVMSILTFETEAEVLERANDTTFGLAAGVFTRDIQRAHRVAAELQAGTCYINNY
NVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVESPFENQ

hide sequence

Ensembl Acc Id:

ENSRNOP00000005611 ⟸ ENSRNOT00000005611

Ensembl Acc Id:

ENSRNOP00000097830 ⟸ ENSRNOT00000105128

Ensembl Acc Id:

ENSRNOP00000096230 ⟸ ENSRNOT00000095838

Protein Domains

Aldehyde dehydrogenase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9JLJ3-F1-model_v2	AlphaFold	Q9JLJ3	1-494	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698973

Promoter ID:

EPDNEW_R9498

Type:

initiation region

Name:

Aldh9a1_1

Description:

aldehyde dehydrogenase 9 family, member A1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	85,580,819 - 85,580,879	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:68409	AgrOrtholog
BioCyc Gene	G2FUF-17522	BioCyc
BioCyc Pathway	PWY-6100 [L-carnitine biosynthesis]	BioCyc
BioCyc Pathway Image	PWY-6100	BioCyc
Ensembl Genes	ENSRNOG00000004027	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005611.6	UniProtKB/TrEMBL
	ENSRNOT00000095838.1	UniProtKB/TrEMBL
	ENSRNOT00000105128.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7104823	IMAGE-MGC_LOAD
InterPro	Ald_DH/histidinol_DH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ald_DH_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ald_DH_CS_CYS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ald_DH_CS_GLU	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ald_DH_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aldehyde_DH_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:64040	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:91695	IMAGE-MGC_LOAD
NCBI Gene	64040	ENTREZGENE
PANTHER	4-TRIMETHYLAMINOBUTYRALDEHYDE DEHYDROGENASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ALDEHYDE DEHYDROGENASE-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Aldedh	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Aldh9a1	PhenoGen
PROSITE	ALDEHYDE_DEHYDR_CYS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ALDEHYDE_DEHYDR_GLU	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000004027	RatGTEx
Superfamily-SCOP	SSF53720	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC228379
UniProt	A0A0G2JSI1_RAT	UniProtKB/TrEMBL
	A0A8I6AQJ5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ASL3_RAT	UniProtKB/TrEMBL
	A6IDL4_RAT	UniProtKB/TrEMBL
	AL9A1_RAT	UniProtKB/Swiss-Prot
	Q6GMM4	ENTREZGENE
	Q9JLJ3	ENTREZGENE
UniProt Secondary	Q6GMM4	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Aldh9a1	aldehyde dehydrogenase 9 family, member A1	LOC100910278	4-trimethylaminobutyraldehyde dehydrogenase-like	Data merged from RGD:6499178	737654	PROVISIONAL
2012-07-05	LOC100910278	4-trimethylaminobutyraldehyde dehydrogenase-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-02-18	Aldh9a1	aldehyde dehydrogenase 9 family, member A1	Aldh9a1	aldehyde dehydrogenase family 9, subfamily A1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Aldh9a1	aldehyde dehydrogenase family 9, subfamily A1			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways