Cth (cystathionine gamma-lyase) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Cth (cystathionine gamma-lyase) Rattus norvegicus
Symbol: Cth
Name: cystathionine gamma-lyase
RGD ID: 2443
Description: Predicted to enable carbon-sulfur lyase activity; identical protein binding activity; and pyridoxal phosphate binding activity. Involved in glutathione metabolic process; negative regulation of cell growth; and negative regulation of cell population proliferation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Used to study cataract. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and cystathioninuria. Orthologous to human CTH (cystathionine gamma-lyase); PARTICIPATES IN cystathioninuria pathway; cysteine metabolic pathway; dihydropyrimidine dehydrogenase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CGL; CSE; CTL target antigen; cystathionase (cystathionine gamma-lyase); cysteine desulfhydrase; cysteine-protein sulfhydrase; gamma-cystathionase; H; homocysteine desulfhydrase; LOC103691744; PRB-RA; probasin-related antigen
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr82249,634,731 - 249,661,066 (-)NCBIGRCr8
mRatBN7.22246,975,888 - 247,002,234 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2246,975,894 - 247,002,234 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2254,708,251 - 254,734,585 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02252,602,078 - 252,628,090 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02247,570,449 - 247,596,765 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02264,266,959 - 264,293,040 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2264,266,984 - 264,293,046 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02282,366,125 - 282,392,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42256,056,562 - 256,082,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12256,071,168 - 256,096,855 (-)NCBI
Celera2238,776,532 - 238,802,647 (-)NCBICelera
Cytogenetic Map2q45NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrylamide  (ISO)
acrylonitrile  (EXP)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
amino acid  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (EXP)
chloroacetaldehyde  (ISO)
chloroprene  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
diiodine  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
etoposide  (ISO)
fenofibrate  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (EXP)
glyphosate  (EXP,ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP,ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
imidacloprid  (EXP)
indometacin  (EXP,ISO)
irinotecan  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
L-cysteine  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
motexafin gadolinium  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
naphthalenes  (EXP)
nefazodone  (EXP)
neomycin  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitric oxide  (EXP)
nitrofen  (EXP)
nitroflurbiprofen  (EXP)
O-methyleugenol  (ISO)
o-xylene  (ISO)
ochratoxin A  (EXP,ISO)
Octicizer  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
pinostrobin  (ISO)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
prothioconazole  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sodium perchlorate  (EXP)
Soman  (EXP)
streptozocin  (ISO)
succimer  (ISO)
sulforaphane  (EXP,ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tauroursodeoxycholic acid  (EXP)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (EXP)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thiabendazole  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
toluene  (ISO)
torcetrapib  (ISO)
tributyl phosphate  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
trovafloxacin  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)


References - curated
# Reference Title Reference Citation
1. Sequence of cDNA for rat cystathionine gamma-lyase and comparison of deduced amino acid sequence with related Escherichia coli enzymes. Erickson PF, etal., Biochem J 1990 Jul 15;269(2):335-40.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Characterization of homocysteine metabolism in the rat kidney. House JD, etal., Biochem J 1997 Nov 15;328 ( Pt 1):287-92.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Vitamin B-6 deficiency in rats reduces hepatic serine hydroxymethyltransferase and cystathionine beta-synthase activities and rates of in vivo protein turnover, homocysteine remethylation and transsulfuration. Martinez M, etal., J Nutr 2000 May;130(5):1115-23.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Identification of probasin-related antigen as cystathionine gamma-lyase by molecular cloning. Nishi N, etal., J Biol Chem 1994 Jan 14;269(2):1015-9.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation. Renga B, etal., World J Gastroenterol. 2009 May 7;15(17):2097-108. doi: 10.3748/wjg.15.2097.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Age-associated oxidative damage leads to absence of gamma-cystathionase in over 50% of rat lenses: relevance in cataractogenesis. Sastre J, etal., Free Radic Biol Med. 2005 Mar 1;38(5):575-82.
18. Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur. Stipanuk MH and Ueki I, J Inherit Metab Dis. 2011 Feb;34(1):17-32. doi: 10.1007/s10545-009-9006-9. Epub 2010 Feb 17.
19. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH). Wang J and Hegele RA, Hum Genet. 2003 Apr;112(4):404-8. Epub 2003 Feb 6.
20. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1. Yang G, etal., J Biol Chem. 2004 Nov 19;279(47):49199-205. Epub 2004 Sep 3.
Additional References at PubMed
PMID:10212249   PMID:12477932   PMID:15038791   PMID:16189514   PMID:16396499   PMID:16507767   PMID:18184479   PMID:19019829   PMID:19056867   PMID:19428278   PMID:19903941   PMID:20439489  
PMID:21055229   PMID:21158086   PMID:21659522   PMID:22093698   PMID:22133746   PMID:22169477   PMID:22244329   PMID:22428706   PMID:22870268   PMID:24610811   PMID:25416956   PMID:25901909  
PMID:26021843   PMID:26319795   PMID:26378818   PMID:26519030   PMID:26963622   PMID:27324218   PMID:27468988   PMID:29880385   PMID:32900241   PMID:33123916   PMID:36197015   PMID:38613810  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr82249,634,731 - 249,661,066 (-)NCBIGRCr8
mRatBN7.22246,975,888 - 247,002,234 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2246,975,894 - 247,002,234 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2254,708,251 - 254,734,585 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02252,602,078 - 252,628,090 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02247,570,449 - 247,596,765 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02264,266,959 - 264,293,040 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2264,266,984 - 264,293,046 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02282,366,125 - 282,392,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42256,056,562 - 256,082,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12256,071,168 - 256,096,855 (-)NCBI
Celera2238,776,532 - 238,802,647 (-)NCBICelera
Cytogenetic Map2q45NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38170,411,268 - 70,439,851 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl170,411,218 - 70,439,851 (+)EnsemblGRCh38hg38GRCh38
GRCh37170,876,951 - 70,905,534 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36170,649,543 - 70,677,841 (+)NCBINCBI36Build 36hg18NCBI36
Build 34170,588,975 - 70,617,273NCBI
Celera169,166,835 - 69,195,464 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef168,987,754 - 69,016,606 (+)NCBIHuRef
CHM1_1170,992,268 - 71,020,901 (+)NCBICHM1_1
T2T-CHM13v2.0170,289,775 - 70,318,361 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm393157,599,885 - 157,630,718 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3157,599,885 - 157,630,714 (-)EnsemblGRCm39 Ensembl
GRCm383157,894,248 - 157,925,081 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3157,894,248 - 157,925,077 (-)EnsemblGRCm38mm10GRCm38
MGSCv373157,557,212 - 157,588,027 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363157,829,541 - 157,860,356 (-)NCBIMGSCv36mm8
Celera3164,361,761 - 164,392,686 (-)NCBICelera
Cytogenetic Map3H4NCBI
cM Map381.55NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542321,542,179 - 21,567,786 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542321,542,587 - 21,567,935 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21156,435,025 - 156,462,647 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11155,594,089 - 155,621,700 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0169,646,608 - 69,674,301 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1171,629,637 - 71,657,322 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,629,333 - 71,677,666 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1675,324,328 - 75,348,476 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl675,324,787 - 75,349,451 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha677,937,741 - 77,962,253 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0675,916,530 - 75,940,965 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1675,469,819 - 75,494,076 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0675,365,148 - 75,389,608 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0675,865,823 - 75,890,332 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440505882,845,843 - 82,870,103 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365911,619,446 - 1,643,665 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365911,619,446 - 1,643,667 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl6142,454,914 - 142,486,367 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16142,454,922 - 142,486,352 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26132,027,445 - 132,050,236 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12062,672,820 - 62,718,608 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2062,690,906 - 62,718,980 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603354,904,075 - 54,931,820 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462474225,619,277 - 25,642,875 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474225,619,261 - 25,642,477 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cth
193 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:286
Count of miRNA genes:193
Interacting mature miRNAs:225
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 41 41 41 29 1
Low 21 16 16 4 6 74 6 34 11 4
Below cutoff 22 3 4 5 5 4


RefSeq Acc Id: ENSRNOT00000067843   ⟹   ENSRNOP00000058914
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2246,975,894 - 247,002,234 (-)Ensembl
Rnor_6.0 Ensembl2264,266,984 - 264,293,046 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082532   ⟹   ENSRNOP00000072582
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2246,978,440 - 247,002,234 (-)Ensembl
Rnor_6.0 Ensembl2264,270,096 - 264,293,010 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089714   ⟹   ENSRNOP00000073415
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2246,985,281 - 247,002,234 (-)Ensembl
Rnor_6.0 Ensembl2264,746,485 - 264,765,085 (-)Ensembl
RefSeq Acc Id: NM_017074   ⟹   NP_058770
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr82249,634,731 - 249,661,066 (-)NCBI
mRatBN7.22246,975,888 - 247,002,219 (-)NCBI
Rnor_6.02264,267,029 - 264,293,016 (-)NCBI
Rnor_5.02282,366,125 - 282,392,112 (+)NCBI
RGSC_v3.42256,056,562 - 256,082,248 (-)RGD
Celera2238,776,532 - 238,802,647 (-)RGD
RefSeq Acc Id: NP_058770   ⟸   NM_017074
- UniProtKB: P18757 (UniProtKB/Swiss-Prot),   Q9EQS4 (UniProtKB/TrEMBL),   A6HWT2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000058914   ⟸   ENSRNOT00000067843
RefSeq Acc Id: ENSRNOP00000072582   ⟸   ENSRNOT00000082532
RefSeq Acc Id: ENSRNOP00000073415   ⟸   ENSRNOT00000089714

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18757-F1-model_v2 AlphaFold P18757 1-398 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691838
Promoter ID:EPDNEW_R2363
Type:multiple initiation site
Description:cystathionine gamma-lyase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.02264,293,054 - 264,293,114EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2443 AgrOrtholog
BioCyc Gene G2FUF-50708 BioCyc
Ensembl Genes ENSRNOG00000010658 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000057089 Ensembl
Ensembl Transcript ENSRNOT00000067843 ENTREZGENE
  ENSRNOT00000067843.3 UniProtKB/TrEMBL
  ENSRNOT00000082532.2 UniProtKB/TrEMBL
  ENSRNOT00000089714.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cys/Met-Metab_PyrdxlP-dep_enz UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24962 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11808 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cys_Met_Meta_PP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cth PhenoGen
PIRSF CGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010658 RatGTEx
  ENSRNOG00000057089 RatGTEx
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K3C5_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Cth  cystathionine gamma-lyase  LOC103691744  cystathionine gamma-lyase  Data merged from RGD:9153842 737654 PROVISIONAL
2014-08-25 LOC103691744  cystathionine gamma-lyase      Symbol and Name status set to provisional 70820 PROVISIONAL
2014-07-09 Cth  cystathionine gamma-lyase  Cth  cystathionase (cystathionine gamma-lyase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Cth  cystathionase (cystathionine gamma-lyase)    CTL target antigen  Name updated 1299863 APPROVED
2002-06-10 Cth  CTL target antigen      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver and brain 1298831
gene_product putative cystathionine gamma-lyase 1298831