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Gene: CTH (cystathionine gamma-lyase) Canis lupus familiaris

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Symbol:

CTH

Name:

cystathionine gamma-lyase

RGD ID:

12146301

Description:

ENCODES a protein that exhibits cystathionine gamma-lyase activity (ortholog); identical protein binding (ortholog); L-cystine L-cysteine-lyase (deaminating) (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); cysteine biosynthetic process via cystathionine (ortholog); glutathione metabolic process (ortholog); PARTICIPATES IN cystathioninuria pathway; cysteine metabolic pathway; dihydropyrimidine dehydrogenase deficiency pathway; ASSOCIATED WITH amino acid metabolic disorder (ortholog); cataract (ortholog); cystathioninuria (ortholog); FOUND IN membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cystathionase (cystathionine gamma-lyase)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CTH (cystathionine gamma-lyase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Cth (cystathionine gamma lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cth (cystathionine gamma-lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cth (cystathionine gamma-lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CTH (cystathionine gamma-lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cth (cystathionine gamma-lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CTH (cystathionine gamma-lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CTH (cystathionine gamma-lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cth (cystathionine gamma-lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	75,324,328 - 75,348,476 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	75,324,787 - 75,349,451 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	77,937,741 - 77,962,253 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	75,916,530 - 75,940,965 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	6	75,469,819 - 75,494,076 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	75,365,148 - 75,389,608 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	75,865,823 - 75,890,332 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amino acid metabolic disorder (ISO)

cataract (ISO)

cystathioninuria (ISO)

Fetal Growth Retardation (ISO)

genetic disease (ISO)

hyperhomocysteinemia (ISO)

intellectual disability (ISO)

melanoma (ISO)

Retinal Neovascularization (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to leukemia inhibitory factor (ISO)

cysteine biosynthetic process (IEA)

cysteine biosynthetic process via cystathionine (ISO)

glutathione metabolic process (ISO)

hydrogen sulfide biosynthetic process (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of apoptotic signaling pathway (ISO)

negative regulation of cell growth (ISO)

negative regulation of cell population proliferation (ISO)

positive regulation of aortic smooth muscle cell differentiation (ISO)

positive regulation of canonical NF-kappaB signal transduction (ISO)

positive regulation of NF-kappaB transcription factor activity (ISO)

protein homotetramerization (ISO)

protein sulfhydration (ISO)

protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine (ISO)

transsulfuration (IEA)

Cellular Component

membrane (IEA)

Molecular Function

cystathionine gamma-lyase activity (ISO)

identical protein binding (ISO)

L-cystine L-cysteine-lyase (deaminating) (ISO)

protein binding (ISO)

pyridoxal phosphate binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

cystathioninuria pathway (ISO)

cysteine metabolic pathway (ISO)

dihydropyrimidine dehydrogenase deficiency pathway (ISO)

dimethylglycine dehydrogenase deficiency pathway (ISO)

glycine N-methyltransferase deficiency pathway (ISO)

homocystinuria pathway (ISO)

hypermethioninemia pathway (ISO)

mercaptolactate-cysteine disulfiduria pathway (ISO)

methionine cycle/metabolic pathway (ISO)

methylenetetrahydrofolate reductase deficiency pathway (ISO)

nonketotic hyperglycinemia pathway (ISO)

ocular nonnephropathic cystinosis pathway (ISO)

sarcosinemia pathway (ISO)

selenoamino acid metabolic pathway (ISO)

transsulfuration pathway of homocysteine metabolism (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CTH
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	75,324,328 - 75,348,476 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	75,324,787 - 75,349,451 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	77,937,741 - 77,962,253 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	75,916,530 - 75,940,965 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	6	75,469,819 - 75,494,076 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	75,365,148 - 75,389,608 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	75,865,823 - 75,890,332 (-)	NCBI		UU_Cfam_GSD_1.0

CTH
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	70,411,268 - 70,439,851 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	70,411,218 - 70,439,851 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	70,876,951 - 70,905,534 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	70,649,543 - 70,677,841 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	70,588,975 - 70,617,273	NCBI
Celera	1	69,166,835 - 69,195,464 (+)	NCBI		Celera
Cytogenetic Map	1	p31.1	NCBI
HuRef	1	68,987,754 - 69,016,606 (+)	NCBI		HuRef
CHM1_1	1	70,992,268 - 71,020,901 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	70,289,775 - 70,318,361 (+)	NCBI		T2T-CHM13v2.0

Cth
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	157,599,885 - 157,630,718 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	157,599,885 - 157,630,714 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	157,894,248 - 157,925,081 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	157,894,248 - 157,925,077 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	157,557,212 - 157,588,027 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	157,829,541 - 157,860,356 (-)	NCBI		MGSCv36	mm8
Celera	3	164,361,761 - 164,392,686 (-)	NCBI		Celera
Cytogenetic Map	3	H4	NCBI
cM Map	3	81.55	NCBI

Cth
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	249,634,731 - 249,661,066 (-)	NCBI		GRCr8
mRatBN7.2	2	246,975,888 - 247,002,234 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	246,975,894 - 247,002,234 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	254,708,251 - 254,734,585 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	252,602,078 - 252,628,090 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	247,570,449 - 247,596,765 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	264,266,959 - 264,293,040 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	264,266,984 - 264,293,046 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	282,366,125 - 282,392,112 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	256,056,562 - 256,082,248 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	256,071,168 - 256,096,855 (-)	NCBI
Celera	2	238,776,532 - 238,802,647 (-)	NCBI		Celera
Cytogenetic Map	2	q45	NCBI

Cth
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	21,542,179 - 21,567,786 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955423	21,542,587 - 21,567,935 (-)	NCBI	ChiLan1.0	ChiLan1.0

CTH
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	156,435,025 - 156,462,647 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	155,594,089 - 155,621,700 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	69,646,608 - 69,674,301 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	71,629,637 - 71,657,322 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	71,629,333 - 71,677,666 (+)	Ensembl	panpan1.1		panPan2

Cth
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	82,845,843 - 82,870,103 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936591	1,619,446 - 1,643,665 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936591	1,619,446 - 1,643,667 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CTH
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	142,454,914 - 142,486,367 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	142,454,922 - 142,486,352 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	132,027,445 - 132,050,236 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CTH
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	62,672,820 - 62,718,608 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	62,690,906 - 62,718,980 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	54,904,075 - 54,931,820 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cth
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	25,619,277 - 25,642,875 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624742	25,619,261 - 25,642,477 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in CTH
520 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_022420631	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038480322	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038541666	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038605806	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038670407	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_537115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000032522 ⟹ ENSCAFP00000030288

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	6	75,324,787 - 75,348,589 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000074669 ⟹ ENSCAFP00000065955

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	6	75,324,787 - 75,348,473 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000076956 ⟹ ENSCAFP00000046454

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	6	75,324,787 - 75,349,451 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000084141 ⟹ ENSCAFP00000053956

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	6	75,324,787 - 75,348,473 (-)	Ensembl

RefSeq Acc Id:

XM_038480322 ⟹ XP_038336250

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	6	75,469,819 - 75,494,076 (-)	NCBI

RefSeq Acc Id:

XM_038541666 ⟹ XP_038397594

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	6	75,865,823 - 75,890,332 (-)	NCBI

RefSeq Acc Id:

XM_038605806 ⟹ XP_038461734

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	6	75,365,148 - 75,389,608 (-)	NCBI

RefSeq Acc Id:

XM_038670407 ⟹ XP_038526335

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	6	75,916,530 - 75,940,965 (-)	NCBI

RefSeq Acc Id:

XM_537115 ⟹ XP_537115

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	6	75,324,328 - 75,348,476 (-)	NCBI
Dog10K_Boxer_Tasha	6	77,937,741 - 77,962,253 (-)	NCBI

Sequence:

show sequence

GTCCAGCGCGCGGAGTGCGGCCTGCGAGCCTGGCGGTCGGCGGCCCCGCGGGCTCCTGCTCCTG
CTCCTGCTCCTGCTCCTGCTCCCGCTCCTGCTCCCGCTCCTGCTCCTGCTCACGCTCCTGCTCC
TGCTCCTGCTCCTGCTCCTGCTCCCGCTCCTGCTCCTGCTCCTGCTCCCGCTCCTGCTCACGCT
CCTGCTCCCGCTCCTGCTCCTGCTCCCGCTCCTGCTCCTGCTCACGCTCCCCCTCCCGCTCCCG
CTCCCGCTCCCCGCGTCTCCGGCCCAGTCGCCGCGGTTCCGGTCGCACCTGCCCCCGCGCTCCG
TCCCCTCCGCGGCCCGGCATGCAGGAGCCGGACGCCGCCCCGAACGGCTTCCAGCCCCGCTTCC
CGCACTTCGCCACGCAGGCCATCCACGTGGGCCAGGAGCCCGAGCAGTGGAGCTCCCAGGCCGT
GGTGCCCCCCATCTCCCTGTCCACCACGTTCAAGCAGGGGGCCCCCGGCCAGCACGCGGGCTTT
GAATACAGCCGTTCTGGAAACCCCACCAGGAATTGCTTGGAAAAAGCCGTGGCGGCCCTAGATG
GGGCCAAGTACAGTTTGGCCTTTGCTTCAGGCTTAGCTGCCACTGTGACTATTACCCATCTCTT
GAAAGCAGGAGACCAAATTATTTGTATGGATGATGTGTACGGAGGTACAAACAGGTACTTCAGG
CAGGTGGCAAGTGAATTTGGATTAAAGATTACTTTCGTGGATTGCTCCAAAATCAAATTGCTAG
AGGCAGCCATTACACCAGAAACCAAGCTTGTTTGGATTGAAACCCCCACAAACCCAAGCTTGAA
GATGATTGACATTGAAGCCTGTGCACACACCGTTCATAAACGTGGCGACATCATTTTGGTCGTG
GATAATACTTTTATGTCAGCATATTTCCAGCGGCCTTTGGCGCTGGGAGCTGATATTTGTATGT
ATTCAGCGACAAAATATATGAATGGCCACAGTGATGTCGTAATGGGCTTAGTGTCTGTTAATTC
TGAGAGCCTCCATAACAGGCTCCGTTTCTTACAAAATTCTATTGGAGCAGTTCCATCCCCTGTG
GACTGTTACCTGTGCAATCGAGGACTAAAGACTCTACACGTCCGAATGGAGAAACATTTCGAGA
ATGGAATGGCAGTTGCTCAGTTTCTGGAATCTAATCCTCGGGTAGAAAAGGTCATCTATCCTGG
GCTGCCCTCGCATCCTCAGCACGAGCTGGCGAAGCGTCAGTGCACCGGCTGCCCGGGCATGATC
ACCTTCTACATCAAGGGCACACTCGTGCACGCCGAGGCGTTTCTCAAGCACCTCAAGCTATTTA
CTCTGGCTGAGAGCTTGGGAGGATACGAAAGTCTTGCTGAGCTGCCGGCAATCATGACCCATGC
ATCGGTGCCTAAGAGCGACAGGGATGTCCTTGGCATTAGTGACACGCTGATCCGACTCTCTGTG
GGCTTAGAGGACAAGAAGGACCTACTCGAAGATCTAGATCAAGCTTTGAAGGCAGCACACCCTC
CAAATGCAGGTCGTAACTAGCCTTCCAGAACTGCTAGTAGAAGTTGCCTCCCAAGAAGATCAAC
TCTAGATAATCGAATGGACCATTAATGAGCCTTTGCAGGATTTTCAAGTGAAAATTTAGAGACA
CCTCATTACTTTTCAGAGCTGTAACCTTCCGGGGATCCTCCTTGTTAAAAGCGGTTTCCTCTTT
CCCTTATTGTAATTGACAGGTCAATTCTGTTAATATCCTTTTGATAATTTTGGTATACATTTGC
CTCTGCAGGAGGTGGGGTTTGTGCTGCTTTTGGGGTTGTGATCTTTTTTTCATAGCTTAAGGTT
TATATCGATCATGTTTACAATACAATGACAATTCATTTTCTATGTTTTTCTGAAGAATTTAAAT
TATTAAATGAATGTTCTTAAATCAAGAGTGATTTTTGCTCTTGTTGAAGACAGCACTCAAAACA
GTGGTTTACAATTAATTATCATAAGCCAAAAAATCAAATACTTGAAAAGCCTACTGTGAAATTC
TGCTGATATAAGGTTGTACTTACTATTTAAAAACAAAATAAATCTAATTACCAAATGCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_038336250	(Get FASTA)	NCBI Sequence Viewer
	XP_038397594	(Get FASTA)	NCBI Sequence Viewer
	XP_038461734	(Get FASTA)	NCBI Sequence Viewer
	XP_038526335	(Get FASTA)	NCBI Sequence Viewer
	XP_537115	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000030288.5
	ENSCAFP00000046454.2
	ENSCAFP00000053956.1
	ENSCAFP00000065955.1
	ENSCAFP00030026774.1
	ENSCAFP00030026830.1
	ENSCAFP00040002664.1
	ENSCAFP00040002671.1
	ENSCAFP00845017989.1
	ENSCAFP00845018025.1

RefSeq Acc Id:

XP_537115 ⟸ XM_537115

- UniProtKB:

A0A8C0NMA5 (UniProtKB/TrEMBL), A0A8P0PEH3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MQEPDAAPNGFQPRFPHFATQAIHVGQEPEQWSSQAVVPPISLSTTFKQGAPGQHAGFEYSRSG
NPTRNCLEKAVAALDGAKYSLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEF
GLKITFVDCSKIKLLEAAITPETKLVWIETPTNPSLKMIDIEACAHTVHKRGDIILVVDNTFMS
AYFQRPLALGADICMYSATKYMNGHSDVVMGLVSVNSESLHNRLRFLQNSIGAVPSPVDCYLCN
RGLKTLHVRMEKHFENGMAVAQFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMITFYIKG
TLVHAEAFLKHLKLFTLAESLGGYESLAELPAIMTHASVPKSDRDVLGISDTLIRLSVGLEDKK
DLLEDLDQALKAAHPPNAGRN

hide sequence

Ensembl Acc Id:

ENSCAFP00000053956 ⟸ ENSCAFT00000084141

Ensembl Acc Id:

ENSCAFP00000065955 ⟸ ENSCAFT00000074669

Ensembl Acc Id:

ENSCAFP00000046454 ⟸ ENSCAFT00000076956

Ensembl Acc Id:

ENSCAFP00000030288 ⟸ ENSCAFT00000032522

RefSeq Acc Id:

XP_038336250 ⟸ XM_038480322

RefSeq Acc Id:

XP_038461734 ⟸ XM_038605806

RefSeq Acc Id:	XP_038526335 ⟸ XM_038670407
- UniProtKB:	A0A8C0KXE5 (UniProtKB/TrEMBL), A0A8C0NMA5 (UniProtKB/TrEMBL), A0A8P0PEH3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038397594 ⟸ XM_038541666
- UniProtKB:	A0A8C0NMA5 (UniProtKB/TrEMBL), A0A8P0PEH3 (UniProtKB/TrEMBL)

Promoters

RGD ID:

13683849

Promoter ID:

EPDNEW_C1919

Type:

multiple initiation site

Name:

CTH_1

Description:

cystathionine gamma-lyase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	6	75,348,207 - 75,348,267	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000020417	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030016511	UniProtKB/TrEMBL
	ENSCAFG00040001572	UniProtKB/TrEMBL
	ENSCAFG00845012905	UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000032522.5	UniProtKB/TrEMBL
	ENSCAFT00000074669.2	UniProtKB/TrEMBL
	ENSCAFT00000076956.2	UniProtKB/TrEMBL
	ENSCAFT00000084141.2	UniProtKB/TrEMBL
	ENSCAFT00030030693.1	UniProtKB/TrEMBL
	ENSCAFT00030030755.1	UniProtKB/TrEMBL
	ENSCAFT00040003088.1	UniProtKB/TrEMBL
	ENSCAFT00040003099.1	UniProtKB/TrEMBL
	ENSCAFT00845022949.1	UniProtKB/TrEMBL
	ENSCAFT00845022994.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.640.10	UniProtKB/TrEMBL
	3.90.1150.10	UniProtKB/TrEMBL
InterPro	Cys/Met-Metab_PyrdxlP-dep_enz	UniProtKB/TrEMBL
	Cys_met_metab_PP	UniProtKB/TrEMBL
	PyrdxlP-dep_Trfase	UniProtKB/TrEMBL
	PyrdxlP-dep_Trfase_major	UniProtKB/TrEMBL
	PyrdxlP-dep_Trfase_small	UniProtKB/TrEMBL
NCBI Gene	CTH	ENTREZGENE
PANTHER	CYSTATHIONINE GAMMA-LYASE	UniProtKB/TrEMBL
	PTHR11808	UniProtKB/TrEMBL
Pfam	Cys_Met_Meta_PP	UniProtKB/TrEMBL
PIRSF	CGS	UniProtKB/TrEMBL
PROSITE	CYS_MET_METAB_PP	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53383	UniProtKB/TrEMBL
UniProt	A0A8C0KXE5	ENTREZGENE
	A0A8C0NMA5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0PR06_CANLF	UniProtKB/TrEMBL
	A0A8I3NI47_CANLF	UniProtKB/TrEMBL
	A0A8I3NI74_CANLF	UniProtKB/TrEMBL
	A0A8P0NLH3_CANLF	UniProtKB/TrEMBL
	A0A8P0PEH3	ENTREZGENE
	A0A8P0SZF9_CANLF	UniProtKB/TrEMBL
UniProt Secondary	A0A8P0PEH3	UniProtKB/TrEMBL
	A0A8P0T6G5	UniProtKB/TrEMBL
VGNC ID	VGNC:39697	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB