Cth (cystathionine gamma-lyase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Cth (cystathionine gamma-lyase) Chinchilla lanigera
Analyze
Symbol: Cth
Name: cystathionine gamma-lyase
RGD ID: 9020582
Description: ENCODES a protein that exhibits cystathionine beta-lyase activity (ortholog); cystathionine gamma-lyase activity (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); cysteine biosynthetic process (ortholog); cysteine biosynthetic process via cystathionine (ortholog); PARTICIPATES IN cystathioninuria pathway; cysteine metabolic pathway; dihydropyrimidine dehydrogenase deficiency pathway; ASSOCIATED WITH amino acid metabolic disorder (ortholog); cataract (ortholog); cystathioninuria (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cystathionase (cystathionine gamma-lyase)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542321,542,179 - 21,567,786 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542321,542,587 - 21,567,935 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline

Genomics

Comparative Map Data
Cth
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542321,542,179 - 21,567,786 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542321,542,587 - 21,567,935 (-)NCBIChiLan1.0ChiLan1.0
CTH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38170,411,268 - 70,439,851 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl170,411,218 - 70,439,851 (+)EnsemblGRCh38hg38GRCh38
GRCh37170,876,951 - 70,905,534 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36170,649,543 - 70,677,841 (+)NCBINCBI36Build 36hg18NCBI36
Build 34170,588,975 - 70,617,273NCBI
Celera169,166,835 - 69,195,464 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef168,987,754 - 69,016,606 (+)NCBIHuRef
CHM1_1170,992,268 - 71,020,901 (+)NCBICHM1_1
T2T-CHM13v2.0170,289,775 - 70,318,361 (+)NCBIT2T-CHM13v2.0
Cth
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393157,599,885 - 157,630,718 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3157,599,885 - 157,630,714 (-)EnsemblGRCm39 Ensembl
GRCm383157,894,248 - 157,925,081 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3157,894,248 - 157,925,077 (-)EnsemblGRCm38mm10GRCm38
MGSCv373157,557,212 - 157,588,027 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363157,829,541 - 157,860,356 (-)NCBIMGSCv36mm8
Celera3164,361,761 - 164,392,686 (-)NCBICelera
Cytogenetic Map3H4NCBI
Cth
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22246,975,888 - 247,002,234 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2246,975,894 - 247,002,234 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2254,708,251 - 254,734,585 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02252,602,078 - 252,628,090 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02247,570,449 - 247,596,765 (-)NCBIRnor_WKY
Rnor_6.02264,266,959 - 264,293,040 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2264,266,984 - 264,293,046 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02282,366,125 - 282,392,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42256,056,562 - 256,082,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12256,071,168 - 256,096,855 (-)NCBI
Celera2238,776,532 - 238,802,647 (-)NCBICelera
Cytogenetic Map2q45NCBI
CTH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1171,629,637 - 71,657,322 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,629,333 - 71,677,666 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0169,646,608 - 69,674,301 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CTH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1675,324,328 - 75,348,476 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl675,324,787 - 75,349,451 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha677,937,741 - 77,962,253 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0675,916,530 - 75,940,965 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1675,469,819 - 75,494,076 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0675,365,148 - 75,389,608 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0675,865,823 - 75,890,332 (-)NCBIUU_Cfam_GSD_1.0
Cth
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505882,845,843 - 82,870,103 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365911,619,446 - 1,643,665 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365911,619,446 - 1,643,667 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6142,454,914 - 142,486,367 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16142,454,922 - 142,486,352 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26132,027,445 - 132,050,236 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12062,672,820 - 62,718,608 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2062,690,906 - 62,718,980 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603354,904,075 - 54,931,820 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cth
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474225,619,277 - 25,642,875 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474225,619,261 - 25,642,477 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000007810   ⟹   ENSCLAP00000007691
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542321,542,179 - 21,567,786 (-)Ensembl
RefSeq Acc Id: XM_005385247   ⟹   XP_005385304
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542321,542,587 - 21,567,935 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005385304 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005385304   ⟸   XM_005385247
- UniProtKB: A0A8C2YLL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000007691   ⟸   ENSCLAT00000007810


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000005393 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000007691 ENTREZGENE
  ENSCLAP00000007691.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000007810 ENTREZGENE
  ENSCLAT00000007810.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.640.10 UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/TrEMBL
InterPro Cys/Met-Metab_PyrdxlP-dep_enz UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_small UniProtKB/TrEMBL
NCBI Gene Cth ENTREZGENE
PANTHER PTHR11808 UniProtKB/TrEMBL
Pfam Cys_Met_Meta_PP UniProtKB/TrEMBL
PIRSF CGS UniProtKB/TrEMBL
PROSITE CYS_MET_METAB_PP UniProtKB/TrEMBL
Superfamily-SCOP SSF53383 UniProtKB/TrEMBL
UniProt A0A8C2YLL9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Cth  cystathionine gamma-lyase    cystathionase (cystathionine gamma-lyase)  Symbol and/or name change 5135510 APPROVED