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Homocysteine (Hcy) metabolism is at the cross-roads of several pathways and is itself a byproduct of the de novo pathway of the methionine metabolic cycle. Hcy can be methylated to methionine via the cobalamin-dependent and independent pathways. The first is the predominant reaction in most tissues and is carried out by methionine synthase (Mtr). The requirement for the 1 carbon (1C) donor 5-methyl tetrahydrofolate and the generation of tetrahydrofolate (THF) in the reaction, engages folate meta

Pathway Diagram:

Ariadne Genomics Inc. 3-sulfinyl pyruvate ---> pyruvate sulfide to sulfate oxidation sulfur dioxide ---> sulfate sulfur dioxide sulfate 3-sulfinyl pyruvate ---> sulfur dioxide pyruvate cysteinesulfinate ---> hypotaurine serine ---> cystathione cystathione ---> alpha-ketobutyrate cystathione ---> ammonium cystathione ---> cysteine Cbs, Cth non-specific reactions 3-sulfinyl pyruvate taurine hypotaurine cysteinesulfinate O2 cysteine hydrogen sulfide alpha-ketobutyrate ammonium cystathione PLP/B6 S-adenosylmethionine serine homocysteine glutathione biosynthesis O2 ---> cysteinesulfinate Cth hypotaurine ---> taurine Csad Cdo1 cysteine ---> hydrogen sulfide cysteine ---> glutathione biosynthesis hydrogen sulfide ---> sulfate cysteinesulfinate ---> 3-sulfinyl pyruvate homocysteine metabolic pathway methionine cycle/metabolic pathway S-adenosylmethionine --+> Cbs Cbs cysteine ---> cysteinesulfinate homocysteine ---> cystathione

Genes in Pathway:

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transsulfuration pathway of homocysteine metabolism term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cbs cystathionine beta synthase JBrowse link 20 10,361,987 10,386,663 RGD:1359024
G Cdo1 cysteine dioxygenase type 1 JBrowse link 18 40,702,027 40,716,901 RGD:7242427
G Csad cysteine sulfinic acid decarboxylase JBrowse link 7 143,781,520 143,810,880 RGD:7242427
G Cth cystathionine gamma-lyase JBrowse link 2 264,266,959 264,293,040 RGD:1359024

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the transsulfuration pathway of homocysteine metabolism

References Associated with the transsulfuration pathway of homocysteine metabolism:

Ontology Path Diagram:

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