Stk25 (serine/threonine kinase 25) - Rat Genome Database

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Gene: Stk25 (serine/threonine kinase 25) Rattus norvegicus
Analyze
Symbol: Stk25
Name: serine/threonine kinase 25
RGD ID: 727809
Description: Predicted to enable protein homodimerization activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including establishment of Golgi localization; intrinsic apoptotic signaling pathway in response to hydrogen peroxide; and positive regulation of stress-activated MAPK cascade. Predicted to act upstream of or within Golgi localization; establishment or maintenance of cell polarity; and positive regulation of axonogenesis. Located in Golgi membrane. Orthologous to human STK25 (serine/threonine kinase 25); INTERACTS WITH 3H-1,2-dithiole-3-thione; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC94619; serine/threonine kinase 25 (STE20 homolog, yeast); serine/threonine-protein kinase 25
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2994,161,834 - 94,174,095 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl994,161,836 - 94,174,244 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9102,597,351 - 102,609,489 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,733,180 - 107,745,363 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09106,089,281 - 106,101,464 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09100,767,578 - 100,779,715 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,767,579 - 100,779,715 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09100,420,925 - 100,433,656 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4992,907,764 - 92,919,903 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1993,112,533 - 93,124,672 (-)NCBI
Celera991,695,836 - 91,707,760 (-)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
Golgi apparatus  (IBA,ISO)
Golgi membrane  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation. Fidalgo M, etal., J Cell Sci. 2010 Apr 15;123(Pt 8):1274-84. doi: 10.1242/jcs.061341. Epub 2010 Mar 23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
5. Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway. Pombo CM, etal., EMBO J 1996 Sep 2;15(17):4537-46.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15037601   PMID:17657516   PMID:19451227   PMID:21111240   PMID:22291017   PMID:22391949   PMID:22652780   PMID:23533145  


Genomics

Comparative Map Data
Stk25
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2994,161,834 - 94,174,095 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl994,161,836 - 94,174,244 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9102,597,351 - 102,609,489 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,733,180 - 107,745,363 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09106,089,281 - 106,101,464 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09100,767,578 - 100,779,715 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,767,579 - 100,779,715 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09100,420,925 - 100,433,656 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4992,907,764 - 92,919,903 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1993,112,533 - 93,124,672 (-)NCBI
Celera991,695,836 - 91,707,760 (-)NCBICelera
Cytogenetic Map9q36NCBI
STK25
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,492,670 - 241,509,572 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,492,670 - 241,509,730 (-)EnsemblGRCh38hg38GRCh38
GRCh372242,432,085 - 242,448,987 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362242,083,105 - 242,096,707 (-)NCBINCBI36Build 36hg18NCBI36
Build 342242,154,422 - 242,168,024NCBI
Celera2236,104,013 - 236,117,625 (-)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2234,189,627 - 234,204,482 (-)NCBIHuRef
CHM1_12242,440,093 - 242,454,954 (-)NCBICHM1_1
T2T-CHM13v2.02241,992,007 - 242,008,899 (-)NCBIT2T-CHM13v2.0
Stk25
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,548,473 - 93,581,937 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,547,473 - 93,586,381 (-)EnsemblGRCm39 Ensembl
GRCm38193,620,751 - 93,654,216 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,619,751 - 93,658,659 (-)EnsemblGRCm38mm10GRCm38
MGSCv37195,517,328 - 95,532,304 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,452,310 - 95,466,056 (-)NCBIMGSCv36mm8
Celera196,566,463 - 96,582,514 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.25NCBI
Stk25
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955542272,715 - 280,110 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955542268,406 - 279,323 (+)NCBIChiLan1.0ChiLan1.0
STK25
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12B144,213,015 - 144,226,459 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B128,766,408 - 128,779,939 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B247,560,624 - 247,574,249 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B247,560,624 - 247,574,249 (-)Ensemblpanpan1.1panPan2
STK25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12551,425,597 - 51,434,479 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2551,425,597 - 51,434,479 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2551,637,993 - 51,646,876 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02551,612,976 - 51,626,491 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2551,617,610 - 51,626,491 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12551,467,502 - 51,476,383 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02551,207,431 - 51,216,291 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02551,483,680 - 51,492,565 (-)NCBIUU_Cfam_GSD_1.0
Stk25
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303192,792,530 - 192,798,829 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936745420,073 - 426,393 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936745420,591 - 426,890 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK25
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15140,144,336 - 140,154,366 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115140,144,334 - 140,154,361 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215154,683,027 - 154,693,144 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STK25
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110127,571,024 - 127,580,628 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10127,571,665 - 127,580,071 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604071,742,570 - 71,772,625 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stk25
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248475,511,007 - 5,530,764 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248475,511,590 - 5,530,773 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stk25
63 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:315
Count of miRNA genes:206
Interacting mature miRNAs:241
Transcripts:ENSRNOT00000024487
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)992491589100929786Rat

Markers in Region
RH128624  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2994,162,008 - 94,162,217 (+)MAPPERmRatBN7.2
Rnor_6.09100,767,737 - 100,767,945NCBIRnor6.0
Rnor_5.09100,421,084 - 100,421,292UniSTSRnor5.0
RGSC_v3.4992,907,923 - 92,908,131UniSTSRGSC3.4
Celera991,695,995 - 91,696,203UniSTS
RH 3.4 Map9809.5UniSTS
Cytogenetic Map9q36UniSTS
BE112873  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2994,162,094 - 94,162,271 (+)MAPPERmRatBN7.2
Rnor_6.09100,767,823 - 100,767,999NCBIRnor6.0
Rnor_5.09100,421,170 - 100,421,346UniSTSRnor5.0
RGSC_v3.4992,908,009 - 92,908,185UniSTSRGSC3.4
Celera991,696,081 - 91,696,257UniSTS
RH 3.4 Map9813.5UniSTS
Cytogenetic Map9q36UniSTS
RH140581  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2994,168,085 - 94,168,269 (+)MAPPERmRatBN7.2
Rnor_6.09100,773,813 - 100,773,996NCBIRnor6.0
Rnor_5.09100,427,754 - 100,427,937UniSTSRnor5.0
RGSC_v3.4992,913,999 - 92,914,182UniSTSRGSC3.4
Celera991,702,070 - 91,702,253UniSTS
RH 3.4 Map9809.6UniSTS
Cytogenetic Map9q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000024487   ⟹   ENSRNOP00000024487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl994,161,836 - 94,174,015 (-)Ensembl
Rnor_6.0 Ensembl9100,767,579 - 100,779,715 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112919   ⟹   ENSRNOP00000080465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl994,161,843 - 94,174,244 (-)Ensembl
RefSeq Acc Id: NM_184049   ⟹   NP_908938
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2994,161,850 - 94,173,990 (-)NCBI
Rnor_6.09100,767,578 - 100,779,715 (-)NCBI
Rnor_5.09100,420,925 - 100,433,656 (-)NCBI
RGSC_v3.4992,907,764 - 92,919,903 (-)RGD
Celera991,695,836 - 91,707,760 (-)RGD
Sequence:
RefSeq Acc Id: XM_039084025   ⟹   XP_038939953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2994,161,834 - 94,173,723 (-)NCBI
RefSeq Acc Id: XM_039084026   ⟹   XP_038939954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2994,163,233 - 94,174,095 (-)NCBI
RefSeq Acc Id: XM_039084027   ⟹   XP_038939955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2994,165,235 - 94,174,095 (-)NCBI
RefSeq Acc Id: NP_908938   ⟸   NM_184049
- UniProtKB: Q6V9V9 (UniProtKB/TrEMBL),   F7ERC6 (UniProtKB/TrEMBL),   A0A8I5ZQ80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024487   ⟸   ENSRNOT00000024487
RefSeq Acc Id: XP_038939953   ⟸   XM_039084025
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038939954   ⟸   XM_039084026
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038939955   ⟸   XM_039084027
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000080465   ⟸   ENSRNOT00000112919
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6V9V9-F1-model_v2 AlphaFold Q6V9V9 1-426 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696878
Promoter ID:EPDNEW_R7403
Type:initiation region
Name:Stk25_1
Description:serine/threonine kinase 25
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.09100,779,731 - 100,779,791EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727809 AgrOrtholog
BioCyc Gene G2FUF-26636 BioCyc
Ensembl Genes ENSRNOG00000018181 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024487 ENTREZGENE
  ENSRNOT00000024487.5 UniProtKB/TrEMBL
  ENSRNOT00000112919.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.12.70 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7190997 IMAGE-MGC_LOAD
InterPro Kinase-like_dom UniProtKB/TrEMBL
  PDC10_dimerisation_sf UniProtKB/TrEMBL
  PDCD10_N UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  STK_STK25 UniProtKB/TrEMBL
KEGG Report rno:373542 UniProtKB/TrEMBL
MGC_CLONE MGC:94619 IMAGE-MGC_LOAD
NCBI Gene 373542 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE 25 UniProtKB/TrEMBL
  STERILE20-LIKE KINASE, ISOFORM B-RELATED UniProtKB/TrEMBL
Pfam PDCD10_N UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Stk25 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018181 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I5ZQ80 ENTREZGENE, UniProtKB/TrEMBL
  A6JR22_RAT UniProtKB/TrEMBL
  F7ERC6 ENTREZGENE, UniProtKB/TrEMBL
  Q6V9V9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Stk25  serine/threonine kinase 25  Stk25  serine/threonine kinase 25 (STE20 homolog, yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Stk25  serine/threonine kinase 25 (STE20 homolog, yeast)      Symbol and Name status set to approved 1299863 APPROVED