Stk25 (serine/threonine kinase 25)

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Gene: Stk25 (serine/threonine kinase 25) Chinchilla lanigera

Analyze

Symbol:

Stk25

Name:

serine/threonine kinase 25

RGD ID:

8720402

Description:

ENCODES a protein that exhibits protein homodimerization activity (ortholog); INVOLVED IN axonogenesis (ortholog); establishment of Golgi localization (ortholog); establishment or maintenance of cell polarity (ortholog); ASSOCIATED WITH Bethlem Myopathy 1 (ortholog); chromosome 2q37 deletion syndrome (ortholog); D-2-hydroxyglutaric aciduria 1 (ortholog); FOUND IN cytoplasm (ortholog); Golgi apparatus (ortholog); Golgi membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

serine/threonine-protein kinase 25

RGD Orthologs

Human

Mouse

Rat

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955542	272,715 - 280,110 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955542	268,406 - 279,323 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bethlem Myopathy 1 (ISO)

chromosome 2q37 deletion syndrome (ISO)

D-2-hydroxyglutaric aciduria 1 (ISO)

genetic disease (ISO)

hereditary spastic paraplegia 30 (ISO)

intellectual disability (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axonogenesis (ISO)

establishment of Golgi localization (ISO)

establishment or maintenance of cell polarity (ISO)

Golgi localization (ISO)

Golgi reassembly (ISO)

intrinsic apoptotic signaling pathway in response to hydrogen peroxide (ISO)

positive regulation of axonogenesis (ISO)

positive regulation of stress-activated MAPK cascade (ISO)

protein autophosphorylation (ISO)

protein phosphorylation (ISO)

response to hydrogen peroxide (ISO)

Cellular Component

cytoplasm (ISO)

Golgi apparatus (ISO)

Golgi membrane (ISO)

Molecular Function

protein binding (ISO)

protein homodimerization activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Genomics

Comparative Map Data

Stk25
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955542	272,715 - 280,110 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955542	268,406 - 279,323 (+)	NCBI	ChiLan1.0	ChiLan1.0

STK25
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	241,492,670 - 241,509,572 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	2	241,492,670 - 241,509,730 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	242,432,085 - 242,448,987 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	242,083,105 - 242,096,707 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	242,154,422 - 242,168,024	NCBI
Celera	2	236,104,013 - 236,117,625 (-)	NCBI		Celera
Cytogenetic Map	2	q37.3	NCBI
HuRef	2	234,189,627 - 234,204,482 (-)	NCBI		HuRef
CHM1_1	2	242,440,093 - 242,454,954 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	241,992,007 - 242,008,899 (-)	NCBI		T2T-CHM13v2.0

Stk25
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	93,548,473 - 93,581,937 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	93,547,473 - 93,586,381 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	93,620,751 - 93,654,216 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	93,619,751 - 93,658,659 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	95,517,328 - 95,532,304 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	95,452,310 - 95,466,056 (-)	NCBI		MGSCv36	mm8
Celera	1	96,566,463 - 96,582,514 (-)	NCBI		Celera
Cytogenetic Map	1	D	NCBI
cM Map	1	47.25	NCBI

Stk25
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	94,161,834 - 94,174,095 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	94,161,836 - 94,174,244 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	102,597,351 - 102,609,489 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	9	107,733,180 - 107,745,363 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	9	106,089,281 - 106,101,464 (-)	NCBI	Rnor_WKY
Rnor_6.0	9	100,767,578 - 100,779,715 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	100,767,579 - 100,779,715 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	100,420,925 - 100,433,656 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	92,907,764 - 92,919,903 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	93,112,533 - 93,124,672 (-)	NCBI
Celera	9	91,695,836 - 91,707,760 (-)	NCBI		Celera
Cytogenetic Map	9	q36	NCBI

STK25
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	2B	144,213,015 - 144,226,459 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	128,766,408 - 128,779,939 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	247,560,624 - 247,574,249 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	247,560,624 - 247,574,249 (-)	Ensembl	panpan1.1		panPan2

STK25
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	51,425,597 - 51,434,479 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	51,425,597 - 51,434,479 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	51,637,993 - 51,646,876 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	51,612,976 - 51,626,491 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	51,617,610 - 51,626,491 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	51,467,502 - 51,476,383 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	51,207,431 - 51,216,291 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	51,483,680 - 51,492,565 (-)	NCBI		UU_Cfam_GSD_1.0

Stk25
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	192,792,530 - 192,798,829 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936745	420,073 - 426,393 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936745	420,591 - 426,890 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

STK25
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	140,144,336 - 140,154,366 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	140,144,334 - 140,154,361 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	154,683,027 - 154,693,144 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

STK25
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	127,571,024 - 127,580,628 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	127,571,665 - 127,580,071 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	71,742,570 - 71,772,625 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Stk25
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624847	5,511,007 - 5,530,764 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624847	5,511,590 - 5,530,773 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005411127	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01071465	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01071466	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCE01001429	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSCLAT00000002887 ⟹ ENSCLAP00000002831

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955542	272,715 - 278,341 (+)	Ensembl

RefSeq Acc Id:

ENSCLAT00000002888 ⟹ ENSCLAP00000002832

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955542	273,325 - 280,110 (+)	Ensembl

RefSeq Acc Id:

XM_005411127 ⟹ XP_005411184

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955542	268,406 - 279,323 (+)	NCBI

Sequence:

show sequence

GGCTGCGGACTCCGAGTCCCAGAGAGCCACGCGCCCGCCACGACGCTGCTTCTCTGGTTGGGAG
GCCCGGGCGTTCCGGTTGACCCAGGCTGCGGGTGGGATCCTCGCTGGCGTTGCGGAGCGGGCCG
GAAGGCGGGGATGGAGCCGCCCGGAGCACTCTCGAGTGGACCCTGAGGAGCTCTTCACCAAGCT
TGACCGCATTGGCAAGGGCTCGTTTGGGGAAGTGTACAAGGGCATCGACAACCACACCAAAGAG
GTGGTGGCCATCAAGATCATCGACCTGGAAGAGGCTGAGGATGAGATCGAGGACATCCAGCAGG
AGATTACTGTGCTCAGCCAGTGTGACAGCCCCTACATCACCCGCTATTTTGGCTCCTACCTGAA
GAGCACCAAGCTGTGGATTATCATGGAGTACCTGGGCGGTGGCTCTGCACTGGACCTGTTGAAA
CCAGGCCCCCTGGAGGAGACCTACATCGCCACCATCCTGCGGGAGATCCTGAAGGGCCTGGACT
ACCTGCACTCAGAGCGCAAGATCCACCGTGACATCAAAGCTGCCAACGTGCTGCTCTCGGAGCA
GGGAGATGTGAAGCTAGCAGACTTCGGGGTGGCAGGGCAGCTCACCGACACTCAGATCAAGAGG
AACACATTTGTGGGCACCCCTTTTTGGATGGCACCAGAGGTCATCAAGCAGTCAGCCTATGACT
TCAAGGCCGACATCTGGTCCCTGGGCATCACGGCCATTGAACTGGCCAAGGGGGAGCCGCCAAA
CTCTGACCTGCACCCCATGCGTGTCCTGTTCCTGATCCCCAAAAACAGCCCACCCACACTGGAA
GGCCACCACAGCAGGCCCTTCAAGGAGTTTGTGGAGGCCTGCCTCAACAAGGACCCCCGATTTC
GGCCCACAGCCAAGGAGCTACTGAAGCACAAGTTCATCACACGCTATACCAAGAAGACCTCCTT
CCTCACGGAGCTCATCGACCGCTACAAGCGCTGGAAGTCAGAGGGGCATGGCGAGGAGTCCAGC
TCTGAGGACTCAGACATAGACGGCGAGGCCGAGGAAGGGGAGCAGGGCCCCATATGGACATTCC
CCCCAACCATCCGGCCCAGCCCGCACAGCAAGCTGCACAAGGGGACGGCCCTGCACAGCTCGCA
GAAGCAGGCGGACCCTATCAAGAGACAGCCACGGTCCCAGTGCCTGTCCACGCTGGTCCGGCCG
GTCTTCGGAGAGCTGAAGGAGAAGCATAGGCAGAGCGGGGGCAGCGTGGGCGCATTGGAGGAGC
TGGAGAATGCCTTCAGCCTGGCTGAGGAGTCCTGCCCTGGCATCTCGGACCAGCTCATGGTGCG
CCTGGTGGAGCGTGTGCAGAGGTTCTCGCACAGCAGAAACCATCTGACGTCCAGCCGCTGAGCA
TGCTGCTCTTCGTGGAGAGGGTGGAGTGTGCTCTGCTGCTGAGCTGAGCATGGGAAGAACTTGA
CTTGGAAGTCCCCCACCCGTGCTGTGTTGTGTCTGCAAGGACTTGTCAGCCTAGGGCCTCATAA
GCTGGGTCACCTTCCACCCAGCACAGTATCCAGTGTCCCTCTCCCCACCTGGCCCACGAACAGG
TGCCCATTGGCAGCCACAGGGCTGTCTTAGGCTTCCCCTAGAAACAGCCCTGTGGCTACTAGGT
CAAGGAGCACAGTGACTGTTGGGCAGTTCTGCCCTCTTCCTTTGGGTTCGGGAAACAGGGCAGC
CTCATGGGGCACCGCAGCCTGCCTTCCTCTCCCTCCCACCCTGATGCTGTCTACAGTGGCCCAA
GATGATCCTAGATCTGCCTTGTGGTGTCAGATCAGGTACTGTGTTTTCTCATAAGTACTCATGT
CACCCCAAATGTGTTTTTAAGAAAACTGAGCTGTTTCCTTTGGTGTTCTGAGGGTACGGTGTTC
ACTTCCTGGAGCACCGAAGGCCCTGACACTTCTAATAAAGACCTGGATGGGAGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005411184	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_005411184 ⟸ XM_005411127

- Sequence:

show sequence

MEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLAD
FGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMR
VLFLIPKNSPPTLEGHHSRPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDR
YKRWKSEGHGEESSSEDSDIDGEAEEGEQGPIWTFPPTIRPSPHSKLHKGTALHSSQKQADPIK
RQPRSQCLSTLVRPVFGELKEKHRQSGGSVGALEELENAFSLAEESCPGISDQLMVRLVERVQR
FSHSRNHLTSSR

hide sequence

RefSeq Acc Id:

ENSCLAP00000002832 ⟸ ENSCLAT00000002888

RefSeq Acc Id:

ENSCLAP00000002831 ⟸ ENSCLAT00000002887

Protein Domains

Protein kinase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000002040	Ensembl, UniProtKB/TrEMBL
Ensembl Protein	ENSCLAP00000002831.1	UniProtKB/TrEMBL
	ENSCLAP00000002832.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000002887.1	UniProtKB/TrEMBL
	ENSCLAT00000002888.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.12.70	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom_sf	UniProtKB/TrEMBL
	PDC10_dimerisation_sf	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	STK_STK25	UniProtKB/TrEMBL
NCBI Gene	Stk25	ENTREZGENE
PANTHER	SERINE/THREONINE-PROTEIN KINASE 25	UniProtKB/TrEMBL
	STERILE20-LIKE KINASE, ISOFORM B-RELATED	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/TrEMBL
UniProt	A0A8C2UNG0_CHILA	UniProtKB/TrEMBL
	A0A8C2UT99_CHILA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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