Abcc1 (ATP binding cassette subfamily C member 1) - Rat Genome Database

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Gene: Abcc1 (ATP binding cassette subfamily C member 1) Rattus norvegicus
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Symbol: Abcc1
Name: ATP binding cassette subfamily C member 1
RGD ID: 3112
Description: Enables several functions, including ATPase-coupled transmembrane transporter activity; glutathione transmembrane transporter activity; and long-chain fatty acid transporter activity. Involved in several processes, including glutathione transmembrane transport; lipid transport; and xenobiotic detoxification by transmembrane export across the plasma membrane. Located in basolateral plasma membrane and cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 77 and chronic obstructive pulmonary disease. Orthologous to human ABCC1 (ATP binding cassette subfamily C member 1); PARTICIPATES IN docetaxel pharmacodynamics pathway; doxorubicin pharmacokinetics pathway; irinotecan pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (R)-adrenaline; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Abcc1a; ATP-binding cassette sub-family C ( CFTR/MRP) member 1a; ATP-binding cassette sub-family C (CFTR/MRP) member 1 (multiple drug resistance-associated protein); ATP-binding cassette sub-family C member 1; ATP-binding cassette, sub-family C ( CFTR/MRP), member 1a; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; ATP-binding cassette, sub-family C, member 1-like; ATP-binding cassette, subfamily C (CFTR/MRP), member 1; Avcc1a; glutathione-S-conjugate-translocating ATPase ABCC1; leukotriene C(4) transporter; LOC100362747; LOC100365034; LOC103693258; LTC4 transporter; Mrp; Mrp1; multidrug resistance protein; Multidrug resistance protein 1; multidrug resistance-associated protein 1; multidrug resistance-associated protein 1-like; multiple drug resistance-associated protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Abcc1-ps1  
Candidate Gene For: Hcar1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210528,961 - 655,179 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10531,812 - 655,114 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx105,228,580 - 5,351,880 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01035,213,968 - 35,337,275 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.010543,174 - 666,513 (-)NCBIRnor_WKY
Rnor_6.010549,537 - 672,235 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10549,883 - 672,196 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01011,232,233 - 11,354,931 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410452,239 - 575,705 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110452,238 - 575,705 (-)NCBI
Celera1011,130,945 - 11,246,232 (-)NCBICelera
Cytogenetic Map10q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(+)-pilocarpine  (EXP)
(+)-taxifolin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-trans-epsilon-viniferin  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-adrenaline  (EXP)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
15alpha-hydroxytestosterone  (ISO)
16alpha-hydroxytestosterone  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 17-glucosiduronic acid  (ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (EXP)
2-naphthol  (ISO)
2-tert-butylhydroquinone  (ISO)
26-hydroxycholesterol  (ISO)
3',4',7-trihydroxyisoflavone  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4',5,7-trihydroxy-3'-methoxyflavone  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxypsoralen  (ISO)
6-carboxyfluorescein  (ISO)
6beta-hydroxytestosterone  (ISO)
8-Br-cAMP  (ISO)
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol  (ISO)
abamectin  (ISO)
acetamide  (EXP)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
acetochlor  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (EXP,ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
afrormosin  (ISO)
aldehydo-D-glucose  (ISO)
allyl alcohol  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antimony(0)  (ISO)
apigenin  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
baicalein  (ISO)
beclomethasone  (ISO)
benzbromarone  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bilirubin IXalpha  (ISO)
biochanin A  (ISO)
biopterin  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcein  (ISO)
calcein am  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
Cannabinol  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carboplatin  (ISO)
celecoxib  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chlorambucil  (ISO)
chlorogenic acid  (ISO)
chloroprene  (ISO)
chloroquine  (ISO)
chlorpropham  (ISO)
chlorpyrifos  (ISO)
cholic acid  (ISO)
choline  (EXP,ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clothianidin  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
dabrafenib  (ISO)
daidzein  (ISO)
daunorubicin  (ISO)
delta-tocotrienol  (ISO)
demethoxycurcumin  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dichlorine  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
dimethylarsinic acid  (EXP,ISO)
dimethylarsinous acid  (ISO)
diosmetin  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disulfiram  (ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
emamectin  (ISO)
epoxiconazole  (ISO)
eriodictyol  (ISO)
etacrynic acid  (ISO)
etoposide  (ISO)
fenitrothion  (ISO)
flavone  (ISO)
flavonoids  (ISO)
Fluo-3  (ISO)
folic acid  (ISO)
formononetin  (ISO)
fosinopril  (ISO)
galangin  (ISO)
gallocatechin  (ISO)
gamma-tocopherol  (ISO)
geneticin  (ISO)
genistein  (EXP,ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (ISO)
glucose  (ISO)
glutathione  (EXP,ISO)
glutathione disulfide  (EXP,ISO)
glyburide  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
Grepafloxacin  (ISO)
haloperidol  (ISO)
heparin  (ISO)
heptachlor  (EXP)
hesperetin  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hypericin  (ISO)
hypochlorous acid  (ISO)
idarubicin  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(III) nitrilotriacetate  (ISO)
isoflavones  (ISO)
isoniazide  (EXP)
isoorientin  (ISO)
isorhamnetin  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (EXP,ISO)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
leukotriene C4  (ISO)
levetiracetam  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
lithocholic acid sulfate  (ISO)
loratadine  (ISO)
lovastatin  (ISO)
luteolin  (ISO)
LY294002  (EXP)
mebendazole  (ISO)
mefloquine  (ISO)
melphalan  (ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
methoxsalen  (ISO)
methoxychlor  (ISO)
methylarsonic acid  (EXP,ISO)
metiram  (ISO)
mitomycin C  (ISO)
MK 571  (EXP,ISO)
montelukast  (ISO)
morin  (ISO)
myricetin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-ethylmaleimide  (ISO)
nelfinavir  (ISO)
nemorubicin  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nimesulide  (ISO)
nimustine  (ISO)
nitric oxide  (ISO)
nobiletin  (ISO)
notoginsenoside R1  (ISO)
NS-398  (ISO)
Nutlin-3  (ISO)
oltipraz  (ISO)
ozone  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
Pentoxifylline  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phenothiazines  (ISO)
phenytoin  (EXP)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
proanthocyanidin  (ISO)
probenecid  (EXP,ISO)
prodigiosin  (ISO)
prostaglandins E  (ISO)
puromycin  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
robinetin  (ISO)
robinin  (ISO)
romidepsin  (ISO)
S-(2,4-dinitrophenyl)glutathione  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
saquinavir  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium azide  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sodium stibogluconate  (ISO)
sorafenib  (ISO)
soybean oil  (EXP)
streptozocin  (ISO)
sulfinpyrazone  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
superoxide  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
taurocholic acid  (ISO)
taurodeoxycholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
taxane  (ISO)
Technetium tc 99m sestamibi  (ISO)
temozolomide  (ISO)
teniposide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thiethylperazine  (ISO)
thioacetamide  (EXP)
Thiotepa  (ISO)
tiagabine  (EXP)
titanium dioxide  (ISO)
tocopherol  (ISO)
toluene  (EXP)
topiramate  (EXP)
triclosan  (ISO)
trimethylarsine oxide  (EXP)
triptonide  (ISO)
tunicamycin  (ISO)
ursodeoxycholic acid  (EXP,ISO)
vadimezan  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (ISO)
verapamil  (ISO)
vincaleukoblastine  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
XAV939  (ISO)
zafirlukast  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (ISO)
zileuton  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. Buchler M, etal., J Biol Chem 1996 Jun 21;271(25):15091-8.
2. Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD. Budulac SE, etal., Respir Res. 2010 May 20;11:60.
3. Cross-functioning between the extraneuronal monoamine transporter and multidrug resistance protein 1 in the uptake of adrenaline and export of 5-(glutathion-S-yl)adrenaline in rat cardiomyocytes. Costa VM, etal., Chem Res Toxicol. 2009 Jan;22(1):129-135.
4. Functional expression of the multidrug resistance protein 1 in microglia. Dallas S, etal., J Pharmacol Exp Ther. 2003 Oct;307(1):282-90. Epub 2003 Jul 31.
5. Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin. Falcao AS, etal., Neuroscience. 2007 Feb 9;144(3):878-88. Epub 2006 Dec 4.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Transport of xenobiotics across the blood-brain barrier. Hagenbuch B, etal., News Physiol Sci 2002 Dec;17:231-4.
9. The antiepileptic drugs phenobarbital and carbamazepine reduce transport of methotrexate in rat choroid plexus by down-regulation of the reduced folate carrier. Halwachs S, etal., Mol Pharmacol. 2011 Oct;80(4):621-9. doi: 10.1124/mol.111.072421. Epub 2011 Jul 7.
10. The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress. Hirrlinger J, etal., J Neurochem 2001 Jan;76(2):627-36.
11. Glutathione release from cultured brain cells: multidrug resistance protein 1 mediates the release of GSH from rat astroglial cells. Hirrlinger J, etal., J Neurosci Res. 2002 Aug 1;69(3):318-26.
12. Evaluation of MRP1-5 gene expression in cystic fibrosis patients homozygous for the delta F508 mutation. Hurbain I, etal., Pediatr Res. 2003 Nov;54(5):627-34. Epub 2003 Aug 20.
13. Localization of multidrug resistance-associated proteins along the blood-testis barrier in rat, macaque, and human testis. Klein DM, etal., Drug Metab Dispos. 2014 Jan;42(1):89-93. doi: 10.1124/dmd.113.054577. Epub 2013 Oct 15.
14. Accumulation of murine amyloid-ß mimics early Alzheimer's disease. Krohn M, etal., Brain. 2015 Aug;138(Pt 8):2370-82. doi: 10.1093/brain/awv137. Epub 2015 May 18.
15. Circ_0048856 competes with ABCC1 for miR-193a-5p/miR-98-5p binding sites to promote the cisplatin resistance and tumorigenesis in lung cancer. Liu L, etal., J Chemother. 2022 Mar 15:1-14. doi: 10.1080/1120009X.2022.2043515.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Mitra P, etal., Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16394-9. Epub 2006 Oct 18.
18. Molecular cloning and pharmacological characterization of rat multidrug resistance protein 1 (mrp1). Nunoya K, etal., Drug Metab Dispos. 2003 Aug;31(8):1016-26.
19. Molecular and functional expression of multidrug resistance-associated protein-1 in primary cultured rat alveolar epithelial cells. Patel LN, etal., J Pharm Sci. 2008 Jun;97(6):2340-9.
20. Increased expression of multidrug resistance-associated protein 1 (mrp1) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats. Pei QL, etal., Hepatol Res. 2002 Jan;22(1):58-64.
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation. Roberts LM, etal., Neuroscience. 2008 Aug 13;155(2):423-38. Epub 2008 Jun 13.
27. Mice lacking the multidrug resistance protein 1 are resistant to Streptococcus pneumoniae-induced pneumonia. Schultz MJ, etal., J Immunol. 2001 Mar 15;166(6):4059-64.
28. Molecular identification and characterization of rat Abcc1 cDNA: existence of two splicing variants and species difference in drug-resistance profile. Takayanagi S and Ishikawa T, J Exp Ther Oncol. 2003 May-Jun;3(3):136-46.
29. Diminished expression of multidrug resistance-associated protein 1 (MRP1) in bronchial epithelium of COPD patients. van der Deen M, etal., Virchows Arch. 2006 Dec;449(6):682-8. Epub 2006 Oct 27.
30. Development and characterization of a recombinant madin-darby canine kidney cell line that expresses rat multidrug resistance-associated protein 1 (rMRP1). Yang Z, etal., AAPS J. 2004;6(1):77-85.
31. Cloning and characterization of the rat multidrug resistance-associated protein 1. Yang Z, etal., AAPS PharmSci 2002;4(3):E15.
32. Development and characterization of a recombinant Madin-Darby canine kidney cell line that expresses rat multidrug resistance-associated protein 1 (rMRP1). Yang Z, etal., AAPS PharmSci. 2004 Mar 9;6(1):E8.
33. Role of multidrug resistance-associated protein 1 in the pathogenesis of allergic airway inflammation. Yoshioka M, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Jan;296(1):L30-6. Epub 2008 Oct 17.
Additional References at PubMed
PMID:7559771   PMID:7961706   PMID:9281595   PMID:9359705   PMID:11689020   PMID:12951053   PMID:14623264   PMID:15328029   PMID:15999530   PMID:16170839   PMID:16868918   PMID:16946557  
PMID:17669244   PMID:18057958   PMID:18290326   PMID:18485102   PMID:18509883   PMID:18680196   PMID:19879335   PMID:19897579   PMID:19946888   PMID:20051532   PMID:20458337   PMID:21297965  
PMID:21495913   PMID:21803151   PMID:22015764   PMID:22563480   PMID:22883408   PMID:23474709   PMID:23940624   PMID:25543328   PMID:25986174   PMID:26200696   PMID:28298215   PMID:28577929  
PMID:35887010  


Genomics

Comparative Map Data
Abcc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210528,961 - 655,179 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10531,812 - 655,114 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx105,228,580 - 5,351,880 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01035,213,968 - 35,337,275 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.010543,174 - 666,513 (-)NCBIRnor_WKY
Rnor_6.010549,537 - 672,235 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10549,883 - 672,196 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01011,232,233 - 11,354,931 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410452,239 - 575,705 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110452,238 - 575,705 (-)NCBI
Celera1011,130,945 - 11,246,232 (-)NCBICelera
Cytogenetic Map10q11NCBI
ABCC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381615,949,143 - 16,143,053 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1615,949,138 - 16,143,257 (+)EnsemblGRCh38hg38GRCh38
GRCh371616,043,473 - 16,236,910 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361615,950,935 - 16,144,432 (+)NCBINCBI36Build 36hg18NCBI36
Build 341615,950,934 - 16,143,774NCBI
Celera1615,781,784 - 15,917,085 (+)NCBICelera
Cytogenetic Map16p13.11NCBI
HuRef1615,436,705 - 15,630,893 (+)NCBIHuRef
CHM1_11616,185,916 - 16,321,192 (+)NCBICHM1_1
T2T-CHM13v2.01615,954,559 - 16,147,908 (+)NCBIT2T-CHM13v2.0
Abcc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391614,179,317 - 14,292,743 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1614,179,422 - 14,293,601 (+)EnsemblGRCm39 Ensembl
GRCm381614,361,453 - 14,474,878 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1614,361,558 - 14,475,737 (+)EnsemblGRCm38mm10GRCm38
MGSCv371614,361,653 - 14,474,968 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361614,275,138 - 14,388,453 (+)NCBIMGSCv36mm8
Celera1614,966,079 - 15,077,783 (+)NCBICelera
Cytogenetic Map16A1NCBI
Abcc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955442729,316 - 860,290 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955442729,322 - 858,826 (+)NCBIChiLan1.0ChiLan1.0
ABCC1
(Pan paniscus - bonobo/pygmy chimpanzee)
No map positions available.
ABCC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1627,855,702 - 27,950,140 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl627,855,702 - 27,989,331 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha629,219,306 - 29,353,121 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0628,018,483 - 28,152,589 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl628,010,824 - 28,152,766 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1627,821,973 - 27,955,836 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0627,711,967 - 27,845,729 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0628,117,166 - 28,251,282 (-)NCBIUU_Cfam_GSD_1.0
Abcc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344115,297,821 - 115,369,238 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365013,401,285 - 3,470,460 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365013,400,971 - 3,467,061 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl328,360,873 - 28,473,456 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1328,360,868 - 28,472,940 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2329,082,788 - 29,172,693 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1514,972,589 - 15,164,594 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl514,972,646 - 15,164,567 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606814,816,018 - 14,953,501 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624782449,288 - 591,310 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624782449,217 - 590,306 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Abcc1
225 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:257
Count of miRNA genes:144
Interacting mature miRNAs:156
Transcripts:ENSRNOT00000041358, ENSRNOT00000044108
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat

Markers in Region
RH142203  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10q11UniSTS
AU047602  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210630,276 - 630,875 (+)MAPPERmRatBN7.2
mRatBN7.21929,362,322 - 29,362,552 (+)MAPPERmRatBN7.2
Rnor_6.01933,035,230 - 33,035,459NCBIRnor6.0
Rnor_6.010647,530 - 648,128NCBIRnor6.0
Rnor_5.01943,927,425 - 43,927,654UniSTSRnor5.0
Rnor_5.01011,330,226 - 11,330,824UniSTSRnor5.0
RGSC_v3.410550,874 - 551,472UniSTSRGSC3.4
RGSC_v3.41931,264,701 - 31,264,930UniSTSRGSC3.4
Celera1928,861,530 - 28,861,755UniSTS
Celera1011,221,486 - 11,222,084UniSTS
Cytogenetic Map19q11UniSTS
Cytogenetic Map10q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 5 18 2 19 2 8 8 68 28 36 11 8
Low 2 38 37 37 37 3 6 7 5
Below cutoff 2 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000044108   ⟹   ENSRNOP00000044445
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10531,812 - 655,114 (-)Ensembl
Rnor_6.0 Ensembl10549,883 - 672,196 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103910   ⟹   ENSRNOP00000091802
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10531,812 - 655,114 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115220   ⟹   ENSRNOP00000087096
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10531,812 - 616,211 (-)Ensembl
RefSeq Acc Id: NM_022281   ⟹   NP_071617
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210531,812 - 655,114 (-)NCBI
Rnor_6.010549,537 - 672,235 (-)NCBI
Rnor_5.01011,232,233 - 11,354,931 (-)NCBI
RGSC_v3.410452,239 - 575,705 (-)RGD
Celera1011,130,945 - 11,246,232 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085193   ⟹   XP_038941121
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210528,961 - 655,179 (-)NCBI
RefSeq Acc Id: XM_039085194   ⟹   XP_038941122
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210528,961 - 655,179 (-)NCBI
RefSeq Acc Id: XM_039085195   ⟹   XP_038941123
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210528,961 - 655,090 (-)NCBI
RefSeq Acc Id: XM_039085196   ⟹   XP_038941124
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210528,961 - 566,085 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_071617   ⟸   NM_022281
- UniProtKB: Q9JHS0 (UniProtKB/Swiss-Prot),   Q8CG09 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000044445   ⟸   ENSRNOT00000044108
RefSeq Acc Id: XP_038941121   ⟸   XM_039085193
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941122   ⟸   XM_039085194
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038941123   ⟸   XM_039085195
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038941124   ⟸   XM_039085196
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000087096   ⟸   ENSRNOT00000115220
RefSeq Acc Id: ENSRNOP00000091802   ⟸   ENSRNOT00000103910
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CG09-F1-model_v2 AlphaFold Q8CG09 1-1532 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696919
Promoter ID:EPDNEW_R7444
Type:multiple initiation site
Name:Abcc1_1
Description:ATP binding cassette subfamily C member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010672,214 - 672,274EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3112 AgrOrtholog
BioCyc Gene G2FUF-26263 BioCyc
BioCyc Pathway PWY-4061 [glutathione-mediated detoxification I] BioCyc
Ensembl Genes ENSRNOG00000022305 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000044445 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOP00000087096.1 UniProtKB/TrEMBL
  ENSRNOP00000091802.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044108 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOT00000103910.1 UniProtKB/TrEMBL
  ENSRNOT00000115220.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Multidrug-R_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24565 UniProtKB/Swiss-Prot
NCBI Gene 24565 ENTREZGENE
Pfam ABC_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ABCC1 RGD
PhenoGen Abcc1 PhenoGen
PROSITE ABC_TM1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90123 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs MRP_assoc_pro UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A6N3_RAT UniProtKB/TrEMBL
  A0A8I6GJW8_RAT UniProtKB/TrEMBL
  E9PT28_RAT UniProtKB/TrEMBL
  MRP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9JHS0 ENTREZGENE
UniProt Secondary Q63346 UniProtKB/Swiss-Prot
  Q810E4 UniProtKB/Swiss-Prot
  Q810G9 UniProtKB/Swiss-Prot
  Q9JHS0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Abcc1  ATP binding cassette subfamily C member 1  LOC103693258  multidrug resistance-associated protein 1-like  Data Merged 737654 PROVISIONAL
2015-11-25 Abcc1  ATP binding cassette subfamily C member 1  Abcc1  ATP-binding cassette, subfamily C (CFTR/MRP), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103693258  multidrug resistance-associated protein 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-03-29 Abcc1  ATP-binding cassette, subfamily C (CFTR/MRP), member 1  LOC100365034  ATP-binding cassette, sub-family C, member 1-like  Data Merged 737654 PROVISIONAL
2013-03-29 Abcc1  ATP-binding cassette, subfamily C (CFTR/MRP), member 1  LOC100362747  multidrug resistance-associated protein 1-like  Data Merged 737654 PROVISIONAL
2010-11-16 Abcc1  ATP-binding cassette, subfamily C (CFTR/MRP), member 1  Abcc1  ATP-binding cassette, sub-family C (CFTR/MRP), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100362747  multidrug resistance-associated protein 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-05-05 LOC100365034  ATP-binding cassette, sub-family C, member 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Abcc1  ATP-binding cassette, sub-family C (CFTR/MRP), member 1    ATP-binding cassette, sub-family C (CFTR/MRP), member 1   Symbol and Name updated 629477 APPROVED
2002-11-06 Abcc1  ATP-binding cassette, sub-family C (CFTR/MRP), member 1   Abcc1a  ATP-binding cassette, sub-family C ( CFTR/MRP), member 1a  Symbol and Name updated 625702 APPROVED
2002-01-14 Abcc1a  ATP-binding cassette, sub-family C ( CFTR/MRP), member 1a      Correction to the spelling of the sybol 68913 APPROVED
2001-11-02 Avcc1a  ATP-binding cassette, sub-family C ( CFTR/MRP), member 1a      Symbol and Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs inhibited by cyclosporin A and the quinoline derivative MK571 631913