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Gene: Crh (corticotropin releasing hormone) Rattus norvegicus
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Symbol: Crh
Name: corticotropin releasing hormone
Description: Exhibits corticotropin-releasing hormone receptor 1 binding activity and corticotropin-releasing hormone receptor 2 binding activity. Involved in several processes, including regulation of ion transport; regulation of secretion by cell; and response to glucocorticoid. Localizes to several cellular components, including extracellular space; perikaryon; and varicosity. Used to study hypoglycemia and obesity. Biomarker of several diseases, including alcohol use disorder; cerebrovascular disease (multiple); extrahepatic cholestasis; sciatic neuropathy; and withdrawal disorder. Human ortholog(s) of this gene implicated in obesity and panic disorder. Orthologous to human CRH (corticotropin releasing hormone); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; long term depression; INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; (S)-colchicine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: corticoliberin; corticotropin-releasing factor; corticotropin-releasing hormone; CRF
Orthologs:
Homo sapiens (human) : CRH (corticotropin releasing hormone)  HGNC  Alliance
Mus musculus (house mouse) : Crh (corticotropin releasing hormone)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Crh (corticotropin releasing hormone)
Pan paniscus (bonobo/pygmy chimpanzee) : CRH (corticotropin releasing hormone)
Canis lupus familiaris (dog) : CRH (corticotropin releasing hormone)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Crh (corticotropin releasing hormone)
Sus scrofa (pig) : CRH (corticotropin releasing hormone)
Chlorocebus sabaeus (African green monkey) : CRH (corticotropin releasing hormone)
Heterocephalus glaber (naked mole-rat) : Crh (corticotropin releasing hormone)
more info ...
Allele / Splice: Crhem1Ionsz  
Genetic Models: SD-Crhem1Ionsz
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02104,459,999 - 104,461,863 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2104,459,999 - 104,461,863 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02124,182,919 - 124,184,783 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42104,764,023 - 104,765,887 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12104,708,984 - 104,710,849 (-)NCBI
Celera297,536,796 - 97,538,660 (-)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Crh
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620505
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.