Mc4r (melanocortin 4 receptor) - Rat Genome Database

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Gene: Mc4r (melanocortin 4 receptor) Rattus norvegicus
Symbol: Mc4r
Name: melanocortin 4 receptor
RGD ID: 3057
Description: Enables melanocortin receptor activity and peptide hormone binding activity. Involved in several processes, including diet induced thermogenesis; negative regulation of feeding behavior; and regulation of grooming behavior. Predicted to be active in cytoplasm and plasma membrane. Used to study obesity. Biomarker of obesity and sciatic neuropathy. Human ortholog(s) of this gene implicated in morbid obesity and obesity. Orthologous to human MC4R (melanocortin 4 receptor); PARTICIPATES IN altered energy homeostasis pathway; altered melanocortin system pathway; G protein mediated signaling pathway via Galphas family; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MC4-R; melanocortin receptor 4
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Mc4rm1Hubr  
Genetic Models: WI-Mc4rm1Hubr
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81862,689,798 - 62,691,685 (-)NCBIGRCr8
mRatBN7.21860,419,832 - 60,421,719 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1860,419,832 - 60,421,719 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1862,493,750 - 62,495,636 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01863,192,468 - 63,194,354 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01861,044,927 - 61,046,814 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01862,612,838 - 62,614,725 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1862,612,838 - 62,614,725 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01861,799,166 - 61,801,053 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41863,390,922 - 63,392,809 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11863,464,122 - 63,465,631 (-)NCBI
Celera1858,529,070 - 58,530,957 (-)NCBICelera
RH 3.4 Map18610.4RGD
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)


References - curated
# Reference Title Reference Citation
1. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. Leptin resistance and desensitization of hypophagia during prolonged inflammatory challenge. Borges BC, etal., Am J Physiol Endocrinol Metab. 2011 May;300(5):E858-69. Epub 2011 Feb 22.
3. Binge eating as a major phenotype of melanocortin 4 receptor gene mutations. Branson R, etal., N Engl J Med. 2003 Mar 20;348(12):1096-103.
4. The melanocortin system in control of inflammation. Catania A, etal., ScientificWorldJournal. 2010 Sep 14;10:1840-53.
5. Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Quebec Family Study. Chagnon YC, etal., Mol Med. 1997 Oct;3(10):663-73.
6. Melanocortin 4 receptor induces hyperalgesia and allodynia after chronic constriction injury by activation of p38 MAPK in DRG. Chu H, etal., Int J Neurosci. 2012 Feb;122(2):74-81. Epub 2011 Nov 24.
7. Perinatal exposure to environmental endocrine disruptor bisphenol A aggravates the onset of non-alcoholic fatty liver disease (NAFLD) in weanling F1 offspring of obese rats. Dabeer S and Raisuddin S, Environ Sci Pollut Res Int. 2023 Jan;30(2):3146-3165. doi: 10.1007/s11356-022-22246-y. Epub 2022 Aug 9.
8. Agouti-related protein has an inhibitory paracrine role in the rat adrenal gland. Dhillo WS, etal., Biochem Biophys Res Commun 2003 Jan 31;301(1):102-7.
9. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. Farooqi IS, etal., N Engl J Med. 2003 Mar 20;348(12):1085-95.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology. Gutierrez-Aguilar R, etal., Obesity (Silver Spring). 2012 Feb;20(2):306-12. doi: 10.1038/oby.2011.236. Epub 2011 Jul 21.
13. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Huszar D, etal., Cell. 1997 Jan 10;88(1):131-41.
14. Altered hypothalamic leptin, insulin, and melanocortin binding associated with moderate-fat diet and predisposition to obesity. Irani BG, etal., Endocrinology. 2007 Jan;148(1):310-6. Epub 2006 Oct 5.
15. Effects of melanocortin receptor ligands on thyrotropin-releasing hormone release: evidence for the differential roles of melanocortin 3 and 4 receptors. Kim MS, etal., J Neuroendocrinol 2002 Apr;14(4):276-82.
16. Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. Kishi T, etal., J Comp Neurol 2003 Mar 10;457(3):213-35.
17. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
18. Anorectic actions of prolactin-releasing peptide are mediated by corticotropin-releasing hormone receptors. Lawrence CB, etal., Am J Physiol Regul Integr Comp Physiol 2004 Jan;286(1):R101-7. Epub 2003 Sep 25.
19. Melanocortin receptors in rat liver cells: change of gene expression and intracellular localization during acute-phase response. Malik IA, etal., Histochem Cell Biol. 2012 Mar;137(3):279-91. Epub 2011 Dec 20.
20. A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity. Mergen M, etal., J Clin Endocrinol Metab. 2001 Jul;86(7):3448.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat. Mul JD, etal., Obesity (Silver Spring). 2012 Mar;20(3):612-21. doi: 10.1038/oby.2011.81. Epub 2011 Apr 28.
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. A pharmacologically active monoclonal antibody against the human melanocortin-4 receptor: effectiveness after peripheral and central administration. Peter JC, etal., J Pharmacol Exp Ther. 2010 May;333(2):478-90. Epub 2010 Jan 29.
26. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Genetic and pharmacologic blockade of central melanocortin signaling attenuates cardiac cachexia in rodent models of heart failure. Scarlett JM, etal., J Endocrinol. 2010 Jul;206(1):121-30. Epub 2010 Apr 6.
31. The critical role of the melanocortin system in the control of energy balance. Seeley RJ, etal., Annu Rev Nutr 2004;24:133-49.
32. Peripheral antinociceptive effects of MC4 receptor antagonists in a rat model of neuropathic pain - a biochemical and behavioral study. Starowicz K, etal., Pharmacol Rep. 2009 Nov-Dec;61(6):1086-95.
33. Vascular effects of deletion of melanocortin-4 receptors in rats. Stepp DW, etal., Physiol Rep. 2013 Nov;1(6):e00146. doi: 10.1002/phy2.146. Epub 2013 Nov 13.
34. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
35. Systematic generation of in vivo G protein-coupled receptor mutants in the rat. van Boxtel R, etal., Pharmacogenomics J. 2011 Oct;11(5):326-36. doi: 10.1038/tpj.2010.44. Epub 2010 Jun 8.
36. Hypothalamic melanocortin system regulates sympathetic nerve activity in brown adipose tissue. Yasuda T, etal., Exp Biol Med (Maywood). 2004 Mar;229(3):235-9.
37. Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms. Yeo GS, etal., Hum Mol Genet. 2003 Mar 1;12(5):561-74.
Additional References at PubMed
PMID:8794897   PMID:9454589   PMID:12675910   PMID:12736185   PMID:12796784   PMID:12959974   PMID:12960080   PMID:14660008   PMID:14688446   PMID:14764818   PMID:15026153   PMID:15033920  
PMID:15123576   PMID:15585943   PMID:15720470   PMID:15927146   PMID:16141392   PMID:16325304   PMID:16380516   PMID:16384863   PMID:16614075   PMID:17595227   PMID:18285617   PMID:18463249  
PMID:18492813   PMID:19297540   PMID:19329486   PMID:19737927   PMID:19743876   PMID:19817504   PMID:19854868   PMID:20817751   PMID:20884347   PMID:20963574   PMID:21803120   PMID:22176700  
PMID:22390932   PMID:22535749   PMID:22643233   PMID:22872662   PMID:22889616   PMID:23416175   PMID:23571710   PMID:23832700   PMID:23946387   PMID:24433867   PMID:24612112   PMID:24635847  
PMID:24636506   PMID:25371525   PMID:25668357   PMID:25695289   PMID:25977231   PMID:25997563   PMID:26547948   PMID:26593415   PMID:27412936   PMID:27534879   PMID:27713523   PMID:28409883  
PMID:28575455   PMID:30466186   PMID:30745360   PMID:31260713   PMID:32035118   PMID:32378055   PMID:35304172  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81862,689,798 - 62,691,685 (-)NCBIGRCr8
mRatBN7.21860,419,832 - 60,421,719 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1860,419,832 - 60,421,719 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1862,493,750 - 62,495,636 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01863,192,468 - 63,194,354 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01861,044,927 - 61,046,814 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01862,612,838 - 62,614,725 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1862,612,838 - 62,614,725 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01861,799,166 - 61,801,053 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41863,390,922 - 63,392,809 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11863,464,122 - 63,465,631 (-)NCBI
Celera1858,529,070 - 58,530,957 (-)NCBICelera
RH 3.4 Map18610.4RGD
Cytogenetic Map18q12.1NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381860,371,062 - 60,372,775 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1860,371,062 - 60,372,775 (-)EnsemblGRCh38hg38GRCh38
GRCh371858,038,295 - 58,040,008 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361856,189,544 - 56,190,981 (-)NCBINCBI36Build 36hg18NCBI36
Build 341856,189,563 - 56,190,562NCBI
Celera1854,756,638 - 54,758,075 (-)NCBICelera
Cytogenetic Map18q21.32NCBI
HuRef1854,747,886 - 54,749,323 (-)NCBIHuRef
CHM1_11858,034,197 - 58,035,634 (-)NCBICHM1_1
T2T-CHM13v2.01860,574,034 - 60,575,747 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391866,990,776 - 66,993,558 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1866,990,775 - 66,993,577 (-)EnsemblGRCm39 Ensembl
GRCm381866,857,705 - 66,860,487 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1866,857,704 - 66,860,506 (-)EnsemblGRCm38mm10GRCm38
MGSCv371867,017,359 - 67,020,126 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361866,983,074 - 66,985,841 (-)NCBIMGSCv36mm8
Celera1868,131,723 - 68,134,491 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1839.72NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540244,455,294 - 44,456,292 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540244,453,973 - 44,456,689 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21777,895,644 - 77,900,374 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11863,588,255 - 63,592,920 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01853,744,172 - 53,747,282 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11857,069,089 - 57,070,670 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1857,069,259 - 57,070,257 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1116,131,829 - 16,132,827 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl116,131,589 - 16,133,079 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha117,102,321 - 17,103,318 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0116,003,681 - 16,004,679 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl116,003,441 - 16,004,931 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1116,032,383 - 16,033,381 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0115,964,379 - 15,965,377 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0116,214,421 - 16,215,419 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494429,397,280 - 29,400,818 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364974,636,758 - 4,637,759 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364974,636,370 - 4,638,205 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1160,772,013 - 160,774,124 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11160,772,013 - 160,774,124 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21178,553,488 - 178,555,752 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11819,380,054 - 19,386,412 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1819,380,849 - 19,381,847 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660606,249,695 - 6,251,517 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247925,866,119 - 5,867,120 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247925,865,902 - 5,867,498 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Mc4r
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:117
Interacting mature miRNAs:126
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)184999995865845095Rat
2293658Bmd23Bone mineral density QTL 237.30.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)185146473363636873Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185229287565845095Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
1600375Mcs22Mammary carcinoma susceptibility QTL 223.3mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)185253976363933058Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185253986365844950Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)185880568763636873Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185933040970263868Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185971241776477814Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647871893566Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.41863,737,840 - 63,737,956UniSTSRGSC3.4
RGSC_v3.41863,737,839 - 63,737,956RGDRGSC3.4
RGSC_v3.11863,811,040 - 63,811,157RGD
Celera1858,870,895 - 58,871,011UniSTS
RH 3.4 Map18616.3RGD
RH 2.0 Map18298.8RGD
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,420,460 - 60,420,938 (+)MAPPERmRatBN7.2
Rnor_6.01862,613,467 - 62,613,944NCBIRnor6.0
Rnor_5.01861,799,795 - 61,800,272UniSTSRnor5.0
RGSC_v3.41863,391,551 - 63,392,028UniSTSRGSC3.4
Celera1858,529,699 - 58,530,176UniSTS
Cytogenetic Map18q12.1UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,419,838 - 60,420,092 (+)MAPPERmRatBN7.2
Rnor_6.01862,612,845 - 62,613,098NCBIRnor6.0
Rnor_5.01861,799,173 - 61,799,426UniSTSRnor5.0
RGSC_v3.41863,390,929 - 63,391,182UniSTSRGSC3.4
Celera1858,529,077 - 58,529,330UniSTS
RH 3.4 Map18610.4UniSTS
Cytogenetic Map18q12.1UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,420,654 - 60,420,924 (+)MAPPERmRatBN7.2
Rnor_6.01862,613,661 - 62,613,930NCBIRnor6.0
Rnor_5.01861,799,989 - 61,800,258UniSTSRnor5.0
RGSC_v3.41863,391,745 - 63,392,014UniSTSRGSC3.4
Celera1858,529,893 - 58,530,162UniSTS
Cytogenetic Map18q12.1UniSTS

Genetic Models
This gene Mc4r is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Low 3 2 2 2 62 18 17 2
Below cutoff 2 16 7 4 6 4 5 8 12 4 15 8 5


RefSeq Acc Id: ENSRNOT00000025223   ⟹   ENSRNOP00000025223
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1860,419,832 - 60,421,719 (-)Ensembl
Rnor_6.0 Ensembl1862,612,838 - 62,614,725 (-)Ensembl
RefSeq Acc Id: NM_013099   ⟹   NP_037231
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81862,689,798 - 62,691,685 (-)NCBI
mRatBN7.21860,419,832 - 60,421,719 (-)NCBI
Rnor_6.01862,612,838 - 62,614,725 (-)NCBI
Rnor_5.01861,799,166 - 61,801,053 (-)NCBI
RGSC_v3.41863,390,922 - 63,392,809 (-)RGD
Celera1858,529,070 - 58,530,957 (-)RGD
Protein Sequences
Protein RefSeqs NP_037231 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB36517 (Get FASTA)   NCBI Sequence Viewer  
  EDM14715 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025223
GenBank Protein P70596 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037231   ⟸   NM_013099
- UniProtKB: P70596 (UniProtKB/Swiss-Prot),   A6IXT4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025223   ⟸   ENSRNOT00000025223
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70596-F1-model_v2 AlphaFold P70596 1-332 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3057 AgrOrtholog
BioCyc Gene G2FUF-7170 BioCyc
Ensembl Genes ENSRNOG00000018692 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055010601 UniProtKB/Swiss-Prot
  ENSRNOG00060010841 UniProtKB/Swiss-Prot
  ENSRNOG00065023286 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025223 ENTREZGENE
  ENSRNOT00000025223.4 UniProtKB/Swiss-Prot
  ENSRNOT00055017943 UniProtKB/Swiss-Prot
  ENSRNOT00060018344 UniProtKB/Swiss-Prot
  ENSRNOT00065039777 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MC3-5R UniProtKB/TrEMBL
  Mcort_rcpt_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Melancort_rcpt UniProtKB/Swiss-Prot
  Melcrt_ACTH_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25635 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mc4r PhenoGen
  MCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MELNOCORTN4R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018692 RatGTEx
  ENSRNOG00055010601 RatGTEx
  ENSRNOG00060010841 RatGTEx
  ENSRNOG00065023286 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC215097

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Mc4r  Melanocortin 4 receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expression found in infralimbic and insular cortices, bed nucleus of the stria terminalis, central nucleus of the amygdala, periaqueductal gray, lateral parabrachial nucleus, nucleus of the solitary tract, dorsal motor nucleus of the vagus (DMV), and intermediolateral nucleus of the spinal cord (IML) 727498
gene_process may be involved in stimulating TRH release 729360