Enables melanocortin receptor activity and peptide hormone binding activity. Involved in several processes, including diet induced thermogenesis; negative regulation of feeding behavior; and regulation of grooming behavior. Predicted to be active in cytoplasm and plasma membrane. Used to study obesity. Biomarker of anxiety disorder; obesity; and sciatic neuropathy. Human ortholog(s) of this gene implicated in morbid obesity and obesity. Orthologous to human MC4R (melanocortin 4 receptor); PARTICIPATES IN altered energy homeostasis pathway; altered melanocortin system pathway; G protein mediated signaling pathway via Galphas family; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
[Flame Retardants co-treated with pentabromodiphenyl ether co-treated with decabromobiphenyl ether co-treated with hexabromocyclododecane] results in increased expression of MC4R mRNA
Perinatal exposure to environmental endocrine disruptor bisphenol A aggravates the onset of non-alcoholic fatty liver disease (NAFLD) in weanling F1 offspring of obese rats.
Effects of melanocortin receptor ligands on thyrotropin-releasing hormone release: evidence for the differential roles of melanocortin 3 and 4 receptors.
Involvement of alpha-melanocyte stimulating hormone (alpha-MSH) in differential ethanol exposure and withdrawal related depression in rat: neuroanatomical-behavioral correlates.
Adolescent Alcohol Exposure-Induced Changes in Alpha-Melanocyte Stimulating Hormone and Neuropeptide Y Pathways via Histone Acetylation in the Brain During Adulthood.
Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms.
mRNA expression found in infralimbic and insular cortices, bed nucleus of the stria terminalis, central nucleus of the amygdala, periaqueductal gray, lateral parabrachial nucleus, nucleus of the solitary tract, dorsal motor nucleus of the vagus (DMV), and intermediolateral nucleus of the spinal cord (IML)