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Gene: Mc4r^m1Hubr (melanocortin 4 receptor; ENU induced mutation 1, Hubr) Rattus norvegicus

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Symbol:	Mc4r^m1Hubr
Name:	melanocortin 4 receptor; ENU induced mutation 1, Hubr
RGD ID:	13825200
Description:	The Mc4r mutation was generated by target-selected ENU-driven mutagenesis and high-throughput resequencing of genomic sequences in Crl:Wistar background. The mutation was identified as revealed an ENU-induced premature stop codon in helix 8 (K314X) of Mc4r. ASSOCIATED WITH decreased heart rate; decreased locomotor activity; decreased mean systemic arterial blood pressure; ASSOCIATED WITH Insulin Resistance; obesity
Type:	allele of Mc4r
Previously known as:	Mc4r^[m1Hubr]
Is Marker For:	Strains: WI-Mc4r^m1Hubr
Latest Assembly:	mRatBN7.2 - mRatBN7.2 Assembly
Position:	No map positions available.

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Disease Annotations Click to see Annotation Detail View

Insulin Resistance (IMP)

obesity (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased heart rate (IMP)

decreased locomotor activity (IMP)

decreased mean systemic arterial blood pressure (IMP)

decreased vasoconstriction (IMP)

increased body length (IMP)

increased body weight (IMP)

increased circulating cholesterol level (IMP)

increased circulating free fatty acids level (IMP)

increased circulating insulin level (IMP)

increased circulating leptin level (IMP)

increased circulating triglyceride level (IMP)

increased defecation amount (IMP)

increased fat cell size (IMP)

increased fluid intake (IMP)

increased glycosylated hemoglobin level (IMP)

increased heart weight (IMP)

increased kidney weight (IMP)

increased subcutaneous adipose tissue amount (IMP)

increased systemic vascular resistance (IMP)

increased vasoconstriction (IMP)

increased white adipose tissue amount (IMP)

obese (IMP)

polyphagia (IMP)

polyuria (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat.	Mul JD, etal., Obesity (Silver Spring). 2012 Mar;20(3):612-21. doi: 10.1038/oby.2011.81. Epub 2011 Apr 28.
2.	Vascular effects of deletion of melanocortin-4 receptors in rats.	Stepp DW, etal., Physiol Rep. 2013 Nov;1(6):e00146. doi: 10.1002/phy2.146. Epub 2013 Nov 13.
3.	Systematic generation of in vivo G protein-coupled receptor mutants in the rat.	van Boxtel R, etal., Pharmacogenomics J. 2011 Oct;11(5):326-36. doi: 10.1038/tpj.2010.44. Epub 2010 Jun 8.

Genomics

Related Rat Strains

The following Strains have been annotated to Mc4r^m1Hubr

WI-Mc4r^m1Hubr

Expression

RNA-SEQ Expression

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Sequence

Nucleotide Sequences

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
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Mammalian Phenotype