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Strain: WI-Mc4rm1Hubr

Symbol: WI-Mc4rm1Hubr
Strain: WI-Mc4rm1
Substrain: Hubr
RGD ID: 13825199
Citation ID: RRID:RGD_13825199
Ontology ID: RS:0004673
Alleles: Mc4rm1Hubr
Previously known as: Mc4r1Hubr; W-Mc4rm1Hubr
Type: mutant
Source: Hubrecht Laboratory, Centre for Biomedical Genetics, 3584 CT Utrecht, The Netherlands. Hera Biolabs, Taconic.
Origin: The Mc4r mutant rat line was generated by target-selected ENU-driven mutagenesis, and high-throughput resequencing of genomic target sequences in progeny from mutagenized rats (Wistar/Crl background) revealed an ENU-induced premature stop codon in helix 8 (K314X) of Mc4r. The heterozygous mutant rat was backcrossed to wild-type Wistar background for six generations to eliminate confounding effects from background mutations induced by ENU.
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,419,832 - 60,421,719RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01862,612,838 - 62,614,725RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01861,799,166 - 61,801,053RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41863,390,922 - 63,392,809RGD_MAPPER_PIPELINERGSC3.4

Disease Annotations     Click to see Annotation Detail View


References - curated
# Reference Title Reference Citation
1. Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat. Mul JD, etal., Obesity (Silver Spring). 2012 Mar;20(3):612-21. doi: 10.1038/oby.2011.81. Epub 2011 Apr 28.
2. Vascular effects of deletion of melanocortin-4 receptors in rats. Stepp DW, etal., Physiol Rep. 2013 Nov;1(6):e00146. doi: 10.1002/phy2.146. Epub 2013 Nov 13.
3. Systematic generation of in vivo G protein-coupled receptor mutants in the rat. van Boxtel R, etal., Pharmacogenomics J. 2011 Oct;11(5):326-36. doi: 10.1038/tpj.2010.44. Epub 2010 Jun 8.


Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-10-09 WI-Mc4rm1Hubr    W-Mc4rm1Hubr    Symbol and/or name change 68913 APPROVED