Pak5 (p21 (RAC1) activated kinase 5) - Rat Genome Database

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Gene: Pak5 (p21 (RAC1) activated kinase 5) Rattus norvegicus
Analyze
Symbol: Pak5
Name: p21 (RAC1) activated kinase 5
RGD ID: 1312009
Description: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction; protein phosphorylation; and regulation of MAPK cascade. Predicted to act upstream of or within learning or memory; locomotory behavior; and negative regulation of extrinsic apoptotic signaling pathway. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in cytoplasm and synapse. Orthologous to human PAK5 (p21 (RAC1) activated kinase 5); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; renal cell carcinoma pathway; T cell receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC311450; p21 (CDKN1A)-activated kinase 7; p21 (RAC1) activated kinase 7; p21 protein (Cdc42/Rac)-activated kinase 7; p21-activated kinase 5; p21-activated kinase 7; PAK-5; PAK-7; Pak7; serine/threonine-protein kinase PAK 5; serine/threonine-protein kinase PAK 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23123,395,678 - 123,703,967 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3123,396,497 - 123,703,930 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3127,299,735 - 127,598,969 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03135,876,723 - 136,175,955 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03133,555,363 - 133,854,570 (-)NCBIRnor_WKY
Rnor_6.03129,042,232 - 129,357,512 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3129,042,742 - 129,357,491 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03135,530,902 - 135,841,101 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43124,152,033 - 124,457,585 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13124,057,603 - 124,363,156 (-)NCBI
Celera3122,127,080 - 122,432,709 (-)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
mitochondrion  (ISO)
nucleoplasm  (IEA,ISO)
synapse  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12897128   PMID:18614015   PMID:18675265   PMID:23593460   PMID:24474471  


Genomics

Comparative Map Data
Pak5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23123,395,678 - 123,703,967 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3123,396,497 - 123,703,930 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3127,299,735 - 127,598,969 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03135,876,723 - 136,175,955 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03133,555,363 - 133,854,570 (-)NCBIRnor_WKY
Rnor_6.03129,042,232 - 129,357,512 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3129,042,742 - 129,357,491 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03135,530,902 - 135,841,101 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43124,152,033 - 124,457,585 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13124,057,603 - 124,363,156 (-)NCBI
Celera3122,127,080 - 122,432,709 (-)NCBICelera
Cytogenetic Map3q36NCBI
PAK5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38209,537,370 - 9,839,076 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl209,537,370 - 9,839,076 (-)EnsemblGRCh38hg38GRCh38
GRCh37209,518,017 - 9,819,724 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36209,466,037 - 9,767,522 (-)NCBINCBI36Build 36hg18NCBI36
Build 34209,466,036 - 9,767,522NCBI
Celera209,588,063 - 9,889,850 (-)NCBICelera
Cytogenetic Map20p12.2NCBI
HuRef209,470,003 - 9,771,581 (-)NCBIHuRef
CHM1_1209,519,190 - 9,820,790 (-)NCBICHM1_1
T2T-CHM13v2.0209,580,273 - 9,881,978 (-)NCBIT2T-CHM13v2.0
Pak5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392135,923,008 - 136,229,899 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2135,923,024 - 136,229,887 (-)EnsemblGRCm39 Ensembl
GRCm382136,081,088 - 136,387,968 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2136,081,104 - 136,387,967 (-)EnsemblGRCm38mm10GRCm38
MGSCv372135,906,824 - 136,213,703 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362135,773,340 - 136,079,379 (-)NCBIMGSCv36mm8
Celera2137,278,994 - 137,585,755 (-)NCBICelera
Cytogenetic Map2F3NCBI
Pak5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541519,511,822 - 19,619,663 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541519,509,727 - 19,826,087 (-)NCBIChiLan1.0ChiLan1.0
PAK5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1209,513,009 - 9,813,708 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl209,513,009 - 9,619,750 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0209,510,789 - 9,812,689 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PAK5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12412,391,739 - 12,671,483 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2412,391,471 - 12,669,404 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2412,210,533 - 12,496,682 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02412,804,073 - 13,084,553 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2412,804,113 - 13,082,849 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12412,410,639 - 12,690,260 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02412,510,137 - 12,789,767 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02412,853,704 - 13,133,934 (+)NCBIUU_Cfam_GSD_1.0
Pak5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640161,148,089 - 161,500,798 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364859,825,425 - 9,932,162 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAK5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1718,461,062 - 18,785,313 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11718,461,060 - 18,785,869 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21720,828,842 - 21,258,863 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PAK5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1228,287,478 - 28,595,382 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl228,288,945 - 28,595,686 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607115,978,895 - 16,289,799 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pak5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474110,476,192 - 10,608,745 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474110,476,172 - 10,823,164 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pak5
2145 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:240
Count of miRNA genes:157
Interacting mature miRNAs:194
Transcripts:ENSRNOT00000007410
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581546Pur13Proteinuria QTL 132.930.0335total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)3115638168135181505Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3115638168135181505Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat

Markers in Region
D3Rat156  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23123,513,284 - 123,513,386 (+)MAPPERmRatBN7.2
Rnor_6.03129,166,111 - 129,166,212NCBIRnor6.0
Rnor_5.03135,651,587 - 135,651,688UniSTSRnor5.0
RGSC_v3.43124,268,926 - 124,269,028RGDRGSC3.4
RGSC_v3.43124,268,927 - 124,269,028UniSTSRGSC3.4
RGSC_v3.13124,174,278 - 124,174,628RGD
Celera3122,243,230 - 122,243,331UniSTS
SHRSP x BN Map360.7499RGD
SHRSP x BN Map360.7499UniSTS
Cytogenetic Map3q36UniSTS
D3Rat254  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23123,471,156 - 123,471,394 (+)MAPPERmRatBN7.2
Rnor_6.03129,123,946 - 129,124,183NCBIRnor6.0
Rnor_5.03135,609,422 - 135,609,659UniSTSRnor5.0
RGSC_v3.43124,226,798 - 124,227,036RGDRGSC3.4
RGSC_v3.43124,226,799 - 124,227,036UniSTSRGSC3.4
RGSC_v3.13124,132,371 - 124,132,609RGD
Celera3122,201,188 - 122,201,425UniSTS
SHRSP x BN Map360.8299RGD
SHRSP x BN Map360.8299UniSTS
Cytogenetic Map3q36UniSTS
RH144603  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23123,475,043 - 123,475,198 (+)MAPPERmRatBN7.2
Rnor_6.03129,127,833 - 129,127,987NCBIRnor6.0
Rnor_5.03135,613,309 - 135,613,463UniSTSRnor5.0
RGSC_v3.43124,230,686 - 124,230,840UniSTSRGSC3.4
Celera3122,205,075 - 122,205,229UniSTS
RH 3.4 Map31087.3UniSTS
Cytogenetic Map3q36UniSTS
BF400086  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23123,687,059 - 123,687,248 (+)MAPPERmRatBN7.2
Rnor_6.03129,340,355 - 129,340,543NCBIRnor6.0
Rnor_5.03135,824,758 - 135,824,946UniSTSRnor5.0
RGSC_v3.43124,440,613 - 124,440,801UniSTSRGSC3.4
Celera3122,415,921 - 122,416,109UniSTS
RH 3.4 Map31088.0UniSTS
Cytogenetic Map3q36UniSTS
BF397900  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23123,431,448 - 123,431,573 (+)MAPPERmRatBN7.2
Rnor_6.03129,077,985 - 129,078,109NCBIRnor6.0
Rnor_5.03135,565,719 - 135,565,843UniSTSRnor5.0
RGSC_v3.43124,187,173 - 124,187,297UniSTSRGSC3.4
Celera3122,161,835 - 122,161,959UniSTS
RH 3.4 Map31086.0UniSTS
Cytogenetic Map3q36UniSTS
BF405154  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23123,396,742 - 123,396,925 (+)MAPPERmRatBN7.2
Rnor_6.03129,043,289 - 129,043,471NCBIRnor6.0
Rnor_5.03135,531,148 - 135,531,330UniSTSRnor5.0
RGSC_v3.43124,152,279 - 124,152,461UniSTSRGSC3.4
Celera3122,127,326 - 122,127,508UniSTS
RH 3.4 Map31084.6UniSTS
Cytogenetic Map3q36UniSTS
RH137684  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23123,395,734 - 123,395,982 (+)MAPPERmRatBN7.2
Rnor_6.03129,042,281 - 129,042,528NCBIRnor6.0
Rnor_5.03135,530,140 - 135,530,387UniSTSRnor5.0
RGSC_v3.43124,151,271 - 124,151,518UniSTSRGSC3.4
Celera3122,126,318 - 122,126,565UniSTS
RH 3.4 Map31087.9UniSTS
Cytogenetic Map3q36UniSTS
RH137907  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23123,421,169 - 123,421,301 (+)MAPPERmRatBN7.2
Rnor_6.03129,067,715 - 129,067,846NCBIRnor6.0
Rnor_5.03135,555,449 - 135,555,580UniSTSRnor5.0
RGSC_v3.43124,176,903 - 124,177,034UniSTSRGSC3.4
Celera3122,151,736 - 122,151,867UniSTS
Cytogenetic Map3q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 68
Low 10 2 2 2 6 6 20
Below cutoff 2 32 30 19 6 19 4 4 16 18 9 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007410   ⟹   ENSRNOP00000007410
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3123,396,497 - 123,703,930 (-)Ensembl
Rnor_6.0 Ensembl3129,043,043 - 129,357,491 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084829   ⟹   ENSRNOP00000071237
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3129,042,742 - 129,357,348 (-)Ensembl
RefSeq Acc Id: NM_001107781   ⟹   NP_001101251
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23123,396,497 - 123,703,930 (-)NCBI
Rnor_6.03129,043,043 - 129,357,491 (-)NCBI
Rnor_5.03135,530,902 - 135,841,101 (-)NCBI
RGSC_v3.43124,152,033 - 124,457,585 (-)RGD
Celera3122,127,080 - 122,432,709 (-)RGD
Sequence:
RefSeq Acc Id: XM_017591756   ⟹   XP_017447245
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23123,395,678 - 123,703,967 (-)NCBI
Rnor_6.03129,042,232 - 129,357,512 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591757   ⟹   XP_017447246
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23123,395,678 - 123,604,729 (-)NCBI
Rnor_6.03129,042,232 - 129,256,582 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105018   ⟹   XP_038960946
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23123,395,678 - 123,703,967 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101251 (Get FASTA)   NCBI Sequence Viewer  
  XP_017447245 (Get FASTA)   NCBI Sequence Viewer  
  XP_017447246 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960946 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D4A280 (Get FASTA)   NCBI Sequence Viewer  
  EDL80300 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001101251   ⟸   NM_001107781
- UniProtKB: D4A280 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017447245   ⟸   XM_017591756
- Peptide Label: isoform X1
- UniProtKB: D4A280 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017447246   ⟸   XM_017591757
- Peptide Label: isoform X1
- UniProtKB: D4A280 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071237   ⟸   ENSRNOT00000084829
RefSeq Acc Id: ENSRNOP00000007410   ⟸   ENSRNOT00000007410
RefSeq Acc Id: XP_038960946   ⟸   XM_039105018
- Peptide Label: isoform X1
- UniProtKB: D4A280 (UniProtKB/Swiss-Prot)
Protein Domains
CRIB   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A280-F1-model_v2 AlphaFold D4A280 1-718 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692468
Promoter ID:EPDNEW_R2987
Type:single initiation site
Name:Pak7_1
Description:p21 activated kinase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03129,357,329 - 129,357,389EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1312009 AgrOrtholog
BioCyc Gene G2FUF-47725 BioCyc
Ensembl Genes ENSRNOG00000005509 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000007410 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007410 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.810.10 UniProtKB/Swiss-Prot
InterPro CRIB_dom UniProtKB/Swiss-Prot
  CRIB_dom_sf UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PAK5 UniProtKB/Swiss-Prot
  PAK_BD UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
KEGG Report rno:311450 UniProtKB/Swiss-Prot
NCBI Gene 311450 ENTREZGENE
PANTHER PTHR45832:SF4 UniProtKB/Swiss-Prot
Pfam PBD UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PhenoGen Pak5 PhenoGen
PROSITE CRIB UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
SMART PBD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt D4A280 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-06-25 Pak5  p21 (RAC1) activated kinase 5  Pak7  p21 (RAC1) activated kinase 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-12 Pak7  p21 (RAC1) activated kinase 7  Pak7  p21 protein (Cdc42/Rac)-activated kinase 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-05-27 Pak7  p21 protein (Cdc42/Rac)-activated kinase 7  Pak7  p21 (CDKN1A)-activated kinase 7   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Pak7  p21 (CDKN1A)-activated kinase 7   Pak7_predicted  p21 (CDKN1A)-activated kinase 7 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pak7_predicted  p21 (CDKN1A)-activated kinase 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED