PAK5 (p21 (RAC1) activated kinase 5) - Rat Genome Database

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Gene: PAK5 (p21 (RAC1) activated kinase 5) Homo sapiens
Analyze
Symbol: PAK5
Name: p21 (RAC1) activated kinase 5
RGD ID: 1323766
HGNC Page HGNC
Description: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including activation of protein kinase activity; protein phosphorylation; and regulation of MAPK cascade. Predicted to act upstream of or within learning or memory; locomotory behavior; and negative regulation of extrinsic apoptotic signaling pathway. Located in nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: KIAA1264; MGC26232; p21 (RAC1) activated kinase 7; p21 protein (Cdc42/Rac)-activated kinase 7; p21(CDKN1A)-activated kinase 7; p21-activated kinase 5; p21-activated kinase 7; p21CDKN1A-activated kinase 7; PAK-5; PAK-7; PAK7; protein kinase PAK5; serine/threonine-protein kinase PAK 5; serine/threonine-protein kinase PAK 7; serine/threonine-protein kinase PAK7
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl209,537,370 - 9,839,076 (-)EnsemblGRCh38hg38GRCh38
GRCh38209,537,370 - 9,839,076 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37209,518,017 - 9,819,724 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36209,466,037 - 9,767,522 (-)NCBINCBI36hg18NCBI36
Build 34209,466,036 - 9,767,522NCBI
Celera209,588,063 - 9,889,850 (-)NCBI
Cytogenetic Map20p12.2NCBI
HuRef209,470,003 - 9,771,581 (-)NCBIHuRef
CHM1_1209,519,190 - 9,820,790 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (TAS)
mitochondrion  (IEA)
nucleoplasm  (IDA)
plasma membrane  (TAS)
synapse  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:9381178   PMID:10521512   PMID:10574462   PMID:10837486   PMID:10880354   PMID:11733543   PMID:11756552   PMID:11780052   PMID:11950587   PMID:12032833   PMID:12477932   PMID:12897128  
PMID:14702039   PMID:16014608   PMID:16189514   PMID:16581795   PMID:17353931   PMID:17620599   PMID:18628988   PMID:19060904   PMID:19415746   PMID:20070256   PMID:20379614   PMID:20564219  
PMID:20877624   PMID:20936779   PMID:21873635   PMID:23106939   PMID:23251661   PMID:23696025   PMID:23836671   PMID:23877225   PMID:24062079   PMID:24474471   PMID:24869804   PMID:25052921  
PMID:25416956   PMID:25436453   PMID:25632266   PMID:25910212   PMID:26116538   PMID:26186194   PMID:26212009   PMID:26682509   PMID:27095851   PMID:27107014   PMID:27323857   PMID:27499296  
PMID:28005267   PMID:28232500   PMID:28514442   PMID:28560394   PMID:28677719   PMID:29041983   PMID:29072688   PMID:30082769   PMID:30245957   PMID:30890765   PMID:31219614   PMID:31515488  
PMID:31638257   PMID:31805288   PMID:31973536   PMID:32296183   PMID:32383357   PMID:32626960   PMID:32721391   PMID:32814053   PMID:33961781  


Genomics

Comparative Map Data
PAK5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl209,537,370 - 9,839,076 (-)EnsemblGRCh38hg38GRCh38
GRCh38209,537,370 - 9,839,076 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37209,518,017 - 9,819,724 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36209,466,037 - 9,767,522 (-)NCBINCBI36hg18NCBI36
Build 34209,466,036 - 9,767,522NCBI
Celera209,588,063 - 9,889,850 (-)NCBI
Cytogenetic Map20p12.2NCBI
HuRef209,470,003 - 9,771,581 (-)NCBIHuRef
CHM1_1209,519,190 - 9,820,790 (-)NCBICHM1_1
Pak5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392135,923,008 - 136,229,899 (-)NCBIGRCm39mm39
GRCm39 Ensembl2135,923,024 - 136,229,887 (-)Ensembl
GRCm382136,081,088 - 136,387,968 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2136,081,104 - 136,387,967 (-)EnsemblGRCm38mm10GRCm38
MGSCv372135,906,824 - 136,213,703 (-)NCBIGRCm37mm9NCBIm37
MGSCv362135,773,340 - 136,079,379 (-)NCBImm8
Celera2137,278,994 - 137,585,755 (-)NCBICelera
Cytogenetic Map2F3NCBI
Pak5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23123,395,678 - 123,703,967 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl3123,396,497 - 123,703,930 (-)Ensembl
Rnor_6.03129,042,232 - 129,357,512 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3129,042,742 - 129,357,491 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03135,530,902 - 135,841,101 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43124,152,033 - 124,457,585 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13124,057,603 - 124,363,156 (-)NCBI
Celera3122,127,080 - 122,432,709 (-)NCBICelera
Cytogenetic Map3q36NCBI
Pak5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541519,511,822 - 19,619,663 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541519,509,727 - 19,826,087 (-)NCBIChiLan1.0ChiLan1.0
PAK5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1209,513,009 - 9,813,708 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl209,513,009 - 9,619,750 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0209,510,789 - 9,812,689 (-)NCBIMhudiblu_PPA_v0panPan3
PAK5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12412,391,739 - 12,671,483 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2412,391,471 - 12,669,404 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2412,210,533 - 12,496,682 (+)NCBI
ROS_Cfam_1.02412,804,073 - 13,084,553 (+)NCBI
UMICH_Zoey_3.12412,410,639 - 12,690,260 (+)NCBI
UNSW_CanFamBas_1.02412,510,137 - 12,789,767 (+)NCBI
UU_Cfam_GSD_1.02412,853,704 - 13,133,934 (+)NCBI
Pak5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640161,148,089 - 161,500,798 (+)NCBI
SpeTri2.0NW_0049364859,825,425 - 9,932,162 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAK5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1718,461,062 - 18,785,313 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11718,461,060 - 18,785,869 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21720,828,842 - 21,258,863 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PAK5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1228,287,478 - 28,595,382 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl228,288,945 - 28,595,686 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607115,978,895 - 16,289,799 (-)NCBIVero_WHO_p1.0
Pak5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474110,476,172 - 10,823,164 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
WI-15350  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37209,518,315 - 9,518,439UniSTSGRCh37
Build 36209,466,315 - 9,466,439RGDNCBI36
Celera209,588,341 - 9,588,465RGD
Cytogenetic Map20p12UniSTS
HuRef209,470,281 - 9,470,405UniSTS
GeneMap99-GB4 RH Map2055.31UniSTS
Whitehead-RH Map2064.7UniSTS
NCBI RH Map2079.8UniSTS
G18107  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37209,593,716 - 9,593,946UniSTSGRCh37
Build 36209,541,716 - 9,541,946RGDNCBI36
Celera209,663,738 - 9,663,968RGD
Cytogenetic Map20p12UniSTS
HuRef209,545,668 - 9,545,898UniSTS
Z94709  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37209,690,195 - 9,690,284UniSTSGRCh37
Build 36209,638,195 - 9,638,284RGDNCBI36
Celera209,760,321 - 9,760,410RGD
Cytogenetic Map20p12UniSTS
HuRef209,642,251 - 9,642,340UniSTS
RH25698  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37209,518,104 - 9,518,233UniSTSGRCh37
Build 36209,466,104 - 9,466,233RGDNCBI36
Celera209,588,130 - 9,588,259RGD
Cytogenetic Map20p12UniSTS
HuRef209,470,070 - 9,470,199UniSTS
AL034531  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37209,602,707 - 9,602,788UniSTSGRCh37
Build 36209,550,707 - 9,550,788RGDNCBI36
Celera209,672,727 - 9,672,808RGD
Cytogenetic Map20p12UniSTS
HuRef209,554,658 - 9,554,739UniSTS
RH121007  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37209,810,230 - 9,810,561UniSTSGRCh37
Build 36209,758,230 - 9,758,561RGDNCBI36
Celera209,880,393 - 9,880,724RGD
Cytogenetic Map20p12UniSTS
HuRef209,762,124 - 9,762,455UniSTS
TNG Radiation Hybrid Map205791.0UniSTS
G59174  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37209,738,166 - 9,738,510UniSTSGRCh37
Build 36209,686,166 - 9,686,510RGDNCBI36
Celera209,808,297 - 9,808,641RGD
Cytogenetic Map20p12UniSTS
TNG Radiation Hybrid Map205750.0UniSTS
D20S503  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37209,765,865 - 9,766,181UniSTSGRCh37
Build 36209,713,865 - 9,714,181RGDNCBI36
Celera209,836,000 - 9,836,316RGD
Cytogenetic Map20p12UniSTS
HuRef209,717,861 - 9,718,177UniSTS
G65503  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37209,560,711 - 9,561,034UniSTSGRCh37
Build 36209,508,711 - 9,509,034RGDNCBI36
Celera209,630,743 - 9,631,066RGD
Cytogenetic Map20p12UniSTS
HuRef209,512,685 - 9,513,008UniSTS
PAK7_1448  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37209,517,973 - 9,518,858UniSTSGRCh37
Build 36209,465,973 - 9,466,858RGDNCBI36
Celera209,587,999 - 9,588,884RGD
HuRef209,469,939 - 9,470,824UniSTS
RH12132  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37209,518,062 - 9,518,214UniSTSGRCh37
Build 36209,466,062 - 9,466,214RGDNCBI36
Celera209,588,088 - 9,588,240RGD
Cytogenetic Map20p12UniSTS
HuRef209,470,028 - 9,470,180UniSTS
GeneMap99-GB4 RH Map2055.11UniSTS
NCBI RH Map2079.8UniSTS
D20S958  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37209,518,326 - 9,518,479UniSTSGRCh37
Build 36209,466,326 - 9,466,479RGDNCBI36
Celera209,588,352 - 9,588,505RGD
Cytogenetic Map20p12UniSTS
HuRef209,470,292 - 9,470,445UniSTS
GeneMap99-GB4 RH Map2055.31UniSTS
Whitehead-RH Map2064.7UniSTS
Whitehead-YAC Contig Map20 UniSTS
NCBI RH Map2079.8UniSTS
D20S723  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37209,519,775 - 9,520,025UniSTSGRCh37
Build 36209,467,775 - 9,468,025RGDNCBI36
Celera209,589,801 - 9,590,051RGD
Cytogenetic Map20p12UniSTS
HuRef209,471,741 - 9,471,991UniSTS
Whitehead-YAC Contig Map20 UniSTS
ATTC013  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371847,345,390 - 47,346,315UniSTSGRCh37
GRCh37209,538,638 - 9,538,745UniSTSGRCh37
Celera1844,202,057 - 44,202,982UniSTS
Celera209,608,663 - 9,608,774UniSTS
HuRef209,490,605 - 9,490,716UniSTS
HuRef1844,199,672 - 44,200,598UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2312
Count of miRNA genes:571
Interacting mature miRNAs:643
Transcripts:ENST00000353224, ENST00000378423, ENST00000378429
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 4 3 1 3 729 3 25
Low 122 676 540 57 21 20 599 79 2117 63 387 73 40 1 383
Below cutoff 1973 1194 937 414 469 290 2652 1276 762 179 825 1144 126 526 1808 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_020341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_177990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017027960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017027961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017027962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017027963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017027964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017027965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB033090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB040812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK307926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL031652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL031682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL034427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL133002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL135935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL353612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX776013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF456813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF456817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF456818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF510483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000353224   ⟹   ENSP00000322957
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl209,537,370 - 9,839,076 (-)Ensembl
RefSeq Acc Id: ENST00000378423   ⟹   ENSP00000367679
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl209,537,389 - 9,838,831 (-)Ensembl
RefSeq Acc Id: ENST00000378429   ⟹   ENSP00000367686
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl209,537,389 - 9,839,041 (-)Ensembl
RefSeq Acc Id: NM_020341   ⟹   NP_065074
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38209,537,370 - 9,839,076 (-)NCBI
GRCh37209,518,037 - 9,819,687 (-)ENTREZGENE
GRCh37209,518,037 - 9,819,687 (-)NCBI
Build 36209,466,037 - 9,767,522 (-)NCBI Archive
HuRef209,470,003 - 9,771,581 (-)ENTREZGENE
CHM1_1209,519,190 - 9,820,790 (-)NCBI
Sequence:
RefSeq Acc Id: NM_177990   ⟹   NP_817127
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38209,537,370 - 9,839,076 (-)NCBI
GRCh37209,518,037 - 9,819,687 (-)ENTREZGENE
GRCh37209,518,037 - 9,819,687 (-)NCBI
Build 36209,466,037 - 9,767,522 (-)NCBI Archive
HuRef209,470,003 - 9,771,581 (-)ENTREZGENE
CHM1_1209,519,190 - 9,820,790 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017027960   ⟹   XP_016883449
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38209,537,390 - 9,839,042 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017027961   ⟹   XP_016883450
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38209,537,390 - 9,839,042 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017027962   ⟹   XP_016883451
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38209,537,390 - 9,839,042 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017027963   ⟹   XP_016883452
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38209,537,390 - 9,720,472 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017027964   ⟹   XP_016883453
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38209,537,390 - 9,765,886 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017027965   ⟹   XP_016883454
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38209,537,390 - 9,726,357 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_817127   ⟸   NM_177990
- UniProtKB: Q9P286 (UniProtKB/Swiss-Prot),   B0AZM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_065074   ⟸   NM_020341
- UniProtKB: Q9P286 (UniProtKB/Swiss-Prot),   B0AZM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016883449   ⟸   XM_017027960
- Peptide Label: isoform X1
- UniProtKB: Q9P286 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016883450   ⟸   XM_017027961
- Peptide Label: isoform X1
- UniProtKB: Q9P286 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016883451   ⟸   XM_017027962
- Peptide Label: isoform X1
- UniProtKB: Q9P286 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016883453   ⟸   XM_017027964
- Peptide Label: isoform X1
- UniProtKB: Q9P286 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016883454   ⟸   XM_017027965
- Peptide Label: isoform X1
- UniProtKB: Q9P286 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016883452   ⟸   XM_017027963
- Peptide Label: isoform X1
- UniProtKB: Q9P286 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000367679   ⟸   ENST00000378423
RefSeq Acc Id: ENSP00000367686   ⟸   ENST00000378429
RefSeq Acc Id: ENSP00000322957   ⟸   ENST00000353224
Protein Domains
CRIB   Protein kinase

Promoters
RGD ID:13206363
Promoter ID:EPDNEW_H26762
Type:single initiation site
Name:PAK7_2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26763  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38209,799,445 - 9,799,505EPDNEW
RGD ID:13206365
Promoter ID:EPDNEW_H26763
Type:initiation region
Name:PAK7_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26762  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38209,838,870 - 9,838,930EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 20p13-11.21(chr20:89939-25697564)x3 copy number gain See cases [RCV000051227] Chr20:89939..25697564 [GRCh38]
Chr20:70580..25678200 [GRCh37]
Chr20:18580..25626200 [NCBI36]
Chr20:20p13-11.21
pathogenic
GRCh38/hg38 20p13-11.23(chr20:89939-19146279)x3 copy number gain See cases [RCV000051041] Chr20:89939..19146279 [GRCh38]
Chr20:70580..19126923 [GRCh37]
Chr20:18580..19074923 [NCBI36]
Chr20:20p13-11.23
pathogenic
GRCh38/hg38 20p12.3-12.2(chr20:7566644-11028694)x1 copy number loss See cases [RCV000052739] Chr20:7566644..11028694 [GRCh38]
Chr20:7547291..11009342 [GRCh37]
Chr20:7495291..10957342 [NCBI36]
Chr20:20p12.3-12.2
pathogenic
GRCh38/hg38 20p13-11.23(chr20:89939-19071495)x3 copy number gain See cases [RCV000052995] Chr20:89939..19071495 [GRCh38]
Chr20:70580..19052139 [GRCh37]
Chr20:18580..19000139 [NCBI36]
Chr20:20p13-11.23
pathogenic
GRCh38/hg38 20p13-11.22(chr20:89939-21787252)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052996]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052996]|See cases [RCV000052996] Chr20:89939..21787252 [GRCh38]
Chr20:70580..21767890 [GRCh37]
Chr20:18580..21715890 [NCBI36]
Chr20:20p13-11.22
pathogenic
GRCh38/hg38 20p13-12.1(chr20:89939-14818511)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052997]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052997]|See cases [RCV000052997] Chr20:89939..14818511 [GRCh38]
Chr20:70580..14799157 [GRCh37]
Chr20:18580..14747157 [NCBI36]
Chr20:20p13-12.1
pathogenic
GRCh38/hg38 20p12.2-q12(chr20:9811433-39316956)x3 copy number gain See cases [RCV000052999] Chr20:9811433..39316956 [GRCh38]
Chr20:9792081..37945599 [GRCh37]
Chr20:9740081..37379013 [NCBI36]
Chr20:20p12.2-q12
pathogenic
NM_020341.3(PAK7):c.1320C>T (p.Val440=) single nucleotide variant Malignant melanoma [RCV000072775] Chr20:9566055 [GRCh38]
Chr20:9546702 [GRCh37]
Chr20:9494702 [NCBI36]
Chr20:20p12.2
not provided
NM_020341.3(PAK7):c.666C>A (p.Ala222=) single nucleotide variant Malignant melanoma [RCV000072776] Chr20:9580469 [GRCh38]
Chr20:9561116 [GRCh37]
Chr20:9509116 [NCBI36]
Chr20:20p12.2
not provided
NM_020341.3(PAK7):c.1498G>A (p.Asp500Asn) single nucleotide variant Malignant melanoma [RCV000063808] Chr20:9563009 [GRCh38]
Chr20:9543656 [GRCh37]
Chr20:9491656 [NCBI36]
Chr20:20p12.2
not provided
NM_020341.3(PAK7):c.961T>G (p.Leu321Val) single nucleotide variant Malignant melanoma [RCV000063809] Chr20:9580174 [GRCh38]
Chr20:9560821 [GRCh37]
Chr20:9508821 [NCBI36]
Chr20:20p12.2
not provided
NM_020341.3(PAK7):c.990+4374C>A single nucleotide variant Lung cancer [RCV000101781] Chr20:9575771 [GRCh38]
Chr20:9556418 [GRCh37]
Chr20:20p12.2
uncertain significance
NM_020341.3(PAK7):c.204+1124A>G single nucleotide variant Lung cancer [RCV000101782] Chr20:9643001 [GRCh38]
Chr20:9623649 [GRCh37]
Chr20:20p12.2
uncertain significance
NM_020341.3(PAK7):c.-162+34146G>T single nucleotide variant Lung cancer [RCV000101783] Chr20:9784534 [GRCh38]
Chr20:9765182 [GRCh37]
Chr20:20p12.2
uncertain significance
GRCh38/hg38 20p13-q11.1(chr20:80106-30227427)x3 copy number gain See cases [RCV000133996] Chr20:80106..30227427 [GRCh38]
Chr20:60747..29462103 [GRCh37]
Chr20:8747..28075764 [NCBI36]
Chr20:20p13-q11.1
pathogenic
GRCh38/hg38 20p12.2-12.1(chr20:9550975-12083434)x1 copy number loss See cases [RCV000135357] Chr20:9550975..12083434 [GRCh38]
Chr20:9531622..12064082 [GRCh37]
Chr20:9479622..12012082 [NCBI36]
Chr20:20p12.2-12.1
pathogenic
GRCh38/hg38 20p12.3-12.1(chr20:6617695-13392559)x1 copy number loss See cases [RCV000135292] Chr20:6617695..13392559 [GRCh38]
Chr20:6598342..13373206 [GRCh37]
Chr20:6546342..13321206 [NCBI36]
Chr20:20p12.3-12.1
pathogenic
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33
pathogenic
GRCh38/hg38 20p12.2-12.1(chr20:9290612-14648536)x3 copy number gain See cases [RCV000138042] Chr20:9290612..14648536 [GRCh38]
Chr20:9271259..14629182 [GRCh37]
Chr20:9219259..14577182 [NCBI36]
Chr20:20p12.2-12.1
uncertain significance
GRCh38/hg38 20p13-12.1(chr20:80106-13029401)x3 copy number gain See cases [RCV000138677] Chr20:80106..13029401 [GRCh38]
Chr20:60747..13010049 [GRCh37]
Chr20:8747..12958049 [NCBI36]
Chr20:20p13-12.1
pathogenic
GRCh38/hg38 20p12.2(chr20:9771030-9988151)x3 copy number gain See cases [RCV000141036] Chr20:9771030..9988151 [GRCh38]
Chr20:9751678..9968799 [GRCh37]
Chr20:9699678..9916799 [NCBI36]
Chr20:20p12.2
likely benign
GRCh38/hg38 20p13-11.1(chr20:80927-26324843)x3 copy number gain See cases [RCV000142017] Chr20:80927..26324843 [GRCh38]
Chr20:61568..26305479 [GRCh37]
Chr20:9568..26253479 [NCBI36]
Chr20:20p13-11.1
pathogenic
GRCh38/hg38 20p13-11.23(chr20:80928-18688031)x3 copy number gain See cases [RCV000143426] Chr20:80928..18688031 [GRCh38]
Chr20:61569..18668675 [GRCh37]
Chr20:9569..18616675 [NCBI36]
Chr20:20p13-11.23
pathogenic
GRCh37/hg19 20p13-11.1(chr20:80198-26075841)x3 copy number gain See cases [RCV000239954] Chr20:80198..26075841 [GRCh37]
Chr20:20p13-11.1
pathogenic
GRCh37/hg19 20p13-12.1(chr20:4392930-12667768)x1 copy number loss See cases [RCV000446718] Chr20:4392930..12667768 [GRCh37]
Chr20:20p13-12.1
pathogenic
GRCh37/hg19 20p12.3-12.1(chr20:9121901-16858469)x1 copy number loss See cases [RCV000448674] Chr20:9121901..16858469 [GRCh37]
Chr20:20p12.3-12.1
pathogenic
GRCh37/hg19 20p12.3-12.1(chr20:7352576-12248958)x3 copy number gain See cases [RCV000448374] Chr20:7352576..12248958 [GRCh37]
Chr20:20p12.3-12.1
uncertain significance
GRCh37/hg19 20p13-q11.21(chr20:80198-26208081)x3 copy number gain not provided [RCV000487461] Chr20:80198..26208081 [GRCh37]
Chr20:20p13-q11.21
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555)x3 copy number gain See cases [RCV000510832] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555) copy number gain See cases [RCV000512450] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-12.2(chr20:61568-10486106)x3 copy number gain See cases [RCV000512556] Chr20:61568..10486106 [GRCh37]
Chr20:20p13-12.2
likely pathogenic
GRCh37/hg19 20p12.3-12.1(chr20:7604120-14739025)x3 copy number gain not provided [RCV000684133] Chr20:7604120..14739025 [GRCh37]
Chr20:20p12.3-12.1
pathogenic
GRCh37/hg19 20p13-12.1(chr20:3092739-17091453)x1 copy number loss not provided [RCV000684134] Chr20:3092739..17091453 [GRCh37]
Chr20:20p13-12.1
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62948788)x3 copy number gain not provided [RCV000741058] Chr20:63244..62948788 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62961294)x3 copy number gain not provided [RCV000741059] Chr20:63244..62961294 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p12.2(chr20:9737413-9876688)x3 copy number gain not provided [RCV000741101] Chr20:9737413..9876688 [GRCh37]
Chr20:20p12.2
benign
GRCh37/hg19 20p12.2(chr20:9737413-9885653)x4 copy number gain not provided [RCV000741102] Chr20:9737413..9885653 [GRCh37]
Chr20:20p12.2
benign
GRCh37/hg19 20p13-q13.33(chr20:63244-62912463)x3 copy number gain not provided [RCV000741057] Chr20:63244..62912463 [GRCh37]
Chr20:20p13-q13.33
pathogenic
NM_020341.4(PAK5):c.1807T>C (p.Leu603=) single nucleotide variant not provided [RCV000968402] Chr20:9544431 [GRCh38]
Chr20:9525078 [GRCh37]
Chr20:20p12.2
benign
NM_177990.4(PAK5):c.999C>T (p.Tyr333=) single nucleotide variant not provided [RCV000948032] Chr20:9566376 [GRCh38]
Chr20:9547023 [GRCh37]
Chr20:20p12.2
benign
NM_177990.4(PAK5):c.648G>A (p.Lys216=) single nucleotide variant not provided [RCV000948033] Chr20:9580487 [GRCh38]
Chr20:9561134 [GRCh37]
Chr20:20p12.2
benign
GRCh37/hg19 20p12.2(chr20:9736492-9881109)x3 copy number gain not provided [RCV000849881] Chr20:9736492..9881109 [GRCh37]
Chr20:20p12.2
uncertain significance
GRCh37/hg19 20p12.2(chr20:9736492-9886643)x3 copy number gain not provided [RCV000849659] Chr20:9736492..9886643 [GRCh37]
Chr20:20p12.2
uncertain significance
GRCh37/hg19 20p12.2(chr20:9736492-9886643)x4 copy number gain not provided [RCV000846657] Chr20:9736492..9886643 [GRCh37]
Chr20:20p12.2
uncertain significance
GRCh37/hg19 20p12.2(chr20:9736492-9886643)x3 copy number gain not provided [RCV000847978] Chr20:9736492..9886643 [GRCh37]
Chr20:20p12.2
uncertain significance
GRCh37/hg19 20p12.3-11.22(chr20:8571696-22088650)x1 copy number loss not provided [RCV001007080] Chr20:8571696..22088650 [GRCh37]
Chr20:20p12.3-11.22
pathogenic
GRCh37/hg19 20p12.2(chr20:9736492-9881437)x3 copy number gain not provided [RCV000846130] Chr20:9736492..9881437 [GRCh37]
Chr20:20p12.2
uncertain significance
NM_020341.4(PAK5):c.516A>G (p.Val172=) single nucleotide variant not provided [RCV000972961] Chr20:9580619 [GRCh38]
Chr20:9561266 [GRCh37]
Chr20:20p12.2
benign
GRCh37/hg19 20p13-11.1(chr20:61568-26305479)x3 copy number gain not provided [RCV001007068] Chr20:61568..26305479 [GRCh37]
Chr20:20p13-11.1
pathogenic
GRCh37/hg19 20p12.3-12.2(chr20:9017816-9752893)x3 copy number gain not provided [RCV001007082] Chr20:9017816..9752893 [GRCh37]
Chr20:20p12.3-12.2
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:15916 AgrOrtholog
COSMIC PAK5 COSMIC
Ensembl Genes ENSG00000101349 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000322957 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000367679 UniProtKB/Swiss-Prot
  ENSP00000367686 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000353224 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000378423 UniProtKB/Swiss-Prot
  ENST00000378429 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.810.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000101349 GTEx
HGNC ID HGNC:15916 ENTREZGENE
Human Proteome Map PAK5 Human Proteome Map
InterPro CRIB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRIB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAK5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAK_BD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:57144 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 57144 ENTREZGENE
OMIM 608038 OMIM
PANTHER PTHR45832:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA32922 PharmGKB
PROSITE CRIB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B0AZM9 ENTREZGENE, UniProtKB/TrEMBL
  PAK5_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A8K5T6 UniProtKB/Swiss-Prot
  D3DW14 UniProtKB/Swiss-Prot
  Q5W115 UniProtKB/Swiss-Prot
  Q8TB93 UniProtKB/Swiss-Prot
  Q9BX09 UniProtKB/Swiss-Prot
  Q9ULF6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-14 PAK5  p21 (RAC1) activated kinase 5  PAK7  p21 (RAC1) activated kinase 7  Symbol and/or name change 5135510 APPROVED
2016-05-10 PAK7  p21 (RAC1) activated kinase 7  PAK7  p21 protein (Cdc42/Rac)-activated kinase 7  Symbol and/or name change 5135510 APPROVED