HBEGF (heparin binding EGF like growth factor) - Rat Genome Database

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Gene: HBEGF (heparin binding EGF like growth factor) Homo sapiens
Analyze
Symbol: HBEGF
Name: heparin binding EGF like growth factor
RGD ID: 1605733
HGNC Page HGNC
Description: Enables growth factor activity; heparin binding activity; and transmembrane receptor protein tyrosine kinase activator activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; positive regulation of protein kinase B signaling; and positive regulation of wound healing. Located in cell surface. Is active in extracellular space. Implicated in glomerulosclerosis and perinatal necrotizing enterocolitis.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor); DTR; DTS; DTSF; HEGFL; heparin-binding EGF-like growth factor; heparin-binding epidermal growth factor; proheparin-binding EGF-like growth factor
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385140,332,843 - 140,346,603 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5140,332,843 - 140,346,603 (-)EnsemblGRCh38hg38GRCh38
GRCh375139,712,428 - 139,726,188 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365139,692,612 - 139,706,358 (-)NCBINCBI36hg18NCBI36
Celera5135,789,059 - 135,802,819 (-)NCBI
Cytogenetic Map5q31.3NCBI
HuRef5134,857,589 - 134,871,349 (-)NCBIHuRef
CHM1_15139,145,572 - 139,159,324 (-)NCBICHM1_1
T2T-CHM13v2.05140,858,275 - 140,872,035 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
1,10-phenanthroline  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,7-dihydropurine-6-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
9-cis-retinoic acid  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-retinal  (EXP)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
alpha-pinene  (EXP)
alprenolol  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apigenin  (EXP)
aripiprazole  (ISO)
aristolochic acid  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
atorvastatin calcium  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
beraprost  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bromobenzene  (ISO)
butan-1-ol  (EXP)
butanal  (EXP)
butane-2,3-dione  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
calcitriol  (EXP)
cannabidiol  (EXP)
capsaicin  (ISO)
carbamazepine  (EXP)
carbon nanotube  (EXP,ISO)
carvedilol  (EXP)
CGP 52608  (EXP)
chloropicrin  (EXP)
cholesterol  (EXP)
choline  (ISO)
chondroitin sulfate  (EXP)
chromium(6+)  (EXP)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
crizotinib  (EXP)
crocidolite asbestos  (EXP)
cyanidin cation  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
cypermethrin  (ISO)
D-glucose  (ISO)
dermatan sulfate  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
diclofenac  (EXP,ISO)
dimethylarsinous acid  (EXP)
dioxygen  (EXP,ISO)
diprotium oxide  (EXP)
disulfiram  (EXP)
divanadium pentaoxide  (EXP)
dobutamine  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
erlotinib hydrochloride  (EXP)
ethanol  (EXP,ISO)
etoposide  (EXP)
fenamidone  (ISO)
fenvalerate  (ISO)
ferric oxide  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
furan  (ISO)
gefitinib  (EXP,ISO)
gentamycin  (ISO)
glucose  (ISO)
graphite  (ISO)
Heptachlor epoxide  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
irinotecan  (EXP)
isotretinoin  (EXP)
L-methionine  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
leflunomide  (EXP)
Licochalcone B  (EXP)
lipopolysaccharide  (EXP,ISO)
luteolin  (EXP)
medroxyprogesterone acetate  (EXP)
mercaptopurine  (ISO)
mercury dichloride  (ISO)
methoxychlor  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
mifepristone  (ISO)
Muraglitazar  (ISO)
myricetin  (EXP)
N-acetyl-L-cysteine  (EXP)
N-Nitrosopyrrolidine  (EXP)
naphthalenes  (ISO)
nickel atom  (EXP)
nitrofen  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
pentanal  (EXP)
pentane-2,3-dione  (ISO)
perfluoroundecanoic acid  (EXP)
phenobarbital  (EXP)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pirinixic acid  (ISO)
potassium chromate  (EXP)
potassium cyanide  (ISO)
propanal  (EXP)
purine-6-thiol  (ISO)
quercetin  (EXP)
rac-lactic acid  (EXP)
raloxifene  (EXP)
reactive oxygen species  (EXP,ISO)
Rebamipide  (ISO)
rifampicin  (EXP)
SB 203580  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
sodium dichromate  (ISO)
Soman  (ISO)
succimer  (ISO)
sucrose  (EXP)
sunitinib  (EXP)
tamoxifen  (EXP)
tebuconazole  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
Tetramethylthiourea  (ISO)
thapsigargin  (EXP)
thimerosal  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (EXP,ISO)
undecane  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vanadyl sulfate  (EXP)
versicolorin A  (EXP)
water  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Comparison of epidermal growth factor and heparin-binding epidermal growth factor-like growth factor for prevention of experimental necrotizing enterocolitis. Dvorak B, etal., J Pediatr Gastroenterol Nutr. 2008 Jul;47(1):11-8. doi: 10.1097/MPG.0b013e3181788618.
2. Control of the epidermal growth factor receptor and its ligands during renal injury. Hise MK, etal., Nephron. 2001 May;88(1):71-9.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
7. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Singh AB and Harris RC, Cell Signal. 2005 Oct;17(10):1183-93.
8. Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. Wharram BL, etal., J Am Soc Nephrol 2005 Oct;16(10):2941-52. Epub 2005 Aug 17.
9. Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle. Zhang H, etal., Circ Res. 2004 Nov 12;95(10):989-97. Epub 2004 Oct 14.
Additional References at PubMed
PMID:1556128   PMID:1577791   PMID:1840698   PMID:1939101   PMID:3436221   PMID:7532176   PMID:7590736   PMID:7836353   PMID:8051092   PMID:8060360   PMID:8125298   PMID:8194524  
PMID:8300582   PMID:8347598   PMID:8702723   PMID:9135143   PMID:9659904   PMID:10576204   PMID:10749879   PMID:11125426   PMID:11340068   PMID:11432822   PMID:11735113   PMID:11761337  
PMID:11769972   PMID:11825873   PMID:11846885   PMID:11920609   PMID:11922634   PMID:11943653   PMID:11983897   PMID:12070119   PMID:12095415   PMID:12099696   PMID:12112577   PMID:12149405  
PMID:12163414   PMID:12230876   PMID:12466384   PMID:12477932   PMID:12568494   PMID:12612909   PMID:12725245   PMID:12743035   PMID:12768307   PMID:12835543   PMID:12882762   PMID:12952982  
PMID:12958167   PMID:14573593   PMID:14597771   PMID:14634113   PMID:14738873   PMID:14764442   PMID:15062539   PMID:15169883   PMID:15219838   PMID:15274392   PMID:15289334   PMID:15331606  
PMID:15358134   PMID:15372022   PMID:15389565   PMID:15489334   PMID:15509542   PMID:15562026   PMID:15755902   PMID:15827558   PMID:15979989   PMID:15988409   PMID:16034135   PMID:16407398  
PMID:16470170   PMID:16557002   PMID:16687414   PMID:16837648   PMID:16901467   PMID:16923819   PMID:16996055   PMID:17001310   PMID:17392284   PMID:17472728   PMID:17525275   PMID:17548351  
PMID:17637826   PMID:17654528   PMID:17655843   PMID:17668298   PMID:17717322   PMID:17855771   PMID:17928891   PMID:17960400   PMID:17962208   PMID:18093224   PMID:18463770   PMID:18686008  
PMID:18691754   PMID:18725202   PMID:18852147   PMID:18925469   PMID:18929421   PMID:19064678   PMID:19127210   PMID:19218109   PMID:19337254   PMID:19389413   PMID:19559571   PMID:19609315  
PMID:19671876   PMID:19682489   PMID:19913121   PMID:19919524   PMID:19961362   PMID:19996587   PMID:20130271   PMID:20131286   PMID:20332144   PMID:20351696   PMID:20424473   PMID:20586269  
PMID:20628086   PMID:20739660   PMID:20847549   PMID:20856931   PMID:20889674   PMID:20946474   PMID:21386996   PMID:21413023   PMID:21640162   PMID:21788507   PMID:21873635   PMID:22009535  
PMID:22110740   PMID:22136955   PMID:22209887   PMID:22291012   PMID:22319602   PMID:22402363   PMID:22592159   PMID:22646534   PMID:22718294   PMID:23146907   PMID:23277101   PMID:23349913  
PMID:23376846   PMID:23443317   PMID:23589494   PMID:23597914   PMID:23598347   PMID:23787814   PMID:23907942   PMID:23917679   PMID:24008408   PMID:24013225   PMID:24038577   PMID:24043629  
PMID:24116709   PMID:24346967   PMID:24828490   PMID:25138066   PMID:25201063   PMID:25359857   PMID:25510766   PMID:25517307   PMID:25589361   PMID:25717241   PMID:26572150   PMID:26974561  
PMID:26980026   PMID:27097072   PMID:27243144   PMID:27496793   PMID:27576135   PMID:27701455   PMID:27888810   PMID:28013056   PMID:28174207   PMID:28183528   PMID:28368403   PMID:28498437  
PMID:28668900   PMID:28731464   PMID:28746898   PMID:28953531   PMID:28970067   PMID:28988771   PMID:29044628   PMID:29502423   PMID:29581578   PMID:29970572   PMID:30285805   PMID:30415904  
PMID:30451982   PMID:30610007   PMID:31036568   PMID:31182584   PMID:31799884   PMID:31882563   PMID:32077785   PMID:32296111   PMID:32627036   PMID:32814053   PMID:33009641   PMID:33400994  
PMID:33961781   PMID:34475044   PMID:34814928  


Genomics

Comparative Map Data
HBEGF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385140,332,843 - 140,346,603 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5140,332,843 - 140,346,603 (-)EnsemblGRCh38hg38GRCh38
GRCh375139,712,428 - 139,726,188 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365139,692,612 - 139,706,358 (-)NCBINCBI36hg18NCBI36
Celera5135,789,059 - 135,802,819 (-)NCBI
Cytogenetic Map5q31.3NCBI
HuRef5134,857,589 - 134,871,349 (-)NCBIHuRef
CHM1_15139,145,572 - 139,159,324 (-)NCBICHM1_1
T2T-CHM13v2.05140,858,275 - 140,872,035 (-)NCBI
Hbegf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391836,637,980 - 36,648,858 (-)NCBIGRCm39mm39
GRCm39 Ensembl1836,637,980 - 36,648,858 (-)Ensembl
GRCm381836,504,927 - 36,515,805 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1836,504,927 - 36,515,805 (-)EnsemblGRCm38mm10GRCm38
MGSCv371836,664,581 - 36,675,459 (-)NCBIGRCm37mm9NCBIm37
MGSCv361836,630,906 - 36,641,748 (-)NCBImm8
Celera1836,954,561 - 36,965,476 (-)NCBICelera
Cytogenetic Map18B2NCBI
cM Map1819.46NCBI
Hbegf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21828,106,284 - 28,116,167 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1828,105,760 - 28,116,441 (-)Ensembl
Rnor_6.01829,330,302 - 29,340,185 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1829,329,764 - 29,340,403 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01829,036,863 - 29,046,746 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41829,143,567 - 29,153,944 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11829,170,212 - 29,180,590 (-)NCBI
Celera1827,834,537 - 27,844,179 (-)NCBICelera
Cytogenetic Map18p11NCBI
Hbegf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955418309,096 - 321,387 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955418259,860 - 321,340 (+)NCBIChiLan1.0ChiLan1.0
HBEGF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15141,816,402 - 141,830,531 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5141,816,402 - 141,830,531 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05135,699,553 - 135,713,366 (-)NCBIMhudiblu_PPA_v0panPan3
HBEGF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1235,551,248 - 35,563,310 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl235,551,250 - 35,563,043 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha232,590,448 - 32,601,580 (-)NCBI
ROS_Cfam_1.0236,006,883 - 36,018,938 (-)NCBI
ROS_Cfam_1.0 Ensembl236,006,888 - 36,018,924 (-)Ensembl
UMICH_Zoey_3.1233,058,605 - 33,070,652 (-)NCBI
UNSW_CanFamBas_1.0233,926,053 - 33,938,108 (-)NCBI
UU_Cfam_GSD_1.0234,678,980 - 34,691,039 (-)NCBI
Hbegf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213152,266,443 - 152,278,566 (+)NCBI
SpeTri2.0NW_0049365319,332,939 - 9,345,039 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HBEGF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2142,102,456 - 142,115,344 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12142,102,455 - 142,115,192 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22148,047,629 - 148,058,091 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HBEGF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12342,981,640 - 42,995,116 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2342,981,640 - 42,994,995 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603434,887,898 - 34,902,819 (+)NCBIVero_WHO_p1.0
Hbegf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474333,112,036 - 33,124,169 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462474333,112,105 - 33,124,145 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
STS-M60278  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375139,712,493 - 139,712,619UniSTSGRCh37
Build 365139,692,677 - 139,692,803RGDNCBI36
Celera5135,789,124 - 135,789,250RGD
Cytogenetic Map5q23UniSTS
HuRef5134,857,654 - 134,857,780UniSTS
GeneMap99-GB4 RH Map5531.62UniSTS
NCBI RH Map5889.1UniSTS
RH93352  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375139,725,877 - 139,726,054UniSTSGRCh37
Build 365139,706,061 - 139,706,238RGDNCBI36
Celera5135,802,508 - 135,802,685RGD
Cytogenetic Map5q23UniSTS
GeneMap99-GB4 RH Map5531.62UniSTS
D5S2374  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375139,713,556 - 139,713,673UniSTSGRCh37
Build 365139,693,740 - 139,693,857RGDNCBI36
Celera5135,790,187 - 135,790,304RGD
Cytogenetic Map5q23UniSTS
HuRef5134,858,717 - 134,858,834UniSTS
TNG Radiation Hybrid Map564628.0UniSTS
Stanford-G3 RH Map55251.0UniSTS
GeneMap99-G3 RH Map55339.0UniSTS
DTR_582  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375139,712,332 - 139,713,218UniSTSGRCh37
Build 365139,692,516 - 139,693,402RGDNCBI36
Celera5135,788,963 - 135,789,849RGD
HuRef5134,857,493 - 134,858,379UniSTS
G10624  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375139,713,335 - 139,713,550UniSTSGRCh37
Build 365139,693,519 - 139,693,734RGDNCBI36
Celera5135,789,966 - 135,790,181RGD
Cytogenetic Map5q23UniSTS
HuRef5134,858,496 - 134,858,711UniSTS
RH65265  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375139,712,513 - 139,712,632UniSTSGRCh37
Build 365139,692,697 - 139,692,816RGDNCBI36
Celera5135,789,144 - 135,789,263RGD
Cytogenetic Map5q23UniSTS
HuRef5134,857,674 - 134,857,793UniSTS
GeneMap99-GB4 RH Map5531.62UniSTS
NCBI RH Map5889.1UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR132hsa-miR-132-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI21853268
MIR132hsa-miR-132-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22310291
MIR132hsa-miR-132-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)17612493

Predicted Target Of
Summary Value
Count of predictions:1482
Count of miRNA genes:730
Interacting mature miRNAs:835
Transcripts:ENST00000230990, ENST00000482211, ENST00000498452, ENST00000507104
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 1
Medium 1616 2046 978 185 547 72 3420 1417 2167 230 995 1433 125 1168 2178 1
Low 816 826 741 433 1183 388 935 776 1541 188 452 172 46 36 610 2
Below cutoff 112 4 4 198 4 1 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000230990   ⟹   ENSP00000230990
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5140,332,843 - 140,346,603 (-)Ensembl
RefSeq Acc Id: ENST00000482211
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5140,333,524 - 140,335,130 (-)Ensembl
RefSeq Acc Id: ENST00000498452
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5140,335,891 - 140,343,062 (-)Ensembl
RefSeq Acc Id: NM_001945   ⟹   NP_001936
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385140,332,843 - 140,346,603 (-)NCBI
GRCh375139,712,428 - 139,726,188 (-)ENTREZGENE
Build 365139,692,612 - 139,706,358 (-)NCBI Archive
HuRef5134,857,589 - 134,871,349 (-)ENTREZGENE
CHM1_15139,145,572 - 139,159,324 (-)NCBI
T2T-CHM13v2.05140,858,275 - 140,872,035 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001936   ⟸   NM_001945
- Peptide Label: precursor
- UniProtKB: Q99075 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000230990   ⟸   ENST00000230990
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99075-F1-model_v2 AlphaFold Q99075 1-208 view protein structure

Promoters
RGD ID:6803244
Promoter ID:HG_KWN:51261
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000317711
Position:
Human AssemblyChrPosition (strand)Source
Build 365139,702,421 - 139,702,921 (-)MPROMDB
RGD ID:6803241
Promoter ID:HG_KWN:51262
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001945,   UC010JFJ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 365139,706,086 - 139,706,586 (-)MPROMDB
RGD ID:6870790
Promoter ID:EPDNEW_H8560
Type:initiation region
Name:HBEGF_1
Description:heparin binding EGF like growth factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385140,346,603 - 140,346,663EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh38/hg38 5q31.2-32(chr5:138871137-145812309)x1 copy number loss See cases [RCV000052142] Chr5:138871137..145812309 [GRCh38]
Chr5:138206826..145191872 [GRCh37]
Chr5:138234725..145172065 [NCBI36]
Chr5:5q31.2-32
pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2
pathogenic
GRCh38/hg38 5q31.2-31.3(chr5:137836682-140696361)x3 copy number gain See cases [RCV000134725] Chr5:137836682..140696361 [GRCh38]
Chr5:137172371..140075946 [GRCh37]
Chr5:137200270..140056130 [NCBI36]
Chr5:5q31.2-31.3
pathogenic
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh38/hg38 5q31.2-31.3(chr5:138942857-144605017)x3 copy number gain See cases [RCV000142806] Chr5:138942857..144605017 [GRCh38]
Chr5:138278546..143984580 [GRCh37]
Chr5:138306445..143964773 [NCBI36]
Chr5:5q31.2-31.3
uncertain significance
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3
likely benign
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3
pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV002231249]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2
pathogenic
GRCh37/hg19 5q31.2-31.3(chr5:139147238-141540491)x1 copy number loss not provided [RCV000682600] Chr5:139147238..141540491 [GRCh37]
Chr5:5q31.2-31.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance
GRCh37/hg19 5q31.2-31.3(chr5:139447779-140047037)x3 copy number gain not provided [RCV000846756] Chr5:139447779..140047037 [GRCh37]
Chr5:5q31.2-31.3
uncertain significance
NC_000005.9:g.(?_136633338)_(140998481_?)dup duplication Autosomal dominant nonsyndromic hearing loss 1 [RCV001319817]|PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome [RCV001339088] Chr5:136633338..140998481 [GRCh37]
Chr5:5q31.2-31.3
uncertain significance
GRCh37/hg19 5q31.2-31.3(chr5:139493717-140517454)x1 copy number loss PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome [RCV001801202] Chr5:139493717..140517454 [GRCh37]
Chr5:5q31.2-31.3
pathogenic
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910) copy number gain not specified [RCV002053526] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3059 AgrOrtholog
COSMIC HBEGF COSMIC
Ensembl Genes ENSG00000113070 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000230990 ENTREZGENE
  ENSP00000230990.6 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000230990 ENTREZGENE
  ENST00000230990.7 UniProtKB/Swiss-Prot
GTEx ENSG00000113070 GTEx
HGNC ID HGNC:3059 ENTREZGENE
Human Proteome Map HBEGF Human Proteome Map
InterPro EGF-like_dom UniProtKB/Swiss-Prot
  EGF_rcpt_ligand UniProtKB/Swiss-Prot
KEGG Report hsa:1839 UniProtKB/Swiss-Prot
NCBI Gene 1839 ENTREZGENE
OMIM 126150 OMIM
PANTHER PTHR10740 UniProtKB/Swiss-Prot
Pfam EGF UniProtKB/Swiss-Prot
PharmGKB PA27513 PharmGKB
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
UniProt HBEGF_HUMAN UniProtKB/Swiss-Prot
  Q1HK36_HUMAN UniProtKB/TrEMBL
  Q99075 ENTREZGENE
UniProt Secondary B2R821 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 HBEGF  heparin binding EGF like growth factor    heparin-binding EGF-like growth factor  Symbol and/or name change 5135510 APPROVED