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Gene: Hsd11b1 (hydroxysteroid 11-beta dehydrogenase 1) Rattus norvegicus
Symbol: Hsd11b1
Name: hydroxysteroid 11-beta dehydrogenase 1
Description: Exhibits 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity; NADP binding activity; and steroid binding activity. Involved in several processes, including cellular response to estradiol stimulus; glucocorticoid metabolic process; and regulation of pentose-phosphate shunt. Localizes to apical part of cell; nuclear membrane; and rough endoplasmic reticulum. Used to study obesity. Biomarker of familial hyperlipidemia; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in cortisone reductase deficiency and cortisone reductase deficiency 2. Orthologous to human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 11-dehydrocorticosterone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 11-beta-HSD1; 11-beta-hydroxysteroid dehydrogenase 1; 11-beta-hydroxysteroid dehydrogenase, type 1; 11-DH; 11beta-HSD1; corticosteroid 11-beta-dehydrogenase isozyme 1; cortocosteroid 11-beta dehydrogenase; hydroxysteroid dehydrogenase 11 beta type 1; hydroxysteroid dehydrogenase, 11 beta type 1; LRRGT00065
Homo sapiens (human) : HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1)  HGNC  Alliance
Mus musculus (house mouse) : Hsd11b1 (hydroxysteroid 11-beta dehydrogenase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsd11b1 (hydroxysteroid 11-beta dehydrogenase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1)
Canis lupus familiaris (dog) : HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsd11b1 (hydroxysteroid 11-beta dehydrogenase 1)
Sus scrofa (pig) : HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1)
Chlorocebus sabaeus (African green monkey) : HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1)
Heterocephalus glaber (naked mole-rat) : Hsd11b1 (hydroxysteroid 11-beta dehydrogenase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.013111,946,626 - 111,996,536 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13111,926,442 - 111,972,603 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013116,502,230 - 116,551,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413109,063,491 - 109,089,468 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.113109,252,609 - 109,278,318 (-)NCBI
Celera13104,178,893 - 104,204,865 (-)NCBICelera
Cytogenetic Map13q27NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Hsd11b1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2834
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.