Hsd11b1 (hydroxysteroid 11-beta dehydrogenase 1) - Rat Genome Database

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Gene: Hsd11b1 (hydroxysteroid 11-beta dehydrogenase 1) Rattus norvegicus
Analyze
Symbol: Hsd11b1
Name: hydroxysteroid 11-beta dehydrogenase 1
RGD ID: 2834
Description: Enables 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity; NADP binding activity; and steroid binding activity. Involved in several processes, including cellular response to estradiol stimulus; glucocorticoid metabolic process; and regulation of pentose-phosphate shunt. Located in apical part of cell; nuclear membrane; and rough endoplasmic reticulum. Used to study obesity. Biomarker of familial hyperlipidemia; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in cortisone reductase deficiency and cortisone reductase deficiency 2. Orthologous to human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 11-dehydrocorticosterone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 11-beta-HSD1; 11-beta-hydroxysteroid dehydrogenase 1; 11-beta-hydroxysteroid dehydrogenase, type 1; 11-DH; 11beta-HSD1; corticosteroid 11-beta-dehydrogenase isozyme 1; cortocosteroid 11-beta dehydrogenase; hydroxysteroid dehydrogenase 11 beta type 1; hydroxysteroid dehydrogenase, 11 beta type 1; LRRGT00065
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.213104,728,539 - 104,798,884 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl13111,926,442 - 111,972,603 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.013111,946,626 - 111,996,536 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013116,502,230 - 116,551,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413109,063,491 - 109,089,468 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.113109,252,609 - 109,278,318 (-)NCBI
Celera13104,178,893 - 104,204,865 (-)NCBICelera
Cytogenetic Map13q27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
11-dehydrocorticosterone  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
7-oxolithocholic acid  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (EXP)
androstane-3,17-diol  (ISO)
arsenic acid  (ISO)
azathioprine  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) adipate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (EXP)
caffeine  (EXP)
calcitriol  (ISO)
CARBENOXOLONE  (EXP,ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
cholic acid  (ISO)
chromium atom  (EXP)
cisplatin  (EXP)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
corticosterone  (EXP,ISO)
cortisol  (EXP,ISO)
cortisone  (EXP,ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (EXP)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
Dicyclohexyl phthalate  (EXP)
diethylstilbestrol  (EXP)
disulfiram  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
drospirenone  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (ISO)
fipronil  (ISO)
fluoranthene  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
furosemide  (EXP)
genistein  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycolithocholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
herbicide  (EXP)
hyodeoxycholic acid  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
kainic acid  (ISO)
ketamine  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
mercaptopurine  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
metyrapone  (ISO)
mifepristone  (EXP,ISO)
monosodium L-glutamate  (ISO)
morphine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (EXP,ISO)
NADP(+)  (EXP,ISO)
nickel atom  (ISO)
nicotine  (EXP,ISO)
Nonylphenol  (EXP)
oxaliplatin  (EXP)
oxycodone  (EXP)
p-tert-Amylphenol  (EXP)
p-toluidine  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
perfluorododecanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
Propiverine  (EXP)
prostaglandin E2  (ISO)
purine-6-thiol  (EXP)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
SB 203580  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
spironolactone  (ISO)
sulforaphane  (ISO)
taurolithocholic acid  (ISO)
tauroursodeoxycholic acid  (EXP,ISO)
tenofovir disoproxil fumarate  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (EXP)
trimethyltin  (EXP,ISO)
triphenylstannane  (EXP)
troglitazone  (EXP,ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zearalenone  (EXP)
zidovudine  (ISO)
zinc protoporphyrin  (ISO)
zinc sulfate  (ISO)
ziram  (EXP)
zoledronic acid  (ISO)

References

References - curated
1. Agarwal AK, etal., J Biol Chem 1989 Nov 15;264(32):18939-43.
2. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Brereton PS, etal., Endocrinology. 2001 Apr;142(4):1644-51.
4. Czegle I, etal., Mol Cell Endocrinol. 2006 Mar 27;248(1-2):24-5. Epub 2005 Dec 6.
5. Draper N, etal., Nat Genet. 2003 Aug;34(4):434-9.
6. Duplomb L, etal., Biochem Biophys Res Commun. 2004 Jan 16;313(3):594-9.
7. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Ge RS, etal., Endocrinology. 2005 Jun;146(6):2657-64. Epub 2005 Mar 10.
9. Ge RS, etal., Mol Cell Endocrinol. 2005 Nov 24;243(1-2):35-42. Epub 2005 Sep 26.
10. KEGG
11. Kwong WY, etal., Mol Reprod Dev. 2007 Jan;74(1):48-56.
12. Li RS, etal., Metabolism. 2004 May;53(5):600-6.
13. Mariniello B, etal., Eur J Endocrinol. 2006 Sep;155(3):435-41.
14. Masuzaki H, etal., Science 2001 Dec 7;294(5549):2166-70.
15. McCormick KL, etal., J Biol Chem. 2006 Jan 6;281(1):341-7. Epub 2005 Oct 18.
16. MGD data from the GO Consortium
17. NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Nobel CS, etal., Protein Expr Purif. 2002 Dec;26(3):349-56.
19. OMIM Disease Annotation Pipeline
20. Pacha J, etal., Steroids 2002 Feb;67(2):119-26.
21. Pipeline to import KEGG annotations from KEGG into RGD
22. Pipeline to import SMPDB annotations from SMPDB into RGD
23. RGD automated data pipeline
24. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. RGD automated import pipeline for gene-chemical interactions
26. Ruiz N, etal., Brain Res. 2011 Dec 2;1426:86-95. Epub 2011 Oct 8.
27. Sheppard KE and Autelitano DJ, Endocrinology 2002 Jan;143(1):198-204.
28. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
29. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
30. Tagawa N, etal., J Endocrinol. 2009 Jul;202(1):131-9. Epub 2009 Apr 20.
31. Waddell BJ, etal., Endocrinology. 2003 Jul;144(7):3101-6.
32. Xiao-feng Z, etal., Int J Toxicol. 2009 Sep-Oct;28(5):448-56.
Additional References at PubMed
PMID:1417845   PMID:1508221   PMID:1733955   PMID:3460996   PMID:8940387   PMID:10497248   PMID:10906322   PMID:12439781   PMID:12700160   PMID:12810555   PMID:14599119   PMID:14973125  
PMID:15095019   PMID:15152005   PMID:15489334   PMID:15512857   PMID:15513927   PMID:15862976   PMID:17070044   PMID:17303657   PMID:17332068   PMID:17919905   PMID:18029473   PMID:18039793  
PMID:18069989   PMID:18187395   PMID:18379559   PMID:18485702   PMID:18550363   PMID:18553955   PMID:18716005   PMID:18826995   PMID:19009916   PMID:19118409   PMID:19208548   PMID:19217779  
PMID:19583995   PMID:19766266   PMID:19946888   PMID:20016029   PMID:20130180   PMID:20358345   PMID:20484633   PMID:20932307   PMID:21083914   PMID:21163329   PMID:21440566   PMID:21513799  
PMID:21696642   PMID:21825133   PMID:21879473   PMID:22142627   PMID:22173247   PMID:22739210   PMID:22792090   PMID:23832962   PMID:23979791   PMID:24397806   PMID:24586766   PMID:25430643  
PMID:26399510   PMID:26528718   PMID:27268236   PMID:33722534  


Genomics

Comparative Map Data
Hsd11b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.213104,728,539 - 104,798,884 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl13111,926,442 - 111,972,603 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.013111,946,626 - 111,996,536 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013116,502,230 - 116,551,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413109,063,491 - 109,089,468 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.113109,252,609 - 109,278,318 (-)NCBI
Celera13104,178,893 - 104,204,865 (-)NCBICelera
Cytogenetic Map13q27NCBI
HSD11B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1209,686,178 - 209,734,949 (+)EnsemblGRCh38hg38GRCh38
GRCh381209,686,179 - 209,734,929 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371209,859,524 - 209,908,274 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361207,926,173 - 207,974,918 (+)NCBINCBI36hg18NCBI36
Build 341206,266,585 - 206,296,690NCBI
Celera1183,090,437 - 183,139,187 (+)NCBI
Cytogenetic Map1q32.2NCBI
HuRef1180,534,794 - 180,583,575 (+)NCBIHuRef
CHM1_11211,131,921 - 211,180,673 (+)NCBICHM1_1
Hsd11b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391192,903,948 - 192,946,353 (-)NCBIGRCm39mm39
GRCm39 Ensembl1192,903,942 - 192,946,383 (-)Ensembl
GRCm381193,221,640 - 193,264,045 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1193,221,634 - 193,264,075 (-)EnsemblGRCm38mm10GRCm38
MGSCv371195,047,834 - 195,090,239 (-)NCBIGRCm37mm9NCBIm37
MGSCv361194,922,413 - 194,964,769 (-)NCBImm8
Celera1200,096,784 - 200,141,189 (-)NCBICelera
Cytogenetic Map1H6NCBI
Hsd11b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554892,497,680 - 2,524,805 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554892,500,928 - 2,524,715 (-)NCBIChiLan1.0ChiLan1.0
HSD11B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11190,086,449 - 190,116,765 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1190,086,449 - 190,116,765 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01185,262,599 - 185,311,417 (+)NCBIMhudiblu_PPA_v0panPan3
HSD11B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.178,344,380 - 8,409,901 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl78,344,447 - 8,409,897 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha77,959,522 - 7,986,906 (+)NCBI
ROS_Cfam_1.078,045,319 - 8,110,393 (+)NCBI
UMICH_Zoey_3.178,012,426 - 8,039,787 (+)NCBI
UNSW_CanFamBas_1.078,109,437 - 8,136,847 (+)NCBI
UU_Cfam_GSD_1.078,170,917 - 8,198,302 (+)NCBI
Hsd11b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934466,118,456 - 66,179,043 (-)NCBI
SpeTri2.0NW_0049365573,358,809 - 3,403,461 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSD11B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9133,231,451 - 133,278,396 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19133,231,451 - 133,278,396 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HSD11B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12519,720,096 - 19,772,806 (-)NCBI
ChlSab1.1 Ensembl2519,719,848 - 19,750,200 (-)Ensembl
Vero_WHO_p1.0NW_02366605520,319,360 - 20,369,697 (-)NCBI
Hsd11b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248072,260,702 - 2,293,962 (-)NCBI

Position Markers
D13Wox22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213104,772,782 - 104,772,955 (+)MAPPERmRatBN7.2
Rnor_6.013111,970,579 - 111,970,751NCBIRnor6.0
Rnor_5.013116,526,349 - 116,526,521UniSTSRnor5.0
RGSC_v3.413109,087,444 - 109,087,616UniSTSRGSC3.4
Celera13104,202,844 - 104,203,016UniSTS
Cytogenetic Map13q27UniSTS
X83202  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213104,749,033 - 104,749,159 (+)MAPPERmRatBN7.2
Rnor_6.013111,946,831 - 111,946,956NCBIRnor6.0
Rnor_5.013116,502,435 - 116,502,560UniSTSRnor5.0
RGSC_v3.413109,063,696 - 109,063,821UniSTSRGSC3.4
Celera13104,179,098 - 104,179,223UniSTS
Cytogenetic Map13q27UniSTS
AU048742  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14q11UniSTS
Cytogenetic Map13q27UniSTS
Cytogenetic Map13q24UniSTS
Cytogenetic Map20q11UniSTS
RH128149  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213104,748,954 - 104,749,140 (+)MAPPERmRatBN7.2
Rnor_6.013111,946,752 - 111,946,937NCBIRnor6.0
Rnor_5.013116,502,356 - 116,502,541UniSTSRnor5.0
RGSC_v3.413109,063,617 - 109,063,802UniSTSRGSC3.4
Celera13104,179,019 - 104,179,204UniSTS
RH 3.4 Map13760.1UniSTS
Cytogenetic Map13q27UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:293
Count of miRNA genes:182
Interacting mature miRNAs:209
Transcripts:ENSRNOT00000007870, ENSRNOT00000048074
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 11 43 27 19 27 8 8 27 17 17 11 8
Low 32 14 14 14 3 47 18 24
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC126166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF542063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY387051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK474613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y10420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000007870   ⟹   ENSRNOP00000007870
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl13111,946,630 - 111,972,603 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000048074   ⟹   ENSRNOP00000050581
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl13111,926,442 - 111,948,753 (-)Ensembl
RefSeq Acc Id: NM_017080   ⟹   NP_058776
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213104,748,829 - 104,774,809 (-)NCBI
Rnor_6.013111,946,626 - 111,972,603 (-)NCBI
Rnor_5.013116,502,230 - 116,551,778 (-)NCBI
RGSC_v3.413109,063,491 - 109,089,468 (-)RGD
Celera13104,178,893 - 104,204,865 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250473   ⟹   XP_006250535
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213104,748,829 - 104,798,770 (-)NCBI
Rnor_6.013111,946,626 - 111,996,536 (-)NCBI
Rnor_5.013116,502,230 - 116,551,778 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090374   ⟹   XP_038946302
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213104,728,539 - 104,798,884 (-)NCBI
RefSeq Acc Id: XM_039090376   ⟹   XP_038946304
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213104,748,829 - 104,788,638 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_058776   ⟸   NM_017080
- UniProtKB: P16232 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006250535   ⟸   XM_006250473
- Peptide Label: isoform X2
- UniProtKB: P16232 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000050581   ⟸   ENSRNOT00000048074
RefSeq Acc Id: ENSRNOP00000007870   ⟸   ENSRNOT00000007870
RefSeq Acc Id: XP_038946302   ⟸   XM_039090374
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946304   ⟸   XM_039090376
- Peptide Label: isoform X2
Protein Domains
Reverse transcriptase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699127
Promoter ID:EPDNEW_R9652
Type:multiple initiation site
Name:Hsd11b1_1
Description:hydroxysteroid 11-beta dehydrogenase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013111,972,368 - 111,972,428EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2834 AgrOrtholog
Ensembl Genes ENSRNOG00000005861 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000007870 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000050581 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007870 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000048074 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.1820 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109256 IMAGE-MGC_LOAD
InterPro DNA/RNA_pol_sf UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RVT UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transposase_L1_sf UniProtKB/TrEMBL
KEGG Report rno:25116 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93529 IMAGE-MGC_LOAD
NCBI Gene 25116 ENTREZGENE
Pfam adh_short UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RVT_1 UniProtKB/TrEMBL
PhenoGen Hsd11b1 PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot
PROSITE ADH_SHORT UniProtKB/Swiss-Prot
  RT_POL UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56672 UniProtKB/TrEMBL
UniProt DHI1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6TUH9_RAT UniProtKB/TrEMBL
UniProt Secondary O09170 UniProtKB/Swiss-Prot
  Q6LDH6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Hsd11b1  hydroxysteroid 11-beta dehydrogenase 1    hydroxysteroid dehydrogenase, 11 beta type 1  Name updated 629478 APPROVED
2002-06-10 Hsd11b1  hydroxysteroid dehydrogenase, 11 beta type 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in both cardiac myocytes and fibroblasts 70436
gene_expression widely expressed 70436
gene_function acts as a reductase converting inactive 11-dehydrocorticosterone to corticosterone 70436
gene_process stimulates serum and glucocorticiod-induced kinase gene 70436