Ccn5 (cellular communication network factor 5) - Rat Genome Database

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Gene: Ccn5 (cellular communication network factor 5) Rattus norvegicus
Analyze
Symbol: Ccn5
Name: cellular communication network factor 5
RGD ID: 621867
Description: Enables integrin binding activity. Involved in negative regulation of cell population proliferation. Located in cell surface; nucleus; and podosome. Orthologous to human CCN5 (cellular communication network factor 5); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CCN family member 5; CCN family protein COP-1; connective tissue growth factor-like protein; CTGF-L; WISP-2; Wisp2; WNT1 inducible signaling pathway protein 2; WNT1-inducible-signaling pathway protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83172,910,670 - 172,922,064 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3172,910,681 - 172,922,062 (+)EnsemblGRCr8
mRatBN7.23152,491,247 - 152,502,639 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3152,491,220 - 152,502,636 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3156,298,712 - 156,310,080 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03164,797,658 - 164,809,026 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03162,541,812 - 162,553,223 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03160,207,969 - 160,219,316 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,207,913 - 160,219,331 (+)Ensemblrn6Rnor6.0
Rnor_5.03166,397,532 - 166,408,879 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43154,748,977 - 154,760,324 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3151,141,719 - 151,153,066 (+)NCBICelera
RGSC_v3.13154,655,012 - 154,666,360 (+)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1-bromopropane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
26-hydroxycholesterol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
aflatoxin B1  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
apigenin  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
cetrorelix  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
choline  (ISO)
copper(II) chloride  (ISO)
coumestrol  (ISO)
desogestrel  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
dioxygen  (ISO)
endosulfan  (EXP,ISO)
Enterolactone  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fonofos  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
graphite  (EXP)
kaempferol  (ISO)
L-methionine  (ISO)
luteolin  (ISO)
methimazole  (EXP)
methyl methacrylate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
nickel dichloride  (ISO)
nicotine  (ISO)
Nonylphenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phytoestrogen  (ISO)
piroxicam  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
propanal  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
terbufos  (ISO)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
tetradecane  (EXP)
titanium dioxide  (ISO)
triazines  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (EXP)
vinclozolin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. The matricellular protein CCN5 regulates podosome function via interaction with integrin αvβ 3. Myers RB, etal., J Cell Commun Signal. 2014 Jun;8(2):135-46. doi: 10.1007/s12079-013-0218-2. Epub 2014 Feb 2.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. CCN5, a secreted protein, localizes to the nucleus. Wiesman KC, etal., J Cell Commun Signal. 2010 Jun;4(2):91-8. doi: 10.1007/s12079-010-0087-x. Epub 2010 Mar 18.
8. Identification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformation. Zhang R, etal., Mol Cell Biol 1998 Oct;18(10):6131-41.
Additional References at PubMed
PMID:10358067   PMID:12477932   PMID:14605002   PMID:20148653   PMID:23359679   PMID:23376485   PMID:24006456   PMID:24451367   PMID:28167681   PMID:32058630  


Genomics

Comparative Map Data
Ccn5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83172,910,670 - 172,922,064 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3172,910,681 - 172,922,062 (+)EnsemblGRCr8
mRatBN7.23152,491,247 - 152,502,639 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3152,491,220 - 152,502,636 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3156,298,712 - 156,310,080 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03164,797,658 - 164,809,026 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03162,541,812 - 162,553,223 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03160,207,969 - 160,219,316 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,207,913 - 160,219,331 (+)Ensemblrn6Rnor6.0
Rnor_5.03166,397,532 - 166,408,879 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43154,748,977 - 154,760,324 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3151,141,719 - 151,153,066 (+)NCBICelera
RGSC_v3.13154,655,012 - 154,666,360 (+)NCBI
Cytogenetic Map3q42NCBI
CCN5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382044,714,861 - 44,727,811 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2044,714,844 - 44,728,509 (+)Ensemblhg38GRCh38
GRCh372043,343,502 - 43,356,452 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362042,777,299 - 42,789,866 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342042,777,298 - 42,789,865NCBI
Celera2040,052,537 - 40,065,103 (+)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2040,085,492 - 40,097,997 (+)NCBIHuRef
CHM1_12043,246,961 - 43,259,528 (+)NCBICHM1_1
T2T-CHM13v2.02046,450,611 - 46,463,559 (+)NCBIT2T-CHM13v2.0
Ccn5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392163,662,724 - 163,675,066 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2163,662,781 - 163,675,066 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382163,820,752 - 163,833,146 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2163,820,861 - 163,833,146 (+)Ensemblmm10GRCm38
MGSCv372163,646,570 - 163,658,882 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362163,500,029 - 163,524,587 (+)NCBIMGSCv36mm8
Celera2169,759,978 - 169,782,816 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map284.49NCBI
Ccn5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544512,621,972 - 12,639,835 (-)Ensembl
ChiLan1.0NW_00495544512,623,333 - 12,640,127 (-)NCBIChiLan1.0ChiLan1.0
CCN5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22150,447,702 - 50,460,650 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12050,440,873 - 50,453,753 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02041,045,205 - 41,058,137 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12042,139,469 - 42,152,564 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2042,139,551 - 42,152,563 (+)EnsemblpanPan2panpan1.1
CCN5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12432,161,703 - 32,174,573 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2432,161,216 - 32,173,866 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2431,802,577 - 31,815,437 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02432,867,945 - 32,880,802 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2432,867,970 - 32,880,797 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12432,129,556 - 32,142,415 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02432,244,176 - 32,257,046 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02432,785,866 - 32,798,724 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ccn5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640192,544,159 - 192,556,755 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365147,997,697 - 8,010,396 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365147,997,802 - 8,010,378 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCN5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1747,131,501 - 47,146,449 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11747,131,236 - 47,146,455 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21752,668,044 - 52,683,120 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCN5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1219,089,944 - 19,103,051 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl219,088,597 - 19,103,136 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605067,758,317 - 67,771,480 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccn5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247909,744,078 - 9,755,375 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247909,744,127 - 9,755,685 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:284
Count of miRNA genes:177
Interacting mature miRNAs:199
Transcripts:ENSRNOT00000014346
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3166376089177728348Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat

Markers in Region
PMC293470P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23152,501,701 - 152,501,847 (+)MAPPERmRatBN7.2
Rnor_6.03160,218,382 - 160,218,527NCBIRnor6.0
Rnor_5.03166,407,945 - 166,408,090UniSTSRnor5.0
RGSC_v3.43154,759,390 - 154,759,535UniSTSRGSC3.4
Celera3151,152,132 - 151,152,277UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 12 61 134 58 58 27 55 27 6 248 148 11 107 54 84 31 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000014346   ⟹   ENSRNOP00000014346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3172,910,681 - 172,922,060 (+)Ensembl
mRatBN7.2 Ensembl3152,491,250 - 152,502,634 (+)Ensembl
Rnor_6.0 Ensembl3160,207,913 - 160,219,331 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118187   ⟹   ENSRNOP00000096670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3152,491,288 - 152,502,504 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118765   ⟹   ENSRNOP00000088907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3172,910,847 - 172,922,062 (+)Ensembl
mRatBN7.2 Ensembl3152,491,220 - 152,502,636 (+)Ensembl
RefSeq Acc Id: NM_031590   ⟹   NP_113778
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83172,910,691 - 172,922,061 (+)NCBI
mRatBN7.23152,491,268 - 152,502,636 (+)NCBI
Rnor_6.03160,207,969 - 160,219,316 (+)NCBI
Rnor_5.03166,397,532 - 166,408,879 (+)NCBI
RGSC_v3.43154,748,977 - 154,760,324 (+)RGD
Celera3151,141,719 - 151,153,066 (+)RGD
Sequence:
RefSeq Acc Id: XM_039104504   ⟹   XP_038960432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83172,910,670 - 172,922,064 (+)NCBI
mRatBN7.23152,491,247 - 152,502,639 (+)NCBI
Protein Sequences
Protein RefSeqs NP_113778 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960432 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF69011 (Get FASTA)   NCBI Sequence Viewer  
  EDL96560 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014346
GenBank Protein Q9JHC6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113778   ⟸   NM_031590
- Peptide Label: precursor
- UniProtKB: Q9JHC6 (UniProtKB/Swiss-Prot),   G3V7F3 (UniProtKB/TrEMBL),   A6JX49 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014346   ⟸   ENSRNOT00000014346
RefSeq Acc Id: XP_038960432   ⟸   XM_039104504
- Peptide Label: isoform X1
- UniProtKB: Q9JHC6 (UniProtKB/Swiss-Prot),   G3V7F3 (UniProtKB/TrEMBL),   A6JX49 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096670   ⟸   ENSRNOT00000118187
Ensembl Acc Id: ENSRNOP00000088907   ⟸   ENSRNOT00000118765
Protein Domains
IGFBP N-terminal   TSP type-1   VWFC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHC6-F1-model_v2 AlphaFold Q9JHC6 1-250 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692642
Promoter ID:EPDNEW_R3165
Type:initiation region
Name:Wisp2_1
Description:WNT1 inducible signaling pathway protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R3166  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03160,207,955 - 160,208,015EPDNEW
RGD ID:13692643
Promoter ID:EPDNEW_R3166
Type:initiation region
Name:Wisp2_2
Description:WNT1 inducible signaling pathway protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R3165  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03160,208,102 - 160,208,162EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621867 AgrOrtholog
BioCyc Gene G2FUF-46891 BioCyc
Ensembl Genes ENSRNOG00000010666 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000014346 ENTREZGENE
Gene3D-CATH 2.20.100.10 UniProtKB/Swiss-Prot
  Complement Module, domain 1 UniProtKB/Swiss-Prot
InterPro CCN UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  IGFBP-like UniProtKB/Swiss-Prot
  Insulin_GF-bd_Cys-rich_CS UniProtKB/Swiss-Prot
  TSP1_CCN UniProtKB/Swiss-Prot
  TSP1_rpt UniProtKB/Swiss-Prot
  TSP1_rpt_sf UniProtKB/Swiss-Prot
  VWF_dom UniProtKB/Swiss-Prot
KEGG Report rno:29576 UniProtKB/Swiss-Prot
NCBI Gene 29576 ENTREZGENE
PANTHER CCN FAMILY MEMBER 5 UniProtKB/Swiss-Prot
  CONNECTIVE TISSUE GROWTH FACTOR-RELATED UniProtKB/Swiss-Prot
Pfam IGFBP UniProtKB/Swiss-Prot
  TSP1_CCN UniProtKB/Swiss-Prot
  VWC UniProtKB/Swiss-Prot
PhenoGen Ccn5 PhenoGen
PROSITE IGFBP_N_1 UniProtKB/Swiss-Prot
  IGFBP_N_2 UniProtKB/Swiss-Prot
  TSP1 UniProtKB/Swiss-Prot
  VWFC_1 UniProtKB/Swiss-Prot
  VWFC_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010666 RatGTEx
SMART SM00121 UniProtKB/Swiss-Prot
  TSP1 UniProtKB/Swiss-Prot
  VWC UniProtKB/Swiss-Prot
Superfamily-SCOP FnI-like domain UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
  SSF82895 UniProtKB/Swiss-Prot
UniProt A0A8I6AR16_RAT UniProtKB/TrEMBL
  A0A8I6GHL0_RAT UniProtKB/TrEMBL
  A6JX49 ENTREZGENE, UniProtKB/TrEMBL
  G3V7F3 ENTREZGENE, UniProtKB/TrEMBL
  Q9JHC6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-10-23 Ccn5  cellular communication network factor 5  Wisp2  WNT1 inducible signaling pathway protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Wisp2  WNT1 inducible signaling pathway protein 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Wisp2  WNT1 inducible signaling pathway protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the cysteine rich CCN family of growth regulators 634515