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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccn5
Name: cellular communication network factor 5
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13514966480464CTDFulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of CCN5 mRNA], Fulvestrant inhibits the reaction [4, 4'-hexafluorisopropylidene diphenol results in increased expression of CCN5 mRNA], Fulvestrant inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased expression of CCN5 mRNA], Fulvestrant inhibits the reaction [bisphenol A results in increased expression of CCN5 mRNA], Fulvestrant inhibits the reaction [Estradiol results in increased expression of CCN5 mRNA]

PMID:10944450, PMID:17872378, PMID:29389661
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.