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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccn5
Name: cellular communication network factor 5
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of CCN5 mRNA

PMID:25181051
increases expressionISORGD:13514966480464CTDbisphenol A analog results in increased expression of CCN5 mRNA, bisphenol A results in increased expression of CCN5 mRNA

PMID:10944450, PMID:23384675, PMID:24062438, PMID:27685785, PMID:29389661
increases expressionISORGD:7371216480464CTDbisphenol A results in increased expression of CCN5 mRNA

PMID:26063408
multiple interactionsISORGD:13514966480464CTDbisphenol A promotes the reaction [ESR1 protein binds to CCN5 promoter], ESR1 protein affects the reaction [bisphenol A results in increased expression of CCN5 mRNA], ESR1 protein inhibits the reaction [bisphenol A analog results in increased expression of CCN5 mRNA], Fulvestrant inhibits the reaction [bisphenol A results in increased expression of CCN5 mRNA]

PMID:23384675, PMID:29389661
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.