Plat (plasminogen activator, tissue type) - Rat Genome Database

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Gene: Plat (plasminogen activator, tissue type) Rattus norvegicus
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Symbol: Plat
Name: plasminogen activator, tissue type
RGD ID: 3342
Description: Predicted to have phosphoprotein binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; plasminogen activation; and positive regulation of ovulation. Localizes to several cellular components, including glutamatergic synapse; neuronal dense core vesicle; and perisynaptic space. Used to study disseminated intravascular coagulation and status epilepticus. Biomarker of brain edema; middle cerebral artery infarction; sciatic neuropathy; transient cerebral ischemia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; factor VIII deficiency; osteonecrosis; and thrombophilia due to decreased release of PLAT. Orthologous to human PLAT (plasminogen activator, tissue type); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; INTERACTS WITH (+)-catechin; (R)-mevalonic acid; (S)-colchicine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC100910418; PATISS; plasminogen activator, tissue; t-PA; t-plasminogen activator; tissue plasminogen activator; tissue-type plasminogen activator; tissue-type plasminogen activator-like; tPA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21669,240,582 - 69,265,177 (-)NCBI
Rnor_6.0 Ensembl1674,098,260 - 74,122,889 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01674,098,263 - 74,122,897 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01673,730,256 - 73,754,851 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,711,323 - 73,736,328 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11673,711,587 - 73,736,593 (-)NCBI
Celera1667,134,451 - 67,159,047 (-)NCBICelera
RH 3.4 Map16644.8RGD
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
acute promyelocytic leukemia  (ISO)
Acute Traumatic Coagulopathy  (IDA,IEP)
Airway Obstruction  (ISO)
allergic contact dermatitis  (ISO)
amphetamine abuse  (ISO)
angioedema  (ISO)
antiphospholipid syndrome  (ISO)
aphasia  (ISO)
Arterial Occlusive Diseases  (ISO)
Arterial Thrombosis  (ISO)
atherosclerosis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
Back Pain  (ISO)
Bacteremia  (ISO)
blood coagulation disease  (ISO)
brain edema  (IEP,ISO)
brain infarction  (ISO)
brain ischemia  (ISO)
Burns  (ISO)
cardiac tamponade  (ISO)
Cardiogenic Shock  (ISO)
Carotid Artery Injuries  (IEP)
Central Nervous System Viral Diseases  (IEP)
Cerebral Hemorrhage  (IDA,ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholesterol embolism  (ISO)
Chronic Hepatitis  (ISO)
congestive heart failure  (ISO)
coronary thrombosis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
disseminated intravascular coagulation  (IDA,ISO)
Embolism  (ISO)
Embolism and Thrombosis  (ISO)
Endotoxemia  (ISO)
Experimental Liver Cirrhosis  (IDA,ISO)
factor VIII deficiency  (ISO)
Femur Head Necrosis  (ISO)
gestational diabetes  (ISO)
Hematoma, Epidural, Spinal  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhage  (ISO)
hemorrhagic disease  (ISO)
Henoch-Schoenlein purpura  (ISO)
hypertension  (ISO)
Hypotension  (ISO)
Hypoxia  (ISO)
Hypoxia-Ischemia, Brain  (IEP)
Intracranial Embolism and Thrombosis  (ISO)
Intracranial Hemorrhages  (ISO)
intracranial thrombosis  (ISO)
intracranial vasospasm  (ISO)
lactic acidosis  (ISO)
leukopenia  (ISO)
Low Back Pain  (ISO)
meningoencephalitis  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (IEP,ISO)
Multiple Organ Failure  (IEP)
myocardial infarction  (ISO)
Nerve Degeneration  (ISO)
Neurologic Manifestations  (ISO)
Noonan syndrome  (ISO)
obesity  (ISO)
pancreatic adenocarcinoma  (ISO)
Paresis  (ISO)
pericardial effusion  (ISO)
peritonitis  (ISO)
pulmonary embolism  (ISO)
Reperfusion Injury  (IDA,ISO)
respiratory failure  (ISO)
Right Ventricular Hypertrophy  (IEP)
sciatic neuropathy  (IEP)
Sepsis  (IDA)
severe acute respiratory syndrome  (ISO)
Spinal Cord Compression  (ISO)
status epilepticus  (IDA)
Stroke  (ISO)
Subdural Hematoma  (ISO)
thrombocytopenia  (ISO)
Thromboembolism  (ISO)
thrombophilia due to decreased release of PLAT  (ISO)
thrombosis  (ISO)
toxic encephalopathy  (ISO)
transient cerebral ischemia  (IEP)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
Venous Thromboembolism  (ISO)
Venous Thrombosis  (ISO)
Ventricular Dysfunction, Left  (ISO)
von Willebrand's disease 1  (ISO)
Wounds and Injuries  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-mevalonic acid  (EXP,ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (EXP)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
aminoguanidine  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-carotene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bucladesine  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calciol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cycloheximide  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
cytochalasin D  (ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
DDT  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dienogest  (ISO)
diethyl maleate  (EXP,ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
diuron  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (ISO)
edaravone  (EXP)
endosulfan  (EXP)
ethanol  (EXP,ISO)
Ethyl icosapentate  (EXP)
ethylenediaminetetraacetic acid  (ISO)
eugenol  (ISO)
fenbuconazole  (ISO)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
geranylgeraniol  (ISO)
gestodene  (ISO)
glucose  (ISO)
Goe 6976  (ISO)
GW 4064  (ISO)
heparin  (ISO)
icatibant  (ISO)
indometacin  (ISO)
irinotecan  (EXP,ISO)
isobutanol  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ketamine  (EXP)
KT 5823  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP)
levonorgestrel  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP)
lovastatin  (EXP,ISO)
malathion  (ISO)
medroxyprogesterone acetate  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
mifepristone  (EXP,ISO)
mitoxantrone  (ISO)
morphine  (ISO)
N-acetylsphingosine  (ISO)
N-nitrosodimethylamine  (EXP)
naphthalene  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
nonanedioic acid  (ISO)
norgestimate  (ISO)
notoginsenoside R1  (ISO)
oxaliplatin  (EXP)
ozone  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
prednisone  (ISO)
procymidone  (EXP)
progesterone  (ISO)
propanal  (ISO)
protoporphyrin  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
Ro 41-5253  (ISO)
rofecoxib  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP,ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sotalol  (EXP)
spironolactone  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
tacrolimus hydrate  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetraethyllead  (EXP)
tetraphene  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
topotecan  (EXP)
Trapidil  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (EXP)
vitamin E  (EXP)
vorinostat  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
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Additional References at PubMed
PMID:1632457   PMID:1695900   PMID:8186264   PMID:8508955   PMID:12431485   PMID:12694198   PMID:12783121   PMID:14750967   PMID:15019809   PMID:15044208   PMID:15372073   PMID:15486301  
PMID:15489334   PMID:15978259   PMID:16019605   PMID:16051896   PMID:16150423   PMID:16303771   PMID:17299772   PMID:17382917   PMID:17849409   PMID:17953365   PMID:17992606   PMID:18037995  
PMID:18523654   PMID:18714030   PMID:18947492   PMID:18982462   PMID:19152029   PMID:19403340   PMID:19584397   PMID:20026244   PMID:20068577   PMID:20458337   PMID:20596602   PMID:21193004  
PMID:21355198   PMID:21355820   PMID:21412817   PMID:21898905   PMID:21919910   PMID:22071631   PMID:22556277   PMID:22610100   PMID:23258228   PMID:23301636   PMID:23376485   PMID:23378038  
PMID:24129569   PMID:24196407   PMID:25425079   PMID:29304073   PMID:31848365  


Genomics

Comparative Map Data
Plat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21669,240,582 - 69,265,177 (-)NCBI
Rnor_6.0 Ensembl1674,098,260 - 74,122,889 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01674,098,263 - 74,122,897 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01673,730,256 - 73,754,851 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,711,323 - 73,736,328 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11673,711,587 - 73,736,593 (-)NCBI
Celera1667,134,451 - 67,159,047 (-)NCBICelera
RH 3.4 Map16644.8RGD
Cytogenetic Map16q12.5NCBI
PLAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl842,174,718 - 42,207,709 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl842,174,718 - 42,207,676 (-)EnsemblGRCh38hg38GRCh38
GRCh38842,174,718 - 42,207,565 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37842,032,236 - 42,065,083 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,151,393 - 42,184,351 (-)NCBINCBI36hg18NCBI36
Build 34842,151,911 - 42,184,351NCBI
Celera840,981,190 - 41,014,147 (-)NCBI
Cytogenetic Map8p11.21NCBI
HuRef840,559,713 - 40,592,984 (-)NCBIHuRef
CHM1_1842,080,535 - 42,113,859 (-)NCBICHM1_1
Plat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,247,655 - 23,272,864 (+)NCBIGRCm39mm39
GRCm39 Ensembl823,247,743 - 23,272,860 (+)Ensembl
GRCm38822,757,722 - 22,782,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,757,727 - 22,782,844 (+)EnsemblGRCm38mm10GRCm38
MGSCv37823,868,216 - 23,893,320 (+)NCBIGRCm37mm9NCBIm37
MGSCv36824,223,313 - 24,248,389 (+)NCBImm8
Celera824,247,228 - 24,272,480 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.42NCBI
Plat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955536730,981 - 756,394 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955536730,962 - 754,333 (+)NCBIChiLan1.0ChiLan1.0
PLAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1838,864,918 - 38,897,776 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl838,864,918 - 38,897,779 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0841,419,415 - 41,451,951 (-)NCBIMhudiblu_PPA_v0panPan3
PLAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11623,469,590 - 23,496,013 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1623,974,129 - 24,000,506 (+)NCBI
ROS_Cfam_1.01625,217,768 - 25,244,182 (+)NCBI
UMICH_Zoey_3.11623,588,653 - 23,615,286 (+)NCBI
UNSW_CanFamBas_1.01624,152,407 - 24,178,867 (+)NCBI
UU_Cfam_GSD_1.01624,203,090 - 24,229,785 (+)NCBI
Plat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494346,519,711 - 46,546,290 (+)NCBI
SpeTri2.0NW_004936785476,200 - 503,371 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1711,195,602 - 11,224,032 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11711,195,599 - 11,223,821 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21713,168,730 - 13,197,126 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLAT
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1840,164,391 - 40,196,627 (-)NCBI
ChlSab1.1 Ensembl840,163,891 - 40,196,555 (-)Ensembl
Plat
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247801,014,429 - 1,063,636 (+)NCBI

Position Markers
RH128197  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01674,098,404 - 74,098,618NCBIRnor6.0
Rnor_5.01673,730,397 - 73,730,611UniSTSRnor5.0
RGSC_v3.41673,711,459 - 73,711,673UniSTSRGSC3.4
Celera1667,134,587 - 67,134,801UniSTS
RH 3.4 Map16662.2UniSTS
Cytogenetic Map16q12.5UniSTS
BE120928  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01673,745,362 - 73,745,524NCBIRnor6.0
Rnor_6.01674,123,127 - 74,123,289NCBIRnor6.0
Rnor_5.01673,755,120 - 73,755,282UniSTSRnor5.0
Rnor_5.01673,377,333 - 73,377,495UniSTSRnor5.0
RGSC_v3.41673,736,597 - 73,736,759UniSTSRGSC3.4
Celera1667,159,316 - 67,159,478UniSTS
RH 3.4 Map16663.8UniSTS
Cytogenetic Map16q12.5UniSTS
RH94475  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01674,098,588 - 74,098,760NCBIRnor6.0
Rnor_5.01673,730,581 - 73,730,753UniSTSRnor5.0
RGSC_v3.41673,711,643 - 73,711,815UniSTSRGSC3.4
Celera1667,134,771 - 67,134,943UniSTS
RH 3.4 Map16644.8UniSTS
Cytogenetic Map16q12.5UniSTS
RH137954  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01674,097,979 - 74,098,118NCBIRnor6.0
Rnor_5.01673,729,972 - 73,730,111UniSTSRnor5.0
RGSC_v3.41673,711,034 - 73,711,173UniSTSRGSC3.4
Celera1667,134,162 - 67,134,301UniSTS
RH 3.4 Map16689.61UniSTS
Cytogenetic Map16q12.5UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)16109005486162972Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)162075555680316424Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163900002184000021Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164151271086512710Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164151271086512710Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164655818890668790Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165781635790668790Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165781635790668790Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165781635790668790Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165928577589248943Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)167321963880115794Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:321
Count of miRNA genes:199
Interacting mature miRNAs:219
Transcripts:ENSRNOT00000025763
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 21 6 8 6 2 2 74 35 33 11 2
Low 36 35 11 35 6 9 8 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025763   ⟹   ENSRNOP00000025764
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1674,098,260 - 74,122,889 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000088219   ⟹   ENSRNOP00000071993
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1673,755,539 - 73,763,312 (+)Ensembl
RefSeq Acc Id: NM_013151   ⟹   NP_037283
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21669,240,587 - 69,265,177 (-)NCBI
Rnor_6.01674,098,268 - 74,122,858 (-)NCBI
Rnor_5.01673,730,256 - 73,754,851 (-)NCBI
RGSC_v3.41673,711,323 - 73,736,328 (-)RGD
Celera1667,134,451 - 67,159,047 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253347   ⟹   XP_006253409
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21669,240,582 - 69,264,980 (-)NCBI
Rnor_6.01674,098,263 - 74,122,761 (-)NCBI
Rnor_5.01673,730,256 - 73,754,851 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771348   ⟹   XP_008769570
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01674,098,263 - 74,122,897 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037283   ⟸   NM_013151
- Peptide Label: precursor
- UniProtKB: P19637 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006253409   ⟸   XM_006253347
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008769570   ⟸   XM_008771348
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000025764   ⟸   ENSRNOT00000025763
RefSeq Acc Id: ENSRNOP00000071993   ⟸   ENSRNOT00000088219
Protein Domains
EGF-like   Fibronectin type-I   Kringle   Peptidase S1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700183
Promoter ID:EPDNEW_R10707
Type:multiple initiation site
Name:Plat_1
Description:plasminogen activator, tissue type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01674,122,858 - 74,122,918EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3342 AgrOrtholog
Ensembl Genes ENSRNOG00000019018 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000060898 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000025764 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000071993 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025763 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000088219 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
  2.40.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6920438 IMAGE-MGC_LOAD
InterPro EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibronectin_type1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Tissue_plasm_act UniProtKB/Swiss-Prot
  tPA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report rno:25692 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72909 IMAGE-MGC_LOAD
NCBI Gene 25692 ENTREZGENE
PANTHER PTHR24264:SF42 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  fn1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot
PhenoGen Plat PhenoGen
PIRSF Tissue_plasm_act UniProtKB/Swiss-Prot
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
  SSF57440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K1V0_RAT UniProtKB/TrEMBL
  P19637 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Plat  plasminogen activator, tissue type  LOC100910418  tissue-type plasminogen activator-like  Data Merged 737654 PROVISIONAL
2016-01-25 Plat  plasminogen activator, tissue type  Plat  plasminogen activator, tissue  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910418  tissue-type plasminogen activator-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Plat  Plasminogen activator, tissue      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs Neuroserpin inhibits its expression in the neurons resulting in the delay of seizure activity by blocking excitotoxin-induced cell death 628337
gene_expression expressed in the brain and central nervous system 628337
gene_process has a role in the central nervous system during processes which require neuronal plasticity 628337
gene_product member of the serine proteinase family 628337
gene_transcript comprised of 14 exons; promoter contains a consensus cAMP-responsive element 729556