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Gene: Plat (plasminogen activator, tissue type) Rattus norvegicus
Symbol: Plat
Name: plasminogen activator, tissue type
Description: Predicted to have phosphoprotein binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; plasminogen activation; and positive regulation of ovulation. Localizes to several cellular components, including glutamatergic synapse; neuronal dense core vesicle; and perisynaptic space. Used to study disseminated intravascular coagulation and status epilepticus. Biomarker of brain edema; middle cerebral artery infarction; sciatic neuropathy; transient cerebral ischemia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; inherited blood coagulation disease (multiple); osteonecrosis; and peritonitis. Orthologous to human PLAT (plasminogen activator, tissue type); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; INTERACTS WITH (+)-catechin; (R)-mevalonic acid; (S)-colchicine.
Type: protein-coding
Also known as: PATISS; plasminogen activator, tissue; t-PA; t-plasminogen activator; tissue plasminogen activator; tissue-type plasminogen activator; tPA
Homo sapiens (human) : PLAT (plasminogen activator, tissue type)  HGNC  Alliance
Mus musculus (house mouse) : Plat (plasminogen activator, tissue)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plat (plasminogen activator, tissue type)
Pan paniscus (bonobo/pygmy chimpanzee) : PLAT (plasminogen activator, tissue type)
Canis lupus familiaris (dog) : PLAT (plasminogen activator, tissue type)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plat (plasminogen activator, tissue type)
Sus scrofa (pig) : PLAT (plasminogen activator, tissue type)
Chlorocebus sabaeus (African green monkey) : PLAT (plasminogen activator, tissue type)
Heterocephalus glaber (naked mole-rat) : Plat (plasminogen activator, tissue type)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01674,098,263 - 74,122,897 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,098,260 - 74,122,889 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01673,730,256 - 73,754,851 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,711,323 - 73,736,328 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11673,711,587 - 73,736,593 (-)NCBI
Celera1667,134,451 - 67,159,047 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
RH 3.4 Map16644.8RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Plat
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3342
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.