PLAT (plasminogen activator, tissue type) - Rat Genome Database

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Gene: PLAT (plasminogen activator, tissue type) Canis lupus familiaris
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Symbol: PLAT
Name: plasminogen activator, tissue type
RGD ID: 12397281
Description: ENCODES a protein that exhibits phosphoprotein binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); cellular response to follicle-stimulating hormone stimulus (ortholog); cellular response to luteinizing hormone stimulus (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure (ortholog); acute promyelocytic leukemia (ortholog); Acute Traumatic Coagulopathy (ortholog); FOUND IN cell surface (ortholog); collagen-containing extracellular matrix (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tissue-type plasminogen activator; TPA
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11623,469,590 - 23,496,013 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1623,974,129 - 24,000,506 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01625,217,768 - 25,244,182 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11623,588,653 - 23,615,286 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01624,152,407 - 24,178,867 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01624,203,090 - 24,229,785 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
acute promyelocytic leukemia  (ISO)
Acute Traumatic Coagulopathy  (ISO)
Airway Obstruction  (ISO)
allergic contact dermatitis  (ISO)
amphetamine abuse  (ISO)
angioedema  (ISO)
antiphospholipid syndrome  (ISO)
aphasia  (ISO)
Arterial Occlusive Diseases  (ISO)
Arterial Thrombosis  (ISO)
atherosclerosis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
Back Pain  (ISO)
Bacteremia  (ISO)
blood coagulation disease  (ISO)
brain edema  (ISO)
Brain Hypoxia-Ischemia  (ISO)
brain infarction  (ISO)
brain ischemia  (ISO)
Burns  (ISO)
cardiac tamponade  (ISO)
Cardiogenic Shock  (ISO)
Carotid Artery Injuries  (ISO)
Central Nervous System Viral Diseases  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholesterol embolism  (ISO)
Chronic Hepatitis  (ISO)
congestive heart failure  (ISO)
coronary thrombosis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
disseminated intravascular coagulation  (ISO)
Embolism  (ISO)
Embolism and Thrombosis  (ISO)
Endotoxemia  (ISO)
Experimental Liver Cirrhosis  (ISO)
factor VIII deficiency  (ISO)
Femur Head Necrosis  (ISO)
gestational diabetes  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhage  (ISO)
hemorrhagic disease  (ISO)
Henoch-Schoenlein purpura  (ISO)
hypertension  (ISO)
Hypotension  (ISO)
Hypoxia  (ISO)
IMMUNODEFICIENCY 15  (ISO)
immunodeficiency 15B  (ISO)
Intracranial Embolism and Thrombosis  (ISO)
Intracranial Hemorrhages  (ISO)
intracranial thrombosis  (ISO)
intracranial vasospasm  (ISO)
lactic acidosis  (ISO)
leukopenia  (ISO)
Low Back Pain  (ISO)
meningoencephalitis  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
Multiple Organ Failure  (ISO)
myocardial infarction  (ISO)
Nerve Degeneration  (ISO)
Neurologic Manifestations  (ISO)
Noonan syndrome  (ISO)
obesity  (ISO)
pancreatic adenocarcinoma  (ISO)
Paresis  (ISO)
pericardial effusion  (ISO)
peritonitis  (ISO)
pulmonary embolism  (ISO)
Reperfusion Injury  (ISO)
respiratory failure  (ISO)
Right Ventricular Hypertrophy  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Compression  (ISO)
Spinal Epidural Hematoma  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
Subdural Hematoma  (ISO)
Thromboembolism  (ISO)
thrombosis  (ISO)
torsion dystonia 6  (ISO)
toxic encephalopathy  (ISO)
transient cerebral ischemia  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Venous Thromboembolism  (ISO)
Venous Thrombosis  (ISO)
Ventricular Dysfunction, Left  (ISO)
von Willebrand's disease 1  (ISO)
Wounds and Injuries  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:17913363   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PLAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11623,469,590 - 23,496,013 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1623,974,129 - 24,000,506 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01625,217,768 - 25,244,182 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11623,588,653 - 23,615,286 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01624,152,407 - 24,178,867 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01624,203,090 - 24,229,785 (+)NCBIUU_Cfam_GSD_1.0
PLAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38842,174,718 - 42,207,565 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl842,174,718 - 42,207,709 (-)EnsemblGRCh38hg38GRCh38
GRCh37842,032,236 - 42,065,083 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,151,393 - 42,184,351 (-)NCBINCBI36Build 36hg18NCBI36
Build 34842,151,911 - 42,184,351NCBI
Celera840,981,190 - 41,014,147 (-)NCBICelera
Cytogenetic Map8p11.21NCBI
HuRef840,559,713 - 40,592,984 (-)NCBIHuRef
CHM1_1842,080,535 - 42,113,811 (-)NCBICHM1_1
T2T-CHM13v2.0842,449,037 - 42,481,874 (-)NCBIT2T-CHM13v2.0
Plat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,247,655 - 23,272,864 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl823,247,743 - 23,272,860 (+)EnsemblGRCm39 Ensembl
GRCm38822,757,722 - 22,782,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,757,727 - 22,782,844 (+)EnsemblGRCm38mm10GRCm38
MGSCv37823,868,216 - 23,893,320 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36824,223,313 - 24,248,389 (+)NCBIMGSCv36mm8
Celera824,247,228 - 24,272,480 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.42NCBI
Plat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81675,943,061 - 76,022,037 (-)NCBIGRCr8
mRatBN7.21669,240,582 - 69,265,177 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,240,585 - 69,268,223 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1674,514,320 - 74,538,910 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01677,946,850 - 77,971,428 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01673,195,994 - 73,220,572 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01674,098,263 - 74,122,897 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,098,260 - 74,122,889 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01673,730,256 - 73,754,851 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,711,323 - 73,736,328 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11673,711,587 - 73,736,593 (-)NCBI
Celera1667,134,451 - 67,159,047 (-)NCBICelera
RH 3.4 Map16644.8RGD
Cytogenetic Map16q12.5NCBI
Plat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955536730,981 - 756,394 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955536730,962 - 754,333 (+)NCBIChiLan1.0ChiLan1.0
PLAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2760,627,599 - 61,135,005 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1836,344,912 - 36,377,468 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0841,419,415 - 41,451,951 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1838,864,918 - 38,897,776 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl838,864,918 - 38,897,779 (-)Ensemblpanpan1.1panPan2
Plat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494346,519,711 - 46,546,290 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936785476,078 - 503,321 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936785476,200 - 503,371 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1711,195,602 - 11,224,032 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11711,195,599 - 11,223,821 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21713,168,730 - 13,197,126 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1840,164,391 - 40,196,627 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl840,163,891 - 40,196,555 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660521,590,000 - 1,622,258 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247801,028,085 - 1,063,649 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247801,014,429 - 1,063,636 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLAT
454 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


RefSeq Acc Id: XM_038497492   ⟹   XP_038353420
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11623,588,653 - 23,615,286 (+)NCBI
RefSeq Acc Id: XM_038559941   ⟹   XP_038415869
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01624,203,090 - 24,229,785 (+)NCBI
RefSeq Acc Id: XM_038623979   ⟹   XP_038479907
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01624,152,407 - 24,178,867 (+)NCBI
RefSeq Acc Id: XM_038689737   ⟹   XP_038545665
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01625,217,768 - 25,244,182 (+)NCBI
RefSeq Acc Id: XM_539955   ⟹   XP_539955
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11623,469,590 - 23,496,013 (+)NCBI
Dog10K_Boxer_Tasha1623,974,129 - 24,000,506 (+)NCBI
Sequence:
RefSeq Acc Id: XP_539955   ⟸   XM_539955
- UniProtKB: A0A8C0PAA7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038353420   ⟸   XM_038497492
RefSeq Acc Id: XP_038479907   ⟸   XM_038623979
RefSeq Acc Id: XP_038545665   ⟸   XM_038689737
- UniProtKB: A0A8C0PAA7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038415869   ⟸   XM_038559941
- UniProtKB: A0A8C0QBE9 (UniProtKB/TrEMBL)
Protein Domains
EGF-like   Fibronectin type-I   Kringle   Peptidase S1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005575 UniProtKB/TrEMBL
  ENSCAFG00030019960 UniProtKB/TrEMBL
  ENSCAFG00040005447 UniProtKB/TrEMBL
  ENSCAFG00845006612 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000008984.5 UniProtKB/TrEMBL
  ENSCAFT00000059778.2 UniProtKB/TrEMBL
  ENSCAFT00000060168.2 UniProtKB/TrEMBL
  ENSCAFT00000077580.2 UniProtKB/TrEMBL
  ENSCAFT00030036777.1 UniProtKB/TrEMBL
  ENSCAFT00040010435.1 UniProtKB/TrEMBL
  ENSCAFT00845011784.1 UniProtKB/TrEMBL
  ENSCAFT00845011879 ENTREZGENE
  ENSCAFT00845011879.1 UniProtKB/TrEMBL
  ENSCAFT00845011938.1 UniProtKB/TrEMBL
  ENSCAFT00845011984.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  2.40.20.10 UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/TrEMBL
  Fibronectin_type1 UniProtKB/TrEMBL
  Kringle UniProtKB/TrEMBL
  Kringle-like UniProtKB/TrEMBL
  Kringle_CS UniProtKB/TrEMBL
  Kringle_sf UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Serine_Proteases_S1 UniProtKB/TrEMBL
  Tissue_plasm_act UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
NCBI Gene PLAT ENTREZGENE
PANTHER PTHR24264:SF42 UniProtKB/TrEMBL
  TRYPSIN-RELATED UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  fn1 UniProtKB/TrEMBL
  Kringle UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PIRSF Tissue_plasm_act UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
  KRINGLE UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  FN1_1 UniProtKB/TrEMBL
  FN1_2 UniProtKB/TrEMBL
  KRINGLE_1 UniProtKB/TrEMBL
  KRINGLE_2 UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  FN1 UniProtKB/TrEMBL
  SM00130 UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  FnI-like domain UniProtKB/TrEMBL
  SSF50494 UniProtKB/TrEMBL
  SSF57440 UniProtKB/TrEMBL
UniProt A0A8C0PAA7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QBE9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MVA5_CANLF UniProtKB/TrEMBL
  A0A8I3MYN3_CANLF UniProtKB/TrEMBL
  A0A8I3MYQ6_CANLF UniProtKB/TrEMBL
  A0A8I3NEX5_CANLF UniProtKB/TrEMBL
  A0A8P0N8B9_CANLF UniProtKB/TrEMBL
  A0A8P0P286_CANLF UniProtKB/TrEMBL
  A0A8P0P9B7_CANLF UniProtKB/TrEMBL
  A0A8P0TAB3_CANLF UniProtKB/TrEMBL