Plat (plasminogen activator, tissue type) - Rat Genome Database
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Gene: Plat (plasminogen activator, tissue type) Ictidomys tridecemlineatus
Analyze
Symbol: Plat
Name: plasminogen activator, tissue type
RGD ID: 12539236
Description: ENCODES a protein that exhibits phosphoprotein binding (ortholog); serine-type endopeptidase activity (ortholog); signaling receptor binding (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); cellular response to follicle-stimulating hormone stimulus (ortholog); cellular response to luteinizing hormone stimulus (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure (ortholog); acute promyelocytic leukemia (ortholog); Acute Traumatic Coagulopathy (ortholog); FOUND IN apical part of cell (ortholog); cell surface (ortholog); collagen-containing extracellular matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: tissue-type plasminogen activator
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936785476,200 - 503,371 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
acute promyelocytic leukemia  (ISO)
Acute Traumatic Coagulopathy  (ISO)
Airway Obstruction  (ISO)
allergic contact dermatitis  (ISO)
amphetamine abuse  (ISO)
angioedema  (ISO)
antiphospholipid syndrome  (ISO)
aphasia  (ISO)
Arterial Occlusive Diseases  (ISO)
Arterial Thrombosis  (ISO)
atherosclerosis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
Back Pain  (ISO)
Bacteremia  (ISO)
blood coagulation disease  (ISO)
brain edema  (ISO)
brain infarction  (ISO)
brain ischemia  (ISO)
Burns  (ISO)
cardiac tamponade  (ISO)
Cardiogenic Shock  (ISO)
Carotid Artery Injuries  (ISO)
Central Nervous System Viral Diseases  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholesterol embolism  (ISO)
Chronic Hepatitis  (ISO)
congestive heart failure  (ISO)
coronary thrombosis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
disseminated intravascular coagulation  (ISO)
Embolism  (ISO)
Embolism and Thrombosis  (ISO)
Endotoxemia  (ISO)
Experimental Liver Cirrhosis  (ISO)
factor VIII deficiency  (ISO)
Femur Head Necrosis  (ISO)
gestational diabetes  (ISO)
Hematoma, Epidural, Spinal  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhage  (ISO)
hemorrhagic disease  (ISO)
Henoch-Schoenlein purpura  (ISO)
hypertension  (ISO)
Hypotension  (ISO)
Hypoxia  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
Intracranial Embolism and Thrombosis  (ISO)
Intracranial Hemorrhages  (ISO)
intracranial thrombosis  (ISO)
intracranial vasospasm  (ISO)
lactic acidosis  (ISO)
leukopenia  (ISO)
Low Back Pain  (ISO)
meningoencephalitis  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
Multiple Organ Failure  (ISO)
myocardial infarction  (ISO)
Nerve Degeneration  (ISO)
Neurologic Manifestations  (ISO)
Noonan syndrome  (ISO)
obesity  (ISO)
pancreatic adenocarcinoma  (ISO)
Paresis  (ISO)
pericardial effusion  (ISO)
peritonitis  (ISO)
pulmonary embolism  (ISO)
Reperfusion Injury  (ISO)
respiratory failure  (ISO)
Right Ventricular Hypertrophy  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Compression  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
Subdural Hematoma  (ISO)
thrombocytopenia  (ISO)
Thromboembolism  (ISO)
thrombophilia due to decreased release of PLAT  (ISO)
thrombosis  (ISO)
toxic encephalopathy  (ISO)
transient cerebral ischemia  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Venous Thromboembolism  (ISO)
Venous Thrombosis  (ISO)
Ventricular Dysfunction, Left  (ISO)
von Willebrand's disease 1  (ISO)
Wounds and Injuries  (ISO)

References

Genomics

Comparative Map Data
Plat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936785476,200 - 503,371 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl842,174,718 - 42,207,709 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl842,174,718 - 42,207,676 (-)EnsemblGRCh38hg38GRCh38
GRCh38842,174,718 - 42,207,565 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37842,032,236 - 42,065,083 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,151,393 - 42,184,351 (-)NCBINCBI36hg18NCBI36
Build 34842,151,911 - 42,184,351NCBI
Celera840,981,190 - 41,014,147 (-)NCBI
Cytogenetic Map8p11.21NCBI
HuRef840,559,713 - 40,592,984 (-)NCBIHuRef
CHM1_1842,080,535 - 42,113,859 (-)NCBICHM1_1
Plat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,247,655 - 23,272,864 (+)NCBIGRCm39mm39
GRCm39 Ensembl823,247,743 - 23,272,860 (+)Ensembl
GRCm38822,757,722 - 22,782,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,757,727 - 22,782,844 (+)EnsemblGRCm38mm10GRCm38
MGSCv37823,868,216 - 23,893,320 (+)NCBIGRCm37mm9NCBIm37
MGSCv36824,223,313 - 24,248,389 (+)NCBImm8
Celera824,247,228 - 24,272,480 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.42NCBI
Plat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21669,240,582 - 69,265,177 (-)NCBI
Rnor_6.0 Ensembl1674,098,260 - 74,122,889 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01674,098,263 - 74,122,897 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01673,730,256 - 73,754,851 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,711,323 - 73,736,328 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11673,711,587 - 73,736,593 (-)NCBI
Celera1667,134,451 - 67,159,047 (-)NCBICelera
RH 3.4 Map16644.8RGD
Cytogenetic Map16q12.5NCBI
Plat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955536730,981 - 756,394 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955536730,962 - 754,333 (+)NCBIChiLan1.0ChiLan1.0
PLAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1838,864,918 - 38,897,776 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl838,864,918 - 38,897,779 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0841,419,415 - 41,451,951 (-)NCBIMhudiblu_PPA_v0panPan3
PLAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11623,469,590 - 23,496,013 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
PLAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1711,195,602 - 11,224,032 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11711,195,599 - 11,223,821 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21713,168,730 - 13,197,126 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLAT
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1840,164,391 - 40,196,627 (-)NCBI
ChlSab1.1 Ensembl840,163,891 - 40,196,555 (-)Ensembl
Plat
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247801,014,429 - 1,063,636 (+)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005340310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGTP01107042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_005340310   ⟹   XP_005340367
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_004936785476,200 - 503,371 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005340367 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005340367   ⟸   XM_005340310
- Sequence:
Protein Domains
EGF-like   Fibronectin type-I   Kringle   Peptidase S1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000009680 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000008687 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000009683 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  2.40.20.10 UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/TrEMBL
  Fibronectin_type1 UniProtKB/TrEMBL
  Kringle UniProtKB/TrEMBL
  Kringle-like UniProtKB/TrEMBL
  Kringle_CS UniProtKB/TrEMBL
  Kringle_sf UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Tissue_plasm_act UniProtKB/TrEMBL
  tPA UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
NCBI Gene Plat ENTREZGENE
PANTHER PTHR24264:SF42 UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  fn1 UniProtKB/TrEMBL
  Kringle UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PIRSF Tissue_plasm_act UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  FN1_1 UniProtKB/TrEMBL
  FN1_2 UniProtKB/TrEMBL
  KRINGLE_1 UniProtKB/TrEMBL
  KRINGLE_2 UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  FN1 UniProtKB/TrEMBL
  SM00130 UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
  SSF57440 UniProtKB/TrEMBL
UniProt I3ME10_ICTTR UniProtKB/TrEMBL