RGD Reference Report - Tissue plasminogen activator for the treatment of intraventricular hematoma: the dose-effect relationship. - Rat Genome Database

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Tissue plasminogen activator for the treatment of intraventricular hematoma: the dose-effect relationship.

Authors: Wang, YC  Lin, CW  Shen, CC  Lai, SC  Kuo, JS 
Citation: Wang YC, etal., J Neurol Sci. 2002 Oct 15;202(1-2):35-41.
RGD ID: 11537477
Pubmed: PMID:12220690   (View Abstract at PubMed)

In this study, we investigated the dose-effect relationship and safety of tissue plasminogen activator (tPA) for the treatment of intraventricular hemorrhage/hematoma (IVH) in rats. Adult male Sprague-Dawley rats were injected with autologous blood into the left lateral ventricle to establish IVH. Two hours later, Ringer's saline or 0.25-2 microg of tPA were administered directly to the IVH over 3 h. The regional cerebral blood flow (rCBF) on the surface of the left parietal cortex was measured with laser Doppler flowmetry. Twenty-four hours after the build-up of IVH, the brains were removed for morphometrical and histological studies. A dose of 0.5-2 microg tPA significantly diminished the IVH in a dose-dependent manner (p < 0.001). However, only the dose of 0.5 microg tPA significantly ameliorated the reduction of rCBF 24 h after IVH (p < 0.01). TPA did not improve the ventricular dilatation on the side with IVH. Instead, 1-2 microg of tPA caused additional injuries, including intraventricular leukocytosis and edema of periventricular tissues and choroid plexus on both hemispheres. These results indicate that higher doses of tPA may have detrimental effects on the brain. The dosage rate of 0.5 microg seems beneficial to treat 5 microl of IVH (equals to a dose of 0.1 mg/ml blood) in our model in terms of the satisfactory fibrinolysis and less damage to the brain.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Cerebral Hemorrhage treatmentISOPlat (Rattus norvegicus)11537477; 11537477human protein in a rat modelRGD 
Cerebral Hemorrhage treatmentIDA 11537477human protein in a rat modelRGD 

Objects Annotated

Genes (Rattus norvegicus)
Plat  (plasminogen activator, tissue type)

Genes (Mus musculus)
Plat  (plasminogen activator, tissue)

Genes (Homo sapiens)
PLAT  (plasminogen activator, tissue type)


Additional Information