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Gene: Plat (plasminogen activator, tissue) Mus musculus
Symbol: Plat
Name: plasminogen activator, tissue
Description: Exhibits serine-type endopeptidase activity. Involved in several processes, including platelet-derived growth factor receptor signaling pathway; smooth muscle cell migration; and trans-synaptic signaling by BDNF, modulating synaptic transmission. Localizes to several cellular components, including the Schaffer collateral - CA1 synapse; glutamatergic synapse; and secretory granule. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; factor VIII deficiency; osteonecrosis; and thrombophilia (multiple). Is expressed in several structures, including embryo ectoderm; liver; spinal cord; testis; and urinary system. Orthologous to human PLAT (plasminogen activator, tissue type).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AU020998; AW212668; D8Ertd2e; MGC18508; t-PA; t-plasminogen activator; tissue-type plasminogen activator; tPA
Homo sapiens (human) : PLAT (plasminogen activator, tissue type)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Plat (plasminogen activator, tissue type)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plat (plasminogen activator, tissue type)
Pan paniscus (bonobo/pygmy chimpanzee) : PLAT (plasminogen activator, tissue type)
Canis lupus familiaris (dog) : PLAT (plasminogen activator, tissue type)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plat (plasminogen activator, tissue type)
Sus scrofa (pig) : PLAT (plasminogen activator, tissue type)
Chlorocebus sabaeus (green monkey) : PLAT (plasminogen activator, tissue type)
Heterocephalus glaber (naked mole-rat) : Plat (plasminogen activator, tissue type)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl822,757,727 - 22,782,844 (+)Ensembl
GRCm38822,757,722 - 22,782,848 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37823,868,216 - 23,893,320 (+)NCBIGRCm37mm9NCBIm37
MGSCv36824,223,313 - 24,248,389 (+)NCBImm8
Celera824,247,228 - 24,272,480 (+)NCBICelera
Cytogenetic Map8 A2NCBI
cM Map811.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Plat
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732079
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.