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Gene: Plat (plasminogen activator, tissue) Mus musculus
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Symbol: Plat
Name: plasminogen activator, tissue
Description: Exhibits serine-type endopeptidase activity. Involved in several processes, including platelet-derived growth factor receptor signaling pathway; smooth muscle cell migration; and trans-synaptic signaling by BDNF, modulating synaptic transmission. Localizes to several cellular components, including the Schaffer collateral - CA1 synapse; glutamatergic synapse; and secretory granule. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; factor VIII deficiency; osteonecrosis; and thrombophilia (multiple). Is expressed in several structures, including embryo ectoderm; liver; spinal cord; testis; and urinary system. Orthologous to human PLAT (plasminogen activator, tissue type).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AU020998; AW212668; D8Ertd2e; MGC18508; t-PA; t-plasminogen activator; tissue-type plasminogen activator; tPA
Orthologs:
Homo sapiens (human) : PLAT (plasminogen activator, tissue type)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Plat (plasminogen activator, tissue type)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plat (plasminogen activator, tissue type)
Pan paniscus (bonobo/pygmy chimpanzee) : PLAT (plasminogen activator, tissue type)
Canis lupus familiaris (dog) : PLAT (plasminogen activator, tissue type)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plat (plasminogen activator, tissue type)
Sus scrofa (pig) : PLAT (plasminogen activator, tissue type)
Chlorocebus sabaeus (green monkey) : PLAT (plasminogen activator, tissue type)
Heterocephalus glaber (naked mole-rat) : Plat (plasminogen activator, tissue type)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl822,757,727 - 22,782,844 (+)Ensembl
GRCm38822,757,722 - 22,782,848 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37823,868,216 - 23,893,320 (+)NCBIGRCm37mm9NCBIm37
MGSCv36824,223,313 - 24,248,389 (+)NCBImm8
Celera824,247,228 - 24,272,480 (+)NCBICelera
Cytogenetic Map8 A2NCBI
cM Map811.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Plat
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732079
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.