Plat (plasminogen activator, tissue) - Rat Genome Database

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Gene: Plat (plasminogen activator, tissue) Mus musculus
Analyze
Symbol: Plat
Name: plasminogen activator, tissue
RGD ID: 732079
MGI Page MGI
Description: Enables serine-type endopeptidase activity. Involved in trans-synaptic signaling by BDNF, modulating synaptic transmission. Acts upstream of or within several processes, including platelet-derived growth factor receptor signaling pathway; response to hypoxia; and smooth muscle cell migration. Located in several cellular components, including apical part of cell; extracellular space; and secretory granule. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; factor VIII deficiency; osteonecrosis; and thrombophilia (multiple). Orthologous to human PLAT (plasminogen activator, tissue type).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AU020998; AW212668; D8Ertd2; D8Ertd2e; MGC18508; t; t-; t-PA; t-plasminogen activator; tissue-type plasminogen activator; tPA
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,247,655 - 23,272,864 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl823,247,743 - 23,272,860 (+)EnsemblGRCm39 Ensembl
GRCm38822,757,722 - 22,782,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,757,727 - 22,782,844 (+)EnsemblGRCm38mm10GRCm38
MGSCv37823,868,216 - 23,893,320 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36824,223,313 - 24,248,389 (+)NCBIMGSCv36mm8
Celera824,247,228 - 24,272,480 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
acute promyelocytic leukemia  (ISO)
Acute Traumatic Coagulopathy  (ISO)
Airway Obstruction  (ISO)
allergic contact dermatitis  (ISO)
amphetamine abuse  (ISO)
angioedema  (ISO)
antiphospholipid syndrome  (ISO)
aphasia  (ISO)
Arterial Occlusive Diseases  (ISO)
Arterial Thrombosis  (ISO)
atherosclerosis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
Back Pain  (ISO)
Bacteremia  (ISO)
blood coagulation disease  (ISO)
brain edema  (ISO)
Brain Hypoxia-Ischemia  (ISO)
brain infarction  (ISO)
brain ischemia  (ISO)
Burns  (ISO)
cardiac tamponade  (ISO)
Cardiogenic Shock  (ISO)
Carotid Artery Injuries  (ISO)
Central Nervous System Viral Diseases  (ISO)
Cerebral Hemorrhage  (IMP,ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholesterol embolism  (ISO)
Chronic Hepatitis  (ISO)
congestive heart failure  (ISO)
coronary thrombosis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
disseminated intravascular coagulation  (ISO)
Embolism  (ISO)
Embolism and Thrombosis  (ISO)
Endotoxemia  (ISO)
Experimental Liver Cirrhosis  (ISO)
factor VIII deficiency  (ISO)
Femur Head Necrosis  (ISO)
gestational diabetes  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhage  (ISO)
hemorrhagic disease  (ISO)
Henoch-Schoenlein purpura  (ISO)
hypertension  (ISO)
Hypotension  (ISO)
Hypoxia  (ISO)
IMMUNODEFICIENCY 15  (ISO)
immunodeficiency 15B  (ISO)
Intracranial Embolism and Thrombosis  (ISO)
Intracranial Hemorrhages  (ISO)
intracranial thrombosis  (ISO)
intracranial vasospasm  (ISO)
lactic acidosis  (ISO)
leukopenia  (ISO)
Low Back Pain  (ISO)
meningoencephalitis  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
Multiple Organ Failure  (ISO)
myocardial infarction  (ISO)
Nerve Degeneration  (ISO)
Neurologic Manifestations  (ISO)
Noonan syndrome  (ISO)
obesity  (ISO)
pancreatic adenocarcinoma  (ISO)
Paresis  (ISO)
pericardial effusion  (ISO)
peritonitis  (ISO)
pulmonary embolism  (ISO)
Reperfusion Injury  (ISO)
respiratory failure  (ISO)
Right Ventricular Hypertrophy  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Compression  (ISO)
Spinal Epidural Hematoma  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
Subdural Hematoma  (ISO)
Thromboembolism  (ISO)
thrombosis  (ISO)
toxic encephalopathy  (ISO)
transient cerebral ischemia  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
Venous Thromboembolism  (ISO)
Venous Thrombosis  (ISO)
Ventricular Dysfunction, Left  (ISO)
von Willebrand's disease 1  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-mevalonic acid  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP)
aldosterone  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
aminoguanidine  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-carotene  (EXP)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bucladesine  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
choline  (EXP)
chromium(6+)  (EXP)
chrysene  (EXP)
cisplatin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP)
daunorubicin  (ISO)
DDT  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (ISO)
dienogest  (ISO)
diethyl maleate  (EXP,ISO)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (EXP,ISO)
dipyridamole  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
edaravone  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
Ethyl icosapentate  (ISO)
ethylenediaminetetraacetic acid  (EXP)
eugenol  (ISO)
fenbuconazole  (ISO)
folic acid  (EXP)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
geranylgeraniol  (ISO)
gestodene  (ISO)
glucose  (EXP)
Goe 6976  (EXP)
GW 4064  (EXP)
heparin  (EXP)
hydrogen peroxide  (ISO)
icatibant  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isobutanol  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ketamine  (ISO)
KT 5823  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (ISO)
lovastatin  (EXP,ISO)
malathion  (ISO)
medroxyprogesterone acetate  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
mifepristone  (ISO)
mitoxantrone  (ISO)
morphine  (EXP)
N-acetylsphingosine  (ISO)
N-nitrosodimethylamine  (ISO)
naphthalene  (EXP)
nickel sulfate  (EXP,ISO)
nicotine  (ISO)
nitric oxide  (EXP)
nonanedioic acid  (ISO)
norgestimate  (ISO)
notoginsenoside R1  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
potassium chromate  (ISO)
prednisone  (ISO)
procymidone  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
protoporphyrin  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
Ro 41-5253  (ISO)
rofecoxib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP,ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
sotalol  (ISO)
sotorasib  (ISO)
spironolactone  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
tacrolimus hydrate  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetraethyllead  (ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
topotecan  (ISO)
trametinib  (ISO)
Trapidil  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal active avoidance behavior  (IAGP)
abnormal acute phase protein level  (IAGP)
abnormal contextual conditioning behavior  (IAGP)
abnormal cued conditioning behavior  (IAGP)
abnormal cytokine level  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal facial skin morphology  (IAGP)
abnormal heart morphology  (IEA)
abnormal microglial cell physiology  (IAGP)
abnormal motor learning  (IAGP)
abnormal outer ear skin morphology  (IAGP)
abnormal response to CNS ischemic injury  (IAGP)
abnormal susceptibility to Coronaviridae infection  (IAGP)
abnormal testis morphology  (IEA)
abnormal thrombosis  (IAGP)
absent long term depression  (IAGP)
arthritis  (IAGP)
cachexia  (IAGP)
cardiac interstitial fibrosis  (IAGP)
cellular necrosis  (IAGP)
chronic joint inflammation  (IAGP)
decreased angiogenesis  (IAGP)
decreased anxiety-related response  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased cerebral infarct size  (IAGP)
decreased dopamine level  (IAGP)
decreased exploration in new environment  (IAGP)
decreased litter size  (IAGP)
decreased retina apoptosis  (IAGP)
decreased susceptibility to induced choroidal neovascularization  (IAGP)
decreased susceptibility to induced retina damage  (IAGP)
decreased ventricle muscle contractility  (IAGP)
decreased vertical activity  (IAGP)
embryonic lethality  (IAGP)
enlarged heart  (IEA)
heart left ventricle hypertrophy  (IAGP)
impaired behavioral response to morphine  (IAGP)
impaired conditioned place preference behavior  (IAGP)
impaired synaptic plasticity  (IAGP)
increased circulating corticosterone level  (IAGP)
increased macrophage cell number  (IAGP)
increased susceptibility to Coronaviridae infection induced morbidity/mortality  (IAGP)
increased susceptibility to induced thrombosis  (IAGP)
intracerebral hemorrhage  (IAGP)
joint swelling  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
pulmonary alveolar hemorrhage  (IAGP)
pulmonary interstitial fibrosis  (IAGP)
rectal prolapse  (IAGP)
reduced fertility  (IAGP)
reduced long term potentiation  (IAGP)
reduced thrombolysis  (IAGP)
respiratory distress  (IAGP)
small testis  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Deleterious effects of plasminogen activators in neonatal cerebral hypoxia-ischemia. Adhami F, etal., Am J Pathol. 2008 Jun;172(6):1704-16. Epub 2008 May 8.
2. Activation of complement and kinin systems after thrombolytic therapy in patients with acute myocardial infarction. A comparison between streptokinase and recombinant tissue-type plasminogen activator. Agostoni A, etal., Circulation. 1994 Dec;90(6):2666-70.
3. The impact of metabolic syndrome and CRP on vascular phenotype in type 2 diabetes mellitus. Alizadeh Dehnavi R, etal., Eur J Intern Med. 2008 Mar;19(2):115-21. Epub 2007 Nov 5.
4. Elevation of plasma free PAI-1 levels as an integrated endothelial response to severe burns. Aoki K, etal., Burns. 2001 Sep;27(6):569-75.
5. Secretion of cardiac plasminogen activator during hypoxia-induced right ventricular hypertrophy. Bansal DD, etal., J Mol Cell Cardiol. 1997 Nov;29(11):3105-14.
6. Thrombomodulin, tissue plasminogen activator and plasminogen activator inhibitor-1 in Henoch-Schonlein purpura. Besbas N, etal., Clin Exp Rheumatol. 1998 Jan-Feb;16(1):95-8.
7. Both tissue-type plasminogen activator and urokinase prevent intraabdominal abscess formation after surgical treatment of peritonitis in the rat. Buyne OR, etal., Surgery. 2008 Jul;144(1):66-73. Epub 2008 May 21.
8. Prothrombotic coagulation abnormalities preceding the hemolytic-uremic syndrome. Chandler WL, etal., N Engl J Med. 2002 Jan 3;346(1):23-32.
9. [Expression of plasminogen activator inhibitor-1 and tissue plasminogen activator in the kidney of KKAy mice with type 2 diabetes] Chen LM, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2005 Jun;27(3):344-8.
10. Antibodies to tissue-type plasminogen activator (tPA) in patients with antiphospholipid syndrome: evidence of interaction between the antibodies and the catalytic domain of tPA in 2 patients. Cugno M, etal., Blood. 2004 Mar 15;103(6):2121-6. Epub 2003 Nov 20.
11. Prevalence of genetic risk factors related with thrombophilia and hypofibrinolysis in patients with osteonecrosis of the femoral head in Poland. Gagala J, etal., BMC Musculoskelet Disord. 2013 Sep 11;14:264. doi: 10.1186/1471-2474-14-264.
12. New atherosclerosis risk factors in obese, hypertensive and diabetic children and adolescents. Glowinska B, etal., Atherosclerosis. 2003 Apr;167(2):275-86.
13. Microvascular tissue plasminogen activator is reduced in diabetic neuropathy. Hafer-Macko CE, etal., Neurology. 2007 Jul 17;69(3):268-74.
14. Expression of type-1 plasminogen activator inhibitor in the kidney of diabetic rat models. Hagiwara H, etal., Thromb Res. 2003;111(4-5):301-9.
15. Influence of white blood cells on the fibrinolytic response to sepsis: studies of septic patients with or without severe leucopenia. Haj MA, etal., Br J Haematol. 1995 Jul;90(3):541-7.
16. Increased plasma tissue-type plasminogen activator levels in patients with chronic thrombocytopenia. Hanss M, etal., Haemostasis. 1990;20(6):341-6.
17. Noble-Collip Drum Trauma Induces Disseminated Intravascular Coagulation But Not Acute Coagulopathy of Trauma-Shock. Hayakawa M, etal., Shock. 2015 Mar;43(3):261-7. doi: 10.1097/SHK.0000000000000281.
18. Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice. Hijazi N, etal., Blood. 2015 Apr 16;125(16):2558-67. doi: 10.1182/blood-2014-08-588442. Epub 2015 Feb 11.
19. Blood coagulation and fibrinolysis before and after exhaustive exercise in patients with IDDM. Hilberg T, etal., Thromb Haemost. 2003 Dec;90(6):1065-73.
20. Hyperbaric oxygen therapy prevents coagulation disorders in an experimental model of multiple organ failure syndrome. Imperatore F, etal., Intensive Care Med. 2006 Nov;32(11):1881-8. Epub 2006 Sep 15.
21. Role of endogenous platelet-derived growth factor in arterial smooth muscle cell migration after balloon catheter injury. Jackson CL, etal., Arterioscler Thromb. 1993 Aug;13(8):1218-26.
22. Fibrinolytic gene polymorphism and ischemic stroke. Jood K, etal., Stroke. 2005 Oct;36(10):2077-81. Epub 2005 Sep 22.
23. Beneficial effects of dalteparin on haemostatic function and local tissue oxygenation in patients with diabetes, severe vascular disease and foot ulcers. Kalani M, etal., Thromb Res. 2007;120(5):653-61. Epub 2007 Feb 2.
24. Impaired fibrinolytic activity in type II diabetes: correlation with urinary albumin excretion and progression of renal disease. Kamgar M, etal., Kidney Int. 2006 May;69(10):1899-903.
25. Effect of troglitazone on serum gamma-glutamyltransferase activity and plasma t-PA/PAI-1 complex in type 2 diabetic patients. Koh H, etal., Arzneimittelforschung. 2006;56(4):288-94.
26. Tissue-type plasminogen activator -7,351C/T enhancer polymorphism is associated with a first myocardial infarction. Ladenvall P, etal., Thromb Haemost. 2002 Jan;87(1):105-9.
27. Increased expression and activity of urokinase-type plasminogen activator during epileptogenesis. Lahtinen L, etal., Eur J Neurosci. 2006 Oct;24(7):1935-45. Epub 2006 Oct 16.
28. Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis. Laudes IJ, etal., Am J Pathol. 2002 May;160(5):1867-75.
29. Identification of biomarkers of human pancreatic adenocarcinomas by expression profiling and validation with gene expression analysis in endoscopic ultrasound-guided fine needle aspiration samples. Laurell H, etal., World J Gastroenterol. 2006 Jun 7;12(21):3344-51.
30. Neurodegeneration induced by PVC-211 murine leukemia virus is associated with increased levels of vascular endothelial growth factor and macrophage inflammatory protein 1 alpha and is inhibited by blocking activation of microglia. Li X, etal., J Virol. 2009 May;83(10):4912-22. doi: 10.1128/JVI.02343-08. Epub 2009 Mar 11.
31. Reductions in mRNA of the neuroprotective agent, neuroserpin, after cerebral ischemia/reperfusion in diabetic rats. Liang W, etal., Brain Res. 2004 Jul 23;1015(1-2):175-80.
32. Nan fang yi ke da xue xue bao = Journal of Southern Medical University Liu BY, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2007 Jan;27(1):35-7.
33. Elevated plasma tissue-type plasminogen activator (t-PA) and soluble thrombomodulin in patients suffering from severe acute respiratory syndrome (SARS) as a possible index for prognosis and treatment strategy. Liu ZH, etal., Biomed Environ Sci. 2005 Aug;18(4):260-4.
34. Basic mechanisms and regulation of fibrinolysis. Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
35. Identification of polyclonal and monoclonal antibodies against tissue plasminogen activator in the antiphospholipid syndrome. Lu CS, etal., Arthritis Rheum. 2005 Dec;52(12):4018-27.
36. Patterns of development of tachyphylaxis in patients with haemophilia and von Willebrand disease after repeated doses of desmopressin (DDAVP). Mannucci PM, etal., Br J Haematol. 1992 Sep;82(1):87-93.
37. Imbalance of plasminogen activator inhibitor type-1 (PAI-1) and tissue plasminogen activator (t-PA) activity in patients with Noonan syndrome. Mehta P and Parker RI, J Pediatr Hematol Oncol. 2010 Oct;32(7):532-6. doi: 10.1097/MPH.0b013e3181e0d152.
38. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
39. MGDs mouse GO annotations MGD data from the GO Consortium
40. MGD IEA MGD IEA
41. Decreased tissue factor and tissue-plasminogen activator antigen in relapsed acute promyelocytic leukemia. Nakasaki T, etal., Am J Hematol. 2000 Jul;64(3):145-50.
42. Behaviour of tissue plasminogen activator, plasminogen activator inhibitor 1 and their complex in various disease states. Niwano H, etal., Blood Coagul Fibrinolysis. 1992 Aug;3(4):389-93.
43. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. NO_AUTHOR N Engl J Med. 1995 Dec 14;333(24):1581-7.
44. Age-related changes in coagulation, fibrinolysis, and platelet aggregation in male WBN/Kob rats. Nobukata H, etal., Thromb Res. 2000 Jun 15;98(6):507-16.
45. Is tissue-plasminogen activator gene polymorphism a risk factor for venous thromboembolism in every population? Oguzulgen IK, etal., J Thromb Thrombolysis. 2005 Feb;19(1):61-3.
46. Clinical experience with recombinant tissue plasminogen activator in the management of intracardiac and arterial thrombosis in children. Olgun H, etal., Blood Coagul Fibrinolysis. 2014 Oct;25(7):726-30. doi: 10.1097/MBC.0000000000000134.
47. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
48. Thrombin activation and increased fibrinolysis in patients with chronic liver disease. Paramo JA, etal., Blood Coagul Fibrinolysis. 1991 Apr;2(2):227-30.
49. Blood brain barrier (BBB) dysfunction associated with increased expression of tissue and urokinase plasminogen activators following peripheral thermal injury. Patel TH, etal., Neurosci Lett. 2008 Oct 31;444(3):222-6. Epub 2008 Aug 13.
50. Fraxinus rhynchophylla ethanol extract attenuates carbon tetrachloride-induced liver fibrosis in rats via down-regulating the expressions of uPA, MMP-2, MMP-9 and TIMP-1. Peng WH, etal., J Ethnopharmacol. 2010 Feb 17;127(3):606-13. Epub 2009 Dec 24.
51. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
52. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
53. Mouse MP Annotation Import Pipeline RGD automated import pipeline
54. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
55. Tissue plasminogen activator (tPA) activity is a novel and early marker of asymptomatic LEAD in type 2 diabetes. Sahli D, etal., Thromb Res. 2009 Mar;123(5):701-6. Epub 2008 Oct 21.
56. Association of PAI-1 4G/5G and -844G/A gene polymorphism and changes in PAI-1/tPA levels in stroke: a case-control study. Saidi S, etal., J Stroke Cerebrovasc Dis. 2007 Jul-Aug;16(4):153-9.
57. Fibrin-modifying serine proteases thrombin, tPA, and plasmin in ischemic stroke: a review. Sheehan JJ and Tsirka SE, Glia. 2005 Jun;50(4):340-50.
58. Role of tissue plasminogen activator/plasmin cascade in delayed neuronal death after transient forebrain ischemia. Takahashi H, etal., Neurosci Lett. 2005 Jun 10-17;381(1-2):189-93. Epub 2005 Mar 2.
59. Effect of activated protein C on impaired fibrinolysis in rats with obstructive jaundice. Uchino R, etal., Eur Surg Res. 1992;24(5):298-301.
60. Plasminogen activator inhibitor-1 and tissue-plasminogen activator in minority adolescents with type 2 diabetes and obesity. Umpaichitra V, etal., Pediatr Res. 2005 Sep;58(3):483-7. Epub 2005 May 18.
61. Epinephrine exerts anticoagulant effects during human endotoxemia. van der Poll T, etal., J Exp Med. 1997 Mar 17;185(6):1143-8.
62. Activation of both coagulation and fibrinolysis in childhood hemolytic uremic syndrome. Van Geet C, etal., Kidney Int. 1998 Oct;54(4):1324-30.
63. Coagulofibrinolytic changes in patients with disseminated intravascular coagulation associated with post-cardiac arrest syndrome--fibrinolytic shutdown and insufficient activation of fibrinolysis lead to organ dysfunction. Wada T, etal., Thromb Res. 2013 Jul;132(1):e64-9. doi: 10.1016/j.thromres.2013.05.010. Epub 2013 May 30.
64. Tissue plasminogen activator for the treatment of intraventricular hematoma: the dose-effect relationship. Wang YC, etal., J Neurol Sci. 2002 Oct 15;202(1-2):35-41.
65. Tissue plasminogen activator, von Willebrand factor, and risk of type 2 diabetes in older men. Wannamethee SG, etal., Diabetes Care. 2008 May;31(5):995-1000. Epub 2008 Jan 30.
66. Elevated plasma tissue plasminogen activator and anti-THP-1 antibodies are independently associated with decreased graft survival in cardiac transplant recipients. Warshofsky MK, etal., Am J Cardiol. 2001 Jul 1;88(1):30-4.
67. Chemical sympathectomy attenuates inflammation, glycocalyx shedding and coagulation disorders in rats with acute traumatic coagulopathy. Xu L, etal., Blood Coagul Fibrinolysis. 2015 Mar;26(2):152-60. doi: 10.1097/MBC.0000000000000211.
68. Impact of beta-adrenoceptor blockade on systemic inflammation and coagulation disturbances in rats with acute traumatic coagulopathy. Xu L, etal., Med Sci Monit. 2015 Feb 12;21:468-76. doi: 10.12659/MSM.893544.
69. The role and mechanism of the up-regulation of fibrinolytic activity in painful peripheral nerve injury. Yong N and Guoping C, Neurochem Res. 2009 Mar;34(3):587-92. Epub 2008 Aug 21.
70. Temporal profile of tissue plasminogen activator (tPA) and inhibitor expression after transient focal cerebral ischemia. Zhao G, etal., Neuroreport. 2003 Sep 15;14(13):1689-92.
71. Evaluation of plasma urokinase-type plasminogen activator and urokinase-type plasminogen-activator receptor in patients with acute and chronic hepatitis B. Zhou H, etal., Thromb Res. 2009;123(3):537-42. Epub 2008 Aug 8.
Additional References at PubMed
PMID:1311971   PMID:1326990   PMID:1347472   PMID:1675193   PMID:1733847   PMID:1968046   PMID:1981050   PMID:2037298   PMID:2067848   PMID:2139228   PMID:2542775   PMID:2821634  
PMID:2826484   PMID:3123315   PMID:7523120   PMID:7543410   PMID:7566088   PMID:7579895   PMID:7613031   PMID:7720560   PMID:7743938   PMID:7873877   PMID:7894176   PMID:7941361  
PMID:8088835   PMID:8119140   PMID:8133887   PMID:8188294   PMID:8226859   PMID:8349806   PMID:8397803   PMID:8417372   PMID:8474450   PMID:8508955   PMID:8559144   PMID:8560424  
PMID:8588930   PMID:8604050   PMID:8618918   PMID:8647936   PMID:8649810   PMID:8650190   PMID:8672127   PMID:8710934   PMID:8801257   PMID:8824331   PMID:8944773   PMID:8959348  
PMID:8979118   PMID:8987777   PMID:9013772   PMID:9044044   PMID:9096311   PMID:9110315   PMID:9119016   PMID:9121423   PMID:9287114   PMID:9344654   PMID:9351457   PMID:9398846  
PMID:9406977   PMID:9428515   PMID:9435220   PMID:9438420   PMID:9576763   PMID:9701458   PMID:9727060   PMID:9754557   PMID:10051567   PMID:10064822   PMID:10087208   PMID:10216203  
PMID:10318667   PMID:10349636   PMID:10357813   PMID:10417613   PMID:10438721   PMID:10487767   PMID:10502816   PMID:10559390   PMID:10570208   PMID:10632583   PMID:10716993   PMID:10725249  
PMID:10762331   PMID:10842103   PMID:10858190   PMID:10880388   PMID:10891445   PMID:10922068   PMID:10961882   PMID:11042159   PMID:11044609   PMID:11076861   PMID:11154109   PMID:11157667  
PMID:11213252   PMID:11217851   PMID:11238040   PMID:11238111   PMID:11306532   PMID:11404420   PMID:11441114   PMID:11557572   PMID:11682111   PMID:11682113   PMID:11818362   PMID:11858492  
PMID:11891190   PMID:11920190   PMID:11934869   PMID:12023855   PMID:12032349   PMID:12070304   PMID:12182903   PMID:12270047   PMID:12356640   PMID:12438450   PMID:12466851   PMID:12477932  
PMID:12486171   PMID:12524546   PMID:12657615   PMID:12692088   PMID:12716930   PMID:12748967   PMID:12854826   PMID:12857855   PMID:12875972   PMID:12917371   PMID:14515193   PMID:14523088  
PMID:14617754   PMID:14630814   PMID:14645112   PMID:14651920   PMID:14709993   PMID:14988509   PMID:15033286   PMID:15284078   PMID:15372073   PMID:15448144   PMID:15451307   PMID:15486301  
PMID:15489334   PMID:15522965   PMID:15528930   PMID:15590153   PMID:15603745   PMID:15625301   PMID:15630096   PMID:15631996   PMID:15659235   PMID:15716416   PMID:15841177   PMID:15851587  
PMID:15922607   PMID:15978259   PMID:16049338   PMID:16051896   PMID:16125860   PMID:16127152   PMID:16141072   PMID:16141073   PMID:16148155   PMID:16303771   PMID:16330749   PMID:16410551  
PMID:16505491   PMID:16601674   PMID:16601837   PMID:16602821   PMID:16682647   PMID:16731507   PMID:16763560   PMID:16818777   PMID:16870729   PMID:16908600   PMID:16940168   PMID:16978586  
PMID:17015433   PMID:17049177   PMID:17080225   PMID:17114493   PMID:17122062   PMID:17170123   PMID:17244650   PMID:17286591   PMID:17301181   PMID:17317018   PMID:17321054   PMID:17382917  
PMID:17434507   PMID:17538930   PMID:17561000   PMID:17576803   PMID:17596135   PMID:17673549   PMID:17717150   PMID:17936515   PMID:17944888   PMID:18000864   PMID:18036193   PMID:18037995  
PMID:18042398   PMID:18195371   PMID:18199802   PMID:18199803   PMID:18204848   PMID:18279442   PMID:18628488   PMID:18667463   PMID:18691680   PMID:18842674   PMID:19114596   PMID:19147818  
PMID:19171142   PMID:19181855   PMID:19210287   PMID:19220707   PMID:19286661   PMID:19461880   PMID:19577227   PMID:19584397   PMID:19592578   PMID:19608750   PMID:19672275   PMID:19718485  
PMID:19934446   PMID:20097831   PMID:20140248   PMID:20152175   PMID:20156421   PMID:20175210   PMID:20359476   PMID:20463217   PMID:20636282   PMID:20639453   PMID:20724593   PMID:20856796  
PMID:20864675   PMID:20974200   PMID:21151895   PMID:21267068   PMID:21339035   PMID:21371535   PMID:21383198   PMID:21392255   PMID:21486949   PMID:21519332   PMID:21576385   PMID:21677750  
PMID:21683144   PMID:21704601   PMID:21802414   PMID:21873635   PMID:21931791   PMID:21931850   PMID:21945298   PMID:22016526   PMID:22162045   PMID:22432023   PMID:22560297   PMID:22677557  
PMID:22815500   PMID:22967998   PMID:22972996   PMID:23063501   PMID:23082219   PMID:23236466   PMID:23249568   PMID:23674688   PMID:23707980   PMID:23919993   PMID:23925701   PMID:23939410  
PMID:23940734   PMID:24126163   PMID:24129569   PMID:24155177   PMID:24194600   PMID:24200922   PMID:24269585   PMID:24290069   PMID:24423642   PMID:24478370   PMID:24612416   PMID:24764453  
PMID:24892761   PMID:24918201   PMID:25131752   PMID:25454795   PMID:25474480   PMID:25499620   PMID:25670857   PMID:25893677   PMID:25922513   PMID:25991438   PMID:26068590   PMID:26176694  
PMID:26237273   PMID:26265072   PMID:26377106   PMID:26377459   PMID:26469975   PMID:26647393   PMID:26929275   PMID:27079292   PMID:27283026   PMID:27427941   PMID:27531677   PMID:27626380  
PMID:27959956   PMID:28270519   PMID:28539818   PMID:28684538   PMID:28754830   PMID:28763805   PMID:29370799   PMID:29454747   PMID:29618843   PMID:30090852   PMID:30201709   PMID:30323866  
PMID:30504459   PMID:30550785   PMID:30995314   PMID:30996120   PMID:31392351   PMID:31610810   PMID:32325033   PMID:32579270   PMID:32657780   PMID:32890773   PMID:32928888   PMID:35104175  
PMID:35576527  


Genomics

Comparative Map Data
Plat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,247,655 - 23,272,864 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl823,247,743 - 23,272,860 (+)EnsemblGRCm39 Ensembl
GRCm38822,757,722 - 22,782,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,757,727 - 22,782,844 (+)EnsemblGRCm38mm10GRCm38
MGSCv37823,868,216 - 23,893,320 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36824,223,313 - 24,248,389 (+)NCBIMGSCv36mm8
Celera824,247,228 - 24,272,480 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.42NCBI
PLAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38842,174,718 - 42,207,565 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl842,174,718 - 42,207,709 (-)EnsemblGRCh38hg38GRCh38
GRCh37842,032,236 - 42,065,083 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,151,393 - 42,184,351 (-)NCBINCBI36Build 36hg18NCBI36
Build 34842,151,911 - 42,184,351NCBI
Celera840,981,190 - 41,014,147 (-)NCBICelera
Cytogenetic Map8p11.21NCBI
HuRef840,559,713 - 40,592,984 (-)NCBIHuRef
CHM1_1842,080,535 - 42,113,811 (-)NCBICHM1_1
T2T-CHM13v2.0842,449,037 - 42,481,874 (-)NCBIT2T-CHM13v2.0
Plat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21669,240,582 - 69,265,177 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,240,585 - 69,268,223 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1674,514,320 - 74,538,910 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01677,946,850 - 77,971,428 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01673,195,994 - 73,220,572 (-)NCBIRnor_WKY
Rnor_6.01674,098,263 - 74,122,897 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,098,260 - 74,122,889 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01673,730,256 - 73,754,851 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,711,323 - 73,736,328 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11673,711,587 - 73,736,593 (-)NCBI
Celera1667,134,451 - 67,159,047 (-)NCBICelera
RH 3.4 Map16644.8RGD
Cytogenetic Map16q12.5NCBI
Plat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955536730,981 - 756,394 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955536730,962 - 754,333 (+)NCBIChiLan1.0ChiLan1.0
PLAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1838,864,918 - 38,897,776 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl838,864,918 - 38,897,779 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0841,419,415 - 41,451,951 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PLAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11623,469,590 - 23,496,013 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1623,974,129 - 24,000,506 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01625,217,768 - 25,244,182 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11623,588,653 - 23,615,286 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01624,152,407 - 24,178,867 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01624,203,090 - 24,229,785 (+)NCBIUU_Cfam_GSD_1.0
Plat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494346,519,711 - 46,546,290 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936785476,078 - 503,321 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936785476,200 - 503,371 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1711,195,602 - 11,224,032 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11711,195,599 - 11,223,821 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21713,168,730 - 13,197,126 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1840,164,391 - 40,196,627 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl840,163,891 - 40,196,555 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660521,590,000 - 1,622,258 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247801,028,085 - 1,063,649 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247801,014,429 - 1,063,636 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:201
Count of miRNA genes:174
Interacting mature miRNAs:184
Transcripts:ENSMUST00000033941
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124751082Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8495000035067154Mouse
1357525Pnhdlc3_mplasma non-HDL cholesterol 3 (mouse)Not determined8721249923753815Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8721249935110107Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
11532713Sluc42_msusceptibility to lung cancer 42 (mouse)81344721035321225Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
4142199Poats1_mpost-ovarectomy adrenal tumor susceptibility 1 (mouse)Not determined1708262628849467Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81945501853455150Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81945501853455150Mouse

Markers in Region
RH136350  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38822,782,396 - 22,782,587UniSTSGRCm38
MGSCv37823,892,868 - 23,893,059UniSTSGRCm37
Celera824,272,028 - 24,272,219UniSTS
Cytogenetic Map8A2UniSTS
cM Map89.0UniSTS
RH136573  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38822,776,270 - 22,776,468UniSTSGRCm38
MGSCv37823,886,742 - 23,886,940UniSTSGRCm37
Celera824,265,862 - 24,266,060UniSTS
Cytogenetic Map8A2UniSTS
cM Map89.0UniSTS
AW212668  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38822,782,556 - 22,782,639UniSTSGRCm38
MGSCv37823,893,028 - 23,893,111UniSTSGRCm37
Celera824,272,188 - 24,272,271UniSTS
Cytogenetic Map8A2UniSTS
cM Map89.0UniSTS
Whitehead/MRC_RH8253.13UniSTS
RH94475  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38822,782,349 - 22,782,523UniSTSGRCm38
MGSCv37823,892,821 - 23,892,995UniSTSGRCm37
Celera824,271,981 - 24,272,155UniSTS
Cytogenetic Map8A2UniSTS
cM Map89.0UniSTS
RH125941  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38822,782,509 - 22,782,734UniSTSGRCm38
MGSCv37823,892,981 - 23,893,206UniSTSGRCm37
Celera824,272,141 - 24,272,366UniSTS
Cytogenetic Map8A2UniSTS
cM Map89.0UniSTS
cM Map88.0UniSTS
Whitehead/MRC_RH8260.61UniSTS
UniSTS:224830  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38822,782,165 - 22,782,323UniSTSGRCm38
MGSCv37823,892,637 - 23,892,795UniSTSGRCm37
Celera824,271,797 - 24,271,955UniSTS
Cytogenetic Map8A2UniSTS
cM Map89.0UniSTS
Plat  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38822,767,110 - 22,768,462UniSTSGRCm38
MGSCv37823,877,582 - 23,878,934UniSTSGRCm37
Celera824,256,684 - 24,258,036UniSTS
Cytogenetic Map8A2UniSTS
cM Map89.0UniSTS
Plat  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38822,776,841 - 22,778,226UniSTSGRCm38
MGSCv37823,887,313 - 23,888,698UniSTSGRCm37
Celera824,266,429 - 24,267,814UniSTS
Cytogenetic Map8A2UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC121835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC142414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ146601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ151826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV644940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000033941   ⟹   ENSMUSP00000033941
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl823,247,763 - 23,272,860 (+)Ensembl
GRCm38.p6 Ensembl822,757,747 - 22,782,844 (+)Ensembl
RefSeq Acc Id: ENSMUST00000210960
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl823,247,743 - 23,266,211 (+)Ensembl
GRCm38.p6 Ensembl822,757,727 - 22,776,195 (+)Ensembl
RefSeq Acc Id: ENSMUST00000211033
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl823,247,811 - 23,249,520 (+)Ensembl
GRCm38.p6 Ensembl822,757,795 - 22,759,504 (+)Ensembl
RefSeq Acc Id: NM_008872   ⟹   NP_032898
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39823,247,738 - 23,272,864 (+)NCBI
GRCm38822,757,722 - 22,782,848 (+)NCBI
MGSCv37823,868,216 - 23,893,320 (+)RGD
Celera824,247,228 - 24,272,480 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036153826   ⟹   XP_036009719
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39823,256,000 - 23,272,862 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036153827   ⟹   XP_036009720
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39823,247,655 - 23,272,862 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032898   ⟸   NM_008872
- Peptide Label: preproprotein
- UniProtKB: Q91VP2 (UniProtKB/Swiss-Prot),   P11214 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000033941   ⟸   ENSMUST00000033941
RefSeq Acc Id: XP_036009720   ⟸   XM_036153827
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036009719   ⟸   XM_036153826
- Peptide Label: isoform X1
- UniProtKB: Q91VP2 (UniProtKB/Swiss-Prot)
Protein Domains
EGF-like   Fibronectin type-I   Kringle   Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11214-F1-model_v2 AlphaFold P11214 1-559 view protein structure

Promoters
RGD ID:8666691
Promoter ID:EPDNEW_M11377
Type:multiple initiation site
Name:Plat_1
Description:Mus musculus plasminogen activator, tissue , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38822,757,754 - 22,757,814EPDNEW
RGD ID:6843617
Promoter ID:MM_KWN:53936
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_008872,   UC009LDW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36823,867,786 - 23,868,357 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97610 AgrOrtholog
Ensembl Genes ENSMUSG00000031538 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000033941 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033941 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
  2.40.20.10 UniProtKB/Swiss-Prot
InterPro EGF-like_dom UniProtKB/Swiss-Prot
  Fibronectin_type1 UniProtKB/Swiss-Prot
  Kringle UniProtKB/Swiss-Prot
  Kringle-like UniProtKB/Swiss-Prot
  Kringle_CS UniProtKB/Swiss-Prot
  Kringle_sf UniProtKB/Swiss-Prot
  Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Tissue_plasm_act UniProtKB/Swiss-Prot
  tPA UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report mmu:18791 UniProtKB/Swiss-Prot
MGD MGI:97610 ENTREZGENE
NCBI Gene 18791 ENTREZGENE
PANTHER PTHR24264:SF42 UniProtKB/Swiss-Prot
Pfam EGF UniProtKB/Swiss-Prot
  fn1 UniProtKB/Swiss-Prot
  Kringle UniProtKB/Swiss-Prot
  Trypsin UniProtKB/Swiss-Prot
PhenoGen Plat PhenoGen
PIRSF Tissue_plasm_act UniProtKB/Swiss-Prot
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  FN1_1 UniProtKB/Swiss-Prot
  FN1_2 UniProtKB/Swiss-Prot
  KRINGLE_1 UniProtKB/Swiss-Prot
  KRINGLE_2 UniProtKB/Swiss-Prot
  TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
SMART EGF UniProtKB/Swiss-Prot
  FN1 UniProtKB/Swiss-Prot
  SM00130 UniProtKB/Swiss-Prot
  Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
  SSF57440 UniProtKB/Swiss-Prot
UniProt P11214 ENTREZGENE
  Q91VP2 ENTREZGENE
  TPA_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q6P7U0 UniProtKB/Swiss-Prot
  Q91VP2 UniProtKB/Swiss-Prot